Q86YR7 (MF2L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable guanine nucleotide exchange factor MCF2L2

Alternative name(s):
Dbs-related Rho family guanine nucleotide exchange factor
MCF2-transforming sequence-like protein 2

Gene names

Name:	MCF2L2
Synonyms:	DRG, KIAA0861

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1114 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably functions as a guanine nucleotide exchange factor By similarity.
Tissue specificity	Significantly expressed in brain and modestly in pancreas, brain and testis. Ref.6
Involvement in disease	Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Sequence similarities	Belongs to the MCF2 family. Contains 1 CRAL-TRIO domain. Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 spectrin repeat.
Sequence caution	The sequence AAO19651.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Diabetes mellitus
Molecular function	Guanine-nucleotide releasing factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86YR7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86YR7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     706-711: KEDLQI → VSLYSQ
     712-1114: Missing.

Isoform 3 (identifier: Q86YR7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     622-628: RIIRDLL → YSSQYFK
     629-1114: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q86YR7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1075-1114: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1114	1114	Probable guanine nucleotide exchange factor MCF2L2		PRO_0000337087
Regions
	Domain	11 – 193	183	CRAL-TRIO
	Repeat	323 – 428	106	Spectrin
	Domain	619 – 822	204	DH
	Domain	834 – 954	121	PH
Natural variations
	Alternative sequence	622 – 628	7	RIIRDLL → YSSQYFK in isoform 3.		VSP_033872
	Alternative sequence	629 – 1114	486	Missing in isoform 3.		VSP_033873
	Alternative sequence	706 – 711	6	KEDLQI → VSLYSQ in isoform 2.		VSP_033874
	Alternative sequence	712 – 1114	403	Missing in isoform 2.		VSP_033875
	Alternative sequence	1075 – 1114	40	Missing in isoform 4.		VSP_033876
	Natural variant	159	1	T → M. Ref.5 Corresponds to variant rs12632177 [ dbSNP | Ensembl ].		VAR_043587
	Natural variant	254	1	L → P in a colorectal cancer sample; somatic mutation. Ref.7		VAR_043588
	Natural variant	277	1	N → S. Corresponds to variant rs13082605 [ dbSNP | Ensembl ].		VAR_043589
	Natural variant	359	1	I → L. Ref.1 Corresponds to variant rs7639705 [ dbSNP | Ensembl ].		VAR_043590
	Natural variant	378	1	Q → L. Ref.3 Corresponds to variant rs2293203 [ dbSNP | Ensembl ].		VAR_043591
	Natural variant	589	1	F → S. Ref.3 Corresponds to variant rs3732602 [ dbSNP | Ensembl ].		VAR_043592
	Natural variant	622	1	R → H in a colorectal cancer sample; somatic mutation. Ref.7		VAR_043593
	Natural variant	772	1	F → L. Corresponds to variant rs9826325 [ dbSNP | Ensembl ].		VAR_043594
	Natural variant	902	1	T → A. Ref.3 Ref.4 Ref.5 Corresponds to variant rs6804951 [ dbSNP | Ensembl ].		VAR_043595
	Natural variant	1015	1	M → T. Corresponds to variant rs35070271 [ dbSNP | Ensembl ].		VAR_043596
	Natural variant	1039	1	L → F in a breast cancer sample; somatic mutation. Ref.7		VAR_043597
Experimental info
	Sequence conflict	373	1	P → S in AAO19651. Ref.4
	Sequence conflict	373	1	P → S in BAA74884. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: CB1F04EC485C746D	FASTA	1,114	126,993
	10 20 30 40 50 60 MLSCLKEEMP PQELTRRLAT VITHVDEIMQ QEVRPLMAVE IIEQLHRQFA ILSGGRGEDG 70 80 90 100 110 120 APIITFPEFS GFKHIPDEDF LNVMTYLTSI PSVEAASIGF IVVIDRRRDK WSSVKASLTR 130 140 150 160 170 180 IAVAFPGNLQ LIFILRPSRF IQRTFTDIGI KYYRNEFKTK VPIIMVNSVS DLHGYIDKSQ 190 200 210 220 230 240 LTRELGGTLE YRHGQWVNHR TAIENFALTL KTTAQMLQTF GSCLATAELP RSMLSTEDLL 250 260 270 280 290 300 MSHTRQRDKL QDELKLLGKQ GTTLLSCIQE PATKCPNSKL NLNQLENVTT MERLLVQLDE 310 320 330 340 350 360 TEKAFSHFWS EHHLKLNQCL QLQHFEHDFC KAKLALDNLL EEQAEFTGIG DSVMHVEQIL 370 380 390 400 410 420 KEHKKLEEKS QEPLEKAQLL ALVGDQLIQS HHYAADAIRP RCVELRHLCD DFINGNKKKW 430 440 450 460 470 480 DILGKSLEFH RQLDKVSQWC EAGIYLLASQ AVDKCQSREG VDIALNDIAT FLGTVKEYPL 490 500 510 520 530 540 LSPKEFYNEF ELLLTLDAKA KAQKVLQRLD DVQEIFHKRQ VSLMKLAAKQ TRPVQPVAPH 550 560 570 580 590 600 PESSPKWVSS KTSQPSTSVP LARPLRTSEE PYTETELNSR GKEDDETKFE VKSEEIFESH 610 620 630 640 650 660 HERGNPELEQ QARLGDLSPR RRIIRDLLET EEIYIKEIKS IIDGYITPMD FIWLKHLIPD 670 680 690 700 710 720 VLQNNKDFLF GNIRELYEFH NRTFLKELEK CAENPELLAH CFLKRKEDLQ IYFKYHKNLP 730 740 750 760 770 780 RARAIWQECQ DCAYFGVCQR QLDHNLPLFK YLKGPSQRLI KYQMLLKGLL DFESPEDMEI 790 800 810 820 830 840 DPGELGGSAK DGPKRTKDSA FSTELQQALA VIEDLIKSCE LAVDLAAVTE CPDDIGKLGK 850 860 870 880 890 900 LLLHGPFSVW TIHKDRYKMK DLIRFKPSQR QIYLFERGIV FCKIRMEPGD QGLSPHYSFK 910 920 930 940 950 960 KTMKLMTLSI RQLGRGSHRK FEIASRNGLE KYILQAASKE IRDCWFSEIS KLLMEQQNNI 970 980 990 1000 1010 1020 KDQGNPQFEM STSKGSGAGS GPWIKNMERA TTSKEDPASS TGGIKGCSSR EFSSMDTFED 1030 1040 1050 1060 1070 1080 CEGAEDMEKE SSALSLAGLF QSDDSHETCS SKSAFLERGE SSQGEKEERD EEETATRSTE 1090 1100 1110 EERAGASTGR LAPAGATAGF QARALRPRTS AQES
	Isoform 2 [UniParc]. Checksum: F3B6D2AB120CBB46	FASTA	711	81,877
	10 20 30 40 50 60 MLSCLKEEMP PQELTRRLAT VITHVDEIMQ QEVRPLMAVE IIEQLHRQFA ILSGGRGEDG 70 80 90 100 110 120 APIITFPEFS GFKHIPDEDF LNVMTYLTSI PSVEAASIGF IVVIDRRRDK WSSVKASLTR 130 140 150 160 170 180 IAVAFPGNLQ LIFILRPSRF IQRTFTDIGI KYYRNEFKTK VPIIMVNSVS DLHGYIDKSQ 190 200 210 220 230 240 LTRELGGTLE YRHGQWVNHR TAIENFALTL KTTAQMLQTF GSCLATAELP RSMLSTEDLL 250 260 270 280 290 300 MSHTRQRDKL QDELKLLGKQ GTTLLSCIQE PATKCPNSKL NLNQLENVTT MERLLVQLDE 310 320 330 340 350 360 TEKAFSHFWS EHHLKLNQCL QLQHFEHDFC KAKLALDNLL EEQAEFTGIG DSVMHVEQIL 370 380 390 400 410 420 KEHKKLEEKS QEPLEKAQLL ALVGDQLIQS HHYAADAIRP RCVELRHLCD DFINGNKKKW 430 440 450 460 470 480 DILGKSLEFH RQLDKVSQWC EAGIYLLASQ AVDKCQSREG VDIALNDIAT FLGTVKEYPL 490 500 510 520 530 540 LSPKEFYNEF ELLLTLDAKA KAQKVLQRLD DVQEIFHKRQ VSLMKLAAKQ TRPVQPVAPH 550 560 570 580 590 600 PESSPKWVSS KTSQPSTSVP LARPLRTSEE PYTETELNSR GKEDDETKFE VKSEEIFESH 610 620 630 640 650 660 HERGNPELEQ QARLGDLSPR RRIIRDLLET EEIYIKEIKS IIDGYITPMD FIWLKHLIPD 670 680 690 700 710 VLQNNKDFLF GNIRELYEFH NRTFLKELEK CAENPELLAH CFLKRVSLYS Q
	Isoform 3 [UniParc]. Checksum: 1BA4CEC31B366D69	FASTA	628	71,912
	10 20 30 40 50 60 MLSCLKEEMP PQELTRRLAT VITHVDEIMQ QEVRPLMAVE IIEQLHRQFA ILSGGRGEDG 70 80 90 100 110 120 APIITFPEFS GFKHIPDEDF LNVMTYLTSI PSVEAASIGF IVVIDRRRDK WSSVKASLTR 130 140 150 160 170 180 IAVAFPGNLQ LIFILRPSRF IQRTFTDIGI KYYRNEFKTK VPIIMVNSVS DLHGYIDKSQ 190 200 210 220 230 240 LTRELGGTLE YRHGQWVNHR TAIENFALTL KTTAQMLQTF GSCLATAELP RSMLSTEDLL 250 260 270 280 290 300 MSHTRQRDKL QDELKLLGKQ GTTLLSCIQE PATKCPNSKL NLNQLENVTT MERLLVQLDE 310 320 330 340 350 360 TEKAFSHFWS EHHLKLNQCL QLQHFEHDFC KAKLALDNLL EEQAEFTGIG DSVMHVEQIL 370 380 390 400 410 420 KEHKKLEEKS QEPLEKAQLL ALVGDQLIQS HHYAADAIRP RCVELRHLCD DFINGNKKKW 430 440 450 460 470 480 DILGKSLEFH RQLDKVSQWC EAGIYLLASQ AVDKCQSREG VDIALNDIAT FLGTVKEYPL 490 500 510 520 530 540 LSPKEFYNEF ELLLTLDAKA KAQKVLQRLD DVQEIFHKRQ VSLMKLAAKQ TRPVQPVAPH 550 560 570 580 590 600 PESSPKWVSS KTSQPSTSVP LARPLRTSEE PYTETELNSR GKEDDETKFE VKSEEIFESH 610 620 HERGNPELEQ QARLGDLSPR RYSSQYFK
	Isoform 4 [UniParc]. Checksum: CF969FBCF6C4EC7D	FASTA	1,074	122,922
	10 20 30 40 50 60 MLSCLKEEMP PQELTRRLAT VITHVDEIMQ QEVRPLMAVE IIEQLHRQFA ILSGGRGEDG 70 80 90 100 110 120 APIITFPEFS GFKHIPDEDF LNVMTYLTSI PSVEAASIGF IVVIDRRRDK WSSVKASLTR 130 140 150 160 170 180 IAVAFPGNLQ LIFILRPSRF IQRTFTDIGI KYYRNEFKTK VPIIMVNSVS DLHGYIDKSQ 190 200 210 220 230 240 LTRELGGTLE YRHGQWVNHR TAIENFALTL KTTAQMLQTF GSCLATAELP RSMLSTEDLL 250 260 270 280 290 300 MSHTRQRDKL QDELKLLGKQ GTTLLSCIQE PATKCPNSKL NLNQLENVTT MERLLVQLDE 310 320 330 340 350 360 TEKAFSHFWS EHHLKLNQCL QLQHFEHDFC KAKLALDNLL EEQAEFTGIG DSVMHVEQIL 370 380 390 400 410 420 KEHKKLEEKS QEPLEKAQLL ALVGDQLIQS HHYAADAIRP RCVELRHLCD DFINGNKKKW 430 440 450 460 470 480 DILGKSLEFH RQLDKVSQWC EAGIYLLASQ AVDKCQSREG VDIALNDIAT FLGTVKEYPL 490 500 510 520 530 540 LSPKEFYNEF ELLLTLDAKA KAQKVLQRLD DVQEIFHKRQ VSLMKLAAKQ TRPVQPVAPH 550 560 570 580 590 600 PESSPKWVSS KTSQPSTSVP LARPLRTSEE PYTETELNSR GKEDDETKFE VKSEEIFESH 610 620 630 640 650 660 HERGNPELEQ QARLGDLSPR RRIIRDLLET EEIYIKEIKS IIDGYITPMD FIWLKHLIPD 670 680 690 700 710 720 VLQNNKDFLF GNIRELYEFH NRTFLKELEK CAENPELLAH CFLKRKEDLQ IYFKYHKNLP 730 740 750 760 770 780 RARAIWQECQ DCAYFGVCQR QLDHNLPLFK YLKGPSQRLI KYQMLLKGLL DFESPEDMEI 790 800 810 820 830 840 DPGELGGSAK DGPKRTKDSA FSTELQQALA VIEDLIKSCE LAVDLAAVTE CPDDIGKLGK 850 860 870 880 890 900 LLLHGPFSVW TIHKDRYKMK DLIRFKPSQR QIYLFERGIV FCKIRMEPGD QGLSPHYSFK 910 920 930 940 950 960 KTMKLMTLSI RQLGRGSHRK FEIASRNGLE KYILQAASKE IRDCWFSEIS KLLMEQQNNI 970 980 990 1000 1010 1020 KDQGNPQFEM STSKGSGAGS GPWIKNMERA TTSKEDPASS TGGIKGCSSR EFSSMDTFED 1030 1040 1050 1060 1070 CEGAEDMEKE SSALSLAGLF QSDDSHETCS SKSAFLERGE SSQGEKEERD EEET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-359. Tissue: Cerebellum.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 804-1114 (ISOFORM 4), VARIANTS LEU-378; SER-589 AND ALA-902. Tissue: Brain and Pancreas.
[4]	"DRG, a novel guanine-nucleotide exchange factor for Rho family." Yamauchi J., Miyamoto Y., Itoh H. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-1114 (ISOFORM 1), VARIANT ALA-902.
[5]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 133-1114 (ISOFORM 1), VARIANTS MET-159 AND ALA-902. Tissue: Brain.
[6]	"Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q." Takeuchi F., Ochiai Y., Serizawa M., Yanai K., Kuzuya N., Kajio H., Honjo S., Takeda N., Kaburagi Y., Yasuda K., Shirasawa S., Sasazuki T., Kato N. J. Hum. Genet. 53:314-324(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN NONINSULIN-DEPENDENT DIABETES MELLITUS, TISSUE SPECIFICITY.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-254; HIS-622 AND PHE-1039.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK124500 mRNA. Translation: BAC85866.1. AC069417 Genomic DNA. No translation available. AC092960 Genomic DNA. No translation available. AC104641 Genomic DNA. No translation available. AC112647 Genomic DNA. No translation available. BC029074 mRNA. Translation: AAH29074.2. BC064632 mRNA. Translation: AAH64632.1. AY172737 mRNA. Translation: AAO19651.1. Different initiation. AB020668 mRNA. Translation: BAA74884.1.
IPI	IPI00175989. IPI00792233. IPI00792687. IPI00893924.
RefSeq	NP_055893.2. NM_015078.2.
UniGene	Hs.208267.
3D structure databases
HSSP	HSSP built from PDB template 1RJ2 based on UniProtKB Q63406.
ProteinModelPortal	Q86YR7.
SMR	Q86YR7. Positions 318-424, 620-956.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86YR7. 3 interactions.
STRING	9606.ENSP00000328118.
PTM databases
PhosphoSite	Q86YR7.
Polymorphism databases
DMDM	189081807.
Proteomic databases
PaxDb	Q86YR7.
PRIDE	Q86YR7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328913; ENSP00000328118; ENSG00000053524. ENST00000414362; ENSP00000414131; ENSG00000053524. ENST00000447025; ENSP00000388190; ENSG00000053524. ENST00000473233; ENSP00000420070; ENSG00000053524.
GeneID	23101.
KEGG	hsa:23101.
UCSC	uc003fli.1. human. uc003flj.1. human.
Organism-specific databases
CTD	23101.
GeneCards	GC03M182895.
HGNC	HGNC:30319. MCF2L2.
HPA	HPA038946. HPA038947.
MIM	125853. phenotype.
neXtProt	NX_Q86YR7.
PharmGKB	PA134863801.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG315020.
HOGENOM	HOG000231361.
HOVERGEN	HBG062385.
InParanoid	Q86YR7.
OMA	CIQEPAT.
OrthoDB	EOG48SGS7.
PhylomeDB	Q86YR7.
Gene expression databases
ArrayExpress	Q86YR7.
Bgee	Q86YR7.
CleanEx	HS_MCF2L2.
Genevestigator	Q86YR7.
Family and domain databases
Gene3D	1.20.900.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR001251. CRAL-TRIO_dom. IPR000219. DH-domain. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR018159. Spectrin/alpha-actinin. [Graphical view]
Pfam	PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00516. SEC14. 1 hit. SM00150. SPEC. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit.
PROSITE	PS50191. CRAL_TRIO. 1 hit. PS00741. DH_1. False negative. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MCF2L2. human.
GenomeRNAi	23101.
NextBio	44281.
SOURCE	Search...

Entry information

Entry name

MF2L2_HUMAN

Accession

Primary (citable) accession number: Q86YR7
Secondary accession number(s): O94942 , Q6P2B8, Q6ZVJ5, Q8N318

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.