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Protein

Homer protein homolog 1

Gene

HOMER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

GO - Molecular functioni

  • G-protein coupled glutamate receptor binding Source: GO_Central
  • ion channel binding Source: BHF-UCL
  • signaling adaptor activity Source: BHF-UCL

GO - Biological processi

  • behavioral response to cocaine Source: Ensembl
  • chemical homeostasis within a tissue Source: Ensembl
  • chemical synaptic transmission Source: ProtInc
  • phospholipase C-activating G-protein coupled glutamate receptor signaling pathway Source: ProtInc
  • positive regulation of calcium ion transport Source: Ensembl
  • positive regulation of signal transduction Source: BHF-UCL
  • regulation of calcium ion import Source: Ensembl
  • regulation of cation channel activity Source: BHF-UCL
  • regulation of store-operated calcium entry Source: BHF-UCL
  • response to calcium ion Source: BHF-UCL
  • skeletal muscle contraction Source: Ensembl
  • skeletal muscle fiber development Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ86YM7.

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 1
Short name:
Homer-1
Gene namesi
Name:HOMER1
Synonyms:SYN47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:17512. HOMER1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134972608.

Polymorphism and mutation databases

DMDMi38604765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Homer protein homolog 1PRO_0000191005Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei306 – 3061PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86YM7.
MaxQBiQ86YM7.
PaxDbiQ86YM7.
PeptideAtlasiQ86YM7.
PRIDEiQ86YM7.

PTM databases

iPTMnetiQ86YM7.
PhosphoSiteiQ86YM7.

Expressioni

Gene expression databases

BgeeiENSG00000152413.
CleanExiHS_HOMER1.
ExpressionAtlasiQ86YM7. baseline and differential.
GenevisibleiQ86YM7. HS.

Organism-specific databases

HPAiCAB004437.
HPA036521.
HPA036522.

Interactioni

Subunit structurei

Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. Interacts with IFT57 and OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
C19orf57Q0VDD73EBI-746815,EBI-741210
HOMER3B2RA105EBI-746815,EBI-10175777
SARGQ9BW044EBI-746815,EBI-2320464

GO - Molecular functioni

  • G-protein coupled glutamate receptor binding Source: GO_Central
  • ion channel binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114845. 44 interactions.
IntActiQ86YM7. 10 interactions.
MINTiMINT-1481241.
STRINGi9606.ENSP00000334382.

Structurei

3D structure databases

ProteinModelPortaliQ86YM7.
SMRiQ86YM7. Positions 1-143, 290-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 110110WH1PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili181 – 352172Sequence analysisAdd
BLAST

Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

Sequence similaritiesi

Belongs to the Homer family.Curated
Contains 1 WH1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGRQ. Eukaryota.
ENOG410XQWT. LUCA.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ86YM7.
KOiK15010.
OMAiQNSEPRP.
OrthoDBiEOG091G0CQ0.
PhylomeDBiQ86YM7.
TreeFamiTF325627.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86YM7-1) [UniParc]FASTAAdd to basket
Also known as: 1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL
60 70 80 90 100
DGSKAIINST ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA
110 120 130 140 150
EKFQEFKEAA RLAKEKSQEK MELTSTPSQE SAGGDLQSPL TPESINGTDD
160 170 180 190 200
ERTPDVTQNS EPRAEPTQNA LPFSHSSAIS KHWEAELATL KGNNAKLTAA
210 220 230 240 250
LLESTANVKQ WKQQLAAYQE EAERLHKRVT ELECVSSQAN AVHTHKTELN
260 270 280 290 300
QTIQELEETL KLKEEEIERL KQEIDNAREL QEQRDSLTQK LQEVEIRNKD
310 320 330 340 350
LEGQLSDLEQ RLEKSQNEQE AFRNNLKTLL EILDGKIFEL TELRDNLAKL

LECS
Length:354
Mass (Da):40,277
Last modified:November 28, 2003 - v2
Checksum:i8C68A56224C98033
GO
Isoform 2 (identifier: Q86YM7-2) [UniParc]FASTAAdd to basket
Also known as: 1e

The sequence of this isoform differs from the canonical sequence as follows:
     99-228: Missing.

Show »
Length:224
Mass (Da):25,843
Checksum:iF94F6A9AB2682629
GO
Isoform 3 (identifier: Q86YM7-3) [UniParc]FASTAAdd to basket
Also known as: 1h

The sequence of this isoform differs from the canonical sequence as follows:
     176-177: SS → RK
     178-354: Missing.

Show »
Length:177
Mass (Da):19,861
Checksum:iB1AE94C8E245CAEF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei99 – 228130Missing in isoform 2. 1 PublicationVSP_009057Add
BLAST
Alternative sequencei176 – 1772SS → RK in isoform 3. 1 PublicationVSP_009058
Alternative sequencei178 – 354177Missing in isoform 3. 1 PublicationVSP_009059Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093262 mRNA. Translation: AAC71026.1.
Y17829 mRNA. Translation: CAA76877.1.
AY189939 mRNA. Translation: AAO38999.1.
AY189941 mRNA. Translation: AAO39001.1.
BT009846 mRNA. Translation: AAP88848.1.
AK312481 mRNA. Translation: BAG35385.1.
CH471084 Genomic DNA. Translation: EAW95836.1.
BC015502 mRNA. Translation: AAH15502.1.
CCDSiCCDS43335.1. [Q86YM7-1]
CCDS64188.1. [Q86YM7-2]
CCDS64189.1. [Q86YM7-3]
RefSeqiNP_001264006.1. NM_001277077.1. [Q86YM7-2]
NP_001264007.1. NM_001277078.1. [Q86YM7-3]
NP_004263.1. NM_004272.4. [Q86YM7-1]
UniGeneiHs.591761.

Genome annotation databases

EnsembliENST00000282260; ENSP00000282260; ENSG00000152413. [Q86YM7-2]
ENST00000334082; ENSP00000334382; ENSG00000152413. [Q86YM7-1]
ENST00000508576; ENSP00000426651; ENSG00000152413. [Q86YM7-3]
GeneIDi9456.
KEGGihsa:9456.
UCSCiuc003kfy.5. human. [Q86YM7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093262 mRNA. Translation: AAC71026.1.
Y17829 mRNA. Translation: CAA76877.1.
AY189939 mRNA. Translation: AAO38999.1.
AY189941 mRNA. Translation: AAO39001.1.
BT009846 mRNA. Translation: AAP88848.1.
AK312481 mRNA. Translation: BAG35385.1.
CH471084 Genomic DNA. Translation: EAW95836.1.
BC015502 mRNA. Translation: AAH15502.1.
CCDSiCCDS43335.1. [Q86YM7-1]
CCDS64188.1. [Q86YM7-2]
CCDS64189.1. [Q86YM7-3]
RefSeqiNP_001264006.1. NM_001277077.1. [Q86YM7-2]
NP_001264007.1. NM_001277078.1. [Q86YM7-3]
NP_004263.1. NM_004272.4. [Q86YM7-1]
UniGeneiHs.591761.

3D structure databases

ProteinModelPortaliQ86YM7.
SMRiQ86YM7. Positions 1-143, 290-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114845. 44 interactions.
IntActiQ86YM7. 10 interactions.
MINTiMINT-1481241.
STRINGi9606.ENSP00000334382.

PTM databases

iPTMnetiQ86YM7.
PhosphoSiteiQ86YM7.

Polymorphism and mutation databases

DMDMi38604765.

Proteomic databases

EPDiQ86YM7.
MaxQBiQ86YM7.
PaxDbiQ86YM7.
PeptideAtlasiQ86YM7.
PRIDEiQ86YM7.

Protocols and materials databases

DNASUi9456.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282260; ENSP00000282260; ENSG00000152413. [Q86YM7-2]
ENST00000334082; ENSP00000334382; ENSG00000152413. [Q86YM7-1]
ENST00000508576; ENSP00000426651; ENSG00000152413. [Q86YM7-3]
GeneIDi9456.
KEGGihsa:9456.
UCSCiuc003kfy.5. human. [Q86YM7-1]

Organism-specific databases

CTDi9456.
GeneCardsiHOMER1.
HGNCiHGNC:17512. HOMER1.
HPAiCAB004437.
HPA036521.
HPA036522.
MIMi604798. gene.
neXtProtiNX_Q86YM7.
PharmGKBiPA134972608.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGRQ. Eukaryota.
ENOG410XQWT. LUCA.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ86YM7.
KOiK15010.
OMAiQNSEPRP.
OrthoDBiEOG091G0CQ0.
PhylomeDBiQ86YM7.
TreeFamiTF325627.

Enzyme and pathway databases

SignaLinkiQ86YM7.

Miscellaneous databases

ChiTaRSiHOMER1. human.
GeneWikiiHOMER1.
GenomeRNAii9456.
PROiQ86YM7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152413.
CleanExiHS_HOMER1.
ExpressionAtlasiQ86YM7. baseline and differential.
GenevisibleiQ86YM7. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHOME1_HUMAN
AccessioniPrimary (citable) accession number: Q86YM7
Secondary accession number(s): B2R688, O96003, Q86YM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: September 7, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.