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Q86ZF2 (FKBP2_PODAS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FK506-binding protein 2

EC=5.2.1.8
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name=PPIase
Rotamase
Gene names
Name:FPR2
ORF Names:Pa5G0006
OrganismPodospora anserina (Pleurage anserina)
Taxonomic identifier5145 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by both FK506 and rapamycin By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the FKBP-type PPIase family. FKBP2 subfamily.

Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionIsomerase
Rotamase
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 185165FK506-binding protein 2
PRO_0000233071

Regions

Domain41 – 12989PPIase FKBP-type
Motif182 – 1854Prevents secretion from ER Potential

Sequences

Sequence LengthMass (Da)Tools
Q86ZF2 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B71660B80858D599

FASTA18519,601
        10         20         30         40         50         60 
MQGLLLSLSL LASAAVGVLA SDDLKIDVTL PVECDRVTKK GDKINVHYKG TLKSNGEKFD 

        70         80         90        100        110        120 
SSYDRQSPFS FKLGAGMVIK GWDEGLVDMC IGEKRTLTIG PSYGYGDRNV GPIPAGSTLV 

       130        140        150        160        170        180 
FETELVGIEG VPKPESIVTK SATDAPESTA SAKVVEKVAS VAKQAAEVVE TIIADTDDTQ 


EHNEL 

« Hide

References

[1]"Characterization of the genomic organization of the region bordering the centromere of chromosome V of Podospora anserina by direct sequencing."
Silar P., Barreau C., Debuchy R., Kicka S., Turcq B., Sainsard-Chanet A., Sellem C.H., Billault A., Cattolico L., Duprat S., Weissenbach J.
Fungal Genet. Biol. 39:250-263(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: s.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL627362 Genomic DNA. Translation: CAD60614.1.

3D structure databases

ProteinModelPortalQ86ZF2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFKBP2_PODAS
AccessionPrimary (citable) accession number: Q86ZF2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families