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Q86YR7

- MF2L2_HUMAN

UniProt

Q86YR7 - MF2L2_HUMAN

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Protein
Probable guanine nucleotide exchange factor MCF2L2
Gene
MCF2L2, DRG, KIAA0861
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably functions as a guanine nucleotide exchange factor By similarity.

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable guanine nucleotide exchange factor MCF2L2
    Alternative name(s):
    Dbs-related Rho family guanine nucleotide exchange factor
    MCF2-transforming sequence-like protein 2
    Gene namesi
    Name:MCF2L2
    Synonyms:DRG, KIAA0861
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30319. MCF2L2.

    Pathology & Biotechi

    Involvement in diseasei

    Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
    Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

    Keywords - Diseasei

    Diabetes mellitus

    Organism-specific databases

    MIMi125853. phenotype.
    PharmGKBiPA134863801.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11141114Probable guanine nucleotide exchange factor MCF2L2
    PRO_0000337087Add
    BLAST

    Proteomic databases

    PaxDbiQ86YR7.
    PRIDEiQ86YR7.

    PTM databases

    PhosphoSiteiQ86YR7.

    Expressioni

    Tissue specificityi

    Significantly expressed in brain and modestly in pancreas, brain and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ86YR7.
    BgeeiQ86YR7.
    CleanExiHS_MCF2L2.
    GenevestigatoriQ86YR7.

    Organism-specific databases

    HPAiHPA038946.
    HPA038947.

    Interactioni

    Protein-protein interaction databases

    BioGridi116728. 1 interaction.
    IntActiQ86YR7. 3 interactions.
    STRINGi9606.ENSP00000328118.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86YR7.
    SMRiQ86YR7. Positions 620-956.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 193183CRAL-TRIO
    Add
    BLAST
    Repeati323 – 428106Spectrin
    Add
    BLAST
    Domaini619 – 822204DH
    Add
    BLAST
    Domaini834 – 954121PH
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the MCF2 family.
    Contains 1 CRAL-TRIO domain.
    Contains 1 PH domain.
    Contains 1 spectrin repeat.

    Phylogenomic databases

    eggNOGiNOG315020.
    HOGENOMiHOG000231361.
    HOVERGENiHBG062385.
    InParanoidiQ86YR7.
    OMAiPRCVELR.
    OrthoDBiEOG7KQ210.
    PhylomeDBiQ86YR7.
    TreeFamiTF318080.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR001251. CRAL-TRIO_dom.
    IPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR018159. Spectrin/alpha-actinin.
    [Graphical view]
    PfamiPF13716. CRAL_TRIO_2. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00516. SEC14. 1 hit.
    SM00150. SPEC. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF52087. SSF52087. 1 hit.
    PROSITEiPS50191. CRAL_TRIO. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86YR7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLSCLKEEMP PQELTRRLAT VITHVDEIMQ QEVRPLMAVE IIEQLHRQFA     50
    ILSGGRGEDG APIITFPEFS GFKHIPDEDF LNVMTYLTSI PSVEAASIGF 100
    IVVIDRRRDK WSSVKASLTR IAVAFPGNLQ LIFILRPSRF IQRTFTDIGI 150
    KYYRNEFKTK VPIIMVNSVS DLHGYIDKSQ LTRELGGTLE YRHGQWVNHR 200
    TAIENFALTL KTTAQMLQTF GSCLATAELP RSMLSTEDLL MSHTRQRDKL 250
    QDELKLLGKQ GTTLLSCIQE PATKCPNSKL NLNQLENVTT MERLLVQLDE 300
    TEKAFSHFWS EHHLKLNQCL QLQHFEHDFC KAKLALDNLL EEQAEFTGIG 350
    DSVMHVEQIL KEHKKLEEKS QEPLEKAQLL ALVGDQLIQS HHYAADAIRP 400
    RCVELRHLCD DFINGNKKKW DILGKSLEFH RQLDKVSQWC EAGIYLLASQ 450
    AVDKCQSREG VDIALNDIAT FLGTVKEYPL LSPKEFYNEF ELLLTLDAKA 500
    KAQKVLQRLD DVQEIFHKRQ VSLMKLAAKQ TRPVQPVAPH PESSPKWVSS 550
    KTSQPSTSVP LARPLRTSEE PYTETELNSR GKEDDETKFE VKSEEIFESH 600
    HERGNPELEQ QARLGDLSPR RRIIRDLLET EEIYIKEIKS IIDGYITPMD 650
    FIWLKHLIPD VLQNNKDFLF GNIRELYEFH NRTFLKELEK CAENPELLAH 700
    CFLKRKEDLQ IYFKYHKNLP RARAIWQECQ DCAYFGVCQR QLDHNLPLFK 750
    YLKGPSQRLI KYQMLLKGLL DFESPEDMEI DPGELGGSAK DGPKRTKDSA 800
    FSTELQQALA VIEDLIKSCE LAVDLAAVTE CPDDIGKLGK LLLHGPFSVW 850
    TIHKDRYKMK DLIRFKPSQR QIYLFERGIV FCKIRMEPGD QGLSPHYSFK 900
    KTMKLMTLSI RQLGRGSHRK FEIASRNGLE KYILQAASKE IRDCWFSEIS 950
    KLLMEQQNNI KDQGNPQFEM STSKGSGAGS GPWIKNMERA TTSKEDPASS 1000
    TGGIKGCSSR EFSSMDTFED CEGAEDMEKE SSALSLAGLF QSDDSHETCS 1050
    SKSAFLERGE SSQGEKEERD EEETATRSTE EERAGASTGR LAPAGATAGF 1100
    QARALRPRTS AQES 1114
    Length:1,114
    Mass (Da):126,993
    Last modified:January 11, 2011 - v3
    Checksum:iCB1F04EC485C746D
    GO
    Isoform 2 (identifier: Q86YR7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         706-711: KEDLQI → VSLYSQ
         712-1114: Missing.

    Show »
    Length:711
    Mass (Da):81,877
    Checksum:iF3B6D2AB120CBB46
    GO
    Isoform 3 (identifier: Q86YR7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         622-628: RIIRDLL → YSSQYFK
         629-1114: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:628
    Mass (Da):71,912
    Checksum:i1BA4CEC31B366D69
    GO
    Isoform 4 (identifier: Q86YR7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1075-1114: Missing.

    Show »
    Length:1,074
    Mass (Da):122,922
    Checksum:iCF969FBCF6C4EC7D
    GO

    Sequence cautioni

    The sequence AAO19651.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti159 – 1591T → M.1 Publication
    Corresponds to variant rs12632177 [ dbSNP | Ensembl ].
    VAR_043587
    Natural varianti254 – 2541L → P in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_043588
    Natural varianti277 – 2771N → S.
    Corresponds to variant rs13082605 [ dbSNP | Ensembl ].
    VAR_043589
    Natural varianti359 – 3591I → L.1 Publication
    Corresponds to variant rs7639705 [ dbSNP | Ensembl ].
    VAR_043590
    Natural varianti378 – 3781Q → L.1 Publication
    Corresponds to variant rs2293203 [ dbSNP | Ensembl ].
    VAR_043591
    Natural varianti589 – 5891F → S.1 Publication
    Corresponds to variant rs3732602 [ dbSNP | Ensembl ].
    VAR_043592
    Natural varianti622 – 6221R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_043593
    Natural varianti772 – 7721F → L.
    Corresponds to variant rs9826325 [ dbSNP | Ensembl ].
    VAR_043594
    Natural varianti902 – 9021T → A.3 Publications
    Corresponds to variant rs6804951 [ dbSNP | Ensembl ].
    VAR_043595
    Natural varianti1015 – 10151M → T.
    Corresponds to variant rs35070271 [ dbSNP | Ensembl ].
    VAR_043596
    Natural varianti1039 – 10391L → F in a breast cancer sample; somatic mutation. 1 Publication
    VAR_043597

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei622 – 6287RIIRDLL → YSSQYFK in isoform 3.
    VSP_033872
    Alternative sequencei629 – 1114486Missing in isoform 3.
    VSP_033873Add
    BLAST
    Alternative sequencei706 – 7116KEDLQI → VSLYSQ in isoform 2.
    VSP_033874
    Alternative sequencei712 – 1114403Missing in isoform 2.
    VSP_033875Add
    BLAST
    Alternative sequencei1075 – 111440Missing in isoform 4.
    VSP_033876Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti373 – 3731P → S in AAO19651. 1 Publication
    Sequence conflicti373 – 3731P → S in BAA74884. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK124500 mRNA. Translation: BAC85866.1.
    AC069417 Genomic DNA. No translation available.
    AC092960 Genomic DNA. No translation available.
    AC104641 Genomic DNA. No translation available.
    AC112647 Genomic DNA. No translation available.
    BC029074 mRNA. Translation: AAH29074.2.
    BC064632 mRNA. Translation: AAH64632.1.
    AY172737 mRNA. Translation: AAO19651.1. Different initiation.
    AB020668 mRNA. Translation: BAA74884.1.
    CCDSiCCDS3243.1. [Q86YR7-1]
    RefSeqiNP_055893.3. NM_015078.3.
    UniGeneiHs.208267.

    Genome annotation databases

    EnsembliENST00000328913; ENSP00000328118; ENSG00000053524. [Q86YR7-1]
    ENST00000414362; ENSP00000414131; ENSG00000053524. [Q86YR7-3]
    ENST00000447025; ENSP00000388190; ENSG00000053524. [Q86YR7-2]
    ENST00000473233; ENSP00000420070; ENSG00000053524. [Q86YR7-4]
    GeneIDi23101.
    KEGGihsa:23101.
    UCSCiuc003fli.1. human. [Q86YR7-1]
    uc003flj.1. human. [Q86YR7-2]

    Polymorphism databases

    DMDMi317373423.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK124500 mRNA. Translation: BAC85866.1 .
    AC069417 Genomic DNA. No translation available.
    AC092960 Genomic DNA. No translation available.
    AC104641 Genomic DNA. No translation available.
    AC112647 Genomic DNA. No translation available.
    BC029074 mRNA. Translation: AAH29074.2 .
    BC064632 mRNA. Translation: AAH64632.1 .
    AY172737 mRNA. Translation: AAO19651.1 . Different initiation.
    AB020668 mRNA. Translation: BAA74884.1 .
    CCDSi CCDS3243.1. [Q86YR7-1 ]
    RefSeqi NP_055893.3. NM_015078.3.
    UniGenei Hs.208267.

    3D structure databases

    ProteinModelPortali Q86YR7.
    SMRi Q86YR7. Positions 620-956.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 116728. 1 interaction.
    IntActi Q86YR7. 3 interactions.
    STRINGi 9606.ENSP00000328118.

    PTM databases

    PhosphoSitei Q86YR7.

    Polymorphism databases

    DMDMi 317373423.

    Proteomic databases

    PaxDbi Q86YR7.
    PRIDEi Q86YR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328913 ; ENSP00000328118 ; ENSG00000053524 . [Q86YR7-1 ]
    ENST00000414362 ; ENSP00000414131 ; ENSG00000053524 . [Q86YR7-3 ]
    ENST00000447025 ; ENSP00000388190 ; ENSG00000053524 . [Q86YR7-2 ]
    ENST00000473233 ; ENSP00000420070 ; ENSG00000053524 . [Q86YR7-4 ]
    GeneIDi 23101.
    KEGGi hsa:23101.
    UCSCi uc003fli.1. human. [Q86YR7-1 ]
    uc003flj.1. human. [Q86YR7-2 ]

    Organism-specific databases

    CTDi 23101.
    GeneCardsi GC03M182895.
    HGNCi HGNC:30319. MCF2L2.
    HPAi HPA038946.
    HPA038947.
    MIMi 125853. phenotype.
    neXtProti NX_Q86YR7.
    PharmGKBi PA134863801.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315020.
    HOGENOMi HOG000231361.
    HOVERGENi HBG062385.
    InParanoidi Q86YR7.
    OMAi PRCVELR.
    OrthoDBi EOG7KQ210.
    PhylomeDBi Q86YR7.
    TreeFami TF318080.

    Miscellaneous databases

    ChiTaRSi MCF2L2. human.
    GenomeRNAii 23101.
    NextBioi 44281.
    PROi Q86YR7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86YR7.
    Bgeei Q86YR7.
    CleanExi HS_MCF2L2.
    Genevestigatori Q86YR7.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR001251. CRAL-TRIO_dom.
    IPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR018159. Spectrin/alpha-actinin.
    [Graphical view ]
    Pfami PF13716. CRAL_TRIO_2. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00516. SEC14. 1 hit.
    SM00150. SPEC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF52087. SSF52087. 1 hit.
    PROSITEi PS50191. CRAL_TRIO. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-359.
      Tissue: Cerebellum.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 804-1114 (ISOFORM 4), VARIANTS LEU-378; SER-589 AND ALA-902.
      Tissue: Brain and Pancreas.
    4. "DRG, a novel guanine-nucleotide exchange factor for Rho family."
      Yamauchi J., Miyamoto Y., Itoh H.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-1114 (ISOFORM 1), VARIANT ALA-902.
    5. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 133-1114 (ISOFORM 1), VARIANTS MET-159 AND ALA-902.
      Tissue: Brain.
    6. Cited for: INVOLVEMENT IN NONINSULIN-DEPENDENT DIABETES MELLITUS, TISSUE SPECIFICITY.
    7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-254; HIS-622 AND PHE-1039.

    Entry informationi

    Entry nameiMF2L2_HUMAN
    AccessioniPrimary (citable) accession number: Q86YR7
    Secondary accession number(s): O94942
    , Q6P2B8, Q6ZVJ5, Q8N318
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: January 11, 2011
    Last modified: September 3, 2014
    This is version 93 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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