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Q86YT6

- MIB1_HUMAN

UniProt

Q86YT6 - MIB1_HUMAN

Protein

E3 ubiquitin-protein ligase MIB1

Gene

MIB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis By similarity. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.By similarity1 Publication

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri79 – 12648ZZ-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri819 – 85436RING-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri866 – 90136RING-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri963 – 99634RING-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. ubiquitin-protein transferase activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. blood vessel development Source: Ensembl
    2. heart looping Source: Ensembl
    3. in utero embryonic development Source: Ensembl
    4. negative regulation of neuron differentiation Source: Ensembl
    5. neural tube formation Source: Ensembl
    6. Notch signaling pathway Source: Reactome
    7. positive regulation of endocytosis Source: Ensembl
    8. somitogenesis Source: Ensembl

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Notch signaling pathway, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    SignaLinkiQ86YT6.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase MIB1 (EC:6.3.2.-)
    Alternative name(s):
    DAPK-interacting protein 1
    Short name:
    DIP-1
    Mind bomb homolog 1
    Zinc finger ZZ type with ankyrin repeat domain protein 2
    Gene namesi
    Name:MIB1
    Synonyms:DIP1, KIAA1323, ZZANK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:21086. MIB1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriolar satellite 1 Publication. Cell membrane By similarity
    Note: Localizes to the plasma membrane By similarity. According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.By similarity

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasmic vesicle Source: Ensembl
    3. cytosol Source: Reactome
    4. plasma membrane Source: UniProtKB-SubCell
    5. postsynaptic density Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Left ventricular non-compaction 7 (LVNC7) [MIM:615092]: A disease due to an arrest of myocardial morphogenesis. It is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti943 – 9431V → F in LVNC7. 1 Publication
    VAR_069620

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi615092. phenotype.
    Orphaneti54260. Left ventricular noncompaction.
    PharmGKBiPA134862722.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10061006E3 ubiquitin-protein ligase MIB1PRO_0000055943Add
    BLAST

    Post-translational modificationi

    Ubiquitinated; possibly via autoubiquitination By similarity. Ubiquitinated; this modification is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.By similarity2 Publications

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ86YT6.
    PaxDbiQ86YT6.
    PRIDEiQ86YT6.

    PTM databases

    PhosphoSiteiQ86YT6.

    Expressioni

    Tissue specificityi

    Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.1 Publication

    Gene expression databases

    ArrayExpressiQ86YT6.
    BgeeiQ86YT6.
    CleanExiHS_MIB1.
    GenevestigatoriQ86YT6.

    Organism-specific databases

    HPAiCAB037044.
    HPA019100.

    Interactioni

    Subunit structurei

    Interacts with CEP131 and PCM1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Azi2Q9QYP62EBI-2129148,EBI-6115874From a different organism.
    TBK1Q9UHD22EBI-2129148,EBI-356402

    Protein-protein interaction databases

    BioGridi121593. 35 interactions.
    IntActiQ86YT6. 13 interactions.
    MINTiMINT-2841371.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86YT6.
    SMRiQ86YT6. Positions 15-70, 154-216, 382-779, 851-908, 953-1003.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 7469MIB/HERC2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini143 – 22179MIB/HERC2 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati430 – 46031ANK 1Add
    BLAST
    Repeati463 – 49230ANK 2Add
    BLAST
    Repeati496 – 52530ANK 3Add
    BLAST
    Repeati529 – 55830ANK 4Add
    BLAST
    Repeati562 – 59130ANK 5Add
    BLAST
    Repeati595 – 62733ANK 6Add
    BLAST
    Repeati631 – 66131ANK 7Add
    BLAST
    Repeati665 – 69430ANK 8Add
    BLAST
    Repeati698 – 72932ANK 9Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili935 – 96228Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 9 ANK repeats.PROSITE-ProRule annotation
    Contains 2 MIB/HERC2 domains.PROSITE-ProRule annotation
    Contains 3 RING-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri79 – 12648ZZ-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri819 – 85436RING-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri866 – 90136RING-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri963 – 99634RING-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0666.
    HOVERGENiHBG068386.
    InParanoidiQ86YT6.
    KOiK10645.
    OMAiHDAISKE.
    OrthoDBiEOG7WHH8P.
    PhylomeDBiQ86YT6.
    TreeFamiTF324147.

    Family and domain databases

    Gene3Di1.25.40.20. 4 hits.
    3.30.40.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR010606. Mib_Herc2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 3 hits.
    PF06701. MIB_HERC2. 2 hits.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 9 hits.
    SM00184. RING. 3 hits.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 6 hits.
    PS51416. MIB_HERC2. 2 hits.
    PS50089. ZF_RING_2. 3 hits.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86YT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNSRNNRVM VEGVGARVVR GPDWKWGKQD GGEGHVGTVR SFESPEEVVV     50
    VWDNGTAANY RCSGAYDLRI LDSAPTGIKH DGTMCDTCRQ QPIIGIRWKC 100
    AECTNYDLCT VCYHGDKHHL RHRFYRITTP GSERVLLESR RKSKKITARG 150
    IFAGARVVRG VDWQWEDQDG GNGRRGKVTE IQDWSASSPH SAAYVLWDNG 200
    AKNLYRVGFE GMSDLKCVQD AKGGSFYRDH CPVLGEQNGN RNPGGLQIGD 250
    LVNIDLDLEI VQSLQHGHGG WTDGMFETLT TTGTVCGIDE DHDIVVQYPS 300
    GNRWTFNPAV LTKANIVRSG DAAQGAEGGT SQFQVGDLVQ VCYDLERIKL 350
    LQRGHGEWAE AMLPTLGKVG RVQQIYSDSD LKVEVCGTSW TYNPAAVSKV 400
    ASAGSAISNA SGERLSQLLK KLFETQESGD LNEELVKAAA NGDVAKVEDL 450
    LKRPDVDVNG QCAGHTAMQA ASQNGHVDIL KLLLKQNVDV EAEDKDGDRA 500
    VHHAAFGDEG AVIEVLHRGS ADLNARNKRR QTPLHIAVNK GHLQVVKTLL 550
    DFGCHPSLQD SEGDTPLHDA ISKKRDDILA VLLEAGADVT ITNNNGFNAL 600
    HHAALRGNPS AMRVLLSKLP RPWIVDEKKD DGYTALHLAA LNNHVEVAEL 650
    LVHQGNANLD IQNVNQQTAL HLAVERQHTQ IVRLLVRAGA KLDIQDKDGD 700
    TPLHEALRHH TLSQLRQLQD MQDVGKVDAA WEPSKNTLIM GLGTQGAEKK 750
    SAASIACFLA ANGADLSIRN KKGQSPLDLC PDPNLCKALA KCHKEKVSGQ 800
    VGSRSPSMIS NDSETLEECM VCSDMKRDTL FGPCGHIATC SLCSPRVKKC 850
    LICKEQVQSR TKIEECVVCS DKKAAVLFQP CGHMCACENC ANLMKKCVQC 900
    RAVVERRVPF IMCCGGKSSE DATDDISSGN IPVLQKDKDN TNVNADVQKL 950
    QQQLQDIKEQ TMCPVCLDRL KNMIFLCGHG TCQLCGDRMS ECPICRKAIE 1000
    RRILLY 1006
    Length:1,006
    Mass (Da):110,136
    Last modified:June 1, 2003 - v1
    Checksum:i5D7D0D91AF98FF18
    GO

    Sequence cautioni

    The sequence AAN18023.1 differs from that shown. Reason: Frameshift at position 3.
    The sequence AAH22403.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC11439.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti327 – 3271E → K in AAN18023. 1 PublicationCurated
    Sequence conflicti398 – 3981S → F in AAN18023. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti174 – 1741R → H Found in a patient with severe mental retardation, psychomotor delay, no speech, sleep disturbances, feeding problems, abnormal breething, deep-set eyes and short philtrum. 1 Publication
    VAR_069385
    Natural varianti943 – 9431V → F in LVNC7. 1 Publication
    VAR_069620

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY149908 mRNA. Translation: AAN75493.1.
    AY147849 mRNA. Translation: AAN18023.1. Frameshift.
    EF444995 Genomic DNA. Translation: ACA06016.1.
    BC022403 mRNA. Translation: AAH22403.1. Different initiation.
    BC110581 mRNA. Translation: AAI10582.1.
    BC110582 mRNA. Translation: AAI10583.1.
    CR749635 mRNA. Translation: CAH18429.1.
    AL713705 mRNA. Translation: CAD28502.1.
    AB037744 mRNA. Translation: BAA92561.1.
    AK075157 mRNA. Translation: BAC11439.1. Different initiation.
    CCDSiCCDS11871.1.
    RefSeqiNP_065825.1. NM_020774.3.
    UniGeneiHs.140903.

    Genome annotation databases

    EnsembliENST00000261537; ENSP00000261537; ENSG00000101752.
    GeneIDi57534.
    KEGGihsa:57534.
    UCSCiuc002ktp.3. human.

    Polymorphism databases

    DMDMi68565512.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY149908 mRNA. Translation: AAN75493.1 .
    AY147849 mRNA. Translation: AAN18023.1 . Frameshift.
    EF444995 Genomic DNA. Translation: ACA06016.1 .
    BC022403 mRNA. Translation: AAH22403.1 . Different initiation.
    BC110581 mRNA. Translation: AAI10582.1 .
    BC110582 mRNA. Translation: AAI10583.1 .
    CR749635 mRNA. Translation: CAH18429.1 .
    AL713705 mRNA. Translation: CAD28502.1 .
    AB037744 mRNA. Translation: BAA92561.1 .
    AK075157 mRNA. Translation: BAC11439.1 . Different initiation.
    CCDSi CCDS11871.1.
    RefSeqi NP_065825.1. NM_020774.3.
    UniGenei Hs.140903.

    3D structure databases

    ProteinModelPortali Q86YT6.
    SMRi Q86YT6. Positions 15-70, 154-216, 382-779, 851-908, 953-1003.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121593. 35 interactions.
    IntActi Q86YT6. 13 interactions.
    MINTi MINT-2841371.

    PTM databases

    PhosphoSitei Q86YT6.

    Polymorphism databases

    DMDMi 68565512.

    Proteomic databases

    MaxQBi Q86YT6.
    PaxDbi Q86YT6.
    PRIDEi Q86YT6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261537 ; ENSP00000261537 ; ENSG00000101752 .
    GeneIDi 57534.
    KEGGi hsa:57534.
    UCSCi uc002ktp.3. human.

    Organism-specific databases

    CTDi 57534.
    GeneCardsi GC18P019284.
    HGNCi HGNC:21086. MIB1.
    HPAi CAB037044.
    HPA019100.
    MIMi 608677. gene.
    615092. phenotype.
    neXtProti NX_Q86YT6.
    Orphaneti 54260. Left ventricular noncompaction.
    PharmGKBi PA134862722.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOVERGENi HBG068386.
    InParanoidi Q86YT6.
    KOi K10645.
    OMAi HDAISKE.
    OrthoDBi EOG7WHH8P.
    PhylomeDBi Q86YT6.
    TreeFami TF324147.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    SignaLinki Q86YT6.

    Miscellaneous databases

    GeneWikii MIB1_(gene).
    GenomeRNAii 57534.
    NextBioi 63948.
    PROi Q86YT6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86YT6.
    Bgeei Q86YT6.
    CleanExi HS_MIB1.
    Genevestigatori Q86YT6.

    Family and domain databases

    Gene3Di 1.25.40.20. 4 hits.
    3.30.40.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR010606. Mib_Herc2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 3 hits.
    PF06701. MIB_HERC2. 2 hits.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 9 hits.
    SM00184. RING. 3 hits.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 6 hits.
    PS51416. MIB_HERC2. 2 hits.
    PS50089. ZF_RING_2. 3 hits.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta."
      Itoh M., Kim C.-H., Palardy G., Oda T., Jiang Y.-J., Maust D., Yeo S.-Y., Lorick K., Wright G.J., Ariza-McNaughton L., Weissman A.M., Lewis J., Chandrasekharappa S.C., Chitnis A.B.
      Dev. Cell 4:67-82(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Yoo K.-W., Chitnis A., Kim C.-H.
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-1006.
      Tissue: Amygdala and Endometrial tumor.
    6. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 611-1006, TISSUE SPECIFICITY.
      Tissue: Brain.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 627-1006.
      Tissue: Placenta.
    8. "Death-associated protein kinase expression in human temporal lobe epilepsy."
      Henshall D.C., Schindler C.K., So N.K., Lan J.-Q., Meller R., Simon R.P.
      Ann. Neurol. 55:485-494(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE SUBCELLULAR LOCATION.
    9. "Mapping a dynamic innate immunity protein interaction network regulating type I interferon production."
      Li S., Wang L., Berman M., Kong Y.Y., Dorf M.E.
      Immunity 35:426-440(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION OF TBK1.
    10. "A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis."
      Villumsen B.H., Danielsen J.R., Povlsen L., Sylvestersen K.B., Merdes A., Beli P., Yang Y.G., Choudhary C., Nielsen M.L., Mailand N., Bekker-Jensen S.
      EMBO J. 32:3029-3040(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN UBIQUITINATION OF CEP131 AND PCM1, FUNCTION IN CILIOGENESIS, UBIQUITINATION, INTERACTION WITH CEP131 AND PCM1, SUBCELLULAR LOCATION.
    11. Cited for: VARIANT HIS-174.
    12. Cited for: VARIANT LVNC7 PHE-943.

    Entry informationi

    Entry nameiMIB1_HUMAN
    AccessioniPrimary (citable) accession number: Q86YT6
    Secondary accession number(s): B0YJ38
    , Q2TB37, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In epilepsy brain tissue, levels of expression are increased in the cytoplasm and microsomal fractions (endoplasmic reticulum).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3