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Protein

Tyrosine-protein kinase SgK223

Gene

SGK223

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1024ATPPROSITE-ProRule annotation1
Active sitei1145Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi984 – 992ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS11039-MONOMER.
SignaLinkiQ86YV5.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase SgK223 (EC:2.7.10.2)
Alternative name(s):
Sugen kinase 223
Gene namesi
Name:SGK223
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Pathology & Biotechi

Organism-specific databases

DisGeNETi157285.
OpenTargetsiENSG00000275342.

Polymorphism and mutation databases

BioMutaiSGK223.
DMDMi327478560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002630081 – 1406Tyrosine-protein kinase SgK223Add BLAST1406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei148PhosphoserineCombined sources1
Modified residuei413PhosphotyrosineBy similarity1
Modified residuei696PhosphoserineCombined sources1
Modified residuei745PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1
Modified residuei826PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86YV5.
PaxDbiQ86YV5.
PeptideAtlasiQ86YV5.
PRIDEiQ86YV5.

PTM databases

iPTMnetiQ86YV5.
PhosphoSitePlusiQ86YV5.

Expressioni

Gene expression databases

BgeeiENSG00000182319.
GenevisibleiQ86YV5. HS.

Organism-specific databases

HPAiHPA012066.

Interactioni

Protein-protein interaction databases

BioGridi127591. 7 interactors.
IntActiQ86YV5. 7 interactors.
MINTiMINT-1413315.
STRINGi9606.ENSP00000330930.

Structurei

3D structure databases

ProteinModelPortaliQ86YV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini978 – 1329Protein kinasePROSITE-ProRule annotationAdd BLAST352

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 58Poly-Pro4
Compositional biasi713 – 718Poly-Pro6

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJMD. Eukaryota.
ENOG4110SRP. LUCA.
GeneTreeiENSGT00460000041554.
HOGENOMiHOG000168455.
HOVERGENiHBG055817.
InParanoidiQ86YV5.
KOiK17537.
OMAiTWHRLHP.
OrthoDBiEOG091G03K2.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86YV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHQTLCLNPE SLKMSACSDF VEHIWKPGSC KNCFCLRSDH QLVAGPPQPR
60 70 80 90 100
AGSLPPPPRL PPRPENCRLE DEGVNSSPYS KPTIAVKPTM MSSEASDVWT
110 120 130 140 150
EANLSAEVSQ VIWRRAPGKL PLPKQEDAPV VYLGSFRGVQ KPAGPSTSPD
160 170 180 190 200
GNSRCPPAYT MVGLHNLEPR GERNIAFHPV SFPEEKAVHK EKPSFPYQDR
210 220 230 240 250
PSTQESFRQK LAAFAGTTSG CHQGPGPLRE SLPSEDDSDQ RCSPSGDSEG
260 270 280 290 300
GEYCSILDCC PGSPVAKAAS QTAGSRGRHG GRDCSPTCWE QGKCSGPAEQ
310 320 330 340 350
EKRGPSFPKE CCSQGPTAHP SCLGPKKLSL TSEAAISSDG LSCGSGSGSG
360 370 380 390 400
SGASSPFVPH LESDYCSLMK EPAPEKQQDP GCPGVTPSRC LGLTGEPQPP
410 420 430 440 450
AHPREATQPE PIYAESTKRK KAAPVPSKSQ AKIEHAAAAQ GQGQVCTGNA
460 470 480 490 500
WAQKAASGWG RDSPDPTPQV SATITVMAAH PEEDHRTIYL SSPDSAVGVQ
510 520 530 540 550
WPRGPVSQNS EVGEEETSAG QGLSSRESHA HSASESKPKE RPAIPPKLSK
560 570 580 590 600
SSPVGSPVSP SAGGPPVSPL ADLSDGSSGG SSIGPQPPSQ GPADPAPSCR
610 620 630 640 650
TNGVAISDPS RCPQPAASSA SEQRRPRFQA GTWSRQCRIE EEEEVEQELL
660 670 680 690 700
SHSWGRETKN GPTDHSNSTT WHRLHPTDGS SGQNSKVGTG MSKSASFAFE
710 720 730 740 750
FPKDRSGIET FSPPPPPPKS RHLLKMNKSS SDLEKVSQGS AESLSPSFRG
760 770 780 790 800
VHVSFTTGST DSLASDSRTC SDGGPSSELA HSPTNSGKKL FAPVPFPSGS
810 820 830 840 850
TEDVSPSGPQ QPPPLPQKKI VSRAASSPDG FFWTQGSPKP GTASPKLNLS
860 870 880 890 900
HSETNVHDES HFSYSLSPGN RHHPVFSSSD PLEKAFKGSG HWLPAAGLAG
910 920 930 940 950
NRGGCGSPGL QCKGAPSASS SQLSVSSQAS TGSTQLQLHG LLSNISSKEG
960 970 980 990 1000
TYAKLGGLYT QSLARLVAKC EDLFMGGQKK ELHFNENNWS LFKLTCNKPC
1010 1020 1030 1040 1050
CDSGDAIYYC ATCSEDPGST YAVKICKAPE PKTVSYCSPS VPVHFNIQQD
1060 1070 1080 1090 1100
CGHFVASVPS SMLSSPDAPK DPVPALPTHP PAQEQDCVVV ITREVPHQTA
1110 1120 1130 1140 1150
SDFVRDSAAS HQAEPEAYER RVCFLLLQLC NGLEHLKEHG IIHRDLCLEN
1160 1170 1180 1190 1200
LLLVHCTLQA GPGPAPAPAP APAPAAAAPP CSSAAPPAGG TLSPAAGPAS
1210 1220 1230 1240 1250
PEGPREKQLP RLIISNFLKA KQKPGGTPNL QQKKSQARLA PEIVSASQYR
1260 1270 1280 1290 1300
KFDEFQTGIL IYELLHQPNP FEVRAQLRER DYRQEDLPPL PALSLYSPGL
1310 1320 1330 1340 1350
QQLAHLLLEA DPIKRIRIGE AKRVLQCLLW GPRRELVQQP GTSEEALCGT
1360 1370 1380 1390 1400
LHNWIDMKRA LMMMKFAEKA VDRRRGVELE DWLCCQYLAS AEPGALLQSL

KLLQLL
Length:1,406
Mass (Da):149,624
Last modified:October 1, 2014 - v4
Checksum:i941BCF315B826148
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1226G → S in BAC56923 (Ref. 2) Curated1
Sequence conflicti1226G → S in CAD38729 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041803122L → I.1 PublicationCorresponds to variant rs55764617dbSNPEnsembl.1
Natural variantiVAR_041804137R → G.1 PublicationCorresponds to variant rs56290960dbSNPEnsembl.1
Natural variantiVAR_041805139V → I.1 PublicationCorresponds to variant rs34346032dbSNPEnsembl.1
Natural variantiVAR_041806404R → Q.2 PublicationsCorresponds to variant rs3896980dbSNPEnsembl.1
Natural variantiVAR_041807569P → L.2 PublicationsCorresponds to variant rs4840955dbSNPEnsembl.1
Natural variantiVAR_041808578S → C.2 PublicationsCorresponds to variant rs4840953dbSNPEnsembl.1
Natural variantiVAR_041809595P → A.1 PublicationCorresponds to variant rs55994745dbSNPEnsembl.1
Natural variantiVAR_041810662P → T.1 PublicationCorresponds to variant rs56351643dbSNPEnsembl.1
Natural variantiVAR_041811814P → L.1 PublicationCorresponds to variant rs56207906dbSNPEnsembl.1
Natural variantiVAR_041812851H → R.1 PublicationCorresponds to variant rs56215812dbSNPEnsembl.1
Natural variantiVAR_0418131003S → L.1 PublicationCorresponds to variant rs56289289dbSNPEnsembl.1
Natural variantiVAR_0418141041V → M.1 PublicationCorresponds to variant rs28533138dbSNPEnsembl.1
Natural variantiVAR_0418151113A → T.3 PublicationsCorresponds to variant rs12549973dbSNPEnsembl.1
Natural variantiVAR_0418161315R → H.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068353 Genomic DNA. No translation available.
AC103957 Genomic DNA. No translation available.
AK122582 mRNA. Translation: BAC56923.1.
AL833872 mRNA. Translation: CAD38729.1.
CCDSiCCDS43706.1.
RefSeqiNP_001074295.2. NM_001080826.2.
XP_005272426.2. XM_005272369.4.
XP_005272427.2. XM_005272370.4.
UniGeneiHs.583863.
Hs.657673.

Genome annotation databases

GeneIDi157285.
KEGGihsa:157285.
UCSCiuc064kbu.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068353 Genomic DNA. No translation available.
AC103957 Genomic DNA. No translation available.
AK122582 mRNA. Translation: BAC56923.1.
AL833872 mRNA. Translation: CAD38729.1.
CCDSiCCDS43706.1.
RefSeqiNP_001074295.2. NM_001080826.2.
XP_005272426.2. XM_005272369.4.
XP_005272427.2. XM_005272370.4.
UniGeneiHs.583863.
Hs.657673.

3D structure databases

ProteinModelPortaliQ86YV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127591. 7 interactors.
IntActiQ86YV5. 7 interactors.
MINTiMINT-1413315.
STRINGi9606.ENSP00000330930.

PTM databases

iPTMnetiQ86YV5.
PhosphoSitePlusiQ86YV5.

Polymorphism and mutation databases

BioMutaiSGK223.
DMDMi327478560.

Proteomic databases

EPDiQ86YV5.
PaxDbiQ86YV5.
PeptideAtlasiQ86YV5.
PRIDEiQ86YV5.

Protocols and materials databases

DNASUi157285.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi157285.
KEGGihsa:157285.
UCSCiuc064kbu.1. human.

Organism-specific databases

CTDi157285.
DisGeNETi157285.
GeneCardsiSGK223.
H-InvDBHIX0007293.
HPAiHPA012066.
neXtProtiNX_Q86YV5.
OpenTargetsiENSG00000275342.

Phylogenomic databases

eggNOGiENOG410IJMD. Eukaryota.
ENOG4110SRP. LUCA.
GeneTreeiENSGT00460000041554.
HOGENOMiHOG000168455.
HOVERGENiHBG055817.
InParanoidiQ86YV5.
KOiK17537.
OMAiTWHRLHP.
OrthoDBiEOG091G03K2.

Enzyme and pathway databases

BioCyciZFISH:HS11039-MONOMER.
SignaLinkiQ86YV5.

Miscellaneous databases

ChiTaRSiSGK223. human.
GenomeRNAii157285.
PROiQ86YV5.

Gene expression databases

BgeeiENSG00000182319.
GenevisibleiQ86YV5. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSG223_HUMAN
AccessioniPrimary (citable) accession number: Q86YV5
Secondary accession number(s): Q8N3N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2014
Last modified: November 2, 2016
This is version 117 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.