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Protein

Transcription factor iws-1

Gene

iws-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor iws-1
Gene namesi
Name:iws-1
ORF Names:B1D14.130, NCU09203
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU09203.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Transcription factor iws-1PRO_0000083362Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini244 – 32178TFIIS N-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the IWS1 family.Curated
Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000206516.
InParanoidiQ870S2.
KOiK17498.
OMAiWSRPILK.
OrthoDBiEOG7N0CHQ.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR017923. TFIIS_N.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS51319. TFIIS_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q870S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAASPAGS PAAEPTEHRD EDQVNETHQD DGSNHGGNDE DNDGGNDKDS
60 70 80 90 100
DVLSEIDENE FGDDYGSRPV DIDENVAMKL KARRKTTTET TKKPKEGRRP
110 120 130 140 150
KKRSRGDDDV DAADDDGERR PRKVRAEGER RARKEVEEQQ AQQEENLTPD
160 170 180 190 200
ERRRRALERA IDAAVKNPTK RRRKKDDIDL EEETDEQIAN LKVAMEKACV
210 220 230 240 250
ADNEAREQKQ PAVHKLKLLP QVTAILNRTA IQDSVLDPEI NFLQSVRYFL
260 270 280 290 300
EPLNDGSLPA YNIQRAIMSA LMKLPINKDV LLSSGIGKVV VYYNKSKSPS
310 320 330 340 350
ADIKRDAERL LGEWSRLILK RTDDYKKRHI EMREIDVGAV KLGQREGGSS
360 370 380 390 400
QVTLTQRPAG KSRYEIERER ALAPEVRNNN RARPVGLPAS YTIAPKSTYI
410 420 430
PGQAPTDHRP IGHSGHEAFR RMTQKGKGKR
Length:430
Mass (Da):48,433
Last modified:June 1, 2003 - v1
Checksum:iBCFB4D9C7303DAB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX295539 Genomic DNA. Translation: CAD79656.1.
CM002236 Genomic DNA. Translation: EAA29911.1.
RefSeqiXP_959147.1. XM_954054.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000008878; EFNCRP00000008860; EFNCRG00000008864.
GeneIDi3875299.
KEGGincr:NCU09203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX295539 Genomic DNA. Translation: CAD79656.1.
CM002236 Genomic DNA. Translation: EAA29911.1.
RefSeqiXP_959147.1. XM_954054.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000008878; EFNCRP00000008860; EFNCRG00000008864.
GeneIDi3875299.
KEGGincr:NCU09203.

Organism-specific databases

EuPathDBiFungiDB:NCU09203.

Phylogenomic databases

HOGENOMiHOG000206516.
InParanoidiQ870S2.
KOiK17498.
OMAiWSRPILK.
OrthoDBiEOG7N0CHQ.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR017923. TFIIS_N.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS51319. TFIIS_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiIWS1_NEUCR
AccessioniPrimary (citable) accession number: Q870S2
Secondary accession number(s): Q1K6D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2003
Last modified: February 17, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.