Q86YS6 (RAB43_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 85.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ras-related protein Rab-43 Alternative name(s): Ras-related protein Rab-41 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 212 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Subcellular location | Cell membrane; Lipid-anchor; Cytoplasmic side Potential. |
| Tissue specificity | Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver. Ref.1 |
| Sequence similarities | Belongs to the small GTPase superfamily. Rab family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing |
| Ligand | GTP-binding Nucleotide-binding |
| PTM | Lipoprotein Methylation Phosphoprotein Prenylation |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | protein transport Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q86YS6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9ULR0-1) Also known as: ISY1-RAB43; The sequence of this isoform can be found in the external entry Q9ULR0. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: Based on a readthrough transcript which may produce a ISY1-RAB43 fusion protein. No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 212 | 212 | Ras-related protein Rab-43 | PRO_0000244615 | ||||||||||||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 25 – 32 | 8 | GTP By similarity | |||||||||||||||||||||||||||||||||||
| Nucleotide binding | 73 – 77 | 5 | GTP By similarity | |||||||||||||||||||||||||||||||||||
| Nucleotide binding | 131 – 134 | 4 | GTP By similarity | |||||||||||||||||||||||||||||||||||
| Motif | 47 – 55 | 9 | Effector region By similarity | |||||||||||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||||||||||
| Modified residue | 82 | 1 | Phosphothreonine By similarity | |||||||||||||||||||||||||||||||||||
| Modified residue | 193 | 1 | Phosphoserine Ref.5 | |||||||||||||||||||||||||||||||||||
| Modified residue | 212 | 1 | Cysteine methyl ester By similarity | |||||||||||||||||||||||||||||||||||
| Lipidation | 210 | 1 | S-geranylgeranyl cysteine By similarity | |||||||||||||||||||||||||||||||||||
| Lipidation | 212 | 1 | S-geranylgeranyl cysteine By similarity | |||||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 17 – 25 | 9 | ||||||||||||||||||||||||||||||||||||
| Helix | 31 – 40 | 10 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 55 – 62 | 8 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 65 – 72 | 8 | ||||||||||||||||||||||||||||||||||||
| Helix | 78 – 80 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 81 – 88 | 8 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 92 – 99 | 8 | ||||||||||||||||||||||||||||||||||||
| Helix | 103 – 107 | 5 | ||||||||||||||||||||||||||||||||||||
| Helix | 109 – 119 | 11 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 125 – 131 | 7 | ||||||||||||||||||||||||||||||||||||
| Helix | 136 – 138 | 3 | ||||||||||||||||||||||||||||||||||||
| Helix | 143 – 152 | 10 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 156 – 160 | 5 | ||||||||||||||||||||||||||||||||||||
| Turn | 163 – 166 | 4 | ||||||||||||||||||||||||||||||||||||
| Helix | 169 – 183 | 15 | ||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation, expression pattern of a novel human RAB gene RAB41 and characterization of its intronless homolog RAB41P." Guo J.H., Chen L., Chen S., Liu X., Saiyin H., Deng Q., Zhuang Y., Wan B., Yu L., Zhao S.Y. DNA Seq. 14:431-435(2003) [PubMed: 15018353] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye. |
| [5] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AY166852 mRNA. Translation: AAO17291.1. AK291014 mRNA. Translation: BAF83703.1. CH471052 Genomic DNA. Translation: EAW79283.1. BC062319 mRNA. Translation: AAH62319.1. | ||||||||||||
| IPI | IPI00329441. | ||||||||||||
| RefSeq | NP_001191812.1. NM_001204883.1. NP_001191813.1. NM_001204884.1. NP_001191814.1. NM_001204885.1. NP_001191815.1. NM_001204886.1. NP_940892.1. NM_198490.2. | ||||||||||||
| UniGene | Hs.546542. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | Q86YS6. | ||||||||||||
| SMR | Q86YS6. Positions 15-186. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | Q86YS6. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q86YS6. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 74727944. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q86YS6. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000315150; ENSP00000319781; ENSG00000172780. ENST00000393304; ENSP00000376981; ENSG00000172780. ENST00000393305; ENSP00000376982; ENSG00000172780. ENST00000393307; ENSP00000376984; ENSG00000172780. ENST00000393308; ENSP00000376985; ENSG00000172780. | ||||||||||||
| GeneID | 339122. | ||||||||||||
| KEGG | hsa:339122. | ||||||||||||
| UCSC | uc003eln.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 339122. | ||||||||||||
| GeneCards | GC03M128806. | ||||||||||||
| H-InvDB | HIX0003664. | ||||||||||||
| HGNC | HGNC:19983. RAB43. | ||||||||||||
| neXtProt | NX_Q86YS6. | ||||||||||||
| PharmGKB | PA134968262. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG10738. | ||||||||||||
| GeneTree | ENSGT00600000084223. | ||||||||||||
| HOVERGEN | HBG009351. | ||||||||||||
| InParanoid | Q86YS6. | ||||||||||||
| OMA | YRSANGV. | ||||||||||||
| OrthoDB | EOG4WQ13N. | ||||||||||||
| PhylomeDB | Q86YS6. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q86YS6. | ||||||||||||
| Bgee | Q86YS6. | ||||||||||||
| CleanEx | HS_RAB41. HS_RAB43. | ||||||||||||
| Genevestigator | Q86YS6. | ||||||||||||
| GermOnline | ENSG00000172780. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view] | ||||||||||||
| KO | K07930. | ||||||||||||
| Pfam | PF00071. Ras. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00449. RASTRNSFRMNG. | ||||||||||||
| SMART | SM00175. RAB. 1 hit. [Graphical view] | ||||||||||||
| TIGRFAMs | TIGR00231. Small_GTP. 1 hit. | ||||||||||||
| PROSITE | PS51419. RAB. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| NextBio | 97235. | ||||||||||||
Entry information
| Entry name | RAB43_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q86YS6 Secondary accession number(s): A8K4P9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

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