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Q86YT5

- S13A5_HUMAN

UniProt

Q86YT5 - S13A5_HUMAN

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Protein
Solute carrier family 13 member 5
Gene
SLC13A5, NACT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.1 Publication

GO - Molecular functioni

  1. citrate transmembrane transporter activity Source: Ensembl
  2. sodium:dicarboxylate symporter activity Source: Ensembl
  3. succinate transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Protein family/group databases

TCDBi2.A.47.1.9. the divalent anion:na(+) symporter (dass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 5
Alternative name(s):
Na(+)/citrate cotransporter
Short name:
NaCT
Sodium-coupled citrate transporter
Sodium-dependent citrate transporter
Gene namesi
Name:SLC13A5
Synonyms:NACT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:23089. SLC13A5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321Helical; Reviewed prediction
Add
BLAST
Transmembranei53 – 7321Helical; Reviewed prediction
Add
BLAST
Transmembranei80 – 10021Helical; Reviewed prediction
Add
BLAST
Transmembranei124 – 14421Helical; Reviewed prediction
Add
BLAST
Transmembranei215 – 23521Helical; Reviewed prediction
Add
BLAST
Transmembranei252 – 27221Helical; Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Reviewed prediction
Add
BLAST
Transmembranei353 – 37321Helical; Reviewed prediction
Add
BLAST
Transmembranei406 – 42621Helical; Reviewed prediction
Add
BLAST
Transmembranei439 – 45921Helical; Reviewed prediction
Add
BLAST
Transmembranei487 – 50721Helical; Reviewed prediction
Add
BLAST
Transmembranei528 – 54821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950956.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Solute carrier family 13 member 5
PRO_0000260101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi562 – 5621N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ86YT5.
PaxDbiQ86YT5.
PRIDEiQ86YT5.

PTM databases

PhosphoSiteiQ86YT5.

Expressioni

Tissue specificityi

Expressed most predominantly in the liver, with moderate expression detectable in the brain and testis.1 Publication

Gene expression databases

ArrayExpressiQ86YT5.
BgeeiQ86YT5.
CleanExiHS_SLC13A5.
GenevestigatoriQ86YT5.

Organism-specific databases

HPAiHPA044343.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000293800.

Structurei

3D structure databases

ProteinModelPortaliQ86YT5.
SMRiQ86YT5. Positions 41-275, 396-534.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0471.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ86YT5.
KOiK14445.
OMAiYMRFNFK.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ86YT5.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86YT5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASALSYVSK FKSFVILFVT PLLLLPLVIL MPAKFVRCAY VIILMAIYWC    50
TEVIPLAVTS LMPVLLFPLF QILDSRQVCV QYMKDTNMLF LGGLIVAVAV 100
ERWNLHKRIA LRTLLWVGAK PARLMLGFMG VTALLSMWIS NTATTAMMVP 150
IVEAILQQME ATSAATEAGL ELVDKGKAKE LPGSQVIFEG PTLGQQEDQE 200
RKRLCKAMTL CICYAASIGG TATLTGTGPN VVLLGQMNEL FPDSKDLVNF 250
ASWFAFAFPN MLVMLLFAWL WLQFVYMRFN FKKSWGCGLE SKKNEKAALK 300
VLQEEYRKLG PLSFAEINVL ICFFLLVILW FSRDPGFMPG WLTVAWVEGE 350
TKYVSDATVA IFVATLLFIV PSQKPKFNFR SQTEEERKTP FYPPPLLDWK 400
VTQEKVPWGI VLLLGGGFAL AKGSEASGLS VWMGKQMEPL HAVPPAAITL 450
ILSLLVAVFT ECTSNVATTT LFLPIFASMS RSIGLNPLYI MLPCTLSASF 500
AFMLPVATPP NAIVFTYGHL KVADMVKTGV IMNIIGVFCV FLAVNTWGRA 550
IFDLDHFPDW ANVTHIET 568
Length:568
Mass (Da):63,062
Last modified:June 1, 2003 - v1
Checksum:iB8995E56618DECCB
GO
Isoform 2 (identifier: Q86YT5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     479-524: Missing.

Note: No experimental confirmation available.

Show »
Length:522
Mass (Da):58,110
Checksum:iCD82CB02F6D574C7
GO
Isoform 3 (identifier: Q86YT5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-140: Missing.

Note: No experimental confirmation available.

Show »
Length:551
Mass (Da):61,210
Checksum:iB14F022B99048FF6
GO
Isoform 4 (identifier: Q86YT5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-77: Missing.

Note: No experimental confirmation available.

Show »
Length:525
Mass (Da):58,092
Checksum:iF2D93F70F424B588
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei35 – 7743Missing in isoform 4.
VSP_055652Add
BLAST
Alternative sequencei124 – 14017Missing in isoform 3.
VSP_054910Add
BLAST
Alternative sequencei479 – 52446Missing in isoform 2.
VSP_043098Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti269 – 2691W → R in BAD18766. 1 Publication
Sequence conflicti330 – 3301W → R in BAH12628. 1 Publication
Sequence conflicti376 – 3761K → R in BAD18766. 1 Publication
Sequence conflicti475 – 4751I → V in BAH12628. 1 Publication
Sequence conflicti548 – 5481G → E in BAH12628. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY151833 mRNA. Translation: AAN86530.1.
AK172785 mRNA. Translation: BAD18766.1.
AK127797 mRNA. Translation: BAG54572.1.
AK297612 mRNA. Translation: BAH12628.1.
AC004706 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90292.1.
BC104795 mRNA. Translation: AAI04796.1.
BC112151 mRNA. Translation: AAI12152.1.
BC143689 mRNA. Translation: AAI43690.1.
CCDSiCCDS11079.1. [Q86YT5-1]
CCDS45593.1. [Q86YT5-2]
CCDS67137.1. [Q86YT5-3]
RefSeqiNP_001137310.1. NM_001143838.2. [Q86YT5-2]
NP_001271438.1. NM_001284509.1. [Q86YT5-3]
NP_001271439.1. NM_001284510.1.
NP_808218.1. NM_177550.4. [Q86YT5-1]
UniGeneiHs.399496.

Genome annotation databases

EnsembliENST00000293800; ENSP00000293800; ENSG00000141485.
ENST00000381074; ENSP00000370464; ENSG00000141485.
ENST00000433363; ENSP00000406220; ENSG00000141485. [Q86YT5-1]
ENST00000573648; ENSP00000459372; ENSG00000141485. [Q86YT5-2]
GeneIDi284111.
KEGGihsa:284111.
UCSCiuc002gdj.3. human. [Q86YT5-1]
uc002gdk.3. human.
uc010vtf.2. human. [Q86YT5-2]

Polymorphism databases

DMDMi74714197.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY151833 mRNA. Translation: AAN86530.1 .
AK172785 mRNA. Translation: BAD18766.1 .
AK127797 mRNA. Translation: BAG54572.1 .
AK297612 mRNA. Translation: BAH12628.1 .
AC004706 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90292.1 .
BC104795 mRNA. Translation: AAI04796.1 .
BC112151 mRNA. Translation: AAI12152.1 .
BC143689 mRNA. Translation: AAI43690.1 .
CCDSi CCDS11079.1. [Q86YT5-1 ]
CCDS45593.1. [Q86YT5-2 ]
CCDS67137.1. [Q86YT5-3 ]
RefSeqi NP_001137310.1. NM_001143838.2. [Q86YT5-2 ]
NP_001271438.1. NM_001284509.1. [Q86YT5-3 ]
NP_001271439.1. NM_001284510.1.
NP_808218.1. NM_177550.4. [Q86YT5-1 ]
UniGenei Hs.399496.

3D structure databases

ProteinModelPortali Q86YT5.
SMRi Q86YT5. Positions 41-275, 396-534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000293800.

Protein family/group databases

TCDBi 2.A.47.1.9. the divalent anion:na(+) symporter (dass) family.

PTM databases

PhosphoSitei Q86YT5.

Polymorphism databases

DMDMi 74714197.

Proteomic databases

MaxQBi Q86YT5.
PaxDbi Q86YT5.
PRIDEi Q86YT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000293800 ; ENSP00000293800 ; ENSG00000141485 .
ENST00000381074 ; ENSP00000370464 ; ENSG00000141485 .
ENST00000433363 ; ENSP00000406220 ; ENSG00000141485 . [Q86YT5-1 ]
ENST00000573648 ; ENSP00000459372 ; ENSG00000141485 . [Q86YT5-2 ]
GeneIDi 284111.
KEGGi hsa:284111.
UCSCi uc002gdj.3. human. [Q86YT5-1 ]
uc002gdk.3. human.
uc010vtf.2. human. [Q86YT5-2 ]

Organism-specific databases

CTDi 284111.
GeneCardsi GC17M006588.
HGNCi HGNC:23089. SLC13A5.
HPAi HPA044343.
MIMi 608305. gene.
neXtProti NX_Q86YT5.
PharmGKBi PA134950956.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0471.
HOGENOMi HOG000278432.
HOVERGENi HBG055339.
InParanoidi Q86YT5.
KOi K14445.
OMAi YMRFNFK.
OrthoDBi EOG7G1V5S.
PhylomeDBi Q86YT5.
TreeFami TF312913.

Enzyme and pathway databases

Reactomei REACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

GenomeRNAii 284111.
NextBioi 35470627.
PROi Q86YT5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86YT5.
Bgeei Q86YT5.
CleanExi HS_SLC13A5.
Genevestigatori Q86YT5.

Family and domain databases

InterProi IPR001898. Na/sul_symport.
[Graphical view ]
Pfami PF00939. Na_sulph_symp. 1 hit.
[Graphical view ]
PROSITEi PS01271. NA_SULFATE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function."
    Inoue K., Zhuang L., Ganapathy V.
    Biochem. Biophys. Res. Commun. 299:465-471(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Brain.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-562.
    Tissue: Liver.

Entry informationi

Entry nameiS13A5_HUMAN
AccessioniPrimary (citable) accession number: Q86YT5
Secondary accession number(s): B3KXR0
, B7Z4P2, B7ZLB4, F8W7N2, Q6ZMG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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