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Protein

Trem-like transcript 1 protein

Gene

TREML1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor that may play a role in the innate and adaptive immune response.1 Publication

GO - Biological processi

  • calcium-mediated signaling Source: UniProtKB
  • innate immune response Source: UniProtKB
  • platelet activation Source: UniProtKB
  • regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Trem-like transcript 1 protein
Short name:
TLT-1
Alternative name(s):
Triggering receptor expressed on myeloid cells-like protein 1
Gene namesi
Name:TREML1
Synonyms:TLT1
ORF Names:UNQ1825/PRO3438
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20434. TREML1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini16 – 162ExtracellularSequence analysisAdd BLAST147
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 311CytoplasmicSequence analysisAdd BLAST128

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • platelet alpha granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi340205.
OpenTargetsiENSG00000161911.
PharmGKBiPA134878709.

Polymorphism and mutation databases

DMDMi116256098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000025385516 – 311Trem-like transcript 1 proteinAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 1041 Publication
Disulfide bondi52 ↔ 591 Publication
Lipidationi196S-palmitoyl cysteine1 Publication1

Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ86YW5.
PeptideAtlasiQ86YW5.
PRIDEiQ86YW5.

PTM databases

iPTMnetiQ86YW5.
PhosphoSitePlusiQ86YW5.
SwissPalmiQ86YW5.

Expressioni

Tissue specificityi

Detected in platelets, monocytic leukemia and in T-cell leukemia.4 Publications

Gene expression databases

BgeeiENSG00000161911.
CleanExiHS_TREML1.
GenevisibleiQ86YW5. HS.

Organism-specific databases

HPAiHPA016700.
HPA017860.

Interactioni

Subunit structurei

When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11.By similarity1 Publication

Protein-protein interaction databases

BioGridi131013. 2 interactors.
STRINGi9606.ENSP00000402855.

Structurei

Secondary structure

1311
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 28Combined sources5
Beta strandi34 – 39Combined sources6
Helixi42 – 44Combined sources3
Beta strandi47 – 55Combined sources9
Beta strandi58 – 64Combined sources7
Beta strandi70 – 73Combined sources4
Turni74 – 76Combined sources3
Beta strandi77 – 83Combined sources7
Beta strandi86 – 91Combined sources6
Helixi96 – 98Combined sources3
Beta strandi100 – 108Combined sources9
Beta strandi111 – 122Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FRGX-ray1.19P20-125[»]
ProteinModelPortaliQ86YW5.
SMRiQ86YW5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86YW5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 121Ig-like V-typeAdd BLAST106

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi279 – 285ITIM7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi126 – 130Poly-Glu5
Compositional biasi221 – 270Pro-richAdd BLAST50

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKSQ. Eukaryota.
ENOG411182M. LUCA.
GeneTreeiENSGT00470000042300.
HOGENOMiHOG000154685.
HOVERGENiHBG094092.
InParanoidiQ86YW5.
KOiK14363.
OMAiCHYRLQD.
OrthoDBiEOG091G0TD0.
PhylomeDBiQ86YW5.
TreeFamiTF337145.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86YW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLTLLLLLL LGLEGQGIVG SLPEVLQAPV GSSILVQCHY RLQDVKAQKV
60 70 80 90 100
WCRFLPEGCQ PLVSSAVDRR APAGRRTFLT DLGGGLLQVE MVTLQEEDAG
110 120 130 140 150
EYGCMVDGAR GPQILHRVSL NILPPEEEEE THKIGSLAEN AFSDPAGSAN
160 170 180 190 200
PLEPSQDEKS IPLIWGAVLL VGLLVAAVVL FAVMAKRKQG NRLGVCGRFL
210 220 230 240 250
SSRVSGMNPS SVVHHVSDSG PAAELPLDVP HIRLDSPPSF DNTTYTSLPL
260 270 280 290 300
DSPSGKPSLP APSSLPPLPP KVLVCSKPVT YATVIFPGGN KGGGTSCGPA
310
QNPPNNQTPS S
Length:311
Mass (Da):32,679
Last modified:October 17, 2006 - v2
Checksum:i60A2B0BDC2B2D4C1
GO
Isoform 2 (identifier: Q86YW5-2) [UniParc]FASTAAdd to basket
Also known as: TLT1sv

The sequence of this isoform differs from the canonical sequence as follows:
     190-199: GNRLGVCGRF → ESLLSGPPRQ
     200-311: Missing.

Show »
Length:199
Mass (Da):21,323
Checksum:i0D6FA45A16A4382A
GO
Isoform 3 (identifier: Q86YW5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-125: Missing.

Show »
Length:200
Mass (Da):20,731
Checksum:i29F0BA02D40D0836
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0355266L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_049950231H → P.Corresponds to variant rs34254490dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02112415 – 125Missing in isoform 3. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_021125190 – 199GNRLGVCGRF → ESLLSGPPRQ in isoform 2. 2 Publications10
Alternative sequenceiVSP_021126200 – 311Missing in isoform 2. 2 PublicationsAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508193 mRNA. Translation: AAO37827.1. Different termination.
AF534822 mRNA. Translation: AAO15020.1.
AF534823 mRNA. Translation: AAO15021.1.
AY358357 mRNA. Translation: AAQ88723.1.
AL133404 Genomic DNA. Translation: CAI19913.1.
BC100944 mRNA. Translation: AAI00945.1.
BC100945 mRNA. Translation: AAI00946.1.
BC100946 mRNA. Translation: AAI00947.1.
CCDSiCCDS4851.1. [Q86YW5-1]
CCDS64420.1. [Q86YW5-3]
CCDS64421.1. [Q86YW5-2]
RefSeqiNP_001258736.1. NM_001271807.1. [Q86YW5-2]
NP_001258737.1. NM_001271808.1. [Q86YW5-3]
NP_835468.1. NM_178174.3. [Q86YW5-1]
XP_016866312.1. XM_017010823.1. [Q86YW5-1]
XP_016866313.1. XM_017010824.1. [Q86YW5-1]
UniGeneiHs.117331.

Genome annotation databases

EnsembliENST00000373127; ENSP00000362219; ENSG00000161911. [Q86YW5-2]
ENST00000426005; ENSP00000402855; ENSG00000161911. [Q86YW5-1]
ENST00000437044; ENSP00000400405; ENSG00000161911. [Q86YW5-3]
GeneIDi340205.
KEGGihsa:340205.
UCSCiuc003opx.5. human. [Q86YW5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508193 mRNA. Translation: AAO37827.1. Different termination.
AF534822 mRNA. Translation: AAO15020.1.
AF534823 mRNA. Translation: AAO15021.1.
AY358357 mRNA. Translation: AAQ88723.1.
AL133404 Genomic DNA. Translation: CAI19913.1.
BC100944 mRNA. Translation: AAI00945.1.
BC100945 mRNA. Translation: AAI00946.1.
BC100946 mRNA. Translation: AAI00947.1.
CCDSiCCDS4851.1. [Q86YW5-1]
CCDS64420.1. [Q86YW5-3]
CCDS64421.1. [Q86YW5-2]
RefSeqiNP_001258736.1. NM_001271807.1. [Q86YW5-2]
NP_001258737.1. NM_001271808.1. [Q86YW5-3]
NP_835468.1. NM_178174.3. [Q86YW5-1]
XP_016866312.1. XM_017010823.1. [Q86YW5-1]
XP_016866313.1. XM_017010824.1. [Q86YW5-1]
UniGeneiHs.117331.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FRGX-ray1.19P20-125[»]
ProteinModelPortaliQ86YW5.
SMRiQ86YW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131013. 2 interactors.
STRINGi9606.ENSP00000402855.

PTM databases

iPTMnetiQ86YW5.
PhosphoSitePlusiQ86YW5.
SwissPalmiQ86YW5.

Polymorphism and mutation databases

DMDMi116256098.

Proteomic databases

PaxDbiQ86YW5.
PeptideAtlasiQ86YW5.
PRIDEiQ86YW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373127; ENSP00000362219; ENSG00000161911. [Q86YW5-2]
ENST00000426005; ENSP00000402855; ENSG00000161911. [Q86YW5-1]
ENST00000437044; ENSP00000400405; ENSG00000161911. [Q86YW5-3]
GeneIDi340205.
KEGGihsa:340205.
UCSCiuc003opx.5. human. [Q86YW5-1]

Organism-specific databases

CTDi340205.
DisGeNETi340205.
GeneCardsiTREML1.
HGNCiHGNC:20434. TREML1.
HPAiHPA016700.
HPA017860.
MIMi609714. gene.
neXtProtiNX_Q86YW5.
OpenTargetsiENSG00000161911.
PharmGKBiPA134878709.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKSQ. Eukaryota.
ENOG411182M. LUCA.
GeneTreeiENSGT00470000042300.
HOGENOMiHOG000154685.
HOVERGENiHBG094092.
InParanoidiQ86YW5.
KOiK14363.
OMAiCHYRLQD.
OrthoDBiEOG091G0TD0.
PhylomeDBiQ86YW5.
TreeFamiTF337145.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiQ86YW5.
GeneWikiiTREML1.
GenomeRNAii340205.
PROiQ86YW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161911.
CleanExiHS_TREML1.
GenevisibleiQ86YW5. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRML1_HUMAN
AccessioniPrimary (citable) accession number: Q86YW5
Secondary accession number(s): Q496B3, Q8IWY1, Q8IWY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.