Serine/threonine-protein kinase bur-1 - Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase bur-1
EC=2.7.11.22
EC=2.7.11.23

Gene names

Name:	bur-1
ORF Names:	B20D17.070, NCU01435

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora ›

Protein attributes

Sequence length	545 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence EAA26759.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: GOC
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activity Inferred from electronic annotation. Source: EC cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 545

545

Serine/threonine-protein kinase bur-1

PRO_0000085685

Regions

Domain

26 – 327

302

Protein kinase

Nucleotide binding

32 – 40

9

ATP By similarity

Compositional bias

366 – 466

101

Gly-rich

Compositional bias

485 – 545

61

Arg-rich

Sites

Active site

157

1

Proton acceptor By similarity

Binding site

55

1

ATP By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q871M9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: C6A4D1DAB59A07DB
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FASTA

545

61,365

        10         20         30         40         50         60 
MSPRAFALAH QRDRGSFVGC SRIADYEVLG KLGEGTFGEV HRARSRKTGA LVALKKIIMH 

        70         80         90        100        110        120 
NERDGFPITA LREIKLLKLL SHKNVLRLEE MAIEHPPRTD KRTRPIVYMV TPYMDHDLSG 

       130        140        150        160        170        180 
LLDNPSVRFT EPQVKCYLLQ LLEGLKYLHA NHILHRDMKA ANLLINNKGV LQIADFGLAR 

       190        200        210        220        230        240 
HYEGDIPQPG KGSGEGKRDY TSLVVTRWYR PPELLMHLKR YTTAIDMWGV GCVFAEMLEG 

       250        260        270        280        290        300 
KPVLQGESDL HQLELVWDLC GTPSEETMPG WRTLPGGQAF SSKPRPGNLA RRFEKHGPVV 

       310        320        330        340        350        360 
ISLLKELFKL DWRSRINAID ALNHPYFRTA PLPALPGDLP TFEESHEFDR RKFQDRKAAL 

       370        380        390        400        410        420 
PPAPKGGTVG RGAVVNSQGP DTGFSGRDGY GGGGRNGANG GRYPPYHRGP PPGDERVPSW 

       430        440        450        460        470        480 
HSARGLPPRP PMPADYHGSG PMDHTDGYRD RPPRRGPGGP PGGGGGPSNV DTYIPSYDRD 

       490        500        510        520        530        540 
GPAPRREDWR RRDDWDDRRG GVDRDRRRPE YDVRSRDSRT RSRTRSRSPV RDRDRGRDRD 


AYARR

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References

[1]

"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

[2]

"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.

Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX294023 Genomic DNA. Translation: CAD70970.1. AABX02000041 Genomic DNA. Translation: EAA26759.2. Sequence problems.
RefSeq	XP_955995.2. XM_950902.2.
UniGene	Ncr.25840.
3D structure databases
ProteinModelPortal	Q871M9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000007599; EFNCRP00000007589; EFNCRG00000007587.
GeneID	3872142.
KEGG	ncr:NCU01435.
Phylogenomic databases
HOGENOM	HOG000233024.
OrthoDB	EOG41K2MW.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BUR1_NEUCR

Accession

Primary (citable) accession number: Q871M9
Secondary accession number(s): Q7RWH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families