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Protein

POTE ankyrin domain family member D

Gene

POTED

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member D
Alternative name(s):
ANKRD26-like family B member 3
Ankyrin repeat domain-containing protein 21
Prostate, ovary, testis-expressed protein
Short name:
Protein POTE
Gene namesi
Name:POTED
Synonyms:A26B3, ANKRD21, POTE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000166351.10
HGNCiHGNC:23822 POTED
MIMi607549 gene
neXtProtiNX_Q86YR6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100288966
317754
OpenTargetsiENSG00000166351
PharmGKBiPA164724756

Polymorphism and mutation databases

BioMutaiPOTED
DMDMi269849632

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669131 – 584POTE ankyrin domain family member DAdd BLAST584

Proteomic databases

PaxDbiQ86YR6
PeptideAtlasiQ86YR6
PRIDEiQ86YR6
ProteomicsDBi70456

PTM databases

iPTMnetiQ86YR6
PhosphoSitePlusiQ86YR6
SwissPalmiQ86YR6

Expressioni

Tissue specificityi

Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. Localizes to basal and terminal prostate epithelial cells.1 Publication

Gene expression databases

BgeeiENSG00000166351
CleanExiHS_POTED
ExpressionAtlasiQ86YR6 baseline
GenevisibleiQ86YR6 HS

Organism-specific databases

HPAiHPA042822

Interactioni

Protein-protein interaction databases

BioGridi130460, 2 interactors
STRINGi9606.ENSP00000299443

Structurei

3D structure databases

ProteinModelPortaliQ86YR6
SMRiQ86YR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati172 – 201ANK 1Add BLAST30
Repeati205 – 234ANK 2Add BLAST30
Repeati238 – 267ANK 3Add BLAST30
Repeati271 – 300ANK 4Add BLAST30
Repeati304 – 333ANK 5Add BLAST30
Repeati337 – 366ANK 6Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili494 – 583Sequence analysisAdd BLAST90

Sequence similaritiesi

Belongs to the POTE family.Curated

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ITJG Eukaryota
COG0666 LUCA
GeneTreeiENSGT00560000076605
InParanoidiQ86YR6
KOiK17299
OrthoDBiEOG091G077A
PhylomeDBiQ86YR6
TreeFamiTF337879

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits

Sequencei

Sequence statusi: Complete.

Q86YR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAEVCSMPT ASTVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD
60 70 80 90 100
DSFMKMLRSK MGKCCRHCFP CCRGSGTSNV GTSGDHENSF MKMLRSKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSNVGAW GDYDHSAFME PRYHIRREDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDMNKRD KEKRTALHLA SANGNSEVVQ LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAIQCQEDE CVLMLLEHGA DRNIPDEYGN TALHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNV
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICELLSDY KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK
410 420 430 440 450
MSQEPEINKD CDREVEEEIK KHGSNPVGLP ENLTNGASAG NGDDGLIPQR
460 470 480 490 500
RSRKPENQQF PDTENEEYHS DEQNDTRKQL SEEQNTGISQ DEILTNKQKQ
510 520 530 540 550
IEVAEQKMNS ELSLSHKKEE DLLRENSVLQ EEIAMLRLEL DETKHQNQLR
560 570 580
ENKILEEIES VKEKTDKLLR AMQLNEEALT KTNI
Length:584
Mass (Da):66,394
Last modified:November 24, 2009 - v2
Checksum:i837E4E63B393BB2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti535M → V in AAO23914 (PubMed:12475935).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016242113G → S1 PublicationCorresponds to variant dbSNP:rs6517869Ensembl.1
Natural variantiVAR_016243135I → V1 PublicationCorresponds to variant dbSNP:rs6517870Ensembl.1
Natural variantiVAR_064765172E → Q1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172978 mRNA Translation: AAO23914.1
AP001465 Genomic DNA No translation available.
CCDSiCCDS13562.1
RefSeqiNP_001244291.1, NM_001257362.1
NP_778146.2, NM_174981.3
UniGeneiHs.442712
Hs.742365

Genome annotation databases

EnsembliENST00000299443; ENSP00000299443; ENSG00000166351
GeneIDi100288966
317754
KEGGihsa:100288966
hsa:317754
UCSCiuc002yjb.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPOTED_HUMAN
AccessioniPrimary (citable) accession number: Q86YR6
Secondary accession number(s): C9JCF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 24, 2009
Last modified: June 20, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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