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Q86YL7

- PDPN_HUMAN

UniProt

Q86YL7 - PDPN_HUMAN

Protein

Podoplanin

Gene

PDPN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.By similarity4 Publications

    GO - Biological processi

    1. cell morphogenesis Source: UniProtKB
    2. cell proliferation Source: Ensembl
    3. cellular component movement Source: Ensembl
    4. embryo development Source: Ensembl
    5. inflammatory response Source: Ensembl
    6. lung alveolus development Source: Ensembl
    7. lung development Source: UniProtKB
    8. lymphangiogenesis Source: UniProtKB
    9. nervous system development Source: Ensembl
    10. positive regulation of cell migration Source: Ensembl
    11. positive regulation of cellular component movement Source: UniProtKB
    12. positive regulation of platelet activation Source: Ensembl
    13. prostaglandin metabolic process Source: Ensembl
    14. regulation of cell shape Source: UniProtKB-KW
    15. regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    16. response to hyperoxia Source: Ensembl
    17. signal transduction Source: Ensembl
    18. single organismal cell-cell adhesion Source: Ensembl
    19. tube morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell shape

    Keywords - Ligandi

    Sialic acid

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Podoplanin
    Alternative name(s):
    Aggrus
    Glycoprotein 36
    Short name:
    Gp36
    PA2.26 antigen
    T1-alpha
    Short name:
    T1A
    Gene namesi
    Name:PDPNImported
    Synonyms:GP361 Publication
    ORF Names:PSEC0003, PSEC0025
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29602. PDPN.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity. Cell projectionfilopodium membrane By similarity; Single-pass type I membrane protein By similarity. Cell projectionlamellipodium membrane By similarity; Single-pass type I membrane protein By similarity. Cell projectionmicrovillus membrane By similarity; Single-pass type I membrane protein By similarity. Cell projectionruffle membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. external side of plasma membrane Source: Ensembl
    3. filopodium Source: UniProtKB
    4. filopodium membrane Source: UniProtKB-SubCell
    5. integral component of plasma membrane Source: ProtInc
    6. lamellipodium Source: UniProtKB
    7. lamellipodium membrane Source: UniProtKB-SubCell
    8. microvillus membrane Source: UniProtKB-SubCell
    9. plasma membrane Source: UniProtKB
    10. ruffle Source: UniProtKB
    11. ruffle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi52 – 521T → A: Eliminates induction of platelet aggregation. 1 Publication

    Organism-specific databases

    PharmGKBiPA142671187.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 162140PodoplaninSequence AnalysisPRO_0000223875Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251O-linked (GalNAc...)Sequence Analysis
    Glycosylationi32 – 321O-linked (GalNAc...)Sequence Analysis
    Glycosylationi34 – 341O-linked (GalNAc...)Sequence Analysis
    Glycosylationi35 – 351O-linked (GalNAc...)Sequence Analysis
    Glycosylationi52 – 521O-linked (GalNAc...)Sequence Analysis
    Glycosylationi55 – 551O-linked (GalNAc...)Sequence Analysis
    Glycosylationi65 – 651O-linked (GalNAc...)Sequence Analysis
    Glycosylationi66 – 661O-linked (GalNAc...)Sequence Analysis
    Glycosylationi76 – 761O-linked (GalNAc...)Sequence Analysis
    Glycosylationi85 – 851O-linked (GalNAc...)Sequence Analysis
    Glycosylationi86 – 861O-linked (GalNAc...)Sequence Analysis
    Glycosylationi88 – 881O-linked (GalNAc...)Sequence Analysis
    Glycosylationi89 – 891O-linked (GalNAc...)Sequence Analysis
    Glycosylationi96 – 961O-linked (GalNAc...)Sequence Analysis
    Glycosylationi98 – 981O-linked (GalNAc...)Sequence Analysis
    Glycosylationi100 – 1001O-linked (GalNAc...)Sequence Analysis
    Glycosylationi102 – 1021O-linked (GalNAc...)Sequence Analysis
    Glycosylationi106 – 1061O-linked (GalNAc...)Sequence Analysis
    Glycosylationi107 – 1071O-linked (GalNAc...)Sequence Analysis
    Glycosylationi109 – 1091O-linked (GalNAc...)Sequence Analysis
    Glycosylationi110 – 1101O-linked (GalNAc...)Sequence Analysis
    Glycosylationi117 – 1171O-linked (GalNAc...)Sequence Analysis
    Glycosylationi119 – 1191O-linked (GalNAc...)Sequence Analysis
    Glycosylationi120 – 1201O-linked (GalNAc...)Sequence Analysis

    Post-translational modificationi

    Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.3 Publications
    The N-terminus is blocked.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ86YL7.
    PRIDEiQ86YL7.

    Expressioni

    Tissue specificityi

    Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.3 Publications

    Gene expression databases

    ArrayExpressiQ86YL7.
    BgeeiQ86YL7.
    CleanExiHS_PDPN.
    GenevestigatoriQ86YL7.

    Organism-specific databases

    HPAiCAB008376.
    HPA007534.

    Interactioni

    Protein-protein interaction databases

    BioGridi115874. 1 interaction.
    IntActiQ86YL7. 1 interaction.
    MINTiMINT-1411422.
    STRINGi9606.ENSP00000294489.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86YL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 131109ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 16210CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei132 – 15221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the podoplanin family.Sequence Analysis

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46902.
    HOVERGENiHBG080131.
    InParanoidiQ86YL7.
    KOiK16778.
    OMAiCDDDITH.
    OrthoDBiEOG7DC25R.
    PhylomeDBiQ86YL7.
    TreeFamiTF337068.

    Family and domain databases

    InterProiIPR008783. Podoplanin.
    [Graphical view]
    PANTHERiPTHR16861. PTHR16861. 1 hit.
    PfamiPF05808. Podoplanin. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q86YL7-1) [UniParc]FASTAAdd to Basket

    Also known as: hT1alpha-21 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWKVSALLFV LGSASLWVLA EGASTGQPED DTETTGLEGG VAMPGAEDDV    50
    VTPGTSEDRY KSGLTTLVAT SVNSVTGIRI EDLPTSESTV HAQEQSPSAT 100
    ASNVATSHST EKVDGDTQTT VEKDGLSTVT LVGIIVGVLL AIGFIGAIIV 150
    VVMRKMSGRY SP 162
    Length:162
    Mass (Da):16,698
    Last modified:November 25, 2008 - v3
    Checksum:iCD96D46FF5BD56A1
    GO
    Isoform 21 Publication (identifier: Q86YL7-2) [UniParc]FASTAAdd to Basket

    Also known as: hT1alpha-11 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-100: Missing.
         101-123: ASNVATSHSTEKVDGDTQTTVEK → MLHILSPMYFFLWGSCFFPLSSS
         162-162: P → EVNSLHPCDR...RQEVHLCPGI

    Show »
    Length:164
    Mass (Da):18,173
    Checksum:i009F6A03EE83F72A
    GO
    Isoform 3 (identifier: Q86YL7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLTPLGKFST...QESNNSTGTM

    Show »
    Length:238
    Mass (Da):24,902
    Checksum:iF6A351B5583198FC
    GO
    Isoform 4 (identifier: Q86YL7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLTPLGKFST...QESNNSTGTM
         160-162: YSP → P

    Show »
    Length:236
    Mass (Da):24,652
    Checksum:i5D85583198FCE2C3
    GO
    Isoform 5 (identifier: Q86YL7-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.
         160-161: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:118
    Mass (Da):12,171
    Checksum:i7EB21A53B3CAA7E5
    GO
    Isoform 6 (identifier: Q86YL7-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:120
    Mass (Da):12,421
    Checksum:i9DE0D2821A53B3CA
    GO

    Sequence cautioni

    The sequence AAM73655.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAO22143.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC11550.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC11557.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG35495.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571E → K in BAC11557. (PubMed:16303743)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti105 – 1051A → G.
    Corresponds to variant rs2486188 [ dbSNP | Ensembl ].
    VAR_028015
    Natural varianti147 – 1471A → G.7 Publications
    Corresponds to variant rs2486188 [ dbSNP | Ensembl ].
    VAR_028016

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 100100Missing in isoform 2. 1 PublicationVSP_051949Add
    BLAST
    Alternative sequencei1 – 4242Missing in isoform 5 and isoform 6. CuratedVSP_046799Add
    BLAST
    Alternative sequencei1 – 11M → MLTPLGKFSTAKFAVRLPRV WEARAPSLSGAPAPTPPAPP PSRSSRLGLWPRCFLIFPQL RILLLGPQESNNSTGTM in isoform 3 and isoform 4. 5 PublicationsVSP_035753
    Alternative sequencei101 – 12323ASNVA…TTVEK → MLHILSPMYFFLWGSCFFPL SSS in isoform 2. 1 PublicationVSP_051950Add
    BLAST
    Alternative sequencei160 – 1623YSP → P in isoform 4. 1 PublicationVSP_035754
    Alternative sequencei160 – 1612Missing in isoform 5. CuratedVSP_046800
    Alternative sequencei162 – 1621P → EVNSLHPCDRQMKAIVSRTQ IFELIEISDISWVWWLVPVV SAAGQLQTSLGNIVRPCLKK IISGTMVMFQSSLLGPLECS GSHLESQCFERLRRQEVHLC PGI in isoform 2. 1 PublicationVSP_051951

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030427 mRNA. Translation: AAD01899.1.
    AF030428 mRNA. Translation: AAD01900.1.
    AJ225022 mRNA. Translation: CAA12352.1.
    AB127958 mRNA. Translation: BAD04046.1.
    AL359771, AL354712 Genomic DNA. Translation: CAI17983.2.
    AL359771, AL354712 Genomic DNA. Translation: CAI17984.2.
    BC014668 mRNA. Translation: AAH14668.2.
    BC022812 mRNA. Translation: AAH22812.2.
    AY194238 mRNA. Translation: AAO22143.1. Different initiation.
    AK312607 mRNA. Translation: BAG35495.1. Different initiation.
    AK075327 mRNA. Translation: BAC11550.1. Different initiation.
    AK075345 mRNA. Translation: BAC11557.1. Different initiation.
    AF390106 mRNA. Translation: AAM73655.1. Different initiation.
    CCDSiCCDS30602.1. [Q86YL7-3]
    CCDS41266.1. [Q86YL7-4]
    CCDS44060.1. [Q86YL7-6]
    CCDS53270.1. [Q86YL7-5]
    RefSeqiNP_001006625.1. NM_001006624.1. [Q86YL7-6]
    NP_001006626.1. NM_001006625.1. [Q86YL7-5]
    NP_006465.3. NM_006474.4. [Q86YL7-3]
    NP_938203.2. NM_198389.2. [Q86YL7-4]
    XP_006710358.1. XM_006710295.1. [Q86YL7-6]
    UniGeneiHs.468675.

    Genome annotation databases

    EnsembliENST00000294489; ENSP00000294489; ENSG00000162493. [Q86YL7-3]
    ENST00000376057; ENSP00000365225; ENSG00000162493. [Q86YL7-4]
    ENST00000376061; ENSP00000365229; ENSG00000162493. [Q86YL7-6]
    ENST00000475043; ENSP00000426063; ENSG00000162493. [Q86YL7-5]
    ENST00000487038; ENSP00000427537; ENSG00000162493. [Q86YL7-6]
    ENST00000513143; ENSP00000425304; ENSG00000162493. [Q86YL7-6]
    GeneIDi10630.
    KEGGihsa:10630.
    UCSCiuc001avc.3. human. [Q86YL7-4]
    uc001avd.3. human. [Q86YL7-3]
    uc001avf.3. human. [Q86YL7-1]

    Polymorphism databases

    DMDMi215274223.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030427 mRNA. Translation: AAD01899.1 .
    AF030428 mRNA. Translation: AAD01900.1 .
    AJ225022 mRNA. Translation: CAA12352.1 .
    AB127958 mRNA. Translation: BAD04046.1 .
    AL359771 , AL354712 Genomic DNA. Translation: CAI17983.2 .
    AL359771 , AL354712 Genomic DNA. Translation: CAI17984.2 .
    BC014668 mRNA. Translation: AAH14668.2 .
    BC022812 mRNA. Translation: AAH22812.2 .
    AY194238 mRNA. Translation: AAO22143.1 . Different initiation.
    AK312607 mRNA. Translation: BAG35495.1 . Different initiation.
    AK075327 mRNA. Translation: BAC11550.1 . Different initiation.
    AK075345 mRNA. Translation: BAC11557.1 . Different initiation.
    AF390106 mRNA. Translation: AAM73655.1 . Different initiation.
    CCDSi CCDS30602.1. [Q86YL7-3 ]
    CCDS41266.1. [Q86YL7-4 ]
    CCDS44060.1. [Q86YL7-6 ]
    CCDS53270.1. [Q86YL7-5 ]
    RefSeqi NP_001006625.1. NM_001006624.1. [Q86YL7-6 ]
    NP_001006626.1. NM_001006625.1. [Q86YL7-5 ]
    NP_006465.3. NM_006474.4. [Q86YL7-3 ]
    NP_938203.2. NM_198389.2. [Q86YL7-4 ]
    XP_006710358.1. XM_006710295.1. [Q86YL7-6 ]
    UniGenei Hs.468675.

    3D structure databases

    ProteinModelPortali Q86YL7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115874. 1 interaction.
    IntActi Q86YL7. 1 interaction.
    MINTi MINT-1411422.
    STRINGi 9606.ENSP00000294489.

    Polymorphism databases

    DMDMi 215274223.

    Proteomic databases

    PaxDbi Q86YL7.
    PRIDEi Q86YL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294489 ; ENSP00000294489 ; ENSG00000162493 . [Q86YL7-3 ]
    ENST00000376057 ; ENSP00000365225 ; ENSG00000162493 . [Q86YL7-4 ]
    ENST00000376061 ; ENSP00000365229 ; ENSG00000162493 . [Q86YL7-6 ]
    ENST00000475043 ; ENSP00000426063 ; ENSG00000162493 . [Q86YL7-5 ]
    ENST00000487038 ; ENSP00000427537 ; ENSG00000162493 . [Q86YL7-6 ]
    ENST00000513143 ; ENSP00000425304 ; ENSG00000162493 . [Q86YL7-6 ]
    GeneIDi 10630.
    KEGGi hsa:10630.
    UCSCi uc001avc.3. human. [Q86YL7-4 ]
    uc001avd.3. human. [Q86YL7-3 ]
    uc001avf.3. human. [Q86YL7-1 ]

    Organism-specific databases

    CTDi 10630.
    GeneCardsi GC01P013909.
    H-InvDB HIX0000141.
    HGNCi HGNC:29602. PDPN.
    HPAi CAB008376.
    HPA007534.
    MIMi 608863. gene.
    neXtProti NX_Q86YL7.
    PharmGKBi PA142671187.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46902.
    HOVERGENi HBG080131.
    InParanoidi Q86YL7.
    KOi K16778.
    OMAi CDDDITH.
    OrthoDBi EOG7DC25R.
    PhylomeDBi Q86YL7.
    TreeFami TF337068.

    Miscellaneous databases

    ChiTaRSi PDPN. human.
    GeneWikii PDPN.
    GenomeRNAii 10630.
    NextBioi 40389.
    PROi Q86YL7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86YL7.
    Bgeei Q86YL7.
    CleanExi HS_PDPN.
    Genevestigatori Q86YL7.

    Family and domain databases

    InterProi IPR008783. Podoplanin.
    [Graphical view ]
    PANTHERi PTHR16861. PTHR16861. 1 hit.
    Pfami PF05808. Podoplanin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence against a role of mouse, rat, and two cloned human T1alpha isoforms as a water channel or a regulator of aquaporin-type water channels."
      Ma T., Yang B., Matthay M.A., Verkman A.S.
      Am. J. Respir. Cell Mol. Biol. 19:143-149(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, VARIANT GLY-147.
    2. "Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium."
      Zimmer G., Oeffner F., von Messling V., Tschernig T., Groene H.-J., Klenk H.-D., Herrler G.
      Biochem. J. 341:277-284(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, GLYCOSYLATION, VARIANT GLY-147.
      Tissue: PlacentaImported.
    3. Kato Y., Fujita N., Tsuruo T.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLY-147.
      Tissue: LungImported.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLY-147.
      Tissue: EyeImported.
    6. "Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas."
      Martin-Villar E., Scholl F.G., Gamallo C., Yurrita M.M., Munoz-Guerra M., Cruces J., Quintanilla M.
      Int. J. Cancer 113:899-910(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-162 (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-162 (ISOFORM 3), VARIANT GLY-147.
      Tissue: Brain.
    8. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-162 (ISOFORM 4), VARIANT GLY-147.
    9. "Molecular cloning and characterization of human podoplanin, a small mucin-type glycoprotein of glomerular podocytes."
      Kowalski H., Kalt R., Auer H., Dontscho K.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-162 (ISOFORM 3), VARIANT GLY-147.
      Tissue: KidneyImported.
    10. "Molecular identification of aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors."
      Kato Y., Fujita N., Kunita A., Sato S., Kaneko M., Osawa M., Tsuruo T.
      J. Biol. Chem. 278:51599-51605(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-52.
    11. "Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells."
      Kaneko M., Kato Y., Kunita A., Fujita N., Tsuruo T., Osawa M.
      J. Biol. Chem. 279:38838-38843(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, GLYCOSYLATION.

    Entry informationi

    Entry nameiPDPN_HUMAN
    AccessioniPrimary (citable) accession number: Q86YL7
    Secondary accession number(s): A9Z1Y2
    , B2R6J8, E9PB68, F6QWX5, O60836, O95128, Q7L375, Q8NBQ8, Q8NBR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3