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Protein

Trem-like transcript 1 protein

Gene

TREML1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor that may play a role in the innate and adaptive immune response.1 Publication

GO - Biological processi

  • calcium-mediated signaling Source: UniProtKB
  • innate immune response Source: UniProtKB
  • platelet activation Source: UniProtKB
  • regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Trem-like transcript 1 protein
Short name:
TLT-1
Alternative name(s):
Triggering receptor expressed on myeloid cells-like protein 1
Gene namesi
Name:TREML1
Synonyms:TLT1
ORF Names:UNQ1825/PRO3438
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20434. TREML1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini16 – 162147ExtracellularSequence analysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Topological domaini184 – 311128CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • platelet alpha granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878709.

Polymorphism and mutation databases

DMDMi116256098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 311296Trem-like transcript 1 proteinPRO_0000253855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 1041 Publication
Disulfide bondi52 ↔ 591 Publication
Lipidationi196 – 1961S-palmitoyl cysteine1 Publication

Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ86YW5.
PeptideAtlasiQ86YW5.
PRIDEiQ86YW5.

PTM databases

iPTMnetiQ86YW5.
PhosphoSiteiQ86YW5.
SwissPalmiQ86YW5.

Expressioni

Tissue specificityi

Detected in platelets, monocytic leukemia and in T-cell leukemia.4 Publications

Gene expression databases

BgeeiQ86YW5.
CleanExiHS_TREML1.
GenevisibleiQ86YW5. HS.

Organism-specific databases

HPAiHPA016700.
HPA017860.

Interactioni

Subunit structurei

When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11.By similarity1 Publication

Protein-protein interaction databases

BioGridi131013. 2 interactions.
STRINGi9606.ENSP00000402855.

Structurei

Secondary structure

1
311
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 285Combined sources
Beta strandi34 – 396Combined sources
Helixi42 – 443Combined sources
Beta strandi47 – 559Combined sources
Beta strandi58 – 647Combined sources
Beta strandi70 – 734Combined sources
Turni74 – 763Combined sources
Beta strandi77 – 837Combined sources
Beta strandi86 – 916Combined sources
Helixi96 – 983Combined sources
Beta strandi100 – 1089Combined sources
Beta strandi111 – 12212Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FRGX-ray1.19P20-125[»]
ProteinModelPortaliQ86YW5.
SMRiQ86YW5. Positions 20-125.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86YW5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 121106Ig-like V-typeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi279 – 2857ITIM

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi126 – 1305Poly-Glu
Compositional biasi221 – 27050Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKSQ. Eukaryota.
ENOG411182M. LUCA.
GeneTreeiENSGT00470000042300.
HOGENOMiHOG000154685.
HOVERGENiHBG094092.
InParanoidiQ86YW5.
KOiK14363.
OMAiCHYRLQD.
OrthoDBiEOG7ZD1W6.
PhylomeDBiQ86YW5.
TreeFamiTF337145.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86YW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLTLLLLLL LGLEGQGIVG SLPEVLQAPV GSSILVQCHY RLQDVKAQKV
60 70 80 90 100
WCRFLPEGCQ PLVSSAVDRR APAGRRTFLT DLGGGLLQVE MVTLQEEDAG
110 120 130 140 150
EYGCMVDGAR GPQILHRVSL NILPPEEEEE THKIGSLAEN AFSDPAGSAN
160 170 180 190 200
PLEPSQDEKS IPLIWGAVLL VGLLVAAVVL FAVMAKRKQG NRLGVCGRFL
210 220 230 240 250
SSRVSGMNPS SVVHHVSDSG PAAELPLDVP HIRLDSPPSF DNTTYTSLPL
260 270 280 290 300
DSPSGKPSLP APSSLPPLPP KVLVCSKPVT YATVIFPGGN KGGGTSCGPA
310
QNPPNNQTPS S
Length:311
Mass (Da):32,679
Last modified:October 17, 2006 - v2
Checksum:i60A2B0BDC2B2D4C1
GO
Isoform 2 (identifier: Q86YW5-2) [UniParc]FASTAAdd to basket

Also known as: TLT1sv

The sequence of this isoform differs from the canonical sequence as follows:
     190-199: GNRLGVCGRF → ESLLSGPPRQ
     200-311: Missing.

Show »
Length:199
Mass (Da):21,323
Checksum:i0D6FA45A16A4382A
GO
Isoform 3 (identifier: Q86YW5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-125: Missing.

Show »
Length:200
Mass (Da):20,731
Checksum:i29F0BA02D40D0836
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61L → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_035526
Natural varianti231 – 2311H → P.
Corresponds to variant rs34254490 [ dbSNP | Ensembl ].
VAR_049950

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei15 – 125111Missing in isoform 3. 1 PublicationVSP_021124Add
BLAST
Alternative sequencei190 – 19910GNRLGVCGRF → ESLLSGPPRQ in isoform 2. 2 PublicationsVSP_021125
Alternative sequencei200 – 311112Missing in isoform 2. 2 PublicationsVSP_021126Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508193 mRNA. Translation: AAO37827.1. Different termination.
AF534822 mRNA. Translation: AAO15020.1.
AF534823 mRNA. Translation: AAO15021.1.
AY358357 mRNA. Translation: AAQ88723.1.
AL133404 Genomic DNA. Translation: CAI19913.1.
BC100944 mRNA. Translation: AAI00945.1.
BC100945 mRNA. Translation: AAI00946.1.
BC100946 mRNA. Translation: AAI00947.1.
CCDSiCCDS4851.1. [Q86YW5-1]
CCDS64420.1. [Q86YW5-3]
CCDS64421.1. [Q86YW5-2]
RefSeqiNP_001258736.1. NM_001271807.1. [Q86YW5-2]
NP_001258737.1. NM_001271808.1. [Q86YW5-3]
NP_835468.1. NM_178174.3. [Q86YW5-1]
UniGeneiHs.117331.

Genome annotation databases

EnsembliENST00000373127; ENSP00000362219; ENSG00000161911. [Q86YW5-2]
ENST00000426005; ENSP00000402855; ENSG00000161911. [Q86YW5-1]
ENST00000437044; ENSP00000400405; ENSG00000161911. [Q86YW5-3]
GeneIDi340205.
KEGGihsa:340205.
UCSCiuc003opx.5. human. [Q86YW5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508193 mRNA. Translation: AAO37827.1. Different termination.
AF534822 mRNA. Translation: AAO15020.1.
AF534823 mRNA. Translation: AAO15021.1.
AY358357 mRNA. Translation: AAQ88723.1.
AL133404 Genomic DNA. Translation: CAI19913.1.
BC100944 mRNA. Translation: AAI00945.1.
BC100945 mRNA. Translation: AAI00946.1.
BC100946 mRNA. Translation: AAI00947.1.
CCDSiCCDS4851.1. [Q86YW5-1]
CCDS64420.1. [Q86YW5-3]
CCDS64421.1. [Q86YW5-2]
RefSeqiNP_001258736.1. NM_001271807.1. [Q86YW5-2]
NP_001258737.1. NM_001271808.1. [Q86YW5-3]
NP_835468.1. NM_178174.3. [Q86YW5-1]
UniGeneiHs.117331.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FRGX-ray1.19P20-125[»]
ProteinModelPortaliQ86YW5.
SMRiQ86YW5. Positions 20-125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131013. 2 interactions.
STRINGi9606.ENSP00000402855.

PTM databases

iPTMnetiQ86YW5.
PhosphoSiteiQ86YW5.
SwissPalmiQ86YW5.

Polymorphism and mutation databases

DMDMi116256098.

Proteomic databases

PaxDbiQ86YW5.
PeptideAtlasiQ86YW5.
PRIDEiQ86YW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373127; ENSP00000362219; ENSG00000161911. [Q86YW5-2]
ENST00000426005; ENSP00000402855; ENSG00000161911. [Q86YW5-1]
ENST00000437044; ENSP00000400405; ENSG00000161911. [Q86YW5-3]
GeneIDi340205.
KEGGihsa:340205.
UCSCiuc003opx.5. human. [Q86YW5-1]

Organism-specific databases

CTDi340205.
GeneCardsiTREML1.
HGNCiHGNC:20434. TREML1.
HPAiHPA016700.
HPA017860.
MIMi609714. gene.
neXtProtiNX_Q86YW5.
PharmGKBiPA134878709.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKSQ. Eukaryota.
ENOG411182M. LUCA.
GeneTreeiENSGT00470000042300.
HOGENOMiHOG000154685.
HOVERGENiHBG094092.
InParanoidiQ86YW5.
KOiK14363.
OMAiCHYRLQD.
OrthoDBiEOG7ZD1W6.
PhylomeDBiQ86YW5.
TreeFamiTF337145.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiQ86YW5.
GeneWikiiTREML1.
GenomeRNAii340205.
PROiQ86YW5.
SOURCEiSearch...

Gene expression databases

BgeeiQ86YW5.
CleanExiHS_TREML1.
GenevisibleiQ86YW5. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster."
    Washington A.V., Quigley L., McVicar D.W.
    Blood 100:3822-3824(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44."
    Allcock R.J.N., Barrow A.D., Forbes S., Beck S., Trowsdale J.
    Eur. J. Immunol. 33:567-577(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  6. "A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets."
    Washington A.V., Schubert R.L., Quigley L., Disipio T., Feltz R., Cho E.H., McVicar D.W.
    Blood 104:1042-1047(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2."
    Barrow A.D., Astoul E., Floto A., Brooke G., Relou I.A.M., Jennings N.S., Smith K.G.C., Ouwehand W., Farndale R.W., Alexander D.R., Trowsdale J.
    J. Immunol. 172:5838-5842(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION, INTERACTION WITH PTPN11, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  8. "Proteomic analysis of palmitoylated platelet proteins."
    Dowal L., Yang W., Freeman M.R., Steen H., Flaumenhaft R.
    Blood 118:E62-E73(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-196.
    Tissue: Platelet.
  9. "The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment."
    Gattis J.L., Washington A.V., Chisholm M.M., Quigley L., Szyk A., McVicar D.W., Lubkowski J.
    J. Biol. Chem. 281:13396-13403(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.19 ANGSTROMS) OF 20-125, DISULFIDE BONDS, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-6.

Entry informationi

Entry nameiTRML1_HUMAN
AccessioniPrimary (citable) accession number: Q86YW5
Secondary accession number(s): Q496B3, Q8IWY1, Q8IWY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.