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Protein

Mannose-6-phosphate isomerase

Gene

103E1.170

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (103E1.170)
  2. Phosphomannomutase (sec53)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109ZincBy similarity1
Metal bindingi111ZincBy similarity1
Metal bindingi136ZincBy similarity1
Metal bindingi289ZincBy similarity1
Active sitei308By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
ORF Names:103E1.170, NCU07165
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

EuPathDBiFungiDB:NCU07165.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942451 – 459Mannose-6-phosphate isomeraseAdd BLAST459

Structurei

3D structure databases

ProteinModelPortaliQ870Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000241277.
InParanoidiQ870Y1.
KOiK01809.
OMAiNYVKLEV.
OrthoDBiEOG092C3NWF.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 2 hits.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q870Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPVPLIQLQ CGVNSYEWGK KGNSSRAAQF AAASLDDNEF KIDEEKPYAE
60 70 80 90 100
LWMGTHPSNP SKDKHTGRTL LELIQDNQAL LSPAIAERYQ NKLPFLFKVL
110 120 130 140 150
SIQKALSIQA HPNKKLAEKL HARDPKNYPD DNHKPEMAIA ISDFEGLCGF
160 170 180 190 200
RPLKEIAHFL DNVPALRQLV GEDKAKAFVE TVKRNDGNES DEATAENKKV
210 220 230 240 250
LQSAFGALMA SSEADMTAAA DKLVQSAKSA GADFTGTAVP SPGGAKLSEL
260 270 280 290 300
VGRLHGQFGA DYGLFVLFFL NFVEMKAGEA IYLRADDIHA YISGDIIECM
310 320 330 340 350
ASSDNVVRAG FTPKFKDVDN LVNMLTYDFA PIEQQKMEPT DYTQDVKNKR
360 370 380 390 400
EAGATLNQTA IDSQSEIVEY NPPIEEFSVV RSLLKSQGSK VTFKPIDGPS
410 420 430 440 450
IIICTQGQGK ISVGPKVQEI KKGHVFFVGA TAECVLESED DKFETFKAFC

VLDEQSNGN
Length:459
Mass (Da):50,364
Last modified:June 1, 2003 - v1
Checksum:iD4962FC4C0AB88F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294028 Genomic DNA. Translation: CAD71127.1.
CM002240 Genomic DNA. Translation: EAA28154.1.
RefSeqiXP_957390.1. XM_952297.2.

Genome annotation databases

EnsemblFungiiEAA28154; EAA28154; NCU07165.
GeneIDi3873528.
KEGGincr:NCU07165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294028 Genomic DNA. Translation: CAD71127.1.
CM002240 Genomic DNA. Translation: EAA28154.1.
RefSeqiXP_957390.1. XM_952297.2.

3D structure databases

ProteinModelPortaliQ870Y1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA28154; EAA28154; NCU07165.
GeneIDi3873528.
KEGGincr:NCU07165.

Organism-specific databases

EuPathDBiFungiDB:NCU07165.

Phylogenomic databases

HOGENOMiHOG000241277.
InParanoidiQ870Y1.
KOiK01809.
OMAiNYVKLEV.
OrthoDBiEOG092C3NWF.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00423.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 2 hits.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPI_NEUCR
AccessioniPrimary (citable) accession number: Q870Y1
Secondary accession number(s): Q1K5X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.