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Protein

Glutamine synthetase

Gene

GLN1

Organism
Tuber borchii (White truffle)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.1.2. 7423.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:GLN1
OrganismiTuber borchii (White truffle)
Taxonomic identifieri42251 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Glutamine synthetasePRO_0000153164Add
BLAST

Interactioni

Subunit structurei

Homooctamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ86ZU6.
SMRiQ86ZU6. Positions 16-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86ZU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENSTIVSN TANLVKFLNL DQKGSILAEY IWIDGANGVR SKTKTLFKKP
60 70 80 90 100
SSVEDLPEWN FDGSSTGQAP GEDSDIYLRP VAIFPDPFRM GDNILVLAEC
110 120 130 140 150
WNADGSPNKF NHRHECAKIM EAHKDQKPWF GLEQEYTLFD LYGNPYGWPK
160 170 180 190 200
GGFPGPQGPY YCGVGTGKVY CRDIVEAHYK ACLFAGIKIS GINAEVLPSQ
210 220 230 240 250
WEFQVGPCVG IEMGDHLWIS RYLLHRVAEE FGVKISFHPK PIPGDWNGSG
260 270 280 290 300
LHTNVSTQAM RDEGGMKAIE EAIQKLSTRH AEHIAVYGDD NTLRLTGRHE
310 320 330 340 350
TGNIDAFSYG VADRGSSIRI PRSCAKEGKG YFEDRRPASN ACPYQITGIM

METICGGI
Length:358
Mass (Da):39,664
Last modified:May 31, 2003 - v1
Checksum:i4BF82095152856E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462037 mRNA. Translation: AAP23163.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462037 mRNA. Translation: AAP23163.1.

3D structure databases

ProteinModelPortaliQ86ZU6.
SMRiQ86ZU6. Positions 16-355.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi6.3.1.2. 7423.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Distinctive properties and expression profiles of glutamine synthetase from a plant symbiotic fungus."
    Montanini B., Betti M., Marquez A.J., Balestrini R., Bonfante P., Ottonello S.
    Biochem. J. 373:357-368(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGLNA_TUBBO
AccessioniPrimary (citable) accession number: Q86ZU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2004
Last sequence update: May 31, 2003
Last modified: January 6, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.