Q86ZF2 (FKBP2_PODAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FK506-binding protein 2
EC=5.2.1.8

Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name=PPIase
Rotamase

Gene names

Name:	FPR2
ORF Names:	Pa5G0006

Organism

Podospora anserina (Pleurage anserina)

Taxonomic identifier

5145 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Lasiosphaeriaceae › Podospora

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Inhibited by both FK506 and rapamycin By similarity.
Subcellular location	Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the FKBP-type PPIase family. FKBP2 subfamily. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Molecular function	Isomerase Rotamase
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 185	165	FK506-binding protein 2		PRO_0000233071
Regions
	Domain	41 – 129	89	PPIase FKBP-type
	Motif	182 – 185	4	Prevents secretion from ER Potential

Sequences

	Sequence		Length	Mass (Da)
	Q86ZF2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B71660B80858D599	FASTA	185	19,601
	10 20 30 40 50 60 MQGLLLSLSL LASAAVGVLA SDDLKIDVTL PVECDRVTKK GDKINVHYKG TLKSNGEKFD 70 80 90 100 110 120 SSYDRQSPFS FKLGAGMVIK GWDEGLVDMC IGEKRTLTIG PSYGYGDRNV GPIPAGSTLV 130 140 150 160 170 180 FETELVGIEG VPKPESIVTK SATDAPESTA SAKVVEKVAS VAKQAAEVVE TIIADTDDTQ EHNEL

References

[1]

"Characterization of the genomic organization of the region bordering the centromere of chromosome V of Podospora anserina by direct sequencing." Silar P., Barreau C., Debuchy R., Kicka S., Turcq B., Sainsard-Chanet A., Sellem C.H., Billault A., Cattolico L., Duprat S., Weissenbach J. Fungal Genet. Biol. 39:250-263(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: s.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL627362 Genomic DNA. Translation: CAD60614.1.
3D structure databases
ProteinModelPortal	Q86ZF2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR023566. PPIase_FKBP. IPR001179. PPIase_FKBP_dom. [Graphical view]
PANTHER	PTHR10516. PTHR10516. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS00014. ER_TARGET. 1 hit. PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FKBP2_PODAS

Accession

Primary (citable) accession number: Q86ZF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	June 1, 2003
Last modified:	October 3, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program