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Q86YV6

- MYLK4_HUMAN

UniProt

Q86YV6 - MYLK4_HUMAN

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Protein

Myosin light chain kinase family member 4

Gene

MYLK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351ATPPROSITE-ProRule annotation
Active sitei227 – 2271Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi112 – 1209ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ86YV6.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain kinase family member 4 (EC:2.7.11.1)
Alternative name(s):
Sugen kinase 85
Short name:
SgK085
Gene namesi
Name:MYLK4
Synonyms:SGK085
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:27972. MYLK4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Myosin light chain kinase family member 4PRO_0000261030Add
BLAST

Proteomic databases

PaxDbiQ86YV6.
PRIDEiQ86YV6.

PTM databases

PhosphoSiteiQ86YV6.

Expressioni

Gene expression databases

BgeeiQ86YV6.
CleanExiHS_MYLK4.
GenevestigatoriQ86YV6.

Organism-specific databases

HPAiHPA015860.

Interactioni

Protein-protein interaction databases

BioGridi131005. 8 interactions.
IntActiQ86YV6. 2 interactions.
STRINGi9606.ENSP00000274643.

Structurei

Secondary structure

1
388
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi96 – 983
Helixi100 – 1023
Beta strandi104 – 1118
Beta strandi120 – 1256
Turni126 – 1283
Beta strandi131 – 1388
Helixi142 – 15514
Beta strandi166 – 1716
Beta strandi173 – 1819
Helixi189 – 1946
Helixi196 – 1983
Helixi201 – 22020
Helixi230 – 2323
Beta strandi233 – 2375
Turni238 – 2414
Beta strandi242 – 2454
Helixi272 – 2754
Helixi282 – 29817
Helixi308 – 31710
Helixi325 – 3273
Helixi332 – 3398
Helixi346 – 3483
Helixi352 – 3576
Helixi359 – 3624
Helixi364 – 3729

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X4FX-ray2.67A/B40-388[»]
ProteinModelPortaliQ86YV6.
SMRiQ86YV6. Positions 81-370.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86YV6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 361256Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000233016.
HOVERGENiHBG095569.
InParanoidiQ86YV6.
KOiK00907.
OrthoDBiEOG73FQMV.
PhylomeDBiQ86YV6.
TreeFamiTF314166.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86YV6) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKVKRLEEF NTCYNSNQLE KMAFFQCREE VEKVKCFLEK NSGDQDSRSG
60 70 80 90 100
HNEAKEVWSN ADLTERMPVK SKRTSALAVD IPAPPAPFDH RIVTAKQGAV
110 120 130 140 150
NSFYTVSKTE ILGGGRFGQV HKCEETATGL KLAAKIIKTR GMKDKEEVKN
160 170 180 190 200
EISVMNQLDH ANLIQLYDAF ESKNDIVLVM EYVDGGELFD RIIDESYNLT
210 220 230 240 250
ELDTILFMKQ ICEGIRHMHQ MYILHLDLKP ENILCVNRDA KQIKIIDFGL
260 270 280 290 300
ARRYKPREKL KVNFGTPEFL APEVVNYDFV SFPTDMWSVG VIAYMLLSGL
310 320 330 340 350
SPFLGDNDAE TLNNILACRW DLEDEEFQDI SEEAKEFISK LLIKEKSWRI
360 370 380
SASEALKHPW LSDHKLHSRL NAQKKKNRGS DAQDFVTK

Note: No experimental confirmation available.

Length:388
Mass (Da):44,508
Last modified:November 28, 2006 - v2
Checksum:iEF710F6145DFC3C9
GO
Isoform 2 (identifier: Q86YV6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-252: LCVNRDAKQIKIIDFGLAR → QCSRFLIDTSILPLCLLNC

Note: Sequence incomplete. No experimental confirmation available.

Show »
Length:388
Mass (Da):44,487
Checksum:i126A576FFF4E5A86
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301E → Q in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication
VAR_040864
Natural varianti39 – 391E → A.
Corresponds to variant rs7770402 [ dbSNP | Ensembl ].
VAR_051650
Natural varianti50 – 501G → R.2 Publications
Corresponds to variant rs2296356 [ dbSNP | Ensembl ].
VAR_040865
Natural varianti78 – 781A → S in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication
VAR_040866
Natural varianti126 – 1261T → M.1 Publication
Corresponds to variant rs34953021 [ dbSNP | Ensembl ].
VAR_040867
Natural varianti217 – 2171H → L in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication
VAR_040868
Natural varianti318 – 3181C → Y.1 Publication
Corresponds to variant rs35609073 [ dbSNP | Ensembl ].
VAR_040869
Natural varianti373 – 3731Q → R.1 Publication
Corresponds to variant rs35211631 [ dbSNP | Ensembl ].
VAR_040870

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei234 – 25219LCVNR…FGLAR → QCSRFLIDTSILPLCLLNC in isoform 2. 1 PublicationVSP_026948Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL138876, AL139092 Genomic DNA. Translation: CAI12221.2.
BC132831 mRNA. Translation: AAI32832.1.
BC132833 mRNA. Translation: AAI32834.1.
AK122581 mRNA. Translation: BAC56922.1.
CCDSiCCDS34330.1. [Q86YV6-1]
RefSeqiNP_001012418.2. NM_001012418.3. [Q86YV6-1]
XP_005249134.1. XM_005249077.1. [Q86YV6-1]
XP_005249135.1. XM_005249078.1. [Q86YV6-1]
XP_005249136.1. XM_005249079.1. [Q86YV6-1]
UniGeneiHs.127830.

Genome annotation databases

EnsembliENST00000274643; ENSP00000274643; ENSG00000145949. [Q86YV6-1]
GeneIDi340156.
KEGGihsa:340156.
UCSCiuc003mty.4. human. [Q86YV6-1]

Polymorphism databases

DMDMi118573873.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL138876 , AL139092 Genomic DNA. Translation: CAI12221.2 .
BC132831 mRNA. Translation: AAI32832.1 .
BC132833 mRNA. Translation: AAI32834.1 .
AK122581 mRNA. Translation: BAC56922.1 .
CCDSi CCDS34330.1. [Q86YV6-1 ]
RefSeqi NP_001012418.2. NM_001012418.3. [Q86YV6-1 ]
XP_005249134.1. XM_005249077.1. [Q86YV6-1 ]
XP_005249135.1. XM_005249078.1. [Q86YV6-1 ]
XP_005249136.1. XM_005249079.1. [Q86YV6-1 ]
UniGenei Hs.127830.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2X4F X-ray 2.67 A/B 40-388 [» ]
ProteinModelPortali Q86YV6.
SMRi Q86YV6. Positions 81-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131005. 8 interactions.
IntActi Q86YV6. 2 interactions.
STRINGi 9606.ENSP00000274643.

Chemistry

BindingDBi Q86YV6.
ChEMBLi CHEMBL5426.
GuidetoPHARMACOLOGYi 2111.

PTM databases

PhosphoSitei Q86YV6.

Polymorphism databases

DMDMi 118573873.

Proteomic databases

PaxDbi Q86YV6.
PRIDEi Q86YV6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274643 ; ENSP00000274643 ; ENSG00000145949 . [Q86YV6-1 ]
GeneIDi 340156.
KEGGi hsa:340156.
UCSCi uc003mty.4. human. [Q86YV6-1 ]

Organism-specific databases

CTDi 340156.
GeneCardsi GC06M002663.
H-InvDB HIX0018128.
HGNCi HGNC:27972. MYLK4.
HPAi HPA015860.
neXtProti NX_Q86YV6.
PharmGKBi PA162396406.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118877.
HOGENOMi HOG000233016.
HOVERGENi HBG095569.
InParanoidi Q86YV6.
KOi K00907.
OrthoDBi EOG73FQMV.
PhylomeDBi Q86YV6.
TreeFami TF314166.

Enzyme and pathway databases

SignaLinki Q86YV6.

Miscellaneous databases

EvolutionaryTracei Q86YV6.
GenomeRNAii 340156.
NextBioi 97719.
PROi Q86YV6.

Gene expression databases

Bgeei Q86YV6.
CleanExi HS_MYLK4.
Genevestigatori Q86YV6.

Family and domain databases

InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24347. PTHR24347. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-50.
  3. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 234-388 (ISOFORM 2).
    Tissue: Spleen.
  4. Cited for: IDENTIFICATION.
  5. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-30; ARG-50; SER-78; MET-126; LEU-217; TYR-318 AND ARG-373.

Entry informationi

Entry nameiMYLK4_HUMAN
AccessioniPrimary (citable) accession number: Q86YV6
Secondary accession number(s): A2RUC0, Q5TAW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3