Reviewed, UniProtKB/Swiss-Prot Q86YN6 (PRGC2_HUMAN)

Names and origin

Protein names

Recommended name:
    Peroxisome proliferator-activated receptor gamma coactivator 1-beta
      Short name=PPAR-gamma coactivator 1-beta
      Short name=PPARGC-1-beta
      Short name=PGC-1-beta
Alternative name(s):
    PGC-1-related estrogen receptor alpha coactivator

Gene names

Name:	PPARGC1B
Synonyms:	PERC, PGC1, PGC1B, PPARGC1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1023 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Ref.1 Ref.2 Ref.7
Subunit structure	Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 By similarity. Interacts with estrogen receptor alpha/ESR1. Ref.1
Subcellular location	Nucleus Ref.1.
Tissue specificity	Ubiquitous with higher expression in heart, brain and skeletal muscle. Ref.1 Ref.2
Induction	Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as well as in pre-diabetics. Ref.7 Ref.6 Ref.9
Domain	Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors By similarity.
Polymorphism	Variation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203 allele being a risk factor for the development of this common disorders.
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	RNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	estrogen receptor signaling pathway Ref.1 Inferred from direct assay. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Ref.1 Inferred from direct assay. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mediator complex Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	AF-2 domain binding Ref.1 Inferred from physical interaction. Source: UniProtKB RNA binding Ref.1 Non-traceable author statement. Source: UniProtKB RNA polymerase II transcription mediator activity Ref.1 Inferred from direct assay. Source: UniProtKB estrogen receptor binding Ref.1 Inferred from direct assay. Source: UniProtKB ligand-dependent nuclear receptor transcription coactivator activity Ref.1 Inferred from direct assay. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro receptor activator activity Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86YN6-1)

Also known as: PGC1beta-1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86YN6-2)

Also known as: PGC1beta-2a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MAGNDCGALLDEELSSFFLNYLADTQ → MGVYK

Isoform 3 (identifier: Q86YN6-3)

Also known as: PGC1beta-1b;

The sequence of this isoform differs from the canonical sequence as follows:
     991-1023: DSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH → GKPLKPSHSLVRLKAWEAVPSLNKTQS

Isoform 4 (identifier: Q86YN6-4)

Also known as: PGC1beta-2b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MAGNDCGALLDEELSSFFLNYLADTQ → MGVYK
     991-1023: DSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH → GKPLKPSHSLVRLKAWEAVPSLNKTQS

Isoform 5 (identifier: Q86YN6-5)

Also known as: PERC-s;

The sequence of this isoform differs from the canonical sequence as follows:
     156-194: Missing.

Note: Lacks LXXLL motif 1 and has a reduced ability to enhance the hormone-dependent activity of estrogen receptor alpha.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1023	1023	Peroxisome proliferator-activated receptor gamma coactivator 1-beta		PRO_0000240158
Regions
	Domain	902 – 976	75	RRM
	Region	1 – 91	91	Abolishes DNA transcriptional activity when missing
	Motif	156 – 160	5	LXXLL motif 1
	Motif	343 – 347	5	LXXLL motif 2
	Motif	691 – 694	4	HCFC1-binding-motif (HBM)
	Compositional bias	430 – 450	21	Glu-rich
	Compositional bias	772 – 823	52	Glu-rich
Amino acid modifications
	Modified residue	524	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	1 – 26	26	MAGND…LADTQ → MGVYK in isoform 2 and isoform 4.		VSP_019299
	Alternative sequence	156 – 194	39	Missing in isoform 5.		VSP_019300
	Alternative sequence	991 – 1023	33	DSNSE…QQSLH → GKPLKPSHSLVRLKAWEAVP SLNKTQS in isoform 3 and isoform 4.		VSP_019301
	Natural variant	203	1	A → P: dbSNP rs7732671. Ref.8		VAR_026698
	Natural variant	265	1	R → Q: dbSNP rs45520937. Ref.2		VAR_026699
	Natural variant	279	1	V → I: dbSNP rs17572019. Ref.8		VAR_026700
	Natural variant	292	1	R → S: dbSNP rs11959820. Ref.8 Ref.5		VAR_026701
Experimental info
	Mutagenesis	92 – 96	5	LLAEL → AAAEA: Reduces DNA transcriptional activity.
	Mutagenesis	155 – 160	6	LLQKLL → AAQKAA: Reduces interaction and activation of ESR1. Loss of interaction and activation of ESR1; when associated with 343-AREAA-347. Ref.1
	Mutagenesis	343 – 347	5	LRELL → AREAA: Reduces interaction and activation of ESR1. Loss of interaction and activation of ESR1; when associated with 155-AAQKAA-160. Ref.1
	Sequence conflict	558	1	E → G in BAC04541. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PGC1beta-1a) [UniParc]. Last modified October 17, 2006. Version 2. Checksum: DC37FCDE4D3CD239	FASTA	1,023	113,222
	10 20 30 40 50 60 MAGNDCGALL DEELSSFFLN YLADTQGGGS GEEQLYADFP ELDLSQLDAS DFDSATCFGE 70 80 90 100 110 120 LQWCPENSET EPNQYSPDDS ELFQIDSENE ALLAELTKTL DDIPEDDVGL AAFPALDGGD 130 140 150 160 170 180 ALSCTSASPA PSSAPPSPAP EKPSAPAPEV DELSLLQKLL LATSYPTSSS DTQKEGTAWR 190 200 210 220 230 240 QAGLRSKSQR PCVKADSTQD KKAPMMQSQS RSCTELHKHL TSAQCCLQDR GLQPPCLQSP 250 260 270 280 290 300 RLPAKEDKEP GEDCPSPQPA PASPRDSLAL GRADPGAPVS QEDMQAMVQL IRYMHTYCLP 310 320 330 340 350 360 QRKLPPQTPE PLPKACSNPS QQVRSRPWSR HHSKASWAEF SILRELLAQD VLCDVSKPYR 370 380 390 400 410 420 LATPVYASLT PRSRPRPPKD SQASPGRPSS VEEVRIAASP KSTGPRPSLR PLRLEVKREV 430 440 450 460 470 480 RRPARLQQQE EEDEEEEEEE EEEEKEEEEE WGRKRPGRGL PWTKLGRKLE SSVCPVRRSR 490 500 510 520 530 540 RLNPELGPWL TFADEPLVPS EPQGALPSLC LAPKAYDVER ELGSPTDEDS GQDQQLLRGP 550 560 570 580 590 600 QIPALESPCE SGCGDMDEDP SCPQLPPRDS PRCLMLALSQ SDPTFGKKSF EQTLTVELCG 610 620 630 640 650 660 TAGLTPPTTP PYKPTEEDPF KPDIKHSLGK EIALSLPSPE GLSLKATPGA AHKLPKKHPE 670 680 690 700 710 720 RSELLSHLRH ATAQPASQAG QKRPFSCSFG DHDYCQVLRP EGVLQRKVLR SWEPSGVHLE 730 740 750 760 770 780 DWPQQGAPWA EAQAPGREED RSCDAGAPPK DSTLLRDHEI RASLTKHFGL LETALEEEDL 790 800 810 820 830 840 ASCKSPEYDT VFEDSSSSSG ESSFLPEEEE EEGEEEEEDD EEEDSGVSPT CSDHCPYQSP 850 860 870 880 890 900 PSKANRQLCS RSRSSSGSSP CHSWSPATRR NFRCESRGPC SDRTPSIRHA RKRREKAIGE 910 920 930 940 950 960 GRVVYIQNLS SDMSSRELKR RFEVFGEIEE CEVLTRNRRG EKYGFITYRC SEHAALSLTK 970 980 990 1000 1010 1020 GAALRKRNEP SFQLSYGGLR HFCWPRYTDY DSNSEEALPA SGKSKYEAMD FDSLLKEAQQ SLH
	Isoform 2 (PGC1beta-2a). Checksum: 8ACBD368E172B27E	FASTA	1,002	110,981
	10 20 30 40 50 60 MGVYKGGGSG EEQLYADFPE LDLSQLDASD FDSATCFGEL QWCPENSETE PNQYSPDDSE 70 80 90 100 110 120 LFQIDSENEA LLAELTKTLD DIPEDDVGLA AFPALDGGDA LSCTSASPAP SSAPPSPAPE 130 140 150 160 170 180 KPSAPAPEVD ELSLLQKLLL ATSYPTSSSD TQKEGTAWRQ AGLRSKSQRP CVKADSTQDK 190 200 210 220 230 240 KAPMMQSQSR SCTELHKHLT SAQCCLQDRG LQPPCLQSPR LPAKEDKEPG EDCPSPQPAP 250 260 270 280 290 300 ASPRDSLALG RADPGAPVSQ EDMQAMVQLI RYMHTYCLPQ RKLPPQTPEP LPKACSNPSQ 310 320 330 340 350 360 QVRSRPWSRH HSKASWAEFS ILRELLAQDV LCDVSKPYRL ATPVYASLTP RSRPRPPKDS 370 380 390 400 410 420 QASPGRPSSV EEVRIAASPK STGPRPSLRP LRLEVKREVR RPARLQQQEE EDEEEEEEEE 430 440 450 460 470 480 EEEKEEEEEW GRKRPGRGLP WTKLGRKLES SVCPVRRSRR LNPELGPWLT FADEPLVPSE 490 500 510 520 530 540 PQGALPSLCL APKAYDVERE LGSPTDEDSG QDQQLLRGPQ IPALESPCES GCGDMDEDPS 550 560 570 580 590 600 CPQLPPRDSP RCLMLALSQS DPTFGKKSFE QTLTVELCGT AGLTPPTTPP YKPTEEDPFK 610 620 630 640 650 660 PDIKHSLGKE IALSLPSPEG LSLKATPGAA HKLPKKHPER SELLSHLRHA TAQPASQAGQ 670 680 690 700 710 720 KRPFSCSFGD HDYCQVLRPE GVLQRKVLRS WEPSGVHLED WPQQGAPWAE AQAPGREEDR 730 740 750 760 770 780 SCDAGAPPKD STLLRDHEIR ASLTKHFGLL ETALEEEDLA SCKSPEYDTV FEDSSSSSGE 790 800 810 820 830 840 SSFLPEEEEE EGEEEEEDDE EEDSGVSPTC SDHCPYQSPP SKANRQLCSR SRSSSGSSPC 850 860 870 880 890 900 HSWSPATRRN FRCESRGPCS DRTPSIRHAR KRREKAIGEG RVVYIQNLSS DMSSRELKRR 910 920 930 940 950 960 FEVFGEIEEC EVLTRNRRGE KYGFITYRCS EHAALSLTKG AALRKRNEPS FQLSYGGLRH 970 980 990 1000 FCWPRYTDYD SNSEEALPAS GKSKYEAMDF DSLLKEAQQS LH
	Isoform 3 (PGC1beta-1b). Checksum: F2229A0A356A2148	FASTA	1,017	112,568
	10 20 30 40 50 60 MAGNDCGALL DEELSSFFLN YLADTQGGGS GEEQLYADFP ELDLSQLDAS DFDSATCFGE 70 80 90 100 110 120 LQWCPENSET EPNQYSPDDS ELFQIDSENE ALLAELTKTL DDIPEDDVGL AAFPALDGGD 130 140 150 160 170 180 ALSCTSASPA PSSAPPSPAP EKPSAPAPEV DELSLLQKLL LATSYPTSSS DTQKEGTAWR 190 200 210 220 230 240 QAGLRSKSQR PCVKADSTQD KKAPMMQSQS RSCTELHKHL TSAQCCLQDR GLQPPCLQSP 250 260 270 280 290 300 RLPAKEDKEP GEDCPSPQPA PASPRDSLAL GRADPGAPVS QEDMQAMVQL IRYMHTYCLP 310 320 330 340 350 360 QRKLPPQTPE PLPKACSNPS QQVRSRPWSR HHSKASWAEF SILRELLAQD VLCDVSKPYR 370 380 390 400 410 420 LATPVYASLT PRSRPRPPKD SQASPGRPSS VEEVRIAASP KSTGPRPSLR PLRLEVKREV 430 440 450 460 470 480 RRPARLQQQE EEDEEEEEEE EEEEKEEEEE WGRKRPGRGL PWTKLGRKLE SSVCPVRRSR 490 500 510 520 530 540 RLNPELGPWL TFADEPLVPS EPQGALPSLC LAPKAYDVER ELGSPTDEDS GQDQQLLRGP 550 560 570 580 590 600 QIPALESPCE SGCGDMDEDP SCPQLPPRDS PRCLMLALSQ SDPTFGKKSF EQTLTVELCG 610 620 630 640 650 660 TAGLTPPTTP PYKPTEEDPF KPDIKHSLGK EIALSLPSPE GLSLKATPGA AHKLPKKHPE 670 680 690 700 710 720 RSELLSHLRH ATAQPASQAG QKRPFSCSFG DHDYCQVLRP EGVLQRKVLR SWEPSGVHLE 730 740 750 760 770 780 DWPQQGAPWA EAQAPGREED RSCDAGAPPK DSTLLRDHEI RASLTKHFGL LETALEEEDL 790 800 810 820 830 840 ASCKSPEYDT VFEDSSSSSG ESSFLPEEEE EEGEEEEEDD EEEDSGVSPT CSDHCPYQSP 850 860 870 880 890 900 PSKANRQLCS RSRSSSGSSP CHSWSPATRR NFRCESRGPC SDRTPSIRHA RKRREKAIGE 910 920 930 940 950 960 GRVVYIQNLS SDMSSRELKR RFEVFGEIEE CEVLTRNRRG EKYGFITYRC SEHAALSLTK 970 980 990 1000 1010 GAALRKRNEP SFQLSYGGLR HFCWPRYTDY GKPLKPSHSL VRLKAWEAVP SLNKTQS
	Isoform 4 (PGC1beta-2b). Checksum: 5265F3916B919ECC	FASTA	996	110,327
	10 20 30 40 50 60 MGVYKGGGSG EEQLYADFPE LDLSQLDASD FDSATCFGEL QWCPENSETE PNQYSPDDSE 70 80 90 100 110 120 LFQIDSENEA LLAELTKTLD DIPEDDVGLA AFPALDGGDA LSCTSASPAP SSAPPSPAPE 130 140 150 160 170 180 KPSAPAPEVD ELSLLQKLLL ATSYPTSSSD TQKEGTAWRQ AGLRSKSQRP CVKADSTQDK 190 200 210 220 230 240 KAPMMQSQSR SCTELHKHLT SAQCCLQDRG LQPPCLQSPR LPAKEDKEPG EDCPSPQPAP 250 260 270 280 290 300 ASPRDSLALG RADPGAPVSQ EDMQAMVQLI RYMHTYCLPQ RKLPPQTPEP LPKACSNPSQ 310 320 330 340 350 360 QVRSRPWSRH HSKASWAEFS ILRELLAQDV LCDVSKPYRL ATPVYASLTP RSRPRPPKDS 370 380 390 400 410 420 QASPGRPSSV EEVRIAASPK STGPRPSLRP LRLEVKREVR RPARLQQQEE EDEEEEEEEE 430 440 450 460 470 480 EEEKEEEEEW GRKRPGRGLP WTKLGRKLES SVCPVRRSRR LNPELGPWLT FADEPLVPSE 490 500 510 520 530 540 PQGALPSLCL APKAYDVERE LGSPTDEDSG QDQQLLRGPQ IPALESPCES GCGDMDEDPS 550 560 570 580 590 600 CPQLPPRDSP RCLMLALSQS DPTFGKKSFE QTLTVELCGT AGLTPPTTPP YKPTEEDPFK 610 620 630 640 650 660 PDIKHSLGKE IALSLPSPEG LSLKATPGAA HKLPKKHPER SELLSHLRHA TAQPASQAGQ 670 680 690 700 710 720 KRPFSCSFGD HDYCQVLRPE GVLQRKVLRS WEPSGVHLED WPQQGAPWAE AQAPGREEDR 730 740 750 760 770 780 SCDAGAPPKD STLLRDHEIR ASLTKHFGLL ETALEEEDLA SCKSPEYDTV FEDSSSSSGE 790 800 810 820 830 840 SSFLPEEEEE EGEEEEEDDE EEDSGVSPTC SDHCPYQSPP SKANRQLCSR SRSSSGSSPC 850 860 870 880 890 900 HSWSPATRRN FRCESRGPCS DRTPSIRHAR KRREKAIGEG RVVYIQNLSS DMSSRELKRR 910 920 930 940 950 960 FEVFGEIEEC EVLTRNRRGE KYGFITYRCS EHAALSLTKG AALRKRNEPS FQLSYGGLRH 970 980 990 FCWPRYTDYG KPLKPSHSLV RLKAWEAVPS LNKTQS
	Isoform 5 (PERC-s). Checksum: 5D91928FD6D6D104	FASTA	984	108,919
	10 20 30 40 50 60 MAGNDCGALL DEELSSFFLN YLADTQGGGS GEEQLYADFP ELDLSQLDAS DFDSATCFGE 70 80 90 100 110 120 LQWCPENSET EPNQYSPDDS ELFQIDSENE ALLAELTKTL DDIPEDDVGL AAFPALDGGD 130 140 150 160 170 180 ALSCTSASPA PSSAPPSPAP EKPSAPAPEV DELSLADSTQ DKKAPMMQSQ SRSCTELHKH 190 200 210 220 230 240 LTSAQCCLQD RGLQPPCLQS PRLPAKEDKE PGEDCPSPQP APASPRDSLA LGRADPGAPV 250 260 270 280 290 300 SQEDMQAMVQ LIRYMHTYCL PQRKLPPQTP EPLPKACSNP SQQVRSRPWS RHHSKASWAE 310 320 330 340 350 360 FSILRELLAQ DVLCDVSKPY RLATPVYASL TPRSRPRPPK DSQASPGRPS SVEEVRIAAS 370 380 390 400 410 420 PKSTGPRPSL RPLRLEVKRE VRRPARLQQQ EEEDEEEEEE EEEEEKEEEE EWGRKRPGRG 430 440 450 460 470 480 LPWTKLGRKL ESSVCPVRRS RRLNPELGPW LTFADEPLVP SEPQGALPSL CLAPKAYDVE 490 500 510 520 530 540 RELGSPTDED SGQDQQLLRG PQIPALESPC ESGCGDMDED PSCPQLPPRD SPRCLMLALS 550 560 570 580 590 600 QSDPTFGKKS FEQTLTVELC GTAGLTPPTT PPYKPTEEDP FKPDIKHSLG KEIALSLPSP 610 620 630 640 650 660 EGLSLKATPG AAHKLPKKHP ERSELLSHLR HATAQPASQA GQKRPFSCSF GDHDYCQVLR 670 680 690 700 710 720 PEGVLQRKVL RSWEPSGVHL EDWPQQGAPW AEAQAPGREE DRSCDAGAPP KDSTLLRDHE 730 740 750 760 770 780 IRASLTKHFG LLETALEEED LASCKSPEYD TVFEDSSSSS GESSFLPEEE EEEGEEEEED 790 800 810 820 830 840 DEEEDSGVSP TCSDHCPYQS PPSKANRQLC SRSRSSSGSS PCHSWSPATR RNFRCESRGP 850 860 870 880 890 900 CSDRTPSIRH ARKRREKAIG EGRVVYIQNL SSDMSSRELK RRFEVFGEIE ECEVLTRNRR 910 920 930 940 950 960 GEKYGFITYR CSEHAALSLT KGAALRKRNE PSFQLSYGGL RHFCWPRYTD YDSNSEEALP 970 980 ASGKSKYEAM DFDSLLKEAQ QSLH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha." Kressler D., Schreiber S.N., Knutti D., Kralli A. J. Biol. Chem. 277:13918-13925(2002) [PubMed: 11854298] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5), SUBCELLULAR LOCATION, MOTIF, TISSUE SPECIFICITY, MUTAGENESIS OF 92-LEU--LEU-96; 155-LEU--LEU-160 AND 343-LEU--LEU-347, INTERACTION WITH ESR1, FUNCTION.
[2]	"Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo." Meirhaeghe A., Crowley V., Lenaghan C., Lelliott C., Green K., Stewart A., Hart K., Schinner S., Sethi J.K., Yeo G., Brand M.D., Cortright R.N., O'Rahilly S., Montague C., Vidal-Puig A.J. Biochem. J. 373:155-165(2003) [PubMed: 12678921] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, FUNCTION, VARIANT GLN-265.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Tongue.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-292.
[6]	"Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1." Patti M.E., Butte A.J., Crunkhorn S., Cusi K., Berria R., Kashyap S., Miyazaki Y., Kohane I., Costello M., Saccone R., Landaker E.J., Goldfine A.B., Mun E., DeFronzo R., Finlayson J., Kahn C.R., Mandarino L.J. Proc. Natl. Acad. Sci. U.S.A. 100:8466-8471(2003) [PubMed: 12832613] [Abstract] Cited for: INDUCTION.
[7]	"Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins." Ling C., Poulsen P., Carlsson E., Ridderstrale M., Almgren P., Wojtaszewski J., Beck-Nielsen H., Groop L., Vaag A. J. Clin. Invest. 114:1518-1526(2004) [PubMed: 15546003] [Abstract] Cited for: FUNCTION, INDUCTION BY INSULIN AND AGING.
[8]	"Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity." Andersen G., Wegner L., Yanagisawa K., Rose C.S., Lin J., Gluemer C., Drivsholm T., Borch-Johnsen K., Jorgensen T., Hansen T., Spiegelman B.M., Pedersen O. J. Med. Genet. 42:402-407(2005) [PubMed: 15863669] [Abstract] Cited for: POLYMORPHISM, VARIANTS PRO-203; ILE-279 AND SER-292.
[9]	"Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro." Staiger H., Staiger K., Haas C., Weisser M., Machicao F., Haering H.-U. Diabetologia 48:2115-2118(2005) [PubMed: 16132959] [Abstract] Cited for: REGULATION BY FATTY ACIDS.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-524, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF468496 mRNA. Translation: AAL78633.1. AF468497 mRNA. Translation: AAL78634.1. AY188947 mRNA. Translation: AAO40022.1. AY188948 mRNA. Translation: AAO40023.1. AY188949 mRNA. Translation: AAO40024.1. AY188950 mRNA. Translation: AAO40025.1. AK095391 mRNA. Translation: BAC04541.1. CH471062 Genomic DNA. Translation: EAW61759.1. BC132971 mRNA. Translation: AAI32972.1. BC132973 mRNA. Translation: AAI32974.1.
IPI	IPI00152517. IPI00163514. IPI00759533. IPI00759561. IPI00759685.
RefSeq	NP_573570.2.
UniGene	Hs.591261
3D structure databases
SMR	Q86YN6. Positions 899-957.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86YN6.
PTM databases
PhosphoSite	Q86YN6.
Proteomic databases
PRIDE	Q86YN6.
Genome annotation databases
Ensembl	ENST00000309241; ENSP00000312649; ENSG00000155846; Homo sapiens. [Genome view]
GeneID	133522.
KEGG	hsa:133522.
UCSC	uc003lrb.1. human. uc003lrd.1. human. uc003lre.1. human. uc003lrf.1. human.
Organism-specific databases
CTD	133522.
GeneCards	GC05P149090.
H-InvDB	HIX0005305.
HGNC	HGNC:30022. PPARGC1B.
MIM	608886. gene.
PharmGKB	PA134953410.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q86YN6.
InParanoid	Q86YN6.
OMA	DHDYCQV.
OrthoDB	EOG9ZPHF4.
PhylomeDB	Q86YN6.
Gene expression databases
ArrayExpress	Q86YN6.
Bgee	Q86YN6.
CleanEx	HS_PPARGC1B.
Genevestigator	Q86YN6.
Family and domain databases
InterPro	IPR012677. a_b_plait_nuc_bd. IPR000504. RRM_RNP1. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit.
Pfam	PF00076. RRM_1. 1 hit. [Graphical view]
SMART	SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	83227.
SOURCE	Search...

Entry information

Entry name

PRGC2_HUMAN

Accession

Primary (citable) accession number: Q86YN6
Secondary accession number(s): A2RUM8 , A2RUN0, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	October 17, 2006
Last modified:	January 19, 2010
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.