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Protein

POTE ankyrin domain family member D

Gene

POTED

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member D
Alternative name(s):
ANKRD26-like family B member 3
Ankyrin repeat domain-containing protein 21
Prostate, ovary, testis-expressed protein
Short name:
Protein POTE
Gene namesi
Name:POTED
Synonyms:A26B3, ANKRD21, POTE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:23822. POTED.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724756.

Polymorphism and mutation databases

BioMutaiPOTED.
DMDMi269849632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584POTE ankyrin domain family member DPRO_0000066913Add
BLAST

Proteomic databases

EPDiQ86YR6.
PaxDbiQ86YR6.
PRIDEiQ86YR6.

PTM databases

iPTMnetiQ86YR6.
PhosphoSiteiQ86YR6.
SwissPalmiQ86YR6.

Expressioni

Tissue specificityi

Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. Localizes to basal and terminal prostate epithelial cells.1 Publication

Gene expression databases

BgeeiQ86YR6.
CleanExiHS_POTED.
ExpressionAtlasiQ86YR6. baseline.
GenevisibleiQ86YR6. HS.

Organism-specific databases

HPAiHPA042822.

Interactioni

Protein-protein interaction databases

BioGridi130460. 2 interactions.
STRINGi9606.ENSP00000299443.

Structurei

3D structure databases

ProteinModelPortaliQ86YR6.
SMRiQ86YR6. Positions 120-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati172 – 20130ANK 1Add
BLAST
Repeati205 – 23430ANK 2Add
BLAST
Repeati238 – 26730ANK 3Add
BLAST
Repeati271 – 30030ANK 4Add
BLAST
Repeati304 – 33330ANK 5Add
BLAST
Repeati337 – 36630ANK 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili494 – 58390Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the POTE family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
InParanoidiQ86YR6.
KOiK17299.
OrthoDBiEOG7FBRHS.
PhylomeDBiQ86YR6.
TreeFamiTF337879.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86YR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAEVCSMPT ASTVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD
60 70 80 90 100
DSFMKMLRSK MGKCCRHCFP CCRGSGTSNV GTSGDHENSF MKMLRSKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSNVGAW GDYDHSAFME PRYHIRREDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDMNKRD KEKRTALHLA SANGNSEVVQ LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAIQCQEDE CVLMLLEHGA DRNIPDEYGN TALHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNV
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICELLSDY KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK
410 420 430 440 450
MSQEPEINKD CDREVEEEIK KHGSNPVGLP ENLTNGASAG NGDDGLIPQR
460 470 480 490 500
RSRKPENQQF PDTENEEYHS DEQNDTRKQL SEEQNTGISQ DEILTNKQKQ
510 520 530 540 550
IEVAEQKMNS ELSLSHKKEE DLLRENSVLQ EEIAMLRLEL DETKHQNQLR
560 570 580
ENKILEEIES VKEKTDKLLR AMQLNEEALT KTNI
Length:584
Mass (Da):66,394
Last modified:November 24, 2009 - v2
Checksum:i837E4E63B393BB2B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti535 – 5351M → V in AAO23914 (PubMed:12475935).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131G → S.1 Publication
Corresponds to variant rs6517869 [ dbSNP | Ensembl ].
VAR_016242
Natural varianti135 – 1351I → V.1 Publication
Corresponds to variant rs117112505 [ dbSNP | Ensembl ].
VAR_016243
Natural varianti172 – 1721E → Q.1 Publication
VAR_064765

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172978 mRNA. Translation: AAO23914.1.
AP001465 Genomic DNA. No translation available.
CCDSiCCDS13562.1.
RefSeqiNP_001244291.1. NM_001257362.1.
NP_778146.2. NM_174981.3.
UniGeneiHs.442712.
Hs.742365.

Genome annotation databases

EnsembliENST00000299443; ENSP00000299443; ENSG00000166351.
GeneIDi100288966.
317754.
KEGGihsa:100288966.
hsa:317754.
UCSCiuc002yjb.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172978 mRNA. Translation: AAO23914.1.
AP001465 Genomic DNA. No translation available.
CCDSiCCDS13562.1.
RefSeqiNP_001244291.1. NM_001257362.1.
NP_778146.2. NM_174981.3.
UniGeneiHs.442712.
Hs.742365.

3D structure databases

ProteinModelPortaliQ86YR6.
SMRiQ86YR6. Positions 120-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130460. 2 interactions.
STRINGi9606.ENSP00000299443.

PTM databases

iPTMnetiQ86YR6.
PhosphoSiteiQ86YR6.
SwissPalmiQ86YR6.

Polymorphism and mutation databases

BioMutaiPOTED.
DMDMi269849632.

Proteomic databases

EPDiQ86YR6.
PaxDbiQ86YR6.
PRIDEiQ86YR6.

Protocols and materials databases

DNASUi317754.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299443; ENSP00000299443; ENSG00000166351.
GeneIDi100288966.
317754.
KEGGihsa:100288966.
hsa:317754.
UCSCiuc002yjb.1. human.

Organism-specific databases

CTDi317754.
GeneCardsiPOTED.
H-InvDBHIX0038118.
HGNCiHGNC:23822. POTED.
HPAiHPA042822.
MIMi607549. gene.
neXtProtiNX_Q86YR6.
PharmGKBiPA164724756.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
InParanoidiQ86YR6.
KOiK17299.
OrthoDBiEOG7FBRHS.
PhylomeDBiQ86YR6.
TreeFamiTF337879.

Miscellaneous databases

PROiQ86YR6.
SOURCEiSearch...

Gene expression databases

BgeeiQ86YR6.
CleanExiHS_POTED.
ExpressionAtlasiQ86YR6. baseline.
GenevisibleiQ86YR6. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer."
    Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V., Lee B., Pastan I.
    Proc. Natl. Acad. Sci. U.S.A. 99:16975-16980(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANTS SER-113 AND VAL-135.
    Tissue: Prostate.
  2. Erratum
    Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V., Lee B., Pastan I.
    Proc. Natl. Acad. Sci. U.S.A. 100:1462-1462(2003)
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths."
    Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.
    Gene 337:45-53(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. Cited for: VARIANT GLN-172.

Entry informationi

Entry nameiPOTED_HUMAN
AccessioniPrimary (citable) accession number: Q86YR6
Secondary accession number(s): C9JCF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 24, 2009
Last modified: June 8, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.