Q86YQ2 (LATH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative latherin

Alternative name(s):
Breast cancer and salivary gland-expressed protein

Gene names

Name:	LATH
Synonyms:	BASE

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Uncertain

General annotation (Comments)

Function	Major protein in sweat, has surfactant properties By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed in breast cancer and salivary gland. Ref.1
Sequence similarities	Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 179	159	Putative latherin		PRO_0000017191

Sequences

	Sequence		Length	Mass (Da)
	Q86YQ2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: D4F2B97941CF9DF2	FASTA	179	19,456
	10 20 30 40 50 60 MLNVSGLFVL LCGLLVSSSA QEVLAGVSSQ LLNDLTQGLL RADFLPSLQT TGLQKPLSSA 70 80 90 100 110 120 FDGVSGLLDI FGPPLTNEIN TVSIQVKNPQ LLHVSIESTP QRKEATVQVP FTSELIVQLL 130 140 150 160 170 TMKPFTANMQ SDIKVQIRLE KNVGGRYELA FGNCRLLPEA IWIQTGVQLA PAQNLLWQT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins." Egland K.A., Vincent J.J., Strausberg R.L., Lee B., Pastan I. Proc. Natl. Acad. Sci. U.S.A. 100:1099-1104(2003) [PubMed: 12538848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY180924 mRNA. Translation: AAO17728.1. AC018694 Genomic DNA. No translation available. BC069128 mRNA. No translation available. BC069315 mRNA. No translation available.
IPI	IPI00329422.
UniGene	Hs.434194.
3D structure databases
ModBase	Search...
Polymorphism databases
DMDM	38257945.
Proteomic databases
PRIDE	Q86YQ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
H-InvDB	HIX0203076.
MIM	607627. gene.
neXtProt	NX_Q86YQ2.
Phylogenomic databases
eggNOG	prNOG21765.
HOVERGEN	HBG079669.
InParanoid	Q86YQ2.
PhylomeDB	Q86YQ2.
Gene expression databases
Genevestigator	Q86YQ2.
GermOnline	ENSG00000183566. Homo sapiens.
Family and domain databases
InterPro	IPR017942. Lipid-bd_serum_glycop_N. [Graphical view]
Pfam	PF01273. LBP_BPI_CETP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

LATH_HUMAN

Accession

Primary (citable) accession number: Q86YQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.