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Q86Z02

- HIPK1_HUMAN

UniProt

Q86Z02 - HIPK1_HUMAN

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Protein

Homeodomain-interacting protein kinase 1

Gene

HIPK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.5 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei219 – 2191ATPCurated
Active sitei315 – 3151Proton acceptorCurated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi196 – 2049ATPCurated

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. definitive hemopoiesis Source: UniProtKB
  3. embryonic camera-type eye morphogenesis Source: Ensembl
  4. embryonic retina morphogenesis in camera-type eye Source: Ensembl
  5. endothelial cell apoptotic process Source: UniProtKB
  6. extrinsic apoptotic signaling pathway Source: UniProtKB
  7. eye development Source: UniProtKB
  8. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  9. iris morphogenesis Source: Ensembl
  10. lens induction in camera-type eye Source: Ensembl
  11. neuron differentiation Source: Ensembl
  12. positive regulation of angiogenesis Source: UniProtKB
  13. positive regulation of cell proliferation Source: Ensembl
  14. regulation of transcription, DNA-templated Source: UniProtKB-KW
  15. regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
  16. retina layer formation Source: Ensembl
  17. smoothened signaling pathway Source: Ensembl
  18. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
SignaLinkiQ86Z02.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeodomain-interacting protein kinase 1 (EC:2.7.11.1)
Alternative name(s):
Nuclear body-associated kinase 2
Gene namesi
Name:HIPK1
Synonyms:KIAA0630, MYAK, NBAK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:19006. HIPK1.

Subcellular locationi

Nucleus. Cytoplasm
Note: Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nuclear speck Source: Ensembl
  3. nucleus Source: UniProtKB
  4. PML body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi25 – 251K → R: Reduced sumoylation and cytoplasmic subcellular location. Impaired sumoylation and cytoplasmic subcellular location; when associated with R-317; R-440; R-556 and R-1203. 1 Publication
Mutagenesisi219 – 2191K → A: Loss of kinase activity. 1 Publication
Mutagenesisi315 – 3151D → N: Loss of kinase activity and impaired MAP3K5-JNK inactivation. 1 Publication
Mutagenesisi317 – 3171K → R: Nuclear subcellular location. Impaired sumoylation and cytoplasmic subcellular location; when associated with R-25; R-440; R-556 and R-1203. 1 Publication
Mutagenesisi440 – 4401K → R: Nuclear subcellular location. Impaired sumoylation and cytoplasmic subcellular location; when associated with R-25; R-317; R-556 and R-1203. 1 Publication
Mutagenesisi556 – 5561K → R: Nuclear subcellular location. Impaired sumoylation and cytoplasmic subcellular location; when associated with R-25; R-317; R-440 and R-1203. 1 Publication
Mutagenesisi1203 – 12031K → R: Nuclear subcellular location. Impaired sumoylation and cytoplasmic subcellular location; when associated with R-25; R-317; R-440 and R-556. 1 Publication

Organism-specific databases

PharmGKBiPA134897980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12101210Homeodomain-interacting protein kinase 1PRO_0000085993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki25 – 25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Modified residuei872 – 8721Phosphoserine1 Publication
Cross-linki1203 – 1203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)Curated

Post-translational modificationi

Autophosphorylated. Phosphorylated and activated by JNK1.2 Publications
Degraded by PARK7 at the protein level.
Sumoylated. When conjugated it is directed to nuclear speckles. SENP1-mediated desumoylation is mediated by TNF in response to stress stimuli, triggering transient translocation from nucleus to cytoplasm.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ86Z02.
PaxDbiQ86Z02.
PRIDEiQ86Z02.

PTM databases

PhosphoSiteiQ86Z02.

Expressioni

Tissue specificityi

Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis.2 Publications

Gene expression databases

BgeeiQ86Z02.
CleanExiHS_HIPK1.
ExpressionAtlasiQ86Z02. baseline and differential.
GenevestigatoriQ86Z02.

Organism-specific databases

HPAiHPA016664.

Interactioni

Subunit structurei

Interacts with Nkx1-2, Nkx2-5, MYB, PARK7, DAXX and p53/TP53. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046372EBI-692891,EBI-366083

Protein-protein interaction databases

BioGridi128490. 17 interactions.
IntActiQ86Z02. 15 interactions.
MINTiMINT-1187651.

Structurei

3D structure databases

ProteinModelPortaliQ86Z02.
SMRiQ86Z02. Positions 188-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini190 – 518329Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni844 – 8474Nuclear localization signal 1 (NLS1)By similarity
Regioni885 – 1093209Interaction with TP53Add
BLAST
Regioni891 – 998108Required for localization to nuclear specklesBy similarityAdd
BLAST
Regioni902 – 92625SUMO interaction motifs (SIM); required for nuclear localization and kinase activityBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119032.
HOVERGENiHBG051908.
InParanoidiQ86Z02.
KOiK08826.
OMAiNKYKPSS.
PhylomeDBiQ86Z02.
TreeFamiTF105417.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86Z02-1) [UniParc]FASTAAdd to Basket

Also known as: HIPK1-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASQLQVFSP PSVSSSAFCS AKKLKIEPSG WDVSGQSSND KYYTHSKTLP
60 70 80 90 100
ATQGQANSSH QVANFNIPAY DQGLLLPAPA VEHIVVTAAD SSGSAATSTF
110 120 130 140 150
QSSQTLTHRS NVSLLEPYQK CGLKRKSEEV DSNGSVQIIE EHPPLMLQNR
160 170 180 190 200
TVVGAAATTT TVTTKSSSSS GEGDYQLVQH EILCSMTNSY EVLEFLGRGT
210 220 230 240 250
FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR LSSENADEYN
260 270 280 290 300
FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA
310 320 330 340 350
TALMKLKSLG LIHADLKPEN IMLVDPVRQP YRVKVIDFGS ASHVSKAVCS
360 370 380 390 400
TYLQSRYYRA PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ
410 420 430 440 450
IRYISQTQGL PAEYLLSAGT KTTRFFNRDP NLGYPLWRLK TPEEHELETG
460 470 480 490 500
IKSKEARKYI FNCLDDMAQV NMSTDLEGTD MLAEKADRRE YIDLLKKMLT
510 520 530 540 550
IDADKRITPL KTLNHQFVTM THLLDFPHSN HVKSCFQNME ICKRRVHMYD
560 570 580 590 600
TVSQIKSPFT THVAPNTSTN LTMSFSNQLN TVHNQASVLA SSSTAAAATL
610 620 630 640 650
SLANSDVSLL NYQSALYPSS AAPVPGVAQQ GVSLQPGTTQ ICTQTDPFQQ
660 670 680 690 700
TFIVCPPAFQ TGLQATTKHS GFPVRMDNAV PIVPQAPAAQ PLQIQSGVLT
710 720 730 740 750
QGSCTPLMVA TLHPQVATIT PQYAVPFTLS CAAGRPALVE QTAAVLQAWP
760 770 780 790 800
GGTQQILLPS TWQQLPGVAL HNSVQPTAMI PEAMGSGQQL ADWRNAHSHG
810 820 830 840 850
NQYSTIMQQP SLLTNHVTLA TAQPLNVGVA HVVRQQQSSS LPSKKNKQSA
860 870 880 890 900
PVSSKSSLDV LPSQVYSLVG SSPLRTTSSY NSLVPVQDQH QPIIIPDTPS
910 920 930 940 950
PPVSVITIRS DTDEEEDNKY KPSSSGLKPR SNVISYVTVN DSPDSDSSLS
960 970 980 990 1000
SPYSTDTLSA LRGNSGSVLE GPGRVVADGT GTRTIIVPPL KTQLGDCTVA
1010 1020 1030 1040 1050
TQASGLLSNK TKPVASVSGQ SSGCCITPTG YRAQRGGTSA AQPLNLSQNQ
1060 1070 1080 1090 1100
QSSAAPTSQE RSSNPAPRRQ QAFVAPLSQA PYTFQHGSPL HSTGHPHLAP
1110 1120 1130 1140 1150
APAHLPSQAH LYTYAAPTSA AALGSTSSIA HLFSPQGSSR HAAAYTTHPS
1160 1170 1180 1190 1200
TLVHQVPVSV GPSLLTSASV APAQYQHQFA TQSYIGSSRG STIYTGYPLS
1210
PTKISQYSYL
Length:1,210
Mass (Da):130,843
Last modified:June 1, 2003 - v1
Checksum:iDB0BBFA6DF152909
GO
Isoform 2 (identifier: Q86Z02-2) [UniParc]FASTAAdd to Basket

Also known as: HIPK1-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1049-1075: NQQSSAAPTSQERSSNPAPRRQQAFVA → VSAMGYCLLFGPCTVVTFWRTLLLAGC
     1076-1210: Missing.

Show »
Length:1,075
Mass (Da):116,731
Checksum:iDC4EE791F0EEC369
GO
Isoform 3 (identifier: Q86Z02-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-374: Missing.

Show »
Length:836
Mass (Da):89,481
Checksum:iED30D5EDCA8D4918
GO
Isoform 4 (identifier: Q86Z02-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-394: Missing.
     395-399: ASEYD → MVLMF

Show »
Length:816
Mass (Da):87,302
Checksum:i97A2176C8995F038
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti721 – 7211P → Q in AAH33012. (PubMed:15489334)Curated
Sequence conflicti747 – 7471Missing in BAA31605. (PubMed:9734811)Curated
Sequence conflicti799 – 7991H → Y in CAD38689. (PubMed:17974005)Curated
Sequence conflicti1054 – 10541A → V in AAH36057. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61Q → R.
Corresponds to variant rs35324789 [ dbSNP | Ensembl ].
VAR_051626
Natural varianti310 – 3101G → C.1 Publication
VAR_040546
Natural varianti1165 – 11651L → V.1 Publication
VAR_046047

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 394394Missing in isoform 4. 1 PublicationVSP_013127Add
BLAST
Alternative sequencei1 – 374374Missing in isoform 3. 1 PublicationVSP_013128Add
BLAST
Alternative sequencei395 – 3995ASEYD → MVLMF in isoform 4. 1 PublicationVSP_013129
Alternative sequencei1049 – 107527NQQSS…QAFVA → VSAMGYCLLFGPCTVVTFWR TLLLAGC in isoform 2. 1 PublicationVSP_013130Add
BLAST
Alternative sequencei1076 – 1210135Missing in isoform 2. 1 PublicationVSP_013131Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089957 mRNA. Translation: BAC57075.1.
AL731797 Genomic DNA. Translation: CAI22792.1.
AL731797 Genomic DNA. Translation: CAI22793.1.
AL731797 Genomic DNA. Translation: CAI22795.1.
AL137856 Genomic DNA. No translation available.
CH471122 Genomic DNA. Translation: EAW56590.1.
BC028408 mRNA. Translation: AAH28408.1.
BC033012 mRNA. Translation: AAH33012.1.
BC036057 mRNA. Translation: AAH36057.1.
AL833829 mRNA. Translation: CAD38689.1.
AB014530 mRNA. Translation: BAA31605.1.
CCDSiCCDS41370.1. [Q86Z02-3]
CCDS867.1. [Q86Z02-1]
CCDS868.1. [Q86Z02-2]
CCDS869.1. [Q86Z02-4]
RefSeqiNP_689909.2. NM_152696.3. [Q86Z02-2]
NP_852003.1. NM_181358.2. [Q86Z02-4]
NP_938009.1. NM_198268.2. [Q86Z02-1]
NP_938010.1. NM_198269.2. [Q86Z02-3]
XP_005270669.1. XM_005270612.2. [Q86Z02-1]
XP_005270670.1. XM_005270613.2. [Q86Z02-1]
UniGeneiHs.532363.

Genome annotation databases

EnsembliENST00000340480; ENSP00000340956; ENSG00000163349. [Q86Z02-3]
ENST00000369553; ENSP00000358566; ENSG00000163349. [Q86Z02-4]
ENST00000369558; ENSP00000358571; ENSG00000163349. [Q86Z02-1]
ENST00000369559; ENSP00000358572; ENSG00000163349. [Q86Z02-2]
ENST00000426820; ENSP00000407442; ENSG00000163349. [Q86Z02-1]
GeneIDi204851.
KEGGihsa:204851.
UCSCiuc001eel.3. human. [Q86Z02-2]
uc001eem.3. human. [Q86Z02-1]
uc001eep.3. human. [Q86Z02-4]

Polymorphism databases

DMDMi34395641.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089957 mRNA. Translation: BAC57075.1 .
AL731797 Genomic DNA. Translation: CAI22792.1 .
AL731797 Genomic DNA. Translation: CAI22793.1 .
AL731797 Genomic DNA. Translation: CAI22795.1 .
AL137856 Genomic DNA. No translation available.
CH471122 Genomic DNA. Translation: EAW56590.1 .
BC028408 mRNA. Translation: AAH28408.1 .
BC033012 mRNA. Translation: AAH33012.1 .
BC036057 mRNA. Translation: AAH36057.1 .
AL833829 mRNA. Translation: CAD38689.1 .
AB014530 mRNA. Translation: BAA31605.1 .
CCDSi CCDS41370.1. [Q86Z02-3 ]
CCDS867.1. [Q86Z02-1 ]
CCDS868.1. [Q86Z02-2 ]
CCDS869.1. [Q86Z02-4 ]
RefSeqi NP_689909.2. NM_152696.3. [Q86Z02-2 ]
NP_852003.1. NM_181358.2. [Q86Z02-4 ]
NP_938009.1. NM_198268.2. [Q86Z02-1 ]
NP_938010.1. NM_198269.2. [Q86Z02-3 ]
XP_005270669.1. XM_005270612.2. [Q86Z02-1 ]
XP_005270670.1. XM_005270613.2. [Q86Z02-1 ]
UniGenei Hs.532363.

3D structure databases

ProteinModelPortali Q86Z02.
SMRi Q86Z02. Positions 188-517.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128490. 17 interactions.
IntActi Q86Z02. 15 interactions.
MINTi MINT-1187651.

Chemistry

BindingDBi Q86Z02.
ChEMBLi CHEMBL5427.
GuidetoPHARMACOLOGYi 2033.

PTM databases

PhosphoSitei Q86Z02.

Polymorphism databases

DMDMi 34395641.

Proteomic databases

MaxQBi Q86Z02.
PaxDbi Q86Z02.
PRIDEi Q86Z02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340480 ; ENSP00000340956 ; ENSG00000163349 . [Q86Z02-3 ]
ENST00000369553 ; ENSP00000358566 ; ENSG00000163349 . [Q86Z02-4 ]
ENST00000369558 ; ENSP00000358571 ; ENSG00000163349 . [Q86Z02-1 ]
ENST00000369559 ; ENSP00000358572 ; ENSG00000163349 . [Q86Z02-2 ]
ENST00000426820 ; ENSP00000407442 ; ENSG00000163349 . [Q86Z02-1 ]
GeneIDi 204851.
KEGGi hsa:204851.
UCSCi uc001eel.3. human. [Q86Z02-2 ]
uc001eem.3. human. [Q86Z02-1 ]
uc001eep.3. human. [Q86Z02-4 ]

Organism-specific databases

CTDi 204851.
GeneCardsi GC01P114471.
HGNCi HGNC:19006. HIPK1.
HPAi HPA016664.
MIMi 608003. gene.
neXtProti NX_Q86Z02.
PharmGKBi PA134897980.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119032.
HOVERGENi HBG051908.
InParanoidi Q86Z02.
KOi K08826.
OMAi NKYKPSS.
PhylomeDBi Q86Z02.
TreeFami TF105417.

Enzyme and pathway databases

Reactomei REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
SignaLinki Q86Z02.

Miscellaneous databases

ChiTaRSi HIPK1. human.
GeneWikii HIPK1.
GenomeRNAii 204851.
NextBioi 90482.
PROi Q86Z02.
SOURCEi Search...

Gene expression databases

Bgeei Q86Z02.
CleanExi HS_HIPK1.
ExpressionAtlasi Q86Z02. baseline and differential.
Genevestigatori Q86Z02.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human HIPK1."
    Miyata Y.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-1210 (ISOFORM 1).
    Tissue: Testis.
  6. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 720-1210 (ISOFORMS 1/3/4).
    Tissue: Brain.
  7. "Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization."
    Song J.J., Lee Y.J.
    J. Biol. Chem. 278:47245-47252(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION BY JNK1.
  8. "Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity."
    Ecsedy J.A., Michaelson J.S., Leder P.
    Mol. Cell. Biol. 23:950-960(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH DAXX.
  9. "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)."
    Kondo S., Lu Y., Debbas M., Lin A.W., Sarosi I., Itie A., Wakeham A., Tuan J., Saris C., Elliott G., Ma W., Benchimol S., Lowe S.W., Mak T.W., Thukral S.K.
    Proc. Natl. Acad. Sci. U.S.A. 100:5431-5436(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53, TISSUE SPECIFICITY, FUNCTION.
  10. "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation."
    Li X., Zhang R., Luo D., Park S.-J., Wang Q., Kim Y., Min W.
    J. Biol. Chem. 280:15061-15070(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DAB2IP AND MAP3K5, SUBCELLULAR LOCATION, SUMOYLATION AT LYS-25 AND LYS-1203, DESUMOYLATION MEDIATED BY TNF, MUTAGENESIS OF LYS-25; ASP-315; LYS-317; LYS-440; LYS-556 AND LYS-1203.
  11. "DJ-1 interacts with HIPK1 and affects H2O2-induced cell death."
    Sekito A., Koide-Yoshida S., Niki T., Taira T., Iguchi-Ariga S.M.M., Ariga H.
    Free Radic. Res. 40:155-165(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ANTI-OXIDATIVE STRESS, INTERACTION WITH PARK7, SUBCELLULAR LOCATION, DEGRADATION BY PARK7.
  12. "SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis."
    Li X., Luo Y., Yu L., Lin Y., Luo D., Zhang H., He Y., Kim Y.-O., Kim Y., Tang S., Min W.
    Cell Death Differ. 15:739-750(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DESUMOYLATION BY SENP1, SUBCELLULAR LOCATION.
  13. "HIPK1 interacts with c-Myb and modulates its activity through phosphorylation."
    Matre V., Nordgaard O., Alm-Kristiansen A.H., Ledsaak M., Gabrielsen O.S.
    Biochem. Biophys. Res. Commun. 388:150-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS MYB KINASE, INTERACTION WITH MYB, MUTAGENESIS OF LYS-219, SUBCELLULAR LOCATION.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-872, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-310 AND VAL-1165.

Entry informationi

Entry nameiHIPK1_HUMAN
AccessioniPrimary (citable) accession number: Q86Z02
Secondary accession number(s): A6NJ34
, O75125, Q5SQL2, Q5SQL4, Q5SQL5, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3