SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q86YV0

- RASL3_HUMAN

UniProt

Q86YV0 - RASL3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

RAS protein activator like-3

Gene
RASAL3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May function as a Ras GTPase-activating protein By similarity.

GO - Molecular functioni

  1. Ras GTPase activator activity Source: RefGenome

GO - Biological processi

  1. negative regulation of Ras protein signal transduction Source: RefGenome
  2. positive regulation of Ras GTPase activity Source: RefGenome
  3. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
RAS protein activator like-3
Gene namesi
Name:RASAL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26129. RASAL3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular vesicular exosome Source: UniProt
  3. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164725297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10111011RAS protein activator like-3PRO_0000322566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181Phosphoserine1 Publication
Modified residuei164 – 1641Phosphoserine1 Publication
Modified residuei167 – 1671Phosphoserine1 Publication
Modified residuei231 – 2311Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86YV0.
PaxDbiQ86YV0.
PRIDEiQ86YV0.

PTM databases

PhosphoSiteiQ86YV0.

Expressioni

Gene expression databases

BgeeiQ86YV0.
GenevestigatoriQ86YV0.

Organism-specific databases

HPAiHPA043417.

Interactioni

Protein-protein interaction databases

BioGridi122348. 2 interactions.
IntActiQ86YV0. 2 interactions.
STRINGi9606.ENSP00000341905.

Structurei

3D structure databases

ProteinModelPortaliQ86YV0.
SMRiQ86YV0. Positions 304-736.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini197 – 29397PHAdd
BLAST
Domaini306 – 38479C2Add
BLAST
Domaini458 – 650193Ras-GAPAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili888 – 988101 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 314Poly-Gly
Compositional biasi96 – 13338Pro-richAdd
BLAST
Compositional biasi789 – 82941Arg-richAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG313834.
HOGENOMiHOG000154074.
InParanoidiQ86YV0.
KOiK17634.
OMAiRRHFQPS.
OrthoDBiEOG7KM5S1.
PhylomeDBiQ86YV0.
TreeFamiTF105303.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR001849. PH_domain.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view]
PfamiPF00616. RasGAP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86YV0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDPPSPSRTS QTQPTATSPL TSYRWHTGGG GEKAAGGFRW GRFAGWGRAL     50
SHQEPMVSTQ PAPRSIFRRV LSAPPKESRT SRLRLSKALW GRHKNPPPEP 100
DPEPEQEAPE LEPEPELEPP TPQIPEAPTP NVPVWDIGGF TLLDGKLVLL 150
GGEEEGPRRP RVGSASSEGS IHVAMGNFRD PDRMPGKTEP ETAGPNQVHN 200
VRGLLKRLKE KKKARLEPRD GPPSALGSRE SLATLSELDL GAERDVRIWP 250
LHPSLLGEPH CFQVTWTGGS RCFSCRSAAE RDRWIEDLRR QFQPTQDNVE 300
REETWLSVWV HEAKGLPRAA AGAPGVRAEL WLDGALLART APRAGPGQLF 350
WAERFHFEAL PPARRLSLRL RGLGPGSAVL GRVALALEEL DAPRAPAAGL 400
ERWFPLLGAP AGAALRARIR ARRLRVLPSE RYKELAEFLT FHYARLCGAL 450
EPALPAQAKE ELAAAMVRVL RATGRAQALV TDLGTAELAR CGGREALLFR 500
ENTLATKAID EYMKLVAQDY LQETLGQVVR RLCASTEDCE VDPSKCPASE 550
LPEHQARLRN SCEEVFETII HSYDWFPAEL GIVFSSWREA CKERGSEVLG 600
PRLVCASLFL RLLCPAILAP SLFGLAPDHP APGPARTLTL IAKVIQNLAN 650
RAPFGEKEAY MGFMNSFLEE HGPAMQCFLD QVAMVDVDAA PSGYQGSGDL 700
ALQLAVLHAQ LCTIFAELDQ TTRDTLEPLP TILRAIEEGQ PVLVSVPMRL 750
PLPPAQVHSS LSAGEKPGFL APRDLPKHTP LISKSQSLRS VRRSESWARP 800
RPDEERPLRR PRPVQRTQSV PVRRPARRRQ SAGPWPRPKG SLSMGPAPRA 850
RPWTRDSASL PRKPSVPWQR QMDQPQDRNQ ALGTHRPVNK LAELQCEVAA 900
LREEQKVLSR LVESLSTQIR ALTEQQEQLR GQLQDLDSRL RAGSSEFDSE 950
HNLTSNEGHS LKNLEHRLNE MERTQAQLRD AVQSLQLSPR TRGSWSQPQP 1000
LKAPCLNGDT T 1011
Length:1,011
Mass (Da):111,898
Last modified:February 26, 2008 - v2
Checksum:i23A7CA251ED3CE33
GO
Isoform 2 (identifier: Q86YV0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     944-1011: Missing.

Show »
Length:943
Mass (Da):104,243
Checksum:i2DD6F0CCA9FCA2A0
GO

Sequence cautioni

The sequence AAH30281.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB15064.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC56928.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAC56928.1 differs from that shown. Reason: Erroneous termination at position 723. Translated as Arg.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti251 – 2511L → V.
Corresponds to variant rs58123634 [ dbSNP | Ensembl ].
VAR_061179
Natural varianti594 – 5941R → C.
Corresponds to variant rs56209154 [ dbSNP | Ensembl ].
VAR_061180
Natural varianti825 – 8251P → T.
Corresponds to variant rs57208996 [ dbSNP | Ensembl ].
VAR_061181

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei944 – 101168Missing in isoform 2. VSP_033824Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122587 mRNA. Translation: BAC56928.1. Sequence problems.
AC011492 Genomic DNA. No translation available.
AK025091 mRNA. Translation: BAB15064.1. Different initiation.
BC030281 mRNA. Translation: AAH30281.1. Different initiation.
CCDSiCCDS46006.1. [Q86YV0-1]
RefSeqiNP_075055.1. NM_022904.1. [Q86YV0-1]
UniGeneiHs.136979.

Genome annotation databases

EnsembliENST00000343625; ENSP00000341905; ENSG00000105122. [Q86YV0-1]
GeneIDi64926.
KEGGihsa:64926.
UCSCiuc002nbe.2. human. [Q86YV0-1]

Polymorphism databases

DMDMi172046741.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122587 mRNA. Translation: BAC56928.1 . Sequence problems.
AC011492 Genomic DNA. No translation available.
AK025091 mRNA. Translation: BAB15064.1 . Different initiation.
BC030281 mRNA. Translation: AAH30281.1 . Different initiation.
CCDSi CCDS46006.1. [Q86YV0-1 ]
RefSeqi NP_075055.1. NM_022904.1. [Q86YV0-1 ]
UniGenei Hs.136979.

3D structure databases

ProteinModelPortali Q86YV0.
SMRi Q86YV0. Positions 304-736.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122348. 2 interactions.
IntActi Q86YV0. 2 interactions.
STRINGi 9606.ENSP00000341905.

PTM databases

PhosphoSitei Q86YV0.

Polymorphism databases

DMDMi 172046741.

Proteomic databases

MaxQBi Q86YV0.
PaxDbi Q86YV0.
PRIDEi Q86YV0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343625 ; ENSP00000341905 ; ENSG00000105122 . [Q86YV0-1 ]
GeneIDi 64926.
KEGGi hsa:64926.
UCSCi uc002nbe.2. human. [Q86YV0-1 ]

Organism-specific databases

CTDi 64926.
GeneCardsi GC19M015562.
H-InvDB HIX0202731.
HGNCi HGNC:26129. RASAL3.
HPAi HPA043417.
neXtProti NX_Q86YV0.
PharmGKBi PA164725297.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313834.
HOGENOMi HOG000154074.
InParanoidi Q86YV0.
KOi K17634.
OMAi RRHFQPS.
OrthoDBi EOG7KM5S1.
PhylomeDBi Q86YV0.
TreeFami TF105303.

Miscellaneous databases

GenomeRNAii 64926.
NextBioi 67081.
PROi Q86YV0.

Gene expression databases

Bgeei Q86YV0.
Genevestigatori Q86YV0.

Family and domain databases

Gene3Di 1.10.506.10. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR001849. PH_domain.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view ]
Pfami PF00616. RasGAP. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEi PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spleen.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 715-1011 (ISOFORM 2).
    Tissue: Colon.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 723-1011 (ISOFORM 1).
    Tissue: Blood.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-164; SER-167 AND SER-231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiRASL3_HUMAN
AccessioniPrimary (citable) accession number: Q86YV0
Secondary accession number(s): Q8N2T9, Q9H735
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 3, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi