Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q86YV5

- SG223_HUMAN

UniProt

Q86YV5 - SG223_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tyrosine-protein kinase SgK223

Gene

SGK223

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1024 – 10241ATPPROSITE-ProRule annotation
Active sitei1145 – 11451Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi984 – 9929ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ86YV5.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase SgK223 (EC:2.7.10.2)
Alternative name(s):
Sugen kinase 223
Gene namesi
Name:SGK223
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14061406Tyrosine-protein kinase SgK223PRO_0000263008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei413 – 4131PhosphotyrosineBy similarity
Modified residuei696 – 6961Phosphoserine1 Publication
Modified residuei745 – 7451Phosphoserine2 Publications
Modified residuei826 – 8261Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86YV5.
PaxDbiQ86YV5.
PRIDEiQ86YV5.

PTM databases

PhosphoSiteiQ86YV5.

Expressioni

Gene expression databases

BgeeiQ86YV5.
GenevestigatoriQ86YV5.

Organism-specific databases

HPAiHPA012066.

Interactioni

Protein-protein interaction databases

BioGridi127591. 7 interactions.
IntActiQ86YV5. 6 interactions.
MINTiMINT-1413315.
STRINGi9606.ENSP00000330930.

Structurei

3D structure databases

ProteinModelPortaliQ86YV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini978 – 1329352Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 584Poly-Pro
Compositional biasi713 – 7186Poly-Pro

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG115841.
GeneTreeiENSGT00460000041554.
HOGENOMiHOG000168455.
HOVERGENiHBG055817.
InParanoidiQ86YV5.
OMAiSHSETNV.
PhylomeDBiQ86YV5.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86YV5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHQTLCLNPE SLKMSACSDF VEHIWKPGSC KNCFCLRSDH QLVAGPPQPR
60 70 80 90 100
AGSLPPPPRL PPRPENCRLE DEGVNSSPYS KPTIAVKPTM MSSEASDVWT
110 120 130 140 150
EANLSAEVSQ VIWRRAPGKL PLPKQEDAPV VYLGSFRGVQ KPAGPSTSPD
160 170 180 190 200
GNSRCPPAYT MVGLHNLEPR GERNIAFHPV SFPEEKAVHK EKPSFPYQDR
210 220 230 240 250
PSTQESFRQK LAAFAGTTSG CHQGPGPLRE SLPSEDDSDQ RCSPSGDSEG
260 270 280 290 300
GEYCSILDCC PGSPVAKAAS QTAGSRGRHG GRDCSPTCWE QGKCSGPAEQ
310 320 330 340 350
EKRGPSFPKE CCSQGPTAHP SCLGPKKLSL TSEAAISSDG LSCGSGSGSG
360 370 380 390 400
SGASSPFVPH LESDYCSLMK EPAPEKQQDP GCPGVTPSRC LGLTGEPQPP
410 420 430 440 450
AHPREATQPE PIYAESTKRK KAAPVPSKSQ AKIEHAAAAQ GQGQVCTGNA
460 470 480 490 500
WAQKAASGWG RDSPDPTPQV SATITVMAAH PEEDHRTIYL SSPDSAVGVQ
510 520 530 540 550
WPRGPVSQNS EVGEEETSAG QGLSSRESHA HSASESKPKE RPAIPPKLSK
560 570 580 590 600
SSPVGSPVSP SAGGPPVSPL ADLSDGSSGG SSIGPQPPSQ GPADPAPSCR
610 620 630 640 650
TNGVAISDPS RCPQPAASSA SEQRRPRFQA GTWSRQCRIE EEEEVEQELL
660 670 680 690 700
SHSWGRETKN GPTDHSNSTT WHRLHPTDGS SGQNSKVGTG MSKSASFAFE
710 720 730 740 750
FPKDRSGIET FSPPPPPPKS RHLLKMNKSS SDLEKVSQGS AESLSPSFRG
760 770 780 790 800
VHVSFTTGST DSLASDSRTC SDGGPSSELA HSPTNSGKKL FAPVPFPSGS
810 820 830 840 850
TEDVSPSGPQ QPPPLPQKKI VSRAASSPDG FFWTQGSPKP GTASPKLNLS
860 870 880 890 900
HSETNVHDES HFSYSLSPGN RHHPVFSSSD PLEKAFKGSG HWLPAAGLAG
910 920 930 940 950
NRGGCGSPGL QCKGAPSASS SQLSVSSQAS TGSTQLQLHG LLSNISSKEG
960 970 980 990 1000
TYAKLGGLYT QSLARLVAKC EDLFMGGQKK ELHFNENNWS LFKLTCNKPC
1010 1020 1030 1040 1050
CDSGDAIYYC ATCSEDPGST YAVKICKAPE PKTVSYCSPS VPVHFNIQQD
1060 1070 1080 1090 1100
CGHFVASVPS SMLSSPDAPK DPVPALPTHP PAQEQDCVVV ITREVPHQTA
1110 1120 1130 1140 1150
SDFVRDSAAS HQAEPEAYER RVCFLLLQLC NGLEHLKEHG IIHRDLCLEN
1160 1170 1180 1190 1200
LLLVHCTLQA GPGPAPAPAP APAPAAAAPP CSSAAPPAGG TLSPAAGPAS
1210 1220 1230 1240 1250
PEGPREKQLP RLIISNFLKA KQKPGGTPNL QQKKSQARLA PEIVSASQYR
1260 1270 1280 1290 1300
KFDEFQTGIL IYELLHQPNP FEVRAQLRER DYRQEDLPPL PALSLYSPGL
1310 1320 1330 1340 1350
QQLAHLLLEA DPIKRIRIGE AKRVLQCLLW GPRRELVQQP GTSEEALCGT
1360 1370 1380 1390 1400
LHNWIDMKRA LMMMKFAEKA VDRRRGVELE DWLCCQYLAS AEPGALLQSL

KLLQLL
Length:1,406
Mass (Da):149,624
Last modified:October 1, 2014 - v4
Checksum:i941BCF315B826148
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1226 – 12261G → S in BAC56923. 1 PublicationCurated
Sequence conflicti1226 – 12261G → S in CAD38729. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221L → I.1 Publication
VAR_041803
Natural varianti137 – 1371R → G.1 Publication
VAR_041804
Natural varianti139 – 1391V → I.1 Publication
VAR_041805
Natural varianti404 – 4041R → Q.2 Publications
VAR_041806
Natural varianti569 – 5691P → L.2 Publications
VAR_041807
Natural varianti578 – 5781S → C.2 Publications
VAR_041808
Natural varianti595 – 5951P → A.1 Publication
VAR_041809
Natural varianti662 – 6621P → T.1 Publication
VAR_041810
Natural varianti814 – 8141P → L.1 Publication
VAR_041811
Natural varianti851 – 8511H → R.1 Publication
VAR_041812
Natural varianti1003 – 10031S → L.1 Publication
VAR_041813
Natural varianti1041 – 10411V → M.1 Publication
VAR_041814
Natural varianti1113 – 11131A → T.3 Publications
VAR_041815
Natural varianti1315 – 13151R → H.1 Publication
VAR_041816

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC068353 Genomic DNA. No translation available.
AC103957 Genomic DNA. No translation available.
AK122582 mRNA. Translation: BAC56923.1.
AL833872 mRNA. Translation: CAD38729.1.
RefSeqiNP_001074295.2. NM_001080826.2.
XP_005272426.2. XM_005272369.2.
XP_005272427.2. XM_005272370.2.
UniGeneiHs.583863.
Hs.657673.

Genome annotation databases

GeneIDi157285.
UCSCiuc003wsh.4. human.

Polymorphism databases

DMDMi327478560.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC068353 Genomic DNA. No translation available.
AC103957 Genomic DNA. No translation available.
AK122582 mRNA. Translation: BAC56923.1 .
AL833872 mRNA. Translation: CAD38729.1 .
RefSeqi NP_001074295.2. NM_001080826.2.
XP_005272426.2. XM_005272369.2.
XP_005272427.2. XM_005272370.2.
UniGenei Hs.583863.
Hs.657673.

3D structure databases

ProteinModelPortali Q86YV5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127591. 7 interactions.
IntActi Q86YV5. 6 interactions.
MINTi MINT-1413315.
STRINGi 9606.ENSP00000330930.

PTM databases

PhosphoSitei Q86YV5.

Polymorphism databases

DMDMi 327478560.

Proteomic databases

MaxQBi Q86YV5.
PaxDbi Q86YV5.
PRIDEi Q86YV5.

Protocols and materials databases

DNASUi 157285.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 157285.
UCSCi uc003wsh.4. human.

Organism-specific databases

CTDi 157285.
GeneCardsi GC08M008175.
H-InvDB HIX0007293.
HPAi HPA012066.
neXtProti NX_Q86YV5.

Phylogenomic databases

eggNOGi NOG115841.
GeneTreei ENSGT00460000041554.
HOGENOMi HOG000168455.
HOVERGENi HBG055817.
InParanoidi Q86YV5.
OMAi SHSETNV.
PhylomeDBi Q86YV5.

Enzyme and pathway databases

SignaLinki Q86YV5.

Miscellaneous databases

ChiTaRSi SGK223. human.
NextBioi 87443.
PROi Q86YV5.

Gene expression databases

Bgeei Q86YV5.
Genevestigatori Q86YV5.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-1406, VARIANTS GLN-404; LEU-569; CYS-578 AND THR-1113.
    Tissue: Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 820-1406, VARIANT THR-1113.
    Tissue: Amygdala.
  4. Cited for: IDENTIFICATION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-696 AND SER-745, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-745, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-122; GLY-137; ILE-139; GLN-404; LEU-569; CYS-578; ALA-595; THR-662; LEU-814; ARG-851; LEU-1003; MET-1041; THR-1113 AND HIS-1315.

Entry informationi

Entry nameiSG223_HUMAN
AccessioniPrimary (citable) accession number: Q86YV5
Secondary accession number(s): Q8N3N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2014
Last modified: October 29, 2014
This is version 96 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3