Q86YR5 (GPSM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein-signaling modulator 1

Alternative name(s):
Activator of G-protein signaling 3

Gene names

Name:	GPSM1
Synonyms:	AGS3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	675 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Ref.6 Ref.7
Subunit structure	Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 By similarity. Interacts with INSC/inscuteable and FRMPD1. Ref.8 Ref.9
Subcellular location	Cytoplasm › cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side Ref.7 Ref.9.
Tissue specificity	Expressed in intestinal cells. Ref.7
Domain	The GoLoco domains mediate interaction with G(i/o) alpha By similarity. The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.
Post-translational modification	Phosphorylation regulates interaction with G(i/o) alpha By similarity.
Sequence similarities	Belongs to the GPSM family. Contains 4 GoLoco domains. Contains 9 TPR repeats.
Sequence caution	The sequence AAH09979.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH17353.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAB55951.1 differs from that shown. Reason: Frameshift at position 657. The sequence CAI19339.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cell membrane Cytoplasm Endoplasmic reticulum Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat TPR repeat
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW regulation of G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GDP-dissociation inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86YR5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86YR5-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1-509: Missing.

Note: Minor isoform.

Isoform 3 (identifier: Q86YR5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     404-457: ARPKRTQRLS...LPVRSRKYQE → EFQGCGGVLL...FFLASGTAQA
     458-675: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q86YR5-4)

Also known as: FL;

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: Major isoform.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 675	675	G-protein-signaling modulator 1		PRO_0000252402
Regions
	Repeat	28 – 61	34	TPR 1
	Repeat	66 – 99	34	TPR 2
	Repeat	106 – 139	34	TPR 3
	Repeat	146 – 181	36	TPR 4
	Repeat	183 – 202	20	TPR 5
	Repeat	209 – 242	34	TPR 6
	Repeat	249 – 282	34	TPR 7
	Repeat	289 – 322	34	TPR 8
	Repeat	329 – 362	34	TPR 9
	Domain	495 – 517	23	GoLoco 1
	Domain	548 – 570	23	GoLoco 2
	Domain	596 – 618	23	GoLoco 3
	Domain	630 – 652	23	GoLoco 4
	Region	1 – 509	509	Mediates association with membranes By similarity
	Region	364 – 487	124	Interaction with STK11/LKB1 By similarity
Amino acid modifications
	Modified residue	413	1	Phosphoserine Ref.12
	Modified residue	471	1	Phosphoserine Ref.11
	Modified residue	492	1	Phosphoserine Ref.11
	Modified residue	493	1	Phosphoserine Ref.11
Natural variations
	Alternative sequence	1 – 509	509	Missing in isoform 2.		VSP_020937
	Alternative sequence	1 – 23	23	Missing in isoform 4.		VSP_039028
	Alternative sequence	404 – 457	54	ARPKR…RKYQE → EFQGCGGVLLPTGTDRIRSC GGVGSRPGQHGGGGSRQKMA PTSQFFLASGTAQA in isoform 3.		VSP_020938
	Alternative sequence	458 – 675	218	Missing in isoform 3.		VSP_020939

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 20, 2010. Version 2. Checksum: 27EB86667EEC1951	FASTA	675	74,510
	10 20 30 40 50 60 MAGPAPPVAD ELPGPAARRL YSRMEASCLE LALEGERLCK AGDFKTGVAF FEAAVQVGTE 70 80 90 100 110 120 DLKTLSAIYS QLGNAYFYLK EHGRALEYHK HDLLLARTIG DRMGEAKASG NLGNTLKVLG 130 140 150 160 170 180 RFDEAAVCCQ RHLSIAQEQG DKVGEARALY NIGNVYHAKG KQLSWNAANA TQDPGHLPPD 190 200 210 220 230 240 VRETLCKASE FYERNLSLVK ELGDRAAQGR AYGNLGNTHY LLGNFTEATT FHKERLAIAK 250 260 270 280 290 300 EFGDKAAERR AYSNLGNAHV FLGRFDVAAE YYKKTLQLSR QLRDQAVEAQ ACYSLGNTYT 310 320 330 340 350 360 LLQDYERAAE YHLRHLLIAQ ELADRVGEGR ACWSLGNAYV SMGRPAQALT FAKKHLQISQ 370 380 390 400 410 420 EIGDRHGELT ARMNVAQLQL VLGRLTSPAA SEKPDLAGYE AQGARPKRTQ RLSAETWDLL 430 440 450 460 470 480 RLPLEREQNG DSHHSGDWRG PSRDSLPLPV RSRKYQEGPD AERRPREGSH SPLDSADVRV 490 500 510 520 530 540 HVPRTSIPRA PSSDEECFFD LLTKFQSSRM DDQRCPLDDG QAGAAEATAA PTLEDRIAQP 550 560 570 580 590 600 SMTASPQTEE FFDLIASSQS RRLDDQRASV GSLPGLRITH SNAGHLRGHG EPQEPGDDFF 610 620 630 640 650 660 NMLIKYQSSR IDDQRCPPPD VLPRGPTMPD EDFFSLIQRV QAKRMDEQRV DLAGGPEQGA 670 GGPPEPQQQC QPGAS
	Isoform 2 (Short) [UniParc]. Checksum: B0009DE5201BD2BD	FASTA	166	18,024
	10 20 30 40 50 60 MDDQRCPLDD GQAGAAEATA APTLEDRIAQ PSMTASPQTE EFFDLIASSQ SRRLDDQRAS 70 80 90 100 110 120 VGSLPGLRIT HSNAGHLRGH GEPQEPGDDF FNMLIKYQSS RIDDQRCPPP DVLPRGPTMP 130 140 150 160 DEDFFSLIQR VQAKRMDEQR VDLAGGPEQG AGGPPEPQQQ CQPGAS
	Isoform 3 [UniParc]. Checksum: 4493B11B5D9986DC	FASTA	457	49,685
	10 20 30 40 50 60 MAGPAPPVAD ELPGPAARRL YSRMEASCLE LALEGERLCK AGDFKTGVAF FEAAVQVGTE 70 80 90 100 110 120 DLKTLSAIYS QLGNAYFYLK EHGRALEYHK HDLLLARTIG DRMGEAKASG NLGNTLKVLG 130 140 150 160 170 180 RFDEAAVCCQ RHLSIAQEQG DKVGEARALY NIGNVYHAKG KQLSWNAANA TQDPGHLPPD 190 200 210 220 230 240 VRETLCKASE FYERNLSLVK ELGDRAAQGR AYGNLGNTHY LLGNFTEATT FHKERLAIAK 250 260 270 280 290 300 EFGDKAAERR AYSNLGNAHV FLGRFDVAAE YYKKTLQLSR QLRDQAVEAQ ACYSLGNTYT 310 320 330 340 350 360 LLQDYERAAE YHLRHLLIAQ ELADRVGEGR ACWSLGNAYV SMGRPAQALT FAKKHLQISQ 370 380 390 400 410 420 EIGDRHGELT ARMNVAQLQL VLGRLTSPAA SEKPDLAGYE AQGEFQGCGG VLLPTGTDRI 430 440 450 RSCGGVGSRP GQHGGGGSRQ KMAPTSQFFL ASGTAQA
	Isoform 4 (FL) [UniParc]. Checksum: FF690E5EC1999611	FASTA	652	72,136
	10 20 30 40 50 60 MEASCLELAL EGERLCKAGD FKTGVAFFEA AVQVGTEDLK TLSAIYSQLG NAYFYLKEHG 70 80 90 100 110 120 RALEYHKHDL LLARTIGDRM GEAKASGNLG NTLKVLGRFD EAAVCCQRHL SIAQEQGDKV 130 140 150 160 170 180 GEARALYNIG NVYHAKGKQL SWNAANATQD PGHLPPDVRE TLCKASEFYE RNLSLVKELG 190 200 210 220 230 240 DRAAQGRAYG NLGNTHYLLG NFTEATTFHK ERLAIAKEFG DKAAERRAYS NLGNAHVFLG 250 260 270 280 290 300 RFDVAAEYYK KTLQLSRQLR DQAVEAQACY SLGNTYTLLQ DYERAAEYHL RHLLIAQELA 310 320 330 340 350 360 DRVGEGRACW SLGNAYVSMG RPAQALTFAK KHLQISQEIG DRHGELTARM NVAQLQLVLG 370 380 390 400 410 420 RLTSPAASEK PDLAGYEAQG ARPKRTQRLS AETWDLLRLP LEREQNGDSH HSGDWRGPSR 430 440 450 460 470 480 DSLPLPVRSR KYQEGPDAER RPREGSHSPL DSADVRVHVP RTSIPRAPSS DEECFFDLLT 490 500 510 520 530 540 KFQSSRMDDQ RCPLDDGQAG AAEATAAPTL EDRIAQPSMT ASPQTEEFFD LIASSQSRRL 550 560 570 580 590 600 DDQRASVGSL PGLRITHSNA GHLRGHGEPQ EPGDDFFNML IKYQSSRIDD QRCPPPDVLP 610 620 630 640 650 RGPTMPDEDF FSLIQRVQAK RMDEQRVDLA GGPEQGAGGP PEPQQQCQPG AS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Cismowski M.J., Kopatz S.A., Puhl H.L. III, Sharma S.V., Aronstam R.S. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Fetal brain and Rhabdomyosarcoma.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 315-675 (ISOFORM 1). Tissue: Mammary cancer.
[6]	"AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin." Natochin M., Lester B., Peterson Y.K., Bernard M.L., Lanier S.M., Artemyev N.O. J. Biol. Chem. 275:40981-40985(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells." Pattingre S., de Vries L., Bauvy C., Chantret I., Cluzeaud F., Ogier-Denis E., Vandewalle A., Codogno P. J. Biol. Chem. 278:20995-21002(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
[8]	"Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3." Izaki T., Kamakura S., Kohjima M., Sumimoto H. Biochem. Biophys. Res. Commun. 341:1001-1006(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH INSC.
[9]	"The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins." An N., Blumer J.B., Bernard M.L., Lanier S.M. J. Biol. Chem. 283:24718-24728(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FRMPD1, SUBCELLULAR LOCATION.
[10]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: T-cell.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-471; SER-492 AND SER-493, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY173053 mRNA. Translation: AAO17260.1. BX649589 Genomic DNA. Translation: CAI19338.1. BX649589 Genomic DNA. Translation: CAI19339.1. Sequence problems. BX649589 Genomic DNA. Translation: CAM27654.1. CH471090 Genomic DNA. Translation: EAW88216.1. BC009979 mRNA. Translation: AAH09979.1. Different initiation. BC017353 mRNA. Translation: AAH17353.1. Different initiation. BC048343 mRNA. Translation: AAH48343.1. AL117478 mRNA. Translation: CAB55951.1. Frameshift.
IPI	IPI00004948. IPI00939203. IPI00941917. IPI00956562.
PIR	T17261.
RefSeq	NP_001139110.1. NM_001145638.1. NP_001139111.1. NM_001145639.1. NP_001186932.1. NM_001200003.1. NP_056412.4. NM_015597.4.
UniGene	Hs.239370.
3D structure databases
ProteinModelPortal	Q86YR5.
SMR	Q86YR5. Positions 26-410.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86YR5. 5 interactions.
MINT	MINT-1453185.
STRING	9606.ENSP00000392828.
PTM databases
PhosphoSite	Q86YR5.
Polymorphism databases
DMDM	294862435.
Proteomic databases
PaxDb	Q86YR5.
PRIDE	Q86YR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000291775; ENSP00000291775; ENSG00000160360. ENST00000354753; ENSP00000346797; ENSG00000160360. ENST00000392944; ENSP00000376673; ENSG00000160360. ENST00000392945; ENSP00000376674; ENSG00000160360. ENST00000429455; ENSP00000390705; ENSG00000160360. ENST00000440944; ENSP00000392828; ENSG00000160360. ENST00000562213; ENSP00000457891; ENSG00000260789. ENST00000563222; ENSP00000456621; ENSG00000260789. ENST00000563430; ENSP00000454556; ENSG00000260789.
GeneID	26086.
KEGG	hsa:26086.
UCSC	uc004chc.3. human. uc004chd.2. human. uc004che.2. human.
Organism-specific databases
CTD	26086.
GeneCards	GC09P139221.
HGNC	HGNC:17858. GPSM1.
HPA	HPA042199.
MIM	609491. gene.
neXtProt	NX_Q86YR5.
PharmGKB	PA134986171.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0457.
HOGENOM	HOG000231543.
HOVERGEN	HBG051823.
InParanoid	Q86YR5.
KO	K15839.
OMA	QEPGDDF.
OrthoDB	EOG4SXNC5.
Gene expression databases
Bgee	Q86YR5.
CleanEx	HS_GPSM1.
Genevestigator	Q86YR5.
GermOnline	ENSG00000160360. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.10. 2 hits.
InterPro	IPR024804. G_prot_signal_mod_1. IPR003109. GoLoco_motif. IPR001440. TPR-1. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
PANTHER	PTHR10098:SF36. PTHR10098:SF36. 1 hit.
Pfam	PF02188. GoLoco. 4 hits. PF00515. TPR_1. 1 hit. PF13176. TPR_7. 1 hit. [Graphical view]
SMART	SM00390. GoLoco. 4 hits. SM00028. TPR. 6 hits. [Graphical view]
PROSITE	PS50877. GOLOCO. 4 hits. PS50005. TPR. 6 hits. PS50293. TPR_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GPSM1. human.
GenomeRNAi	26086.
NextBio	48007.
SOURCE	Search...

Entry information

Entry name

GPSM1_HUMAN

Accession

Primary (citable) accession number: Q86YR5
Secondary accession number(s): A9Z1X4 , B1B0W3, Q86SR5, Q969T1, Q9UFS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.