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Q86ZF1 (ACEA_LEPMC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate lyase

Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL1
OrganismLeptosphaeria maculans (Blackleg fungus) (Phoma lingam)
Taxonomic identifier5022 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaeLeptosphaeriaceaeLeptosphaeriaLeptosphaeria maculans complex

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 537537Isocitrate lyase
PRO_0000068792

Sites

Active site2061 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q86ZF1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 681DDBDD138CAC92

FASTA53760,126
        10         20         30         40         50         60 
MSHMDAEDAQ FQKEVAEVKQ WWNDSRWRYT KRTFTAEEIV SKRGNLKITY PSNSQSKKLW 

        70         80         90        100        110        120 
NIVEHRFKNK DVSYTYGCLD PVMVTQMAKY LDTVYVSGWQ ASSTASSTDE PGPDLADYPY 

       130        140        150        160        170        180 
TTVPNKVGHL FMAQLFHDRK QREERLTTPK ADRAKVANVD YLRPIIADAD TGHGGLTAIM 

       190        200        210        220        230        240 
KLTKLFIEKG AAGIHIEDQA PGTKKCGHMA GKVLVPISEH INRLVAIRAQ ADIMGTDLLA 

       250        260        270        280        290        300 
VARTDSEAAT LITSTIDPRD HYYIQGCTNP ALQPLSELMY AAEQSGKSGS ELQAIEDAWV 

       310        320        330        340        350        360 
KEANLKLFHE AVVDTINAGV HVNKQELINQ FLEQSKGKSN AEARTIAQGL TGVDVYFNWD 

       370        380        390        400        410        420 
AARTREGYYR YKGGCQCAIN RAIAYAPFCD MIWMESKLPD YAQAKEFADG VHAVWPEQKL 

       430        440        450        460        470        480 
AYNLSPSFNW KAAMPRDEQE TYIQRLAQLG YCWQFITLAG LHQSALMADT FSKAYSKQGM 

       490        500        510        520        530 
RAYGEIIQEP EAENKVDVLT HQKWSGANYV DNMLKMVSGG VSSTAAMGKG VTEDQFK 

« Hide

References

[1]"Isocitrate lyase is essential for pathogenicity of the fungus Leptosphaeria maculans on canola (Brassica napus)."
Idnurm A., Howlett B.J.
Eukaryot. Cell 1:719-724(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY118108 Genomic DNA. Translation: AAM89498.1.

3D structure databases

ProteinModelPortalQ86ZF1.
SMRQ86ZF1. Positions 2-520.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_LEPMC
AccessionPrimary (citable) accession number: Q86ZF1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways