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Protein

Rab11 family-interacting protein 4

Gene

RAB11FIP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi62 – 73PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • ADP-ribosylation factor binding Source: UniProtKB
  • calcium ion binding Source: InterPro
  • protein homodimerization activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

  • neural retina development Source: Ensembl
  • positive regulation of G1 to G0 transition Source: Ensembl
  • regulation of cytokinesis Source: UniProtKB
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processHost-virus interaction, Transport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab11 family-interacting protein 4
Short name:
FIP4-Rab11
Short name:
Rab11-FIP4
Alternative name(s):
Arfophilin-2
Gene namesi
Name:RAB11FIP4
Synonyms:ARFO2, KIAA1821
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000131242.15
HGNCiHGNC:30267 RAB11FIP4
MIMi611999 gene
neXtProtiNX_Q86YS3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi627D → A: Abolishes Rab11-binding. 1 Publication1

Organism-specific databases

DisGeNETi84440
OpenTargetsiENSG00000131242
PharmGKBiPA134978007

Polymorphism and mutation databases

BioMutaiRAB11FIP4
DMDMi67472134

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000738801 – 637Rab11 family-interacting protein 4Add BLAST637

Proteomic databases

EPDiQ86YS3
MaxQBiQ86YS3
PaxDbiQ86YS3
PeptideAtlasiQ86YS3
PRIDEiQ86YS3

PTM databases

iPTMnetiQ86YS3
PhosphoSitePlusiQ86YS3

Expressioni

Tissue specificityi

Present at high level in testis (at protein level). Weakly expressed in other tissues.1 Publication

Gene expression databases

BgeeiENSG00000131242
CleanExiHS_RAB11FIP4
ExpressionAtlasiQ86YS3 baseline and differential
GenevisibleiQ86YS3 HS

Organism-specific databases

HPAiHPA021595
HPA063203

Interactioni

Subunit structurei

Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Forms a heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with HCMV (human cytomegalovirus) gM/UL100. Interacts with ECPAS.6 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ADP-ribosylation factor binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124079, 17 interactors
DIPiDIP-47495N
IntActiQ86YS3, 7 interactors
MINTiQ86YS3
STRINGi9606.ENSP00000312837

Structurei

3D structure databases

ProteinModelPortaliQ86YS3
SMRiQ86YS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 84EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini574 – 636FIP-RBDPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 637Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerizationAdd BLAST556

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili280 – 617Sequence analysisAdd BLAST338

Domaini

The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0982 Eukaryota
ENOG4111K32 LUCA
GeneTreeiENSGT00440000033742
HOGENOMiHOG000063670
HOVERGENiHBG054059
InParanoidiQ86YS3
KOiK12485
OMAiGRQLMHS
OrthoDBiEOG091G0421
PhylomeDBiQ86YS3
TreeFamiTF327221

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR037245 FIP-RBD_C_sf
IPR019018 Rab-bd_FIP-RBD
PfamiView protein in Pfam
PF09457 RBD-FIP, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS51511 FIP_RBD, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86YS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGAGWSGA PAALLRSVRR LREVFEVCGR DPDGFLRVER VAALGLRFGQ
60 70 80 90 100
GEEVEKLVKY LDPNDLGRIN FKDFCRGVFA MKGCEELLKD VLSVESAGTL
110 120 130 140 150
PCAPEIPDCV EQGSEVTGPT FADGELIPRE PGFFPEDEEE AMTLAPPEGP
160 170 180 190 200
QELYTDSPME STQSLEGSVG SPAEKDGGLG GLFLPEDKSL VHTPSMTTSD
210 220 230 240 250
LSTHSTTSLI SNEEQFEDYG EGDDVDCAPS SPCPDDETRT NVYSDLGSSV
260 270 280 290 300
SSSAGQTPRK MRHVYNSELL DVYCSQCCKK INLLNDLEAR LKNLKANSPN
310 320 330 340 350
RKISSTAFGR QLMHSSNFSS SNGSTEDLFR DSIDSCDNDI TEKVSFLEKK
360 370 380 390 400
VTELENDSLT NGDLKSKLKQ ENTQLVHRVH ELEEMVKDQE TTAEQALEEE
410 420 430 440 450
ARRHREAYGK LEREKATEVE LLNARVQQLE EENTELRTTV TRLKSQTEKL
460 470 480 490 500
DEERQRMSDR LEDTSLRLKD EMDLYKRMMD KLRQNRLEFQ KEREATQELI
510 520 530 540 550
EDLRKELEHL QMYKLDCERP GRGRSASSGL GEFNARAREV ELEHEVKRLK
560 570 580 590 600
QENYKLRDQN DDLNGQILSL SLYEAKNLFA AQTKAQSLAA EIDTASRDEL
610 620 630
MEALKEQEEI NFRLRQYMDK IILAILDHNP SILEIKH
Length:637
Mass (Da):71,928
Last modified:June 1, 2003 - v1
Checksum:i8A5CDB9799383342
GO
Isoform 2 (identifier: Q86YS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.
     103-111: APEIPDCVE → MRTPPALGS

Show »
Length:535
Mass (Da):60,771
Checksum:i7ECB4806726B7D5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti417T → I in BAC05045 (PubMed:14702039).Curated1
Sequence conflicti518E → G in BAC05045 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0137241 – 102Missing in isoform 2. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_013725103 – 111APEIPDCVE → MRTPPALGS in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169244 mRNA Translation: AAO21970.1
AK097424 mRNA Translation: BAC05045.1
BC093914 mRNA Translation: AAH93914.1
BC101517 mRNA Translation: AAI01518.1
AJ314646 mRNA Translation: CAC44535.1
AB058724 mRNA Translation: BAB47450.1
AL831830 mRNA Translation: CAD38543.1
CCDSiCCDS11267.1 [Q86YS3-1]
CCDS76985.1 [Q86YS3-2]
RefSeqiNP_001290471.2, NM_001303542.2 [Q86YS3-2]
NP_001333677.1, NM_001346748.1
NP_001333678.1, NM_001346749.1
NP_116321.2, NM_032932.5 [Q86YS3-1]
UniGeneiHs.406788

Genome annotation databases

EnsembliENST00000394744; ENSP00000378227; ENSG00000131242 [Q86YS3-2]
ENST00000621161; ENSP00000482620; ENSG00000131242 [Q86YS3-1]
GeneIDi84440
KEGGihsa:84440
UCSCiuc032fao.2 human [Q86YS3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRFIP4_HUMAN
AccessioniPrimary (citable) accession number: Q86YS3
Secondary accession number(s): Q52LI1
, Q8N829, Q8NDT7, Q969D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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