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Q86YR7

- MF2L2_HUMAN

UniProt

Q86YR7 - MF2L2_HUMAN

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Protein

Probable guanine nucleotide exchange factor MCF2L2

Gene

MCF2L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Probably functions as a guanine nucleotide exchange factor.By similarity

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Probable guanine nucleotide exchange factor MCF2L2
Alternative name(s):
Dbs-related Rho family guanine nucleotide exchange factor
MCF2-transforming sequence-like protein 2
Gene namesi
Name:MCF2L2
Synonyms:DRG, KIAA0861
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30319. MCF2L2.

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

MIMi125853. phenotype.
PharmGKBiPA134863801.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11141114Probable guanine nucleotide exchange factor MCF2L2PRO_0000337087Add
BLAST

Proteomic databases

PaxDbiQ86YR7.
PRIDEiQ86YR7.

PTM databases

PhosphoSiteiQ86YR7.

Expressioni

Tissue specificityi

Significantly expressed in brain and modestly in pancreas, brain and testis.1 Publication

Gene expression databases

BgeeiQ86YR7.
CleanExiHS_MCF2L2.
ExpressionAtlasiQ86YR7. baseline.
GenevestigatoriQ86YR7.

Organism-specific databases

HPAiHPA038946.
HPA038947.

Interactioni

Protein-protein interaction databases

BioGridi116728. 1 interaction.
IntActiQ86YR7. 3 interactions.
STRINGi9606.ENSP00000328118.

Structurei

3D structure databases

ProteinModelPortaliQ86YR7.
SMRiQ86YR7. Positions 620-956.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 193183CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Repeati323 – 428106SpectrinAdd
BLAST
Domaini619 – 822204DHPROSITE-ProRule annotationAdd
BLAST
Domaini834 – 954121PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MCF2 family.Curated
Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 spectrin repeat.Curated

Phylogenomic databases

eggNOGiNOG315020.
GeneTreeiENSGT00760000119030.
HOGENOMiHOG000231361.
HOVERGENiHBG062385.
InParanoidiQ86YR7.
OMAiPRCVELR.
OrthoDBiEOG7KQ210.
PhylomeDBiQ86YR7.
TreeFamiTF318080.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00516. SEC14. 1 hit.
SM00150. SPEC. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86YR7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSCLKEEMP PQELTRRLAT VITHVDEIMQ QEVRPLMAVE IIEQLHRQFA
60 70 80 90 100
ILSGGRGEDG APIITFPEFS GFKHIPDEDF LNVMTYLTSI PSVEAASIGF
110 120 130 140 150
IVVIDRRRDK WSSVKASLTR IAVAFPGNLQ LIFILRPSRF IQRTFTDIGI
160 170 180 190 200
KYYRNEFKTK VPIIMVNSVS DLHGYIDKSQ LTRELGGTLE YRHGQWVNHR
210 220 230 240 250
TAIENFALTL KTTAQMLQTF GSCLATAELP RSMLSTEDLL MSHTRQRDKL
260 270 280 290 300
QDELKLLGKQ GTTLLSCIQE PATKCPNSKL NLNQLENVTT MERLLVQLDE
310 320 330 340 350
TEKAFSHFWS EHHLKLNQCL QLQHFEHDFC KAKLALDNLL EEQAEFTGIG
360 370 380 390 400
DSVMHVEQIL KEHKKLEEKS QEPLEKAQLL ALVGDQLIQS HHYAADAIRP
410 420 430 440 450
RCVELRHLCD DFINGNKKKW DILGKSLEFH RQLDKVSQWC EAGIYLLASQ
460 470 480 490 500
AVDKCQSREG VDIALNDIAT FLGTVKEYPL LSPKEFYNEF ELLLTLDAKA
510 520 530 540 550
KAQKVLQRLD DVQEIFHKRQ VSLMKLAAKQ TRPVQPVAPH PESSPKWVSS
560 570 580 590 600
KTSQPSTSVP LARPLRTSEE PYTETELNSR GKEDDETKFE VKSEEIFESH
610 620 630 640 650
HERGNPELEQ QARLGDLSPR RRIIRDLLET EEIYIKEIKS IIDGYITPMD
660 670 680 690 700
FIWLKHLIPD VLQNNKDFLF GNIRELYEFH NRTFLKELEK CAENPELLAH
710 720 730 740 750
CFLKRKEDLQ IYFKYHKNLP RARAIWQECQ DCAYFGVCQR QLDHNLPLFK
760 770 780 790 800
YLKGPSQRLI KYQMLLKGLL DFESPEDMEI DPGELGGSAK DGPKRTKDSA
810 820 830 840 850
FSTELQQALA VIEDLIKSCE LAVDLAAVTE CPDDIGKLGK LLLHGPFSVW
860 870 880 890 900
TIHKDRYKMK DLIRFKPSQR QIYLFERGIV FCKIRMEPGD QGLSPHYSFK
910 920 930 940 950
KTMKLMTLSI RQLGRGSHRK FEIASRNGLE KYILQAASKE IRDCWFSEIS
960 970 980 990 1000
KLLMEQQNNI KDQGNPQFEM STSKGSGAGS GPWIKNMERA TTSKEDPASS
1010 1020 1030 1040 1050
TGGIKGCSSR EFSSMDTFED CEGAEDMEKE SSALSLAGLF QSDDSHETCS
1060 1070 1080 1090 1100
SKSAFLERGE SSQGEKEERD EEETATRSTE EERAGASTGR LAPAGATAGF
1110
QARALRPRTS AQES
Length:1,114
Mass (Da):126,993
Last modified:January 11, 2011 - v3
Checksum:iCB1F04EC485C746D
GO
Isoform 2 (identifier: Q86YR7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     706-711: KEDLQI → VSLYSQ
     712-1114: Missing.

Show »
Length:711
Mass (Da):81,877
Checksum:iF3B6D2AB120CBB46
GO
Isoform 3 (identifier: Q86YR7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     622-628: RIIRDLL → YSSQYFK
     629-1114: Missing.

Note: No experimental confirmation available.

Show »
Length:628
Mass (Da):71,912
Checksum:i1BA4CEC31B366D69
GO
Isoform 4 (identifier: Q86YR7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1075-1114: Missing.

Show »
Length:1,074
Mass (Da):122,922
Checksum:iCF969FBCF6C4EC7D
GO

Sequence cautioni

The sequence AAO19651.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti373 – 3731P → S in AAO19651. 1 PublicationCurated
Sequence conflicti373 – 3731P → S in BAA74884. (PubMed:10048485)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591T → M.1 Publication
Corresponds to variant rs12632177 [ dbSNP | Ensembl ].
VAR_043587
Natural varianti254 – 2541L → P in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_043588
Natural varianti277 – 2771N → S.
Corresponds to variant rs13082605 [ dbSNP | Ensembl ].
VAR_043589
Natural varianti359 – 3591I → L.1 Publication
Corresponds to variant rs7639705 [ dbSNP | Ensembl ].
VAR_043590
Natural varianti378 – 3781Q → L.1 Publication
Corresponds to variant rs2293203 [ dbSNP | Ensembl ].
VAR_043591
Natural varianti589 – 5891F → S.1 Publication
Corresponds to variant rs3732602 [ dbSNP | Ensembl ].
VAR_043592
Natural varianti622 – 6221R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_043593
Natural varianti772 – 7721F → L.
Corresponds to variant rs9826325 [ dbSNP | Ensembl ].
VAR_043594
Natural varianti902 – 9021T → A.3 Publications
Corresponds to variant rs6804951 [ dbSNP | Ensembl ].
VAR_043595
Natural varianti1015 – 10151M → T.
Corresponds to variant rs35070271 [ dbSNP | Ensembl ].
VAR_043596
Natural varianti1039 – 10391L → F in a breast cancer sample; somatic mutation. 1 Publication
VAR_043597

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei622 – 6287RIIRDLL → YSSQYFK in isoform 3. 1 PublicationVSP_033872
Alternative sequencei629 – 1114486Missing in isoform 3. 1 PublicationVSP_033873Add
BLAST
Alternative sequencei706 – 7116KEDLQI → VSLYSQ in isoform 2. 1 PublicationVSP_033874
Alternative sequencei712 – 1114403Missing in isoform 2. 1 PublicationVSP_033875Add
BLAST
Alternative sequencei1075 – 111440Missing in isoform 4. 1 PublicationVSP_033876Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124500 mRNA. Translation: BAC85866.1.
AC069417 Genomic DNA. No translation available.
AC092960 Genomic DNA. No translation available.
AC104641 Genomic DNA. No translation available.
AC112647 Genomic DNA. No translation available.
BC029074 mRNA. Translation: AAH29074.2.
BC064632 mRNA. Translation: AAH64632.1.
AY172737 mRNA. Translation: AAO19651.1. Different initiation.
AB020668 mRNA. Translation: BAA74884.1.
CCDSiCCDS3243.1. [Q86YR7-1]
RefSeqiNP_055893.3. NM_015078.3.
UniGeneiHs.208267.

Genome annotation databases

EnsembliENST00000328913; ENSP00000328118; ENSG00000053524. [Q86YR7-1]
ENST00000414362; ENSP00000414131; ENSG00000053524. [Q86YR7-3]
ENST00000447025; ENSP00000388190; ENSG00000053524. [Q86YR7-2]
ENST00000473233; ENSP00000420070; ENSG00000053524. [Q86YR7-4]
GeneIDi23101.
KEGGihsa:23101.
UCSCiuc003fli.1. human. [Q86YR7-1]
uc003flj.1. human. [Q86YR7-2]

Polymorphism databases

DMDMi317373423.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124500 mRNA. Translation: BAC85866.1 .
AC069417 Genomic DNA. No translation available.
AC092960 Genomic DNA. No translation available.
AC104641 Genomic DNA. No translation available.
AC112647 Genomic DNA. No translation available.
BC029074 mRNA. Translation: AAH29074.2 .
BC064632 mRNA. Translation: AAH64632.1 .
AY172737 mRNA. Translation: AAO19651.1 . Different initiation.
AB020668 mRNA. Translation: BAA74884.1 .
CCDSi CCDS3243.1. [Q86YR7-1 ]
RefSeqi NP_055893.3. NM_015078.3.
UniGenei Hs.208267.

3D structure databases

ProteinModelPortali Q86YR7.
SMRi Q86YR7. Positions 620-956.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116728. 1 interaction.
IntActi Q86YR7. 3 interactions.
STRINGi 9606.ENSP00000328118.

PTM databases

PhosphoSitei Q86YR7.

Polymorphism databases

DMDMi 317373423.

Proteomic databases

PaxDbi Q86YR7.
PRIDEi Q86YR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328913 ; ENSP00000328118 ; ENSG00000053524 . [Q86YR7-1 ]
ENST00000414362 ; ENSP00000414131 ; ENSG00000053524 . [Q86YR7-3 ]
ENST00000447025 ; ENSP00000388190 ; ENSG00000053524 . [Q86YR7-2 ]
ENST00000473233 ; ENSP00000420070 ; ENSG00000053524 . [Q86YR7-4 ]
GeneIDi 23101.
KEGGi hsa:23101.
UCSCi uc003fli.1. human. [Q86YR7-1 ]
uc003flj.1. human. [Q86YR7-2 ]

Organism-specific databases

CTDi 23101.
GeneCardsi GC03M182895.
HGNCi HGNC:30319. MCF2L2.
HPAi HPA038946.
HPA038947.
MIMi 125853. phenotype.
neXtProti NX_Q86YR7.
PharmGKBi PA134863801.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315020.
GeneTreei ENSGT00760000119030.
HOGENOMi HOG000231361.
HOVERGENi HBG062385.
InParanoidi Q86YR7.
OMAi PRCVELR.
OrthoDBi EOG7KQ210.
PhylomeDBi Q86YR7.
TreeFami TF318080.

Miscellaneous databases

ChiTaRSi MCF2L2. human.
GenomeRNAii 23101.
NextBioi 44281.
PROi Q86YR7.
SOURCEi Search...

Gene expression databases

Bgeei Q86YR7.
CleanExi HS_MCF2L2.
ExpressionAtlasi Q86YR7. baseline.
Genevestigatori Q86YR7.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR018159. Spectrin/alpha-actinin.
[Graphical view ]
Pfami PF13716. CRAL_TRIO_2. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00516. SEC14. 1 hit.
SM00150. SPEC. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-359.
    Tissue: Cerebellum.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 804-1114 (ISOFORM 4), VARIANTS LEU-378; SER-589 AND ALA-902.
    Tissue: Brain and Pancreas.
  4. "DRG, a novel guanine-nucleotide exchange factor for Rho family."
    Yamauchi J., Miyamoto Y., Itoh H.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-1114 (ISOFORM 1), VARIANT ALA-902.
  5. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 133-1114 (ISOFORM 1), VARIANTS MET-159 AND ALA-902.
    Tissue: Brain.
  6. Cited for: INVOLVEMENT IN NONINSULIN-DEPENDENT DIABETES MELLITUS, TISSUE SPECIFICITY.
  7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-254; HIS-622 AND PHE-1039.

Entry informationi

Entry nameiMF2L2_HUMAN
AccessioniPrimary (citable) accession number: Q86YR7
Secondary accession number(s): O94942
, Q6P2B8, Q6ZVJ5, Q8N318
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3