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Protein

Complement C1q-like protein 4

Gene

C1QL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33074-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q-like protein 4
Alternative name(s):
C1q and tumor necrosis factor-related protein 11
Short name:
C1q/TNF-related protein 11
Gene namesi
Name:C1QL4
Synonyms:CTRP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:31416. C1QL4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186897.
PharmGKBiPA142672536.

Polymorphism and mutation databases

BioMutaiC1QL4.
DMDMi74759547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000027433816 – 238Complement C1q-like protein 4Add BLAST223

Proteomic databases

EPDiQ86Z23.
PaxDbiQ86Z23.
PeptideAtlasiQ86Z23.
PRIDEiQ86Z23.

PTM databases

iPTMnetiQ86Z23.
PhosphoSitePlusiQ86Z23.

Expressioni

Tissue specificityi

Highest expression levels in testis and adipose tissue, lower levels in skeletal muscle and kidney.1 Publication

Gene expression databases

BgeeiENSG00000186897.
CleanExiHS_C1QL4.

Interactioni

Subunit structurei

Forms homooligomers, predominantly dimers or trimers. Forms heterooligomers with C1QL1, C1QL2 and C1QL3, when proteins are coexpressed; this interaction does not occur after secretion. Interacts with ADGRB3.By similarity

Protein-protein interaction databases

BioGridi130794. 29 interactors.
IntActiQ86Z23. 3 interactors.
STRINGi9606.ENSP00000335285.

Structurei

3D structure databases

ProteinModelPortaliQ86Z23.
SMRiQ86Z23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 96Collagen-likeAdd BLAST44
Domaini105 – 238C1qPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IGNK. Eukaryota.
ENOG41102YT. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ86Z23.
OMAiCDPYTPQ.
OrthoDBiEOG091G0UOF.
PhylomeDBiQ86Z23.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86Z23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLLLVAIP LLVHSSRGPA HYEMLGRCRM VCDPHGPRGP GPDGAPASVP
60 70 80 90 100
PFPPGAKGEV GRRGKAGLRG PPGPPGPRGP PGEPGRPGPP GPPGPGPGGV
110 120 130 140 150
APAAGYVPRI AFYAGLRRPH EGYEVLRFDD VVTNVGNAYE AASGKFTCPM
160 170 180 190 200
PGVYFFAYHV LMRGGDGTSM WADLMKNGQV RASAIAQDAD QNYDYASNSV
210 220 230
ILHLDVGDEV FIKLDGGKVH GGNTNKYSTF SGFIIYPD
Length:238
Mass (Da):24,909
Last modified:June 1, 2003 - v1
Checksum:iD89BD2793555AEF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466366 mRNA. Translation: AAO33387.1.
BC110812 mRNA. Translation: AAI10813.1.
CCDSiCCDS31793.1.
RefSeqiNP_001008224.1. NM_001008223.1.
UniGeneiHs.380386.

Genome annotation databases

EnsembliENST00000334221; ENSP00000335285; ENSG00000186897.
GeneIDi338761.
KEGGihsa:338761.
UCSCiuc001rtz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466366 mRNA. Translation: AAO33387.1.
BC110812 mRNA. Translation: AAI10813.1.
CCDSiCCDS31793.1.
RefSeqiNP_001008224.1. NM_001008223.1.
UniGeneiHs.380386.

3D structure databases

ProteinModelPortaliQ86Z23.
SMRiQ86Z23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130794. 29 interactors.
IntActiQ86Z23. 3 interactors.
STRINGi9606.ENSP00000335285.

PTM databases

iPTMnetiQ86Z23.
PhosphoSitePlusiQ86Z23.

Polymorphism and mutation databases

BioMutaiC1QL4.
DMDMi74759547.

Proteomic databases

EPDiQ86Z23.
PaxDbiQ86Z23.
PeptideAtlasiQ86Z23.
PRIDEiQ86Z23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334221; ENSP00000335285; ENSG00000186897.
GeneIDi338761.
KEGGihsa:338761.
UCSCiuc001rtz.2. human.

Organism-specific databases

CTDi338761.
GeneCardsiC1QL4.
HGNCiHGNC:31416. C1QL4.
MIMi615229. gene.
neXtProtiNX_Q86Z23.
OpenTargetsiENSG00000186897.
PharmGKBiPA142672536.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGNK. Eukaryota.
ENOG41102YT. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ86Z23.
OMAiCDPYTPQ.
OrthoDBiEOG091G0UOF.
PhylomeDBiQ86Z23.
TreeFamiTF329591.

Enzyme and pathway databases

BioCyciZFISH:G66-33074-MONOMER.

Miscellaneous databases

GenomeRNAii338761.
PROiQ86Z23.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186897.
CleanExiHS_C1QL4.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1QL4_HUMAN
AccessioniPrimary (citable) accession number: Q86Z23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.