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Q86ZF1

- ACEA_LEPMC

UniProt

Q86ZF1 - ACEA_LEPMC

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Protein

Isocitrate lyase

Gene
ICL1
Organism
Leptosphaeria maculans (Blackleg fungus) (Phoma lingam)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate = succinate + glyoxylate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei206 – 2061 By similarity

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:ICL1
OrganismiLeptosphaeria maculans (Blackleg fungus) (Phoma lingam)
Taxonomic identifieri5022 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaeLeptosphaeriaceaeLeptosphaeriaLeptosphaeria maculans complex

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Isocitrate lyasePRO_0000068792Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ86ZF1.
SMRiQ86ZF1. Positions 2-520.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86ZF1-1 [UniParc]FASTAAdd to Basket

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MSHMDAEDAQ FQKEVAEVKQ WWNDSRWRYT KRTFTAEEIV SKRGNLKITY    50
PSNSQSKKLW NIVEHRFKNK DVSYTYGCLD PVMVTQMAKY LDTVYVSGWQ 100
ASSTASSTDE PGPDLADYPY TTVPNKVGHL FMAQLFHDRK QREERLTTPK 150
ADRAKVANVD YLRPIIADAD TGHGGLTAIM KLTKLFIEKG AAGIHIEDQA 200
PGTKKCGHMA GKVLVPISEH INRLVAIRAQ ADIMGTDLLA VARTDSEAAT 250
LITSTIDPRD HYYIQGCTNP ALQPLSELMY AAEQSGKSGS ELQAIEDAWV 300
KEANLKLFHE AVVDTINAGV HVNKQELINQ FLEQSKGKSN AEARTIAQGL 350
TGVDVYFNWD AARTREGYYR YKGGCQCAIN RAIAYAPFCD MIWMESKLPD 400
YAQAKEFADG VHAVWPEQKL AYNLSPSFNW KAAMPRDEQE TYIQRLAQLG 450
YCWQFITLAG LHQSALMADT FSKAYSKQGM RAYGEIIQEP EAENKVDVLT 500
HQKWSGANYV DNMLKMVSGG VSSTAAMGKG VTEDQFK 537
Length:537
Mass (Da):60,126
Last modified:June 1, 2003 - v1
Checksum:i681DDBDD138CAC92
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY118108 Genomic DNA. Translation: AAM89498.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY118108 Genomic DNA. Translation: AAM89498.1 .

3D structure databases

ProteinModelPortali Q86ZF1.
SMRi Q86ZF1. Positions 2-520.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isocitrate lyase is essential for pathogenicity of the fungus Leptosphaeria maculans on canola (Brassica napus)."
    Idnurm A., Howlett B.J.
    Eukaryot. Cell 1:719-724(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiACEA_LEPMC
AccessioniPrimary (citable) accession number: Q86ZF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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