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Q86ZF9

- GLNA_NEUCR

UniProt

Q86ZF9 - GLNA_NEUCR

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Protein
Glutamine synthetase
Gene
gln-1, B11H7.090, NCU06724
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13460.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:gln-1
ORF Names:B11H7.090, NCU06724
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 2, Linkage Group V

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Glutamine synthetase
PRO_0000153161Add
BLAST

Interactioni

Subunit structurei

Homooctamer By similarity.

Protein-protein interaction databases

STRINGi5141.NCU06724.1.

Structurei

3D structure databases

ProteinModelPortaliQ86ZF9.
SMRiQ86ZF9. Positions 17-357.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000061500.
KOiK01915.
OMAiRIPRNVG.
OrthoDBiEOG7GTTD8.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86ZF9-1 [UniParc]FASTAAdd to Basket

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MASESTILSN AENLKKFLRL PQNGQLIAEY IWIDSEGGTR SKSRTLPEKE    50
SQYLPEELPI WNFDGSSTGQ APGENSDVYL KPVAVFPDPF RGSPNILVLS 100
ECWNADGTPN KFNHRHEAAK LMEAHADQVP WFGLEQEYTL LDINDRPYGW 150
PRNGFPAPQG PYYCGVGTGK VVQRDIVEAH YKCCLYAGVK ISGTNAEVMP 200
AQWEFQVGPC DGIEMGDHLW LARFLLHRVS EEFGAKVSFD PKPIPGDWNG 250
AGLHTNFSTE NMRKEGGMKY IEDAIKKLEA RHKEHIAVYG EGNDKRLTGR 300
HETGSIDSFT YGVANRGASI RIPRECGAKG YGYFEDRRPA SNADPYQITG 350
IIMETCFGAV SE 362
Length:362
Mass (Da):40,372
Last modified:June 1, 2003 - v1
Checksum:i04DE6583D222ADF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294092 Genomic DNA. Translation: CAD71248.1.
CM002240 Genomic DNA. Translation: EAA31668.2.
RefSeqiXP_960904.2. XM_955811.2.
UniGeneiNcr.25115.

Genome annotation databases

EnsemblFungiiEFNCRT00000006625; EFNCRP00000006616; EFNCRG00000006613.
GeneIDi3877042.
KEGGincr:NCU06724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294092 Genomic DNA. Translation: CAD71248.1 .
CM002240 Genomic DNA. Translation: EAA31668.2 .
RefSeqi XP_960904.2. XM_955811.2.
UniGenei Ncr.25115.

3D structure databases

ProteinModelPortali Q86ZF9.
SMRi Q86ZF9. Positions 17-357.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5141.NCU06724.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000006625 ; EFNCRP00000006616 ; EFNCRG00000006613 .
GeneIDi 3877042.
KEGGi ncr:NCU06724.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000061500.
KOi K01915.
OMAi RIPRNVG.
OrthoDBi EOG7GTTD8.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-13460.

Family and domain databases

Gene3Di 3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiGLNA_NEUCR
AccessioniPrimary (citable) accession number: Q86ZF9
Secondary accession number(s): Q7RVC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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