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Q86YT5

- S13A5_HUMAN

UniProt

Q86YT5 - S13A5_HUMAN

Protein

Solute carrier family 13 member 5

Gene

SLC13A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.1 Publication

    GO - Molecular functioni

    1. citrate transmembrane transporter activity Source: Ensembl
    2. sodium:dicarboxylate symporter activity Source: Ensembl
    3. succinate transmembrane transporter activity Source: Ensembl
    4. transporter activity Source: InterPro

    GO - Biological processi

    1. sodium ion transport Source: InterPro
    2. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

    Protein family/group databases

    TCDBi2.A.47.1.9. the divalent anion:na(+) symporter (dass) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 13 member 5
    Alternative name(s):
    Na(+)/citrate cotransporter
    Short name:
    NaCT
    Sodium-coupled citrate transporter
    Sodium-dependent citrate transporter
    Gene namesi
    Name:SLC13A5
    Synonyms:NACT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:23089. SLC13A5.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: InterPro
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134950956.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568Solute carrier family 13 member 5PRO_0000260101Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi562 – 5621N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ86YT5.
    PaxDbiQ86YT5.
    PRIDEiQ86YT5.

    PTM databases

    PhosphoSiteiQ86YT5.

    Expressioni

    Tissue specificityi

    Expressed most predominantly in the liver, with moderate expression detectable in the brain and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ86YT5.
    BgeeiQ86YT5.
    CleanExiHS_SLC13A5.
    GenevestigatoriQ86YT5.

    Organism-specific databases

    HPAiHPA044343.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000293800.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86YT5.
    SMRiQ86YT5. Positions 41-275, 396-534.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei353 – 37321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei406 – 42621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei439 – 45921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei487 – 50721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei528 – 54821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0471.
    HOGENOMiHOG000278432.
    HOVERGENiHBG055339.
    InParanoidiQ86YT5.
    KOiK14445.
    OMAiYMRFNFK.
    OrthoDBiEOG7G1V5S.
    PhylomeDBiQ86YT5.
    TreeFamiTF312913.

    Family and domain databases

    InterProiIPR001898. Na/sul_symport.
    [Graphical view]
    PfamiPF00939. Na_sulph_symp. 1 hit.
    [Graphical view]
    PROSITEiPS01271. NA_SULFATE. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86YT5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASALSYVSK FKSFVILFVT PLLLLPLVIL MPAKFVRCAY VIILMAIYWC    50
    TEVIPLAVTS LMPVLLFPLF QILDSRQVCV QYMKDTNMLF LGGLIVAVAV 100
    ERWNLHKRIA LRTLLWVGAK PARLMLGFMG VTALLSMWIS NTATTAMMVP 150
    IVEAILQQME ATSAATEAGL ELVDKGKAKE LPGSQVIFEG PTLGQQEDQE 200
    RKRLCKAMTL CICYAASIGG TATLTGTGPN VVLLGQMNEL FPDSKDLVNF 250
    ASWFAFAFPN MLVMLLFAWL WLQFVYMRFN FKKSWGCGLE SKKNEKAALK 300
    VLQEEYRKLG PLSFAEINVL ICFFLLVILW FSRDPGFMPG WLTVAWVEGE 350
    TKYVSDATVA IFVATLLFIV PSQKPKFNFR SQTEEERKTP FYPPPLLDWK 400
    VTQEKVPWGI VLLLGGGFAL AKGSEASGLS VWMGKQMEPL HAVPPAAITL 450
    ILSLLVAVFT ECTSNVATTT LFLPIFASMS RSIGLNPLYI MLPCTLSASF 500
    AFMLPVATPP NAIVFTYGHL KVADMVKTGV IMNIIGVFCV FLAVNTWGRA 550
    IFDLDHFPDW ANVTHIET 568
    Length:568
    Mass (Da):63,062
    Last modified:June 1, 2003 - v1
    Checksum:iB8995E56618DECCB
    GO
    Isoform 2 (identifier: Q86YT5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         479-524: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:522
    Mass (Da):58,110
    Checksum:iCD82CB02F6D574C7
    GO
    Isoform 3 (identifier: Q86YT5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-140: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:551
    Mass (Da):61,210
    Checksum:iB14F022B99048FF6
    GO
    Isoform 4 (identifier: Q86YT5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         35-77: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:525
    Mass (Da):58,092
    Checksum:iF2D93F70F424B588
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti269 – 2691W → R in BAD18766. (PubMed:14702039)Curated
    Sequence conflicti330 – 3301W → R in BAH12628. (PubMed:14702039)Curated
    Sequence conflicti376 – 3761K → R in BAD18766. (PubMed:14702039)Curated
    Sequence conflicti475 – 4751I → V in BAH12628. (PubMed:14702039)Curated
    Sequence conflicti548 – 5481G → E in BAH12628. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei35 – 7743Missing in isoform 4. 1 PublicationVSP_055652Add
    BLAST
    Alternative sequencei124 – 14017Missing in isoform 3. 1 PublicationVSP_054910Add
    BLAST
    Alternative sequencei479 – 52446Missing in isoform 2. 1 PublicationVSP_043098Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY151833 mRNA. Translation: AAN86530.1.
    AK172785 mRNA. Translation: BAD18766.1.
    AK127797 mRNA. Translation: BAG54572.1.
    AK297612 mRNA. Translation: BAH12628.1.
    AC004706 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90292.1.
    BC104795 mRNA. Translation: AAI04796.1.
    BC112151 mRNA. Translation: AAI12152.1.
    BC143689 mRNA. Translation: AAI43690.1.
    CCDSiCCDS11079.1. [Q86YT5-1]
    CCDS45593.1. [Q86YT5-2]
    CCDS67137.1. [Q86YT5-3]
    RefSeqiNP_001137310.1. NM_001143838.2. [Q86YT5-2]
    NP_001271438.1. NM_001284509.1. [Q86YT5-3]
    NP_001271439.1. NM_001284510.1.
    NP_808218.1. NM_177550.4. [Q86YT5-1]
    UniGeneiHs.399496.

    Genome annotation databases

    EnsembliENST00000293800; ENSP00000293800; ENSG00000141485. [Q86YT5-3]
    ENST00000381074; ENSP00000370464; ENSG00000141485. [Q86YT5-4]
    ENST00000433363; ENSP00000406220; ENSG00000141485. [Q86YT5-1]
    ENST00000573648; ENSP00000459372; ENSG00000141485. [Q86YT5-2]
    GeneIDi284111.
    KEGGihsa:284111.
    UCSCiuc002gdj.3. human. [Q86YT5-1]
    uc002gdk.3. human.
    uc010vtf.2. human. [Q86YT5-2]

    Polymorphism databases

    DMDMi74714197.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY151833 mRNA. Translation: AAN86530.1 .
    AK172785 mRNA. Translation: BAD18766.1 .
    AK127797 mRNA. Translation: BAG54572.1 .
    AK297612 mRNA. Translation: BAH12628.1 .
    AC004706 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90292.1 .
    BC104795 mRNA. Translation: AAI04796.1 .
    BC112151 mRNA. Translation: AAI12152.1 .
    BC143689 mRNA. Translation: AAI43690.1 .
    CCDSi CCDS11079.1. [Q86YT5-1 ]
    CCDS45593.1. [Q86YT5-2 ]
    CCDS67137.1. [Q86YT5-3 ]
    RefSeqi NP_001137310.1. NM_001143838.2. [Q86YT5-2 ]
    NP_001271438.1. NM_001284509.1. [Q86YT5-3 ]
    NP_001271439.1. NM_001284510.1.
    NP_808218.1. NM_177550.4. [Q86YT5-1 ]
    UniGenei Hs.399496.

    3D structure databases

    ProteinModelPortali Q86YT5.
    SMRi Q86YT5. Positions 41-275, 396-534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000293800.

    Protein family/group databases

    TCDBi 2.A.47.1.9. the divalent anion:na(+) symporter (dass) family.

    PTM databases

    PhosphoSitei Q86YT5.

    Polymorphism databases

    DMDMi 74714197.

    Proteomic databases

    MaxQBi Q86YT5.
    PaxDbi Q86YT5.
    PRIDEi Q86YT5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293800 ; ENSP00000293800 ; ENSG00000141485 . [Q86YT5-3 ]
    ENST00000381074 ; ENSP00000370464 ; ENSG00000141485 . [Q86YT5-4 ]
    ENST00000433363 ; ENSP00000406220 ; ENSG00000141485 . [Q86YT5-1 ]
    ENST00000573648 ; ENSP00000459372 ; ENSG00000141485 . [Q86YT5-2 ]
    GeneIDi 284111.
    KEGGi hsa:284111.
    UCSCi uc002gdj.3. human. [Q86YT5-1 ]
    uc002gdk.3. human.
    uc010vtf.2. human. [Q86YT5-2 ]

    Organism-specific databases

    CTDi 284111.
    GeneCardsi GC17M006588.
    HGNCi HGNC:23089. SLC13A5.
    HPAi HPA044343.
    MIMi 608305. gene.
    neXtProti NX_Q86YT5.
    PharmGKBi PA134950956.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0471.
    HOGENOMi HOG000278432.
    HOVERGENi HBG055339.
    InParanoidi Q86YT5.
    KOi K14445.
    OMAi YMRFNFK.
    OrthoDBi EOG7G1V5S.
    PhylomeDBi Q86YT5.
    TreeFami TF312913.

    Enzyme and pathway databases

    Reactomei REACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

    Miscellaneous databases

    GenomeRNAii 284111.
    NextBioi 35470627.
    PROi Q86YT5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86YT5.
    Bgeei Q86YT5.
    CleanExi HS_SLC13A5.
    Genevestigatori Q86YT5.

    Family and domain databases

    InterProi IPR001898. Na/sul_symport.
    [Graphical view ]
    Pfami PF00939. Na_sulph_symp. 1 hit.
    [Graphical view ]
    PROSITEi PS01271. NA_SULFATE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function."
      Inoue K., Zhuang L., Ganapathy V.
      Biochem. Biophys. Res. Commun. 299:465-471(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
      Tissue: Brain.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-562.
      Tissue: Liver.

    Entry informationi

    Entry nameiS13A5_HUMAN
    AccessioniPrimary (citable) accession number: Q86YT5
    Secondary accession number(s): B3KXR0
    , B7Z4P2, B7ZLB4, F8W7N2, Q6ZMG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3