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Q871M9

- BUR1_NEUCR

UniProt

Q871M9 - BUR1_NEUCR

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Protein
Serine/threonine-protein kinase bur1
Gene
stk-1, bur1, B20D17.070, NCU01435
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the mus-8/ubc2 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691ATP By similarity
Active sitei171 – 1711Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 549ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase bur1 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Serine-threonine kinase 1
Gene namesi
Name:stk-1
Synonyms:bur1
ORF Names:B20D17.070, NCU01435
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 2, Linkage Group V

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Serine/threonine-protein kinase bur1
PRO_0000085685Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 341302Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi380 – 480101Gly-rich
Add
BLAST
Compositional biasi499 – 55961Arg-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024.
KOiK15562.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q871M9-1 [UniParc]FASTAAdd to Basket

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MSIDEAKEGG GGPAMSPRAF ALAHQRDRGS FVGCSRIADY EVLGKLGEGT    50
FGEVHRARSR KTGALVALKK IIMHNERDGF PITALREIKL LKLLSHKNVL 100
RLEEMAIEHP PRTDKRTRPI VYMVTPYMDH DLSGLLDNPS VRFTEPQVKC 150
YLLQLLEGLK YLHANHILHR DMKAANLLIN NKGVLQIADF GLARHYEGDI 200
PQPGKGSGEG KRDYTSLVVT RWYRPPELLM HLKRYTTAID MWGVGCVFAE 250
MLEGKPVLQG ESDLHQLELV WDLCGTPSEE TMPGWRTLPG GQAFSSKPRP 300
GNLARRFEKH GPVVISLLKE LFKLDWRSRI NAIDALNHPY FRTAPLPALP 350
GDLPTFEESH EFDRRKFQDR KAALPPAPKG GTVGRGAVVN SQGPDTGFSG 400
RDGYGGGGRN GANGGRYPPY HRGPPPGDER VPSWHSARGL PPRPPMPADY 450
HGSGPMDHTD GYRDRPPRRG PGGPPGGGGG PSNVDTYIPS YDRDGPAPRR 500
EDWRRRDDWD DRRGGVDRDR RRPEYDVRSR DSRTRSRTRS RSPVRDRDRG 550
RDRDAYARR 559
Length:559
Mass (Da):62,666
Last modified:March 19, 2014 - v2
Checksum:i43F1136CB67D8CA2
GO

Sequence cautioni

The sequence CAD70970.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294023 Genomic DNA. Translation: CAD70970.1. Different initiation.
CM002240 Genomic DNA. Translation: EAA26759.3.
RefSeqiXP_955995.2. XM_950902.2.
UniGeneiNcr.25840.

Genome annotation databases

EnsemblFungiiEFNCRT00000007599; EFNCRP00000007589; EFNCRG00000007587.
GeneIDi3872142.
KEGGincr:NCU01435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294023 Genomic DNA. Translation: CAD70970.1 . Different initiation.
CM002240 Genomic DNA. Translation: EAA26759.3 .
RefSeqi XP_955995.2. XM_950902.2.
UniGenei Ncr.25840.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000007599 ; EFNCRP00000007589 ; EFNCRG00000007587 .
GeneIDi 3872142.
KEGGi ncr:NCU01435.

Phylogenomic databases

HOGENOMi HOG000233024.
KOi K15562.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiBUR1_NEUCR
AccessioniPrimary (citable) accession number: Q871M9
Secondary accession number(s): Q7RWH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 19, 2014
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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