Q86YR6 (POTED_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
POTE ankyrin domain family member D

Alternative name(s):
ANKRD26-like family B member 3
Ankyrin repeat domain-containing protein 21
Prostate, ovary, testis-expressed protein
Short name=Protein POTE

Gene names

Name:	POTED
Synonyms:	A26B3, ANKRD21, POTE

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	584 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Peripheral membrane protein Ref.1 Ref.4.
Tissue specificity	Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. Localizes to basal and terminal prostate epithelial cells. Ref.1
Sequence similarities	Belongs to the POTE family. Contains 6 ANK repeats.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	ANK repeat Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 584	584	POTE ankyrin domain family member D		PRO_0000066913
Regions
	Repeat	172 – 201	30	ANK 1
	Repeat	205 – 234	30	ANK 2
	Repeat	238 – 267	30	ANK 3
	Repeat	271 – 300	30	ANK 4
	Repeat	304 – 333	30	ANK 5
	Repeat	337 – 366	30	ANK 6
	Coiled coil	494 – 583	90	Potential
Natural variations
	Natural variant	113	1	G → S. Ref.1 Corresponds to variant rs6517869 [ dbSNP | Ensembl ].		VAR_016242
	Natural variant	135	1	I → V. Ref.1 Corresponds to variant rs6517870 [ dbSNP | Ensembl ].		VAR_016243
	Natural variant	172	1	E → Q. Ref.5		VAR_064765
Experimental info
	Sequence conflict	535	1	M → V in AAO23914. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q86YR6 [UniParc]. Last modified November 24, 2009. Version 2. Checksum: 837E4E63B393BB2B	FASTA	584	66,394
	10 20 30 40 50 60 MVAEVCSMPT ASTVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD DSFMKMLRSK 70 80 90 100 110 120 MGKCCRHCFP CCRGSGTSNV GTSGDHENSF MKMLRSKMGK WCCHCFPCCR GSGKSNVGAW 130 140 150 160 170 180 GDYDHSAFME PRYHIRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KEKRTALHLA 190 200 210 220 230 240 SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAIQCQEDE CVLMLLEHGA DRNIPDEYGN 250 260 270 280 290 300 TALHYAIYNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNV 310 320 330 340 350 360 LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY 370 380 390 400 410 420 KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK MSQEPEINKD CDREVEEEIK 430 440 450 460 470 480 KHGSNPVGLP ENLTNGASAG NGDDGLIPQR RSRKPENQQF PDTENEEYHS DEQNDTRKQL 490 500 510 520 530 540 SEEQNTGISQ DEILTNKQKQ IEVAEQKMNS ELSLSHKKEE DLLRENSVLQ EEIAMLRLEL 550 560 570 580 DETKHQNQLR ENKILEEIES VKEKTDKLLR AMQLNEEALT KTNI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer." Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V., Lee B., Pastan I. Proc. Natl. Acad. Sci. U.S.A. 99:16975-16980(2002) [PubMed: 12475935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANTS SER-113 AND VAL-135. Tissue: Prostate.
[2]	Erratum Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V., Lee B., Pastan I. Proc. Natl. Acad. Sci. U.S.A. 100:1462-1462(2003)
[3]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths." Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I. Gene 337:45-53(2004) [PubMed: 15276201] [Abstract] Cited for: SUBCELLULAR LOCATION.
[5]	"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A. Nature 469:539-542(2011) [PubMed: 21248752] [Abstract] Cited for: VARIANT GLN-172.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY172978 mRNA. Translation: AAO23914.1. AP001465 Genomic DNA. No translation available.
IPI	IPI00878981.
RefSeq	NP_778146.2. NM_174981.3. XP_002343914.1. XM_002343873.2.
UniGene	Hs.442712. Hs.722865.
3D structure databases
ProteinModelPortal	Q86YR6.
SMR	Q86YR6. Positions 138-365.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86YR6.
Polymorphism databases
DMDM	269849632.
Proteomic databases
PRIDE	Q86YR6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327822; ENSP00000329990; ENSG00000237375.
GeneID	100288966. 317754.
KEGG	hsa:100288966. hsa:317754.
UCSC	uc002yjb.1. human.
Organism-specific databases
CTD	317754.
GeneCards	GC00M6B0108. GC21P014982.
H-InvDB	HIX0038118.
HGNC	HGNC:23822. POTED.
MIM	607549. gene.
neXtProt	NX_Q86YR6.
PharmGKB	PA134979978. PA164724756.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17475.
GeneTree	ENSGT00560000076605.
InParanoid	Q86YR6.
OMA	TAMENSP.
OrthoDB	EOG4SN1NB.
PhylomeDB	Q86YR6.
Gene expression databases
CleanEx	HS_POTED.
Genevestigator	Q86YR6.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 2 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 6 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

POTED_HUMAN

Accession

Primary (citable) accession number: Q86YR6
Secondary accession number(s): C9JCF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	November 24, 2009
Last modified:	December 14, 2011
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.