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Protein

Junctional adhesion molecule-like

Gene

JAML

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.4 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: UniProtKB
  • integrin binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • gamma-delta T cell activation Source: UniProtKB
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • leukocyte migration Source: Reactome
  • monocyte extravasation Source: UniProtKB
  • neutrophil chemotaxis Source: UniProtKB
  • neutrophil extravasation Source: UniProtKB
  • positive regulation of epithelial cell proliferation involved in wound healing Source: UniProtKB
  • regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule-likeImported
Alternative name(s):
Adhesion molecule interacting with CXADR antigen 1
Dendritic cell-specific protein CREA7-1
Gene namesi
Name:JAMLImported
Synonyms:AMICA1
ORF Names:UNQ722/PRO1387
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19084. JAML.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 275256ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29621HelicalSequence analysisAdd
BLAST
Topological domaini297 – 39498CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • bicellular tight junction Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi54 – 541K → E: Loss of the ability to homodimerize, loss of interaction with CXADR and loss of function in cell-cell adhesion. 2 Publications

Organism-specific databases

PharmGKBiPA38792.

Polymorphism and mutation databases

BioMutaiAMICA1.
DMDMi71151910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 394375Junctional adhesion molecule-likePRO_0000015074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 116PROSITE-ProRule annotation
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi155 ↔ 234PROSITE-ProRule annotation
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86YT9.
PeptideAtlasiQ86YT9.
PRIDEiQ86YT9.

PTM databases

iPTMnetiQ86YT9.
PhosphoSiteiQ86YT9.
SwissPalmiQ86YT9.

Expressioni

Tissue specificityi

Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).3 Publications

Inductioni

Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells.1 Publication

Gene expression databases

BgeeiQ86YT9.
CleanExiHS_AMICA1.
ExpressionAtlasiQ86YT9. baseline and differential.
GenevisibleiQ86YT9. HS.

Organism-specific databases

HPAiHPA047919.

Interactioni

Subunit structurei

Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization.2 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: UniProtKB
  • integrin binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi125686. 1 interaction.
IntActiQ86YT9. 4 interactions.
STRINGi9606.ENSP00000348635.

Structurei

3D structure databases

ProteinModelPortaliQ86YT9.
SMRiQ86YT9. Positions 28-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 132113Ig-like V-type 1Add
BLAST
Domaini137 – 250114Ig-like V-type 2Add
BLAST

Domaini

The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062).By similarity2 Publications

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKEA. Eukaryota.
ENOG4111DWB. LUCA.
GeneTreeiENSGT00440000034341.
HOGENOMiHOG000294145.
HOVERGENiHBG055209.
InParanoidiQ86YT9.
OMAiGHFQNRV.
OrthoDBiEOG7NW6CW.
PhylomeDBiQ86YT9.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR029871. JAML.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 2 hits.
PTHR13869:SF22. PTHR13869:SF22. 2 hits.
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86YT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFCPLKLILL PVLLDYSLGL NDLNVSPPEL TVHVGDSALM GCVFQSTEDK
60 70 80 90 100
CIFKIDWTLS PGEHAKDEYV LYYYSNLSVP IGRFQNRVHL MGDILCNDGS
110 120 130 140 150
LLLQDVQEAD QGTYICEIRL KGESQVFKKA VVLHVLPEEP KELMVHVGGL
160 170 180 190 200
IQMGCVFQST EVKHVTKVEW IFSGRRAKEE IVFRYYHKLR MSVEYSQSWG
210 220 230 240 250
HFQNRVNLVG DIFRNDGSIM LQGVRESDGG NYTCSIHLGN LVFKKTIVLH
260 270 280 290 300
VSPEEPRTLV TPAALRPLVL GGNQLVIIVG IVCATILLLP VLILIVKKTC
310 320 330 340 350
GNKSSVNSTV LVKNTKKTNP EIKEKPCHFE RCEGEKHIYS PIIVREVIEE
360 370 380 390
EEPSEKSEAT YMTMHPVWPS LRSDRNNSLE KKSGGGMPKT QQAF
Length:394
Mass (Da):44,339
Last modified:June 1, 2003 - v1
Checksum:i64B542F9384C7642
GO
Isoform 2 (identifier: Q86YT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MFCPLKLILLPVLL → MVSG

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):43,119
Checksum:iD7C7F025BB22C026
GO
Isoform 3 (identifier: Q86YT9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-259: TL → SI
     260-394: Missing.

Note: No experimental confirmation available.
Show »
Length:259
Mass (Da):29,422
Checksum:iCD776E7F57AE0CC9
GO
Isoform 4 (identifier: Q86YT9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Note: No experimental confirmation available.
Show »
Length:355
Mass (Da):40,136
Checksum:iF123D30ECFC3694F
GO

Sequence cautioni

The sequence BAC03390.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti283 – 2831C → G in AAM15730 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941I → N.2 Publications
Corresponds to variant rs17121881 [ dbSNP | Ensembl ].
VAR_049974
Natural varianti193 – 1931V → A.3 Publications
Corresponds to variant rs1793174 [ dbSNP | Ensembl ].
VAR_049975
Natural varianti322 – 3221I → M.
Corresponds to variant rs2298831 [ dbSNP | Ensembl ].
VAR_049976

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3939Missing in isoform 4. 1 PublicationVSP_054911Add
BLAST
Alternative sequencei1 – 1414MFCPL…LPVLL → MVSG in isoform 2. 1 PublicationVSP_014830Add
BLAST
Alternative sequencei258 – 2592TL → SI in isoform 3. 1 PublicationVSP_014831
Alternative sequencei260 – 394135Missing in isoform 3. 1 PublicationVSP_014832Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ515553 mRNA. Translation: CAD56620.2.
AY093686 mRNA. Translation: AAM15730.1.
AY138965 mRNA. Translation: AAN52117.1.
AY358362 mRNA. Translation: AAQ88728.1.
AK090409 mRNA. Translation: BAC03390.1. Different initiation.
AK094399 mRNA. Translation: BAC04347.1.
EF444945 Genomic DNA. Translation: ACA05929.1.
EF444945 Genomic DNA. Translation: ACA05930.1.
AP002800 Genomic DNA. No translation available.
BC100797 mRNA. Translation: AAI00798.1.
CCDSiCCDS41723.1. [Q86YT9-1]
CCDS66240.1. [Q86YT9-4]
CCDS8391.1. [Q86YT9-2]
RefSeqiNP_001091996.1. NM_001098526.1. [Q86YT9-1]
NP_001273499.1. NM_001286570.1. [Q86YT9-4]
NP_001273500.1. NM_001286571.1. [Q86YT9-4]
NP_694938.2. NM_153206.2. [Q86YT9-2]
XP_011540908.1. XM_011542606.1. [Q86YT9-1]
UniGeneiHs.16291.

Genome annotation databases

EnsembliENST00000292067; ENSP00000292067; ENSG00000160593. [Q86YT9-2]
ENST00000356289; ENSP00000348635; ENSG00000160593. [Q86YT9-1]
ENST00000526620; ENSP00000431218; ENSG00000160593. [Q86YT9-4]
GeneIDi120425.
KEGGihsa:120425.
UCSCiuc001psi.3. human. [Q86YT9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ515553 mRNA. Translation: CAD56620.2.
AY093686 mRNA. Translation: AAM15730.1.
AY138965 mRNA. Translation: AAN52117.1.
AY358362 mRNA. Translation: AAQ88728.1.
AK090409 mRNA. Translation: BAC03390.1. Different initiation.
AK094399 mRNA. Translation: BAC04347.1.
EF444945 Genomic DNA. Translation: ACA05929.1.
EF444945 Genomic DNA. Translation: ACA05930.1.
AP002800 Genomic DNA. No translation available.
BC100797 mRNA. Translation: AAI00798.1.
CCDSiCCDS41723.1. [Q86YT9-1]
CCDS66240.1. [Q86YT9-4]
CCDS8391.1. [Q86YT9-2]
RefSeqiNP_001091996.1. NM_001098526.1. [Q86YT9-1]
NP_001273499.1. NM_001286570.1. [Q86YT9-4]
NP_001273500.1. NM_001286571.1. [Q86YT9-4]
NP_694938.2. NM_153206.2. [Q86YT9-2]
XP_011540908.1. XM_011542606.1. [Q86YT9-1]
UniGeneiHs.16291.

3D structure databases

ProteinModelPortaliQ86YT9.
SMRiQ86YT9. Positions 28-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125686. 1 interaction.
IntActiQ86YT9. 4 interactions.
STRINGi9606.ENSP00000348635.

PTM databases

iPTMnetiQ86YT9.
PhosphoSiteiQ86YT9.
SwissPalmiQ86YT9.

Polymorphism and mutation databases

BioMutaiAMICA1.
DMDMi71151910.

Proteomic databases

PaxDbiQ86YT9.
PeptideAtlasiQ86YT9.
PRIDEiQ86YT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292067; ENSP00000292067; ENSG00000160593. [Q86YT9-2]
ENST00000356289; ENSP00000348635; ENSG00000160593. [Q86YT9-1]
ENST00000526620; ENSP00000431218; ENSG00000160593. [Q86YT9-4]
GeneIDi120425.
KEGGihsa:120425.
UCSCiuc001psi.3. human. [Q86YT9-1]

Organism-specific databases

CTDi120425.
GeneCardsiAMICA1.
HGNCiHGNC:19084. JAML.
HPAiHPA047919.
MIMi609770. gene.
neXtProtiNX_Q86YT9.
PharmGKBiPA38792.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKEA. Eukaryota.
ENOG4111DWB. LUCA.
GeneTreeiENSGT00440000034341.
HOGENOMiHOG000294145.
HOVERGENiHBG055209.
InParanoidiQ86YT9.
OMAiGHFQNRV.
OrthoDBiEOG7NW6CW.
PhylomeDBiQ86YT9.
TreeFamiTF331728.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

ChiTaRSiAMICA1. human.
GeneWikiiAMICA1.
GenomeRNAii120425.
PROiQ86YT9.
SOURCEiSearch...

Gene expression databases

BgeeiQ86YT9.
CleanExiHS_AMICA1.
ExpressionAtlasiQ86YT9. baseline and differential.
GenevisibleiQ86YT9. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR029871. JAML.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 2 hits.
PTHR13869:SF22. PTHR13869:SF22. 2 hits.
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells."
    Moog-Lutz C., Cave-Riant F., Guibal F.C., Breau M.A., Di Gioia Y., Couraud P.O., Cayre Y.E., Bourdoulous S., Lutz P.G.
    Blood 102:3371-3378(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION IN LEUKOCYTE MIGRATION, INDUCTION, SUBCELLULAR LOCATION, DOMAIN, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-54, VARIANT ALA-193.
    Tissue: Bone marrow.
  2. "Dendritic cell specific protein Crea7-1."
    Ahn J.H., Jung H.R., Lee B.-H., Jeon C.J., Bae Y.-S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ASN-94 AND ALA-193.
    Tissue: Dendritic cell.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS ASN-94 AND ALA-193.
    Tissue: Cerebellum and Spleen.
  5. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-34.
  9. "Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils."
    Zen K., Liu Y., McCall I.C., Wu T., Lee W., Babbin B.A., Nusrat A., Parkos C.A.
    Mol. Biol. Cell 16:2694-2703(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LEUKOCYTE MIGRATION, INTERACTION WITH CXADR, SUBCELLULAR LOCATION, DOMAIN.
  10. "JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation."
    Luissint A.C., Lutz P.G., Calderwood D.A., Couraud P.O., Bourdoulous S.
    J. Cell Biol. 183:1159-1173(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LEUKOCYTE MIGRATION, HOMODIMERIZATION, MUTAGENESIS OF LYS-54, INTERACTION WITH CXADR, TISSUE SPECIFICITY.
  11. "Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration."
    Guo Y.L., Bai R., Chen C.X., Liu D.Q., Liu Y., Zhang C.Y., Zen K.
    Arterioscler. Thromb. Vasc. Biol. 29:75-83(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LEUKOCYTE MIGRATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiJAML_HUMAN
AccessioniPrimary (citable) accession number: Q86YT9
Secondary accession number(s): B0YIV1
, B0YIV2, Q496M1, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.