Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q86YV5 (SG223_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase SgK223

EC=2.7.10.2
Alternative name(s):
Sugen kinase 223
Gene names
Name:SGK223
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1402 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sequence similarities

Belongs to the protein kinase superfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14021402Tyrosine-protein kinase SgK223
PRO_0000263008

Regions

Domain976 – 1325350Protein kinase
Nucleotide binding982 – 9909ATP By similarity
Compositional bias55 – 584Poly-Pro
Compositional bias434 – 4374Poly-Ala
Compositional bias638 – 6469Poly-Glu
Compositional bias711 – 7166Poly-Pro

Sites

Active site11431Proton acceptor By similarity
Binding site10221ATP By similarity

Amino acid modifications

Modified residue4111Phosphotyrosine By similarity
Modified residue6941Phosphoserine Ref.5
Modified residue7431Phosphoserine Ref.5 Ref.6
Modified residue8241Phosphoserine Ref.7

Natural variations

Natural variant1221L → I. Ref.8
VAR_041803
Natural variant1371R → G. Ref.8
VAR_041804
Natural variant1391V → I. Ref.8
VAR_041805
Natural variant4021R → Q. Ref.2 Ref.8
VAR_041806
Natural variant5671P → L. Ref.2 Ref.8
VAR_041807
Natural variant5761S → C. Ref.2 Ref.8
VAR_041808
Natural variant5931P → A. Ref.8
VAR_041809
Natural variant6601P → T. Ref.8
VAR_041810
Natural variant8121P → L. Ref.8
VAR_041811
Natural variant8491H → R. Ref.8
VAR_041812
Natural variant10011S → L. Ref.8
VAR_041813
Natural variant10391V → M. Ref.8
VAR_041814
Natural variant11111A → T. Ref.2 Ref.3 Ref.8
VAR_041815
Natural variant13111R → H. Ref.8
VAR_041816

Experimental info

Sequence conflict3431C → CGS in BAC56923. Ref.2
Sequence conflict11611G → GPA in BAC56923. Ref.2
Sequence conflict11611G → GPA in CAD38729. Ref.3
Sequence conflict12221G → S in BAC56923. Ref.2
Sequence conflict12221G → S in CAD38729. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q86YV5 [UniParc].

Last modified April 5, 2011. Version 3.
Checksum: 02ED4F05890A70B8

FASTA1,402149,311
        10         20         30         40         50         60 
MHQTLCLNPE SLKMSACSDF VEHIWKPGSC KNCFCLRSDH QLVAGPPQPR AGSLPPPPRL 

        70         80         90        100        110        120 
PPRPENCRLE DEGVNSSPYS KPTIAVKPTM MSSEASDVWT EANLSAEVSQ VIWRRAPGKL 

       130        140        150        160        170        180 
PLPKQEDAPV VYLGSFRGVQ KPAGPSTSPD GNSRCPPAYT MVGLHNLEPR GERNIAFHPV 

       190        200        210        220        230        240 
SFPEEKAVHK EKPSFPYQDR PSTQESFRQK LAAFAGTTSG CHQGPGPLRE SLPSEDDSDQ 

       250        260        270        280        290        300 
RCSPSGDSEG GEYCSILDCC PGSPVAKAAS QTAGSRGRHG GRDCSPTCWE QGKCSGPAEQ 

       310        320        330        340        350        360 
EKRGPSFPKE CCSQGPTAHP SCLGPKKLSL TSEAAISSDG LSCGSGSGSG ASSPFVPHLE 

       370        380        390        400        410        420 
SDYCSLMKEP APEKQQDPGC PGVTPSRCLG LTGEPQPPAH PREATQPEPI YAESTKRKKA 

       430        440        450        460        470        480 
APVPSKSQAK IEHAAAAQGQ GQVCTGNAWA QKAASGWGRD SPDPTPQVSA TITVMAAHPE 

       490        500        510        520        530        540 
EDHRTIYLSS PDSAVGVQWP RGPVSQNSEV GEEETSAGQG LSSRESHAHS ASESKPKERP 

       550        560        570        580        590        600 
AIPPKLSKSS PVGSPVSPSA GGPPVSPLAD LSDGSSGGSS IGPQPPSQGP ADPAPSCRTN 

       610        620        630        640        650        660 
GVAISDPSRC PQPAASSASE QRRPRFQAGT WSRQCRIEEE EEVEQELLSH SWGRETKNGP 

       670        680        690        700        710        720 
TDHSNSTTWH RLHPTDGSSG QNSKVGTGMS KSASFAFEFP KDRSGIETFS PPPPPPKSRH 

       730        740        750        760        770        780 
LLKMNKSSSD LEKVSQGSAE SLSPSFRGVH VSFTTGSTDS LASDSRTCSD GGPSSELAHS 

       790        800        810        820        830        840 
PTNSGKKLFA PVPFPSGSTE DVSPSGPQQP PPLPQKKIVS RAASSPDGFF WTQGSPKPGT 

       850        860        870        880        890        900 
ASPKLNLSHS ETNVHDESHF SYSLSPGNRH HPVFSSSDPL EKAFKGSGHW LPAAGLAGNR 

       910        920        930        940        950        960 
GGCGSPGLQC KGAPSASSSQ LSVSSQASTG STQLQLHGLL SNISSKEGTY AKLGGLYTQS 

       970        980        990       1000       1010       1020 
LARLVAKCED LFMGGQKKEL HFNENNWSLF KLTCNKPCCD SGDAIYYCAT CSEDPGSTYA 

      1030       1040       1050       1060       1070       1080 
VKICKAPEPK TVSYCSPSVP VHFNIQQDCG HFVASVPSSM LSSPDAPKDP VPALPTHPPA 

      1090       1100       1110       1120       1130       1140 
QEQDCVVVIT REVPHQTASD FVRDSAASHQ AEPEAYERRV CFLLLQLCNG LEHLKEHGII 

      1150       1160       1170       1180       1190       1200 
HRDLCLENLL LVHCTLQAGP GPAPAPAPAP AAAAPPCSSA APPAGGTLSP AAGPASPEGP 

      1210       1220       1230       1240       1250       1260 
REKQLPRLII SNFLKAKQKP GGTPNLQQKK SQARLAPEIV SASQYRKFDE FQTGILIYEL 

      1270       1280       1290       1300       1310       1320 
LHQPNPFEVR AQLRERDYRQ EDLPPLPALS LYSPGLQQLA HLLLEADPIK RIRIGEAKRV 

      1330       1340       1350       1360       1370       1380 
LQCLLWGPRR ELVQQPGTSE EALCGTLHNW IDMKRALMMM KFAEKAVDRR RGVELEDWLC 

      1390       1400 
CQYLASAEPG ALLQSLKLLQ LL 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The nucleotide sequence of a long cDNA clone isolated from human spleen."
Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-1402, VARIANTS GLN-402; LEU-567; CYS-576 AND THR-1111.
Tissue: Spleen.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 818-1402, VARIANT THR-1111.
Tissue: Amygdala.
[4]"The protein kinase complement of the human genome."
Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S.
Science 298:1912-1934(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694 AND SER-743, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-743, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-824, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-122; GLY-137; ILE-139; GLN-402; LEU-567; CYS-576; ALA-593; THR-660; LEU-812; ARG-849; LEU-1001; MET-1039; THR-1111 AND HIS-1311.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC068353 Genomic DNA. No translation available.
AC103957 Genomic DNA. No translation available.
AK122582 mRNA. Translation: BAC56923.1.
AL833872 mRNA. Translation: CAD38729.1.
RefSeqNP_001074295.2. NM_001080826.2.
UniGeneHs.583863.
Hs.657673.

3D structure databases

ProteinModelPortalQ86YV5.
SMRQ86YV5. Positions 1086-1152.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127591. 7 interactions.
IntActQ86YV5. 6 interactions.
MINTMINT-1413315.
STRING9606.ENSP00000330930.

PTM databases

PhosphoSiteQ86YV5.

Polymorphism databases

DMDM327478560.

Proteomic databases

MaxQBQ86YV5.
PaxDbQ86YV5.
PRIDEQ86YV5.

Protocols and materials databases

DNASU157285.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID157285.
KEGGhsa:157285.
UCSCuc003wsh.4. human.

Organism-specific databases

CTD157285.
GeneCardsGC08M008175.
H-InvDBHIX0007293.
HPAHPA012066.
neXtProtNX_Q86YV5.

Phylogenomic databases

eggNOGNOG115841.
HOGENOMHOG000168455.
HOVERGENHBG055817.
InParanoidQ86YV5.
KOK17537.
OMASHSETNV.
PhylomeDBQ86YV5.

Enzyme and pathway databases

SignaLinkQ86YV5.

Gene expression databases

BgeeQ86YV5.
GenevestigatorQ86YV5.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSGK223. human.
GenomeRNAi157285.
NextBio87443.
PROQ86YV5.

Entry information

Entry nameSG223_HUMAN
AccessionPrimary (citable) accession number: Q86YV5
Secondary accession number(s): Q8N3N5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM