Q87022 (RDRP_SCVLA) Reviewed, UniProtKB/Swiss-Prot
Last modified April 3, 2013. Version 48. History...
Names and origin
|Protein names||Recommended name:|
Probable RNA-directed RNA polymerase
|Organism||Saccharomyces cerevisiae virus L-A (ScV-L-A) (ScVL1) [Reference proteome]|
|Taxonomic identifier||11008 [NCBI]|
|Taxonomic lineage||Viruses › dsRNA viruses › Totiviridae › Totivirus|
|Virus host||Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932]|
|Sequence length||1505 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
RNA-dependent RNA polymerase which replicates the viral genome. Catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded from the virion into the cytoplasm where they function as mRNAs for translation of viral proteins and also as substrates for encapsidation to form new virions. Once encapsidated, the positive strand is converted to dsRNA by the RNA-directed RNA polymerase. Displays ssRNA-binding activity.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
One molecule or two of Gag capsid protein is replaced in the virion by Gag-Pol because the fusion protein is essential for RNA encapsidation and replication.
Belongs to the totiviridae RNA-directed RNA polymerase family.
The sequence AAA50507.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence AAA50508.1 differs from that shown. Reason: Erroneous gene model prediction.
|Biological process||Viral RNA replication|
|Coding sequence diversity||Ribosomal frameshifting|
RNA-directed RNA polymerase
|Technical term||Complete proteome|
|Gene Ontology (GO)|
Inferred from electronic annotation. Source: InterPro
Inferred from electronic annotation. Source: UniProtKB-KWRNA-directed RNA polymerase activity
Inferred from electronic annotation. Source: UniProtKB-KWhydrolase activity
Inferred from electronic annotation. Source: UniProtKB-KWnucleotide binding
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
|This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]|
|Isoform RNA-directed RNA polymerase (identifier: Q87022-1) |
Also known as: Pol protein;
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
|Note: Produced by -1 ribosomal frameshifting.|
|Isoform Major capsid protein (identifier: P32503-1) |
Also known as: Gag protein;
The sequence of this isoform can be found in the external entry P32503.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
|Note: Produced by conventional translation.|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 1505||1505||Probable RNA-directed RNA polymerase||PRO_0000402407|
|J04692 Genomic RNA. Translation: AAA50507.1. Sequence problems.|
J04692 Genomic RNA. Translation: AAA50508.1. Sequence problems.
|RefSeq||NP_620493.1. NC_003745.1. |
3D structure databases
Protocols and materials databases
Genome annotation databases
Family and domain databases
|InterPro||IPR015302. Major_coat_LA-virus. |
|Pfam||PF09220. LA-virus_coat. 1 hit. |
PF02123. RdRP_4. 1 hit.
|SUPFAM||SSF82856. Major_coat_LA-virus. 1 hit. |
|Accession||Primary (citable) accession number: Q87022|
Secondary accession number(s): Q87023
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families