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Q86YR5

- GPSM1_HUMAN

UniProt

Q86YR5 - GPSM1_HUMAN

Protein

G-protein-signaling modulator 1

Gene

GPSM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.2 Publications

    GO - Molecular functioni

    1. GDP-dissociation inhibitor activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. nervous system development Source: UniProtKB-KW
    3. regulation of G-protein coupled receptor protein signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein-signaling modulator 1
    Alternative name(s):
    Activator of G-protein signaling 3
    Gene namesi
    Name:GPSM1
    Synonyms:AGS3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:17858. GPSM1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. Golgi membrane Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134986171.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 675675G-protein-signaling modulator 1PRO_0000252402Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei413 – 4131Phosphoserine1 Publication
    Modified residuei471 – 4711Phosphoserine1 Publication
    Modified residuei492 – 4921Phosphoserine1 Publication
    Modified residuei493 – 4931Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation regulates interaction with G(i/o) alpha.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86YR5.
    PaxDbiQ86YR5.
    PRIDEiQ86YR5.

    PTM databases

    PhosphoSiteiQ86YR5.

    Expressioni

    Tissue specificityi

    Expressed in intestinal cells.1 Publication

    Gene expression databases

    BgeeiQ86YR5.
    CleanExiHS_GPSM1.
    GenevestigatoriQ86YR5.

    Organism-specific databases

    HPAiHPA042199.

    Interactioni

    Subunit structurei

    Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 By similarity. Interacts with INSC/inscuteable and FRMPD1.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi117539. 14 interactions.
    IntActiQ86YR5. 5 interactions.
    MINTiMINT-1453185.
    STRINGi9606.ENSP00000392828.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86YR5.
    SMRiQ86YR5. Positions 26-567, 595-650.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati28 – 6134TPR 1Add
    BLAST
    Repeati66 – 9934TPR 2Add
    BLAST
    Repeati106 – 13934TPR 3Add
    BLAST
    Repeati146 – 18136TPR 4Add
    BLAST
    Repeati183 – 20220TPR 5Add
    BLAST
    Repeati209 – 24234TPR 6Add
    BLAST
    Repeati249 – 28234TPR 7Add
    BLAST
    Repeati289 – 32234TPR 8Add
    BLAST
    Repeati329 – 36234TPR 9Add
    BLAST
    Domaini495 – 51723GoLoco 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini548 – 57023GoLoco 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini596 – 61823GoLoco 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini630 – 65223GoLoco 4PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 509509Mediates association with membranesBy similarityAdd
    BLAST
    Regioni364 – 487124Interaction with STK11/LKB1By similarityAdd
    BLAST

    Domaini

    The GoLoco domains mediate interaction with G(i/o) alpha By similarity. The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.By similarity

    Sequence similaritiesi

    Belongs to the GPSM family.Curated
    Contains 4 GoLoco domains.PROSITE-ProRule annotation
    Contains 9 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    HOGENOMiHOG000231543.
    HOVERGENiHBG051823.
    InParanoidiQ86YR5.
    KOiK15839.
    OMAiEPNENGH.
    OrthoDBiEOG7WHH8W.
    PhylomeDBiQ86YR5.
    TreeFamiTF328344.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR024804. G_prot_signal_mod_1.
    IPR003109. GoLoco_motif.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR10098:SF36. PTHR10098:SF36. 1 hit.
    PfamiPF02188. GoLoco. 4 hits.
    PF00515. TPR_1. 1 hit.
    PF13176. TPR_7. 1 hit.
    [Graphical view]
    SMARTiSM00390. GoLoco. 4 hits.
    SM00028. TPR. 6 hits.
    [Graphical view]
    PROSITEiPS50877. GOLOCO. 4 hits.
    PS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86YR5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGPAPPVAD ELPGPAARRL YSRMEASCLE LALEGERLCK AGDFKTGVAF    50
    FEAAVQVGTE DLKTLSAIYS QLGNAYFYLK EHGRALEYHK HDLLLARTIG 100
    DRMGEAKASG NLGNTLKVLG RFDEAAVCCQ RHLSIAQEQG DKVGEARALY 150
    NIGNVYHAKG KQLSWNAANA TQDPGHLPPD VRETLCKASE FYERNLSLVK 200
    ELGDRAAQGR AYGNLGNTHY LLGNFTEATT FHKERLAIAK EFGDKAAERR 250
    AYSNLGNAHV FLGRFDVAAE YYKKTLQLSR QLRDQAVEAQ ACYSLGNTYT 300
    LLQDYERAAE YHLRHLLIAQ ELADRVGEGR ACWSLGNAYV SMGRPAQALT 350
    FAKKHLQISQ EIGDRHGELT ARMNVAQLQL VLGRLTSPAA SEKPDLAGYE 400
    AQGARPKRTQ RLSAETWDLL RLPLEREQNG DSHHSGDWRG PSRDSLPLPV 450
    RSRKYQEGPD AERRPREGSH SPLDSADVRV HVPRTSIPRA PSSDEECFFD 500
    LLTKFQSSRM DDQRCPLDDG QAGAAEATAA PTLEDRIAQP SMTASPQTEE 550
    FFDLIASSQS RRLDDQRASV GSLPGLRITH SNAGHLRGHG EPQEPGDDFF 600
    NMLIKYQSSR IDDQRCPPPD VLPRGPTMPD EDFFSLIQRV QAKRMDEQRV 650
    DLAGGPEQGA GGPPEPQQQC QPGAS 675
    Length:675
    Mass (Da):74,510
    Last modified:April 20, 2010 - v2
    Checksum:i27EB86667EEC1951
    GO
    Isoform 2 (identifier: Q86YR5-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         1-509: Missing.

    Note: Minor isoform.

    Show »
    Length:166
    Mass (Da):18,024
    Checksum:iB0009DE5201BD2BD
    GO
    Isoform 3 (identifier: Q86YR5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         404-457: ARPKRTQRLS...LPVRSRKYQE → EFQGCGGVLL...FFLASGTAQA
         458-675: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:457
    Mass (Da):49,685
    Checksum:i4493B11B5D9986DC
    GO
    Isoform 4 (identifier: Q86YR5-4) [UniParc]FASTAAdd to Basket

    Also known as: FL

    The sequence of this isoform differs from the canonical sequence as follows:
         1-23: Missing.

    Note: Major isoform.

    Show »
    Length:652
    Mass (Da):72,136
    Checksum:iFF690E5EC1999611
    GO

    Sequence cautioni

    The sequence CAB55951.1 differs from that shown. Reason: Frameshift at position 657.
    The sequence AAH09979.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH17353.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAI19339.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 509509Missing in isoform 2. 1 PublicationVSP_020937Add
    BLAST
    Alternative sequencei1 – 2323Missing in isoform 4. 1 PublicationVSP_039028Add
    BLAST
    Alternative sequencei404 – 45754ARPKR…RKYQE → EFQGCGGVLLPTGTDRIRSC GGVGSRPGQHGGGGSRQKMA PTSQFFLASGTAQA in isoform 3. 1 PublicationVSP_020938Add
    BLAST
    Alternative sequencei458 – 675218Missing in isoform 3. 1 PublicationVSP_020939Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY173053 mRNA. Translation: AAO17260.1.
    BX649589 Genomic DNA. Translation: CAI19338.1.
    BX649589 Genomic DNA. Translation: CAI19339.1. Sequence problems.
    BX649589 Genomic DNA. Translation: CAM27654.1.
    CH471090 Genomic DNA. Translation: EAW88216.1.
    BC009979 mRNA. Translation: AAH09979.1. Different initiation.
    BC017353 mRNA. Translation: AAH17353.1. Different initiation.
    BC048343 mRNA. Translation: AAH48343.1.
    AL117478 mRNA. Translation: CAB55951.1. Frameshift.
    CCDSiCCDS48055.1. [Q86YR5-1]
    CCDS48056.1. [Q86YR5-2]
    CCDS6996.2. [Q86YR5-3]
    PIRiT17261.
    RefSeqiNP_001139110.2. NM_001145638.2.
    NP_001139111.1. NM_001145639.1. [Q86YR5-2]
    NP_001186932.1. NM_001200003.1. [Q86YR5-2]
    NP_056412.5. NM_015597.5.
    UniGeneiHs.239370.

    Genome annotation databases

    EnsembliENST00000291775; ENSP00000291775; ENSG00000160360. [Q86YR5-2]
    ENST00000354753; ENSP00000346797; ENSG00000160360. [Q86YR5-4]
    ENST00000392944; ENSP00000376673; ENSG00000160360. [Q86YR5-2]
    ENST00000429455; ENSP00000390705; ENSG00000160360. [Q86YR5-2]
    ENST00000440944; ENSP00000392828; ENSG00000160360. [Q86YR5-1]
    GeneIDi26086.
    KEGGihsa:26086.
    UCSCiuc004chc.3. human. [Q86YR5-3]
    uc004chd.2. human. [Q86YR5-1]
    uc004che.2. human. [Q86YR5-2]

    Polymorphism databases

    DMDMi294862435.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY173053 mRNA. Translation: AAO17260.1 .
    BX649589 Genomic DNA. Translation: CAI19338.1 .
    BX649589 Genomic DNA. Translation: CAI19339.1 . Sequence problems.
    BX649589 Genomic DNA. Translation: CAM27654.1 .
    CH471090 Genomic DNA. Translation: EAW88216.1 .
    BC009979 mRNA. Translation: AAH09979.1 . Different initiation.
    BC017353 mRNA. Translation: AAH17353.1 . Different initiation.
    BC048343 mRNA. Translation: AAH48343.1 .
    AL117478 mRNA. Translation: CAB55951.1 . Frameshift.
    CCDSi CCDS48055.1. [Q86YR5-1 ]
    CCDS48056.1. [Q86YR5-2 ]
    CCDS6996.2. [Q86YR5-3 ]
    PIRi T17261.
    RefSeqi NP_001139110.2. NM_001145638.2.
    NP_001139111.1. NM_001145639.1. [Q86YR5-2 ]
    NP_001186932.1. NM_001200003.1. [Q86YR5-2 ]
    NP_056412.5. NM_015597.5.
    UniGenei Hs.239370.

    3D structure databases

    ProteinModelPortali Q86YR5.
    SMRi Q86YR5. Positions 26-567, 595-650.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117539. 14 interactions.
    IntActi Q86YR5. 5 interactions.
    MINTi MINT-1453185.
    STRINGi 9606.ENSP00000392828.

    PTM databases

    PhosphoSitei Q86YR5.

    Polymorphism databases

    DMDMi 294862435.

    Proteomic databases

    MaxQBi Q86YR5.
    PaxDbi Q86YR5.
    PRIDEi Q86YR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000291775 ; ENSP00000291775 ; ENSG00000160360 . [Q86YR5-2 ]
    ENST00000354753 ; ENSP00000346797 ; ENSG00000160360 . [Q86YR5-4 ]
    ENST00000392944 ; ENSP00000376673 ; ENSG00000160360 . [Q86YR5-2 ]
    ENST00000429455 ; ENSP00000390705 ; ENSG00000160360 . [Q86YR5-2 ]
    ENST00000440944 ; ENSP00000392828 ; ENSG00000160360 . [Q86YR5-1 ]
    GeneIDi 26086.
    KEGGi hsa:26086.
    UCSCi uc004chc.3. human. [Q86YR5-3 ]
    uc004chd.2. human. [Q86YR5-1 ]
    uc004che.2. human. [Q86YR5-2 ]

    Organism-specific databases

    CTDi 26086.
    GeneCardsi GC09P139221.
    HGNCi HGNC:17858. GPSM1.
    HPAi HPA042199.
    MIMi 609491. gene.
    neXtProti NX_Q86YR5.
    PharmGKBi PA134986171.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0457.
    HOGENOMi HOG000231543.
    HOVERGENi HBG051823.
    InParanoidi Q86YR5.
    KOi K15839.
    OMAi EPNENGH.
    OrthoDBi EOG7WHH8W.
    PhylomeDBi Q86YR5.
    TreeFami TF328344.

    Miscellaneous databases

    ChiTaRSi GPSM1. human.
    GeneWikii GPSM1.
    GenomeRNAii 26086.
    NextBioi 48007.
    PROi Q86YR5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86YR5.
    CleanExi HS_GPSM1.
    Genevestigatori Q86YR5.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR024804. G_prot_signal_mod_1.
    IPR003109. GoLoco_motif.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR10098:SF36. PTHR10098:SF36. 1 hit.
    Pfami PF02188. GoLoco. 4 hits.
    PF00515. TPR_1. 1 hit.
    PF13176. TPR_7. 1 hit.
    [Graphical view ]
    SMARTi SM00390. GoLoco. 4 hits.
    SM00028. TPR. 6 hits.
    [Graphical view ]
    PROSITEi PS50877. GOLOCO. 4 hits.
    PS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Cismowski M.J., Kopatz S.A., Puhl H.L. III, Sharma S.V., Aronstam R.S.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Fetal brain and Rhabdomyosarcoma.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 315-675 (ISOFORM 1).
      Tissue: Mammary cancer.
    6. "AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin."
      Natochin M., Lester B., Peterson Y.K., Bernard M.L., Lanier S.M., Artemyev N.O.
      J. Biol. Chem. 275:40981-40985(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells."
      Pattingre S., de Vries L., Bauvy C., Chantret I., Cluzeaud F., Ogier-Denis E., Vandewalle A., Codogno P.
      J. Biol. Chem. 278:20995-21002(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
    8. "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3."
      Izaki T., Kamakura S., Kohjima M., Sumimoto H.
      Biochem. Biophys. Res. Commun. 341:1001-1006(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH INSC.
    9. "The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins."
      An N., Blumer J.B., Bernard M.L., Lanier S.M.
      J. Biol. Chem. 283:24718-24728(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FRMPD1, SUBCELLULAR LOCATION.
    10. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-471; SER-492 AND SER-493, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGPSM1_HUMAN
    AccessioniPrimary (citable) accession number: Q86YR5
    Secondary accession number(s): A9Z1X4
    , B1B0W3, Q86SR5, Q969T1, Q9UFS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

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