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Protein

Dolichyldiphosphatase 1

Gene

DOLPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).By similarity

Catalytic activityi

Dolichyl diphosphate + H2O = dolichyl phosphate + phosphate.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-HSA-446199. Synthesis of Dolichyl-phosphate.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyldiphosphatase 1 (EC:3.6.1.43)
Alternative name(s):
Dolichyl pyrophosphate phosphatase 1
Gene namesi
Name:DOLPP1
Synonyms:LSFR2
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:29565. DOLPP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937229.

Polymorphism and mutation databases

BioMutaiDOLPP1.
DMDMi45476905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Dolichyldiphosphatase 1PRO_0000215626Add
BLAST

Proteomic databases

EPDiQ86YN1.
MaxQBiQ86YN1.
PaxDbiQ86YN1.
PeptideAtlasiQ86YN1.
PRIDEiQ86YN1.

PTM databases

SwissPalmiQ86YN1.

Expressioni

Gene expression databases

BgeeiQ86YN1.
CleanExiHS_DOLPP1.
ExpressionAtlasiQ86YN1. baseline and differential.
GenevisibleiQ86YN1. HS.

Organism-specific databases

HPAiHPA019179.

Interactioni

Protein-protein interaction databases

BioGridi121423. 10 interactions.
IntActiQ86YN1. 2 interactions.
STRINGi9606.ENSP00000361625.

Structurei

3D structure databases

ProteinModelPortaliQ86YN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dolichyldiphosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3146. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00390000013112.
HOGENOMiHOG000201506.
HOVERGENiHBG051392.
InParanoidiQ86YN1.
KOiK07252.
OMAiLWFEYTN.
OrthoDBiEOG7Z3F5H.
PhylomeDBiQ86YN1.
TreeFamiTF323451.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86YN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADGQCSLP ASWRPVTLTH VEYPAGDLSG HLLAYLSLSP VFVIVGFVTL
60 70 80 90 100
IIFKRELHTI SFLGGLALNE GVNWLIKNVI QEPRPCGGPH TAVGTKYGMP
110 120 130 140 150
SSHSQFMWFF SVYSFLFLYL RMHQTNNARF LDLLWRHVLS LGLLAVAFLV
160 170 180 190 200
SYSRVYLLYH TWSQVLYGGI AGGLMAIAWF IFTQEVLTPL FPRIAAWPVS
210 220 230
EFFLIRDTSL IPNVLWFEYT VTRAEARNRQ RKLGTKLQ
Length:238
Mass (Da):27,031
Last modified:June 1, 2003 - v1
Checksum:i3A9DD3383C61BE94
GO
Isoform 2 (identifier: Q86YN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-197: Missing.

Show »
Length:195
Mass (Da):22,134
Checksum:i3AF3D9D8494397B0
GO

Sequence cautioni

The sequence CAB44348.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei155 – 19743Missing in isoform 2. 1 PublicationVSP_042210Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY189675 mRNA. Translation: AAO34712.1.
AK290713 mRNA. Translation: BAF83402.1.
AK293627 mRNA. Translation: BAG57084.1.
AL592211 Genomic DNA. Translation: CAI12369.1.
AL592211 Genomic DNA. Translation: CAQ10247.1.
CH471090 Genomic DNA. Translation: EAW87868.1.
CH471090 Genomic DNA. Translation: EAW87872.1.
BC009493 mRNA. Translation: AAH09493.2.
BC033686 mRNA. Translation: AAH33686.1.
Y17455 Genomic DNA. Translation: CAB44348.1. Sequence problems.
CCDSiCCDS48039.1. [Q86YN1-2]
CCDS6918.1. [Q86YN1-1]
RefSeqiNP_001129389.1. NM_001135917.1. [Q86YN1-2]
NP_065171.2. NM_020438.4. [Q86YN1-1]
UniGeneiHs.21701.

Genome annotation databases

EnsembliENST00000372546; ENSP00000361625; ENSG00000167130. [Q86YN1-1]
ENST00000406974; ENSP00000384043; ENSG00000167130. [Q86YN1-2]
GeneIDi57171.
KEGGihsa:57171.
UCSCiuc004bxc.4. human. [Q86YN1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY189675 mRNA. Translation: AAO34712.1.
AK290713 mRNA. Translation: BAF83402.1.
AK293627 mRNA. Translation: BAG57084.1.
AL592211 Genomic DNA. Translation: CAI12369.1.
AL592211 Genomic DNA. Translation: CAQ10247.1.
CH471090 Genomic DNA. Translation: EAW87868.1.
CH471090 Genomic DNA. Translation: EAW87872.1.
BC009493 mRNA. Translation: AAH09493.2.
BC033686 mRNA. Translation: AAH33686.1.
Y17455 Genomic DNA. Translation: CAB44348.1. Sequence problems.
CCDSiCCDS48039.1. [Q86YN1-2]
CCDS6918.1. [Q86YN1-1]
RefSeqiNP_001129389.1. NM_001135917.1. [Q86YN1-2]
NP_065171.2. NM_020438.4. [Q86YN1-1]
UniGeneiHs.21701.

3D structure databases

ProteinModelPortaliQ86YN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121423. 10 interactions.
IntActiQ86YN1. 2 interactions.
STRINGi9606.ENSP00000361625.

PTM databases

SwissPalmiQ86YN1.

Polymorphism and mutation databases

BioMutaiDOLPP1.
DMDMi45476905.

Proteomic databases

EPDiQ86YN1.
MaxQBiQ86YN1.
PaxDbiQ86YN1.
PeptideAtlasiQ86YN1.
PRIDEiQ86YN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372546; ENSP00000361625; ENSG00000167130. [Q86YN1-1]
ENST00000406974; ENSP00000384043; ENSG00000167130. [Q86YN1-2]
GeneIDi57171.
KEGGihsa:57171.
UCSCiuc004bxc.4. human. [Q86YN1-1]

Organism-specific databases

CTDi57171.
GeneCardsiDOLPP1.
HGNCiHGNC:29565. DOLPP1.
HPAiHPA019179.
MIMi614516. gene.
neXtProtiNX_Q86YN1.
PharmGKBiPA134937229.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3146. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00390000013112.
HOGENOMiHOG000201506.
HOVERGENiHBG051392.
InParanoidiQ86YN1.
KOiK07252.
OMAiLWFEYTN.
OrthoDBiEOG7Z3F5H.
PhylomeDBiQ86YN1.
TreeFamiTF323451.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-HSA-446199. Synthesis of Dolichyl-phosphate.

Miscellaneous databases

ChiTaRSiDOLPP1. human.
GenomeRNAii57171.
PROiQ86YN1.
SOURCEiSearch...

Gene expression databases

BgeeiQ86YN1.
CleanExiHS_DOLPP1.
ExpressionAtlasiQ86YN1. baseline and differential.
GenevisibleiQ86YN1. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Dolichyl pyrophosphate phosphatase (human CWH8)."
    Denecke J., Marquardt T., Kranz C.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum and Lung.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and LungImported.
  6. "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes."
    Gilley J., Fried M.
    Hum. Mol. Genet. 8:1313-1320(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 198-227.

Entry informationi

Entry nameiDOPP1_HUMAN
AccessioniPrimary (citable) accession number: Q86YN1
Secondary accession number(s): A8K3U8
, B0QZG4, Q96GF8, Q9Y3G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.