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Q86YV5

- SG223_HUMAN

UniProt

Q86YV5 - SG223_HUMAN

Protein

Tyrosine-protein kinase SgK223

Gene

SGK223

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 4 (01 Oct 2014)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1024 – 10241ATPPROSITE-ProRule annotation
    Active sitei1145 – 11451Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi984 – 9929ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ86YV5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase SgK223 (EC:2.7.10.2)
    Alternative name(s):
    Sugen kinase 223
    Gene namesi
    Name:SGK223
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14061406Tyrosine-protein kinase SgK223PRO_0000263008Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei413 – 4131PhosphotyrosineBy similarity
    Modified residuei696 – 6961Phosphoserine1 Publication
    Modified residuei745 – 7451Phosphoserine2 Publications
    Modified residuei826 – 8261Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86YV5.
    PaxDbiQ86YV5.
    PRIDEiQ86YV5.

    PTM databases

    PhosphoSiteiQ86YV5.

    Expressioni

    Gene expression databases

    BgeeiQ86YV5.
    GenevestigatoriQ86YV5.

    Organism-specific databases

    HPAiHPA012066.

    Interactioni

    Protein-protein interaction databases

    BioGridi127591. 7 interactions.
    IntActiQ86YV5. 6 interactions.
    MINTiMINT-1413315.
    STRINGi9606.ENSP00000330930.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86YV5.
    SMRiQ86YV5. Positions 1086-1152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini978 – 1329352Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi55 – 584Poly-Pro
    Compositional biasi713 – 7186Poly-Pro

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG115841.
    HOGENOMiHOG000168455.
    HOVERGENiHBG055817.
    InParanoidiQ86YV5.
    OMAiSHSETNV.
    PhylomeDBiQ86YV5.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86YV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHQTLCLNPE SLKMSACSDF VEHIWKPGSC KNCFCLRSDH QLVAGPPQPR     50
    AGSLPPPPRL PPRPENCRLE DEGVNSSPYS KPTIAVKPTM MSSEASDVWT 100
    EANLSAEVSQ VIWRRAPGKL PLPKQEDAPV VYLGSFRGVQ KPAGPSTSPD 150
    GNSRCPPAYT MVGLHNLEPR GERNIAFHPV SFPEEKAVHK EKPSFPYQDR 200
    PSTQESFRQK LAAFAGTTSG CHQGPGPLRE SLPSEDDSDQ RCSPSGDSEG 250
    GEYCSILDCC PGSPVAKAAS QTAGSRGRHG GRDCSPTCWE QGKCSGPAEQ 300
    EKRGPSFPKE CCSQGPTAHP SCLGPKKLSL TSEAAISSDG LSCGSGSGSG 350
    SGASSPFVPH LESDYCSLMK EPAPEKQQDP GCPGVTPSRC LGLTGEPQPP 400
    AHPREATQPE PIYAESTKRK KAAPVPSKSQ AKIEHAAAAQ GQGQVCTGNA 450
    WAQKAASGWG RDSPDPTPQV SATITVMAAH PEEDHRTIYL SSPDSAVGVQ 500
    WPRGPVSQNS EVGEEETSAG QGLSSRESHA HSASESKPKE RPAIPPKLSK 550
    SSPVGSPVSP SAGGPPVSPL ADLSDGSSGG SSIGPQPPSQ GPADPAPSCR 600
    TNGVAISDPS RCPQPAASSA SEQRRPRFQA GTWSRQCRIE EEEEVEQELL 650
    SHSWGRETKN GPTDHSNSTT WHRLHPTDGS SGQNSKVGTG MSKSASFAFE 700
    FPKDRSGIET FSPPPPPPKS RHLLKMNKSS SDLEKVSQGS AESLSPSFRG 750
    VHVSFTTGST DSLASDSRTC SDGGPSSELA HSPTNSGKKL FAPVPFPSGS 800
    TEDVSPSGPQ QPPPLPQKKI VSRAASSPDG FFWTQGSPKP GTASPKLNLS 850
    HSETNVHDES HFSYSLSPGN RHHPVFSSSD PLEKAFKGSG HWLPAAGLAG 900
    NRGGCGSPGL QCKGAPSASS SQLSVSSQAS TGSTQLQLHG LLSNISSKEG 950
    TYAKLGGLYT QSLARLVAKC EDLFMGGQKK ELHFNENNWS LFKLTCNKPC 1000
    CDSGDAIYYC ATCSEDPGST YAVKICKAPE PKTVSYCSPS VPVHFNIQQD 1050
    CGHFVASVPS SMLSSPDAPK DPVPALPTHP PAQEQDCVVV ITREVPHQTA 1100
    SDFVRDSAAS HQAEPEAYER RVCFLLLQLC NGLEHLKEHG IIHRDLCLEN 1150
    LLLVHCTLQA GPGPAPAPAP APAPAAAAPP CSSAAPPAGG TLSPAAGPAS 1200
    PEGPREKQLP RLIISNFLKA KQKPGGTPNL QQKKSQARLA PEIVSASQYR 1250
    KFDEFQTGIL IYELLHQPNP FEVRAQLRER DYRQEDLPPL PALSLYSPGL 1300
    QQLAHLLLEA DPIKRIRIGE AKRVLQCLLW GPRRELVQQP GTSEEALCGT 1350
    LHNWIDMKRA LMMMKFAEKA VDRRRGVELE DWLCCQYLAS AEPGALLQSL 1400
    KLLQLL 1406
    Length:1,406
    Mass (Da):149,624
    Last modified:October 1, 2014 - v4
    Checksum:i941BCF315B826148
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1226 – 12261G → S in BAC56923. 1 PublicationCurated
    Sequence conflicti1226 – 12261G → S in CAD38729. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti122 – 1221L → I.1 Publication
    VAR_041803
    Natural varianti137 – 1371R → G.1 Publication
    VAR_041804
    Natural varianti139 – 1391V → I.1 Publication
    VAR_041805
    Natural varianti404 – 4041R → Q.2 Publications
    VAR_041806
    Natural varianti569 – 5691P → L.2 Publications
    VAR_041807
    Natural varianti578 – 5781S → C.2 Publications
    VAR_041808
    Natural varianti595 – 5951P → A.1 Publication
    VAR_041809
    Natural varianti662 – 6621P → T.1 Publication
    VAR_041810
    Natural varianti814 – 8141P → L.1 Publication
    VAR_041811
    Natural varianti851 – 8511H → R.1 Publication
    VAR_041812
    Natural varianti1003 – 10031S → L.1 Publication
    VAR_041813
    Natural varianti1041 – 10411V → M.1 Publication
    VAR_041814
    Natural varianti1113 – 11131A → T.3 Publications
    VAR_041815
    Natural varianti1315 – 13151R → H.1 Publication
    VAR_041816

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC068353 Genomic DNA. No translation available.
    AC103957 Genomic DNA. No translation available.
    AK122582 mRNA. Translation: BAC56923.1.
    AL833872 mRNA. Translation: CAD38729.1.
    RefSeqiNP_001074295.2. NM_001080826.2.
    UniGeneiHs.583863.
    Hs.657673.

    Genome annotation databases

    GeneIDi157285.
    UCSCiuc003wsh.4. human.

    Polymorphism databases

    DMDMi327478560.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC068353 Genomic DNA. No translation available.
    AC103957 Genomic DNA. No translation available.
    AK122582 mRNA. Translation: BAC56923.1 .
    AL833872 mRNA. Translation: CAD38729.1 .
    RefSeqi NP_001074295.2. NM_001080826.2.
    UniGenei Hs.583863.
    Hs.657673.

    3D structure databases

    ProteinModelPortali Q86YV5.
    SMRi Q86YV5. Positions 1086-1152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127591. 7 interactions.
    IntActi Q86YV5. 6 interactions.
    MINTi MINT-1413315.
    STRINGi 9606.ENSP00000330930.

    PTM databases

    PhosphoSitei Q86YV5.

    Polymorphism databases

    DMDMi 327478560.

    Proteomic databases

    MaxQBi Q86YV5.
    PaxDbi Q86YV5.
    PRIDEi Q86YV5.

    Protocols and materials databases

    DNASUi 157285.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 157285.
    UCSCi uc003wsh.4. human.

    Organism-specific databases

    GeneCardsi GC08M008175.
    H-InvDB HIX0007293.
    HPAi HPA012066.
    neXtProti NX_Q86YV5.

    Phylogenomic databases

    eggNOGi NOG115841.
    HOGENOMi HOG000168455.
    HOVERGENi HBG055817.
    InParanoidi Q86YV5.
    OMAi SHSETNV.
    PhylomeDBi Q86YV5.

    Enzyme and pathway databases

    SignaLinki Q86YV5.

    Miscellaneous databases

    ChiTaRSi SGK223. human.
    GenomeRNAii 157285.
    NextBioi 87443.
    PROi Q86YV5.

    Gene expression databases

    Bgeei Q86YV5.
    Genevestigatori Q86YV5.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-1406, VARIANTS GLN-404; LEU-569; CYS-578 AND THR-1113.
      Tissue: Spleen.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 820-1406, VARIANT THR-1113.
      Tissue: Amygdala.
    4. Cited for: IDENTIFICATION.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-696 AND SER-745, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-745, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-122; GLY-137; ILE-139; GLN-404; LEU-569; CYS-578; ALA-595; THR-662; LEU-814; ARG-851; LEU-1003; MET-1041; THR-1113 AND HIS-1315.

    Entry informationi

    Entry nameiSG223_HUMAN
    AccessioniPrimary (citable) accession number: Q86YV5
    Secondary accession number(s): Q8N3N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: October 1, 2014
    Last modified: October 1, 2014
    This is version 95 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3