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Q86ZF2

- FKBP2_PODAS

UniProt

Q86ZF2 - FKBP2_PODAS

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Protein

FK506-binding protein 2

Gene
FPR2, Pa5G0006
Organism
Podospora anserina (Pleurage anserina)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin By similarity.

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein 2 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:FPR2
ORF Names:Pa5G0006
OrganismiPodospora anserina (Pleurage anserina)
Taxonomic identifieri5145 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora

Subcellular locationi

Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 185165FK506-binding protein 2PRO_0000233071Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ86ZF2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 12989PPIase FKBP-typeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi182 – 1854Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86ZF2-1 [UniParc]FASTAAdd to Basket

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MQGLLLSLSL LASAAVGVLA SDDLKIDVTL PVECDRVTKK GDKINVHYKG    50
TLKSNGEKFD SSYDRQSPFS FKLGAGMVIK GWDEGLVDMC IGEKRTLTIG 100
PSYGYGDRNV GPIPAGSTLV FETELVGIEG VPKPESIVTK SATDAPESTA 150
SAKVVEKVAS VAKQAAEVVE TIIADTDDTQ EHNEL 185
Length:185
Mass (Da):19,601
Last modified:June 1, 2003 - v1
Checksum:iB71660B80858D599
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL627362 Genomic DNA. Translation: CAD60614.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL627362 Genomic DNA. Translation: CAD60614.1 .

3D structure databases

ProteinModelPortali Q86ZF2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the genomic organization of the region bordering the centromere of chromosome V of Podospora anserina by direct sequencing."
    Silar P., Barreau C., Debuchy R., Kicka S., Turcq B., Sainsard-Chanet A., Sellem C.H., Billault A., Cattolico L., Duprat S., Weissenbach J.
    Fungal Genet. Biol. 39:250-263(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: s.

Entry informationi

Entry nameiFKBP2_PODAS
AccessioniPrimary (citable) accession number: Q86ZF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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