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Protein

Podoplanin

Gene

PDPN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.By similarity4 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell shape

Keywords - Ligandi

Sialic acid

Enzyme and pathway databases

ReactomeiR-HSA-114604. GPVI-mediated activation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Podoplanin
Alternative name(s):
Aggrus
Glycoprotein 36
Short name:
Gp36
PA2.26 antigen
T1-alpha
Short name:
T1A
Gene namesi
Name:PDPNImported
Synonyms:GP361 Publication
ORF Names:PSEC0003, PSEC0025
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29602. PDPN.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 131ExtracellularSequence analysisAdd BLAST109
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 162CytoplasmicSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi52T → A: Eliminates induction of platelet aggregation. 1 Publication1

Organism-specific databases

DisGeNETi10630.
OpenTargetsiENSG00000162493.
PharmGKBiPA142671187.

Polymorphism and mutation databases

BioMutaiPDPN.
DMDMi215274223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000022387523 – 162PodoplaninSequence analysisAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25O-linked (GalNAc...)Sequence analysis1
Glycosylationi32O-linked (GalNAc...)Sequence analysis1
Glycosylationi34O-linked (GalNAc...)Sequence analysis1
Glycosylationi35O-linked (GalNAc...)Sequence analysis1
Glycosylationi52O-linked (GalNAc...)Sequence analysis1
Glycosylationi55O-linked (GalNAc...)Sequence analysis1
Glycosylationi65O-linked (GalNAc...)Sequence analysis1
Glycosylationi66O-linked (GalNAc...)Sequence analysis1
Glycosylationi76O-linked (GalNAc...)Sequence analysis1
Glycosylationi85O-linked (GalNAc...)Sequence analysis1
Glycosylationi86O-linked (GalNAc...)Sequence analysis1
Glycosylationi88O-linked (GalNAc...)Sequence analysis1
Glycosylationi89O-linked (GalNAc...)Sequence analysis1
Glycosylationi96O-linked (GalNAc...)Sequence analysis1
Glycosylationi98O-linked (GalNAc...)Sequence analysis1
Glycosylationi100O-linked (GalNAc...)Sequence analysis1
Glycosylationi102O-linked (GalNAc...)Sequence analysis1
Glycosylationi106O-linked (GalNAc...)Sequence analysis1
Glycosylationi107O-linked (GalNAc...)Sequence analysis1
Glycosylationi109O-linked (GalNAc...)Sequence analysis1
Glycosylationi110O-linked (GalNAc...)Sequence analysis1
Glycosylationi117O-linked (GalNAc...)Sequence analysis1
Glycosylationi119O-linked (GalNAc...)Sequence analysis1
Glycosylationi120O-linked (GalNAc...)Sequence analysis1

Post-translational modificationi

Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.3 Publications
The N-terminus is blocked.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86YL7.
PeptideAtlasiQ86YL7.
PRIDEiQ86YL7.

PTM databases

PhosphoSitePlusiQ86YL7.

Expressioni

Tissue specificityi

Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.3 Publications

Gene expression databases

BgeeiENSG00000162493.
CleanExiHS_PDPN.
ExpressionAtlasiQ86YL7. baseline and differential.
GenevisibleiQ86YL7. HS.

Organism-specific databases

HPAiCAB008376.
HPA007534.

Interactioni

Protein-protein interaction databases

BioGridi115874. 1 interactor.
DIPiDIP-61333N.
IntActiQ86YL7. 1 interactor.
MINTiMINT-1411422.
STRINGi9606.ENSP00000294489.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WSRX-ray1.91C/D38-54[»]
4YO0X-ray1.56E/F38-51[»]
ProteinModelPortaliQ86YL7.
SMRiQ86YL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the podoplanin family.Sequence analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J49G. Eukaryota.
ENOG41116TP. LUCA.
GeneTreeiENSGT00390000000013.
HOVERGENiHBG080131.
InParanoidiQ86YL7.
KOiK16778.
OrthoDBiEOG091G0ZYJ.
PhylomeDBiQ86YL7.
TreeFamiTF337068.

Family and domain databases

InterProiIPR008783. Podoplanin.
[Graphical view]
PfamiPF05808. Podoplanin. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q86YL7-1) [UniParc]FASTAAdd to basket
Also known as: hT1alpha-21 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWKVSALLFV LGSASLWVLA EGASTGQPED DTETTGLEGG VAMPGAEDDV
60 70 80 90 100
VTPGTSEDRY KSGLTTLVAT SVNSVTGIRI EDLPTSESTV HAQEQSPSAT
110 120 130 140 150
ASNVATSHST EKVDGDTQTT VEKDGLSTVT LVGIIVGVLL AIGFIGAIIV
160
VVMRKMSGRY SP
Length:162
Mass (Da):16,698
Last modified:November 25, 2008 - v3
Checksum:iCD96D46FF5BD56A1
GO
Isoform 21 Publication (identifier: Q86YL7-2) [UniParc]FASTAAdd to basket
Also known as: hT1alpha-11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.
     101-123: ASNVATSHSTEKVDGDTQTTVEK → MLHILSPMYFFLWGSCFFPLSSS
     162-162: P → EVNSLHPCDR...RQEVHLCPGI

Show »
Length:164
Mass (Da):18,173
Checksum:i009F6A03EE83F72A
GO
Isoform 3 (identifier: Q86YL7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLTPLGKFST...QESNNSTGTM

Show »
Length:238
Mass (Da):24,902
Checksum:iF6A351B5583198FC
GO
Isoform 4 (identifier: Q86YL7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLTPLGKFST...QESNNSTGTM
     160-162: YSP → P

Show »
Length:236
Mass (Da):24,652
Checksum:i5D85583198FCE2C3
GO
Isoform 5 (identifier: Q86YL7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     160-161: Missing.

Note: No experimental confirmation available.
Show »
Length:118
Mass (Da):12,171
Checksum:i7EB21A53B3CAA7E5
GO
Isoform 6 (identifier: Q86YL7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.
Show »
Length:120
Mass (Da):12,421
Checksum:i9DE0D2821A53B3CA
GO

Sequence cautioni

The sequence AAM73655 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO22143 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11550 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11557 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG35495 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57E → K in BAC11557 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028015105A → G.Corresponds to variant rs2486188dbSNPEnsembl.1
Natural variantiVAR_028016147A → G.7 PublicationsCorresponds to variant rs2486188dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0519491 – 100Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_0467991 – 42Missing in isoform 5 and isoform 6. CuratedAdd BLAST42
Alternative sequenceiVSP_0357531M → MLTPLGKFSTAKFAVRLPRV WEARAPSLSGAPAPTPPAPP PSRSSRLGLWPRCFLIFPQL RILLLGPQESNNSTGTM in isoform 3 and isoform 4. 5 Publications1
Alternative sequenceiVSP_051950101 – 123ASNVA…TTVEK → MLHILSPMYFFLWGSCFFPL SSS in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_035754160 – 162YSP → P in isoform 4. 1 Publication3
Alternative sequenceiVSP_046800160 – 161Missing in isoform 5. Curated2
Alternative sequenceiVSP_051951162P → EVNSLHPCDRQMKAIVSRTQ IFELIEISDISWVWWLVPVV SAAGQLQTSLGNIVRPCLKK IISGTMVMFQSSLLGPLECS GSHLESQCFERLRRQEVHLC PGI in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030427 mRNA. Translation: AAD01899.1.
AF030428 mRNA. Translation: AAD01900.1.
AJ225022 mRNA. Translation: CAA12352.1.
AB127958 mRNA. Translation: BAD04046.1.
AL359771, AL354712 Genomic DNA. Translation: CAI17983.2.
AL359771, AL354712 Genomic DNA. Translation: CAI17984.2.
BC014668 mRNA. Translation: AAH14668.2.
BC022812 mRNA. Translation: AAH22812.2.
AY194238 mRNA. Translation: AAO22143.1. Different initiation.
AK312607 mRNA. Translation: BAG35495.1. Different initiation.
AK075327 mRNA. Translation: BAC11550.1. Different initiation.
AK075345 mRNA. Translation: BAC11557.1. Different initiation.
AF390106 mRNA. Translation: AAM73655.1. Different initiation.
CCDSiCCDS30602.1. [Q86YL7-3]
CCDS41266.1. [Q86YL7-4]
CCDS44060.1. [Q86YL7-6]
CCDS53270.1. [Q86YL7-5]
RefSeqiNP_001006625.1. NM_001006624.1. [Q86YL7-6]
NP_001006626.1. NM_001006625.1. [Q86YL7-5]
NP_006465.3. NM_006474.4. [Q86YL7-3]
NP_938203.2. NM_198389.2. [Q86YL7-4]
XP_006710358.1. XM_006710295.1. [Q86YL7-6]
UniGeneiHs.468675.

Genome annotation databases

EnsembliENST00000294489; ENSP00000294489; ENSG00000162493. [Q86YL7-3]
ENST00000376057; ENSP00000365225; ENSG00000162493. [Q86YL7-4]
ENST00000376061; ENSP00000365229; ENSG00000162493. [Q86YL7-6]
ENST00000475043; ENSP00000426063; ENSG00000162493. [Q86YL7-5]
ENST00000487038; ENSP00000427537; ENSG00000162493. [Q86YL7-6]
ENST00000513143; ENSP00000425304; ENSG00000162493. [Q86YL7-6]
ENST00000617617; ENSP00000479591; ENSG00000162493. [Q86YL7-3]
ENST00000621990; ENSP00000478125; ENSG00000162493. [Q86YL7-1]
GeneIDi10630.
KEGGihsa:10630.
UCSCiuc001avc.4. human. [Q86YL7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030427 mRNA. Translation: AAD01899.1.
AF030428 mRNA. Translation: AAD01900.1.
AJ225022 mRNA. Translation: CAA12352.1.
AB127958 mRNA. Translation: BAD04046.1.
AL359771, AL354712 Genomic DNA. Translation: CAI17983.2.
AL359771, AL354712 Genomic DNA. Translation: CAI17984.2.
BC014668 mRNA. Translation: AAH14668.2.
BC022812 mRNA. Translation: AAH22812.2.
AY194238 mRNA. Translation: AAO22143.1. Different initiation.
AK312607 mRNA. Translation: BAG35495.1. Different initiation.
AK075327 mRNA. Translation: BAC11550.1. Different initiation.
AK075345 mRNA. Translation: BAC11557.1. Different initiation.
AF390106 mRNA. Translation: AAM73655.1. Different initiation.
CCDSiCCDS30602.1. [Q86YL7-3]
CCDS41266.1. [Q86YL7-4]
CCDS44060.1. [Q86YL7-6]
CCDS53270.1. [Q86YL7-5]
RefSeqiNP_001006625.1. NM_001006624.1. [Q86YL7-6]
NP_001006626.1. NM_001006625.1. [Q86YL7-5]
NP_006465.3. NM_006474.4. [Q86YL7-3]
NP_938203.2. NM_198389.2. [Q86YL7-4]
XP_006710358.1. XM_006710295.1. [Q86YL7-6]
UniGeneiHs.468675.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WSRX-ray1.91C/D38-54[»]
4YO0X-ray1.56E/F38-51[»]
ProteinModelPortaliQ86YL7.
SMRiQ86YL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115874. 1 interactor.
DIPiDIP-61333N.
IntActiQ86YL7. 1 interactor.
MINTiMINT-1411422.
STRINGi9606.ENSP00000294489.

PTM databases

PhosphoSitePlusiQ86YL7.

Polymorphism and mutation databases

BioMutaiPDPN.
DMDMi215274223.

Proteomic databases

PaxDbiQ86YL7.
PeptideAtlasiQ86YL7.
PRIDEiQ86YL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294489; ENSP00000294489; ENSG00000162493. [Q86YL7-3]
ENST00000376057; ENSP00000365225; ENSG00000162493. [Q86YL7-4]
ENST00000376061; ENSP00000365229; ENSG00000162493. [Q86YL7-6]
ENST00000475043; ENSP00000426063; ENSG00000162493. [Q86YL7-5]
ENST00000487038; ENSP00000427537; ENSG00000162493. [Q86YL7-6]
ENST00000513143; ENSP00000425304; ENSG00000162493. [Q86YL7-6]
ENST00000617617; ENSP00000479591; ENSG00000162493. [Q86YL7-3]
ENST00000621990; ENSP00000478125; ENSG00000162493. [Q86YL7-1]
GeneIDi10630.
KEGGihsa:10630.
UCSCiuc001avc.4. human. [Q86YL7-1]

Organism-specific databases

CTDi10630.
DisGeNETi10630.
GeneCardsiPDPN.
H-InvDBHIX0000141.
HGNCiHGNC:29602. PDPN.
HPAiCAB008376.
HPA007534.
MIMi608863. gene.
neXtProtiNX_Q86YL7.
OpenTargetsiENSG00000162493.
PharmGKBiPA142671187.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J49G. Eukaryota.
ENOG41116TP. LUCA.
GeneTreeiENSGT00390000000013.
HOVERGENiHBG080131.
InParanoidiQ86YL7.
KOiK16778.
OrthoDBiEOG091G0ZYJ.
PhylomeDBiQ86YL7.
TreeFamiTF337068.

Enzyme and pathway databases

ReactomeiR-HSA-114604. GPVI-mediated activation cascade.

Miscellaneous databases

ChiTaRSiPDPN. human.
GeneWikiiPDPN.
GenomeRNAii10630.
PROiQ86YL7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162493.
CleanExiHS_PDPN.
ExpressionAtlasiQ86YL7. baseline and differential.
GenevisibleiQ86YL7. HS.

Family and domain databases

InterProiIPR008783. Podoplanin.
[Graphical view]
PfamiPF05808. Podoplanin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDPN_HUMAN
AccessioniPrimary (citable) accession number: Q86YL7
Secondary accession number(s): A9Z1Y2
, B2R6J8, E9PB68, F6QWX5, O60836, O95128, Q7L375, Q8NBQ8, Q8NBR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.