##gff-version 3 Q86YV5 UniProtKB Chain 1 1406 . . . ID=PRO_0000263008;Note=Inactive tyrosine-protein kinase PRAG1 Q86YV5 UniProtKB Domain 978 1329 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Q86YV5 UniProtKB Region 184 205 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Region 217 248 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Region 372 470 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Region 484 854 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Region 933 976 . . . Note=Required for homodimerization;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D3ZMK9 Q86YV5 UniProtKB Region 1163 1206 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Region 1331 1406 . . . Note=Required for homodimerization;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D3ZMK9 Q86YV5 UniProtKB Compositional bias 502 529 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Compositional bias 530 544 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Compositional bias 603 630 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Compositional bias 654 692 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Compositional bias 730 784 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Compositional bias 828 851 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Compositional bias 1163 1181 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YV5 UniProtKB Modified residue 148 148 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569 Q86YV5 UniProtKB Modified residue 253 253 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D3ZMK9 Q86YV5 UniProtKB Modified residue 365 365 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D3ZMK9 Q86YV5 UniProtKB Modified residue 413 413 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D3ZMK9 Q86YV5 UniProtKB Modified residue 696 696 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q86YV5 UniProtKB Modified residue 745 745 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332 Q86YV5 UniProtKB Modified residue 782 782 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q86YV5 UniProtKB Modified residue 826 826 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Q86YV5 UniProtKB Natural variant 122 122 . . . ID=VAR_041803;Note=L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55764617,PMID:17344846 Q86YV5 UniProtKB Natural variant 137 137 . . . ID=VAR_041804;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56290960,PMID:17344846 Q86YV5 UniProtKB Natural variant 139 139 . . . ID=VAR_041805;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34346032,PMID:17344846 Q86YV5 UniProtKB Natural variant 404 404 . . . ID=VAR_041806;Note=R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3896980,PMID:17344846 Q86YV5 UniProtKB Natural variant 569 569 . . . ID=VAR_041807;Note=P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|Ref.2;Dbxref=dbSNP:rs4840955,PMID:17344846 Q86YV5 UniProtKB Natural variant 578 578 . . . ID=VAR_041808;Note=S->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|Ref.2;Dbxref=dbSNP:rs4840953,PMID:17344846 Q86YV5 UniProtKB Natural variant 595 595 . . . ID=VAR_041809;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55994745,PMID:17344846 Q86YV5 UniProtKB Natural variant 662 662 . . . ID=VAR_041810;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56351643,PMID:17344846 Q86YV5 UniProtKB Natural variant 814 814 . . . ID=VAR_041811;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56207906,PMID:17344846 Q86YV5 UniProtKB Natural variant 851 851 . . . ID=VAR_041812;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56215812,PMID:17344846 Q86YV5 UniProtKB Natural variant 1003 1003 . . . ID=VAR_041813;Note=S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56289289,PMID:17344846 Q86YV5 UniProtKB Natural variant 1041 1041 . . . ID=VAR_041814;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs28533138,PMID:17344846 Q86YV5 UniProtKB Natural variant 1113 1113 . . . ID=VAR_041815;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:17974005,ECO:0000269|Ref.2;Dbxref=dbSNP:rs12549973,PMID:17344846,PMID:17974005 Q86YV5 UniProtKB Natural variant 1315 1315 . . . ID=VAR_041816;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1314830862,PMID:17344846 Q86YV5 UniProtKB Mutagenesis 955 955 . . . Note=Decreases homodimerization. Abolished interaction with PEAK1. No effect on cell migration. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29079850;Dbxref=PMID:29079850 Q86YV5 UniProtKB Mutagenesis 966 966 . . . Note=Decreases homodimerization. Abolished interaction with PEAK1. Decreases cell migration. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29079850;Dbxref=PMID:29079850 Q86YV5 UniProtKB Mutagenesis 1243 1243 . . . Note=No effect on homodimerization. Decreases oligomerization. Decreases interaction with PEAK1. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29079850;Dbxref=PMID:29079850 Q86YV5 UniProtKB Mutagenesis 1271 1271 . . . Note=Decreases homodimerization. Decreases interaction with PEAK1. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29079850;Dbxref=PMID:29079850 Q86YV5 UniProtKB Mutagenesis 1278 1278 . . . Note=Decreases homodimerization. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29079850;Dbxref=PMID:29079850 Q86YV5 UniProtKB Mutagenesis 1282 1282 . . . Note=No effect on homodimerization. Decreases oligomerization. Decreases interaction with PEAK1. No effect on cell migration. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29079850;Dbxref=PMID:29079850 Q86YV5 UniProtKB Mutagenesis 1366 1366 . . . Note=Decreases homodimerization. Abolished interaction with PEAK1. Decreases cell migration. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29079850;Dbxref=PMID:29079850 Q86YV5 UniProtKB Mutagenesis 1382 1382 . . . Note=Decreases homodimerization. Abolished interaction with PEAK1. Decreases cell migration. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29079850;Dbxref=PMID:29079850 Q86YV5 UniProtKB Sequence conflict 1226 1226 . . . Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86YV5 UniProtKB Helix 948 974 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 988 991 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Beta strand 992 995 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Beta strand 1000 1002 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Beta strand 1004 1016 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Beta strand 1020 1026 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Beta strand 1050 1059 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1060 1063 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Beta strand 1084 1094 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Beta strand 1096 1099 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1100 1105 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1108 1113 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1115 1138 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1148 1150 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Beta strand 1151 1154 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Beta strand 1211 1214 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1246 1250 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1252 1264 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1270 1272 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1275 1279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1284 1286 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1296 1307 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Turn 1312 1314 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1318 1329 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1348 1369 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1379 1389 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6 Q86YV5 UniProtKB Helix 1393 1402 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VE6