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Q871M9 (BUR1_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase bur1

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Serine-threonine kinase 1
Gene names
Name:stk-1
Synonyms:bur1
ORF Names:B20D17.070, NCU01435
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the mus-8/ubc2 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence CAD70970.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Serine/threonine-protein kinase bur1
PRO_0000085685

Regions

Domain40 – 341302Protein kinase
Nucleotide binding46 – 549ATP By similarity
Compositional bias380 – 480101Gly-rich
Compositional bias499 – 55961Arg-rich

Sites

Active site1711Proton acceptor By similarity
Binding site691ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q871M9 [UniParc].

Last modified March 19, 2014. Version 2.
Checksum: 43F1136CB67D8CA2

FASTA55962,666
        10         20         30         40         50         60 
MSIDEAKEGG GGPAMSPRAF ALAHQRDRGS FVGCSRIADY EVLGKLGEGT FGEVHRARSR 

        70         80         90        100        110        120 
KTGALVALKK IIMHNERDGF PITALREIKL LKLLSHKNVL RLEEMAIEHP PRTDKRTRPI 

       130        140        150        160        170        180 
VYMVTPYMDH DLSGLLDNPS VRFTEPQVKC YLLQLLEGLK YLHANHILHR DMKAANLLIN 

       190        200        210        220        230        240 
NKGVLQIADF GLARHYEGDI PQPGKGSGEG KRDYTSLVVT RWYRPPELLM HLKRYTTAID 

       250        260        270        280        290        300 
MWGVGCVFAE MLEGKPVLQG ESDLHQLELV WDLCGTPSEE TMPGWRTLPG GQAFSSKPRP 

       310        320        330        340        350        360 
GNLARRFEKH GPVVISLLKE LFKLDWRSRI NAIDALNHPY FRTAPLPALP GDLPTFEESH 

       370        380        390        400        410        420 
EFDRRKFQDR KAALPPAPKG GTVGRGAVVN SQGPDTGFSG RDGYGGGGRN GANGGRYPPY 

       430        440        450        460        470        480 
HRGPPPGDER VPSWHSARGL PPRPPMPADY HGSGPMDHTD GYRDRPPRRG PGGPPGGGGG 

       490        500        510        520        530        540 
PSNVDTYIPS YDRDGPAPRR EDWRRRDDWD DRRGGVDRDR RRPEYDVRSR DSRTRSRTRS 

       550 
RSPVRDRDRG RDRDAYARR 

« Hide

References

[1]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX294023 Genomic DNA. Translation: CAD70970.1. Different initiation.
CM002240 Genomic DNA. Translation: EAA26759.3.
RefSeqXP_955995.2. XM_950902.2.
UniGeneNcr.25840.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000007599; EFNCRP00000007589; EFNCRG00000007587.
GeneID3872142.
KEGGncr:NCU01435.

Phylogenomic databases

HOGENOMHOG000233024.
KOK15562.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBUR1_NEUCR
AccessionPrimary (citable) accession number: Q871M9
Secondary accession number(s): Q7RWH6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 19, 2014
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families