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Q86YL7

- PDPN_HUMAN

UniProt

Q86YL7 - PDPN_HUMAN

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Protein

Podoplanin

Gene

PDPN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.By similarity4 Publications

GO - Biological processi

  1. cell morphogenesis Source: UniProtKB
  2. cell proliferation Source: Ensembl
  3. cellular component movement Source: Ensembl
  4. embryo development Source: Ensembl
  5. inflammatory response Source: Ensembl
  6. lung alveolus development Source: Ensembl
  7. lung development Source: UniProtKB
  8. lymphangiogenesis Source: UniProtKB
  9. nervous system development Source: Ensembl
  10. positive regulation of cell migration Source: Ensembl
  11. positive regulation of cellular component movement Source: UniProtKB
  12. positive regulation of platelet activation Source: Ensembl
  13. prostaglandin metabolic process Source: Ensembl
  14. regulation of cell shape Source: UniProtKB-KW
  15. regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  16. response to hyperoxia Source: Ensembl
  17. signal transduction Source: Ensembl
  18. single organismal cell-cell adhesion Source: Ensembl
  19. tube morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell shape

Keywords - Ligandi

Sialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Podoplanin
Alternative name(s):
Aggrus
Glycoprotein 36
Short name:
Gp36
PA2.26 antigen
T1-alpha
Short name:
T1A
Gene namesi
Name:PDPNImported
Synonyms:GP361 Publication
ORF Names:PSEC0003, PSEC0025
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29602. PDPN.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity. Cell projectionfilopodium membrane By similarity; Single-pass type I membrane protein By similarity. Cell projectionlamellipodium membrane By similarity; Single-pass type I membrane protein By similarity. Cell projectionmicrovillus membrane By similarity; Single-pass type I membrane protein By similarity. Cell projectionruffle membrane By similarity; Single-pass type I membrane protein By similarity
Note: Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 131109ExtracellularSequence AnalysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence AnalysisAdd
BLAST
Topological domaini153 – 16210CytoplasmicSequence Analysis

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. external side of plasma membrane Source: Ensembl
  3. filopodium Source: UniProtKB
  4. integral component of plasma membrane Source: ProtInc
  5. lamellipodium Source: UniProtKB
  6. plasma membrane Source: UniProtKB
  7. ruffle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi52 – 521T → A: Eliminates induction of platelet aggregation. 1 Publication

Organism-specific databases

PharmGKBiPA142671187.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 162140PodoplaninSequence AnalysisPRO_0000223875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251O-linked (GalNAc...)Sequence Analysis
Glycosylationi32 – 321O-linked (GalNAc...)Sequence Analysis
Glycosylationi34 – 341O-linked (GalNAc...)Sequence Analysis
Glycosylationi35 – 351O-linked (GalNAc...)Sequence Analysis
Glycosylationi52 – 521O-linked (GalNAc...)Sequence Analysis
Glycosylationi55 – 551O-linked (GalNAc...)Sequence Analysis
Glycosylationi65 – 651O-linked (GalNAc...)Sequence Analysis
Glycosylationi66 – 661O-linked (GalNAc...)Sequence Analysis
Glycosylationi76 – 761O-linked (GalNAc...)Sequence Analysis
Glycosylationi85 – 851O-linked (GalNAc...)Sequence Analysis
Glycosylationi86 – 861O-linked (GalNAc...)Sequence Analysis
Glycosylationi88 – 881O-linked (GalNAc...)Sequence Analysis
Glycosylationi89 – 891O-linked (GalNAc...)Sequence Analysis
Glycosylationi96 – 961O-linked (GalNAc...)Sequence Analysis
Glycosylationi98 – 981O-linked (GalNAc...)Sequence Analysis
Glycosylationi100 – 1001O-linked (GalNAc...)Sequence Analysis
Glycosylationi102 – 1021O-linked (GalNAc...)Sequence Analysis
Glycosylationi106 – 1061O-linked (GalNAc...)Sequence Analysis
Glycosylationi107 – 1071O-linked (GalNAc...)Sequence Analysis
Glycosylationi109 – 1091O-linked (GalNAc...)Sequence Analysis
Glycosylationi110 – 1101O-linked (GalNAc...)Sequence Analysis
Glycosylationi117 – 1171O-linked (GalNAc...)Sequence Analysis
Glycosylationi119 – 1191O-linked (GalNAc...)Sequence Analysis
Glycosylationi120 – 1201O-linked (GalNAc...)Sequence Analysis

Post-translational modificationi

Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.3 Publications
The N-terminus is blocked.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86YL7.
PRIDEiQ86YL7.

Expressioni

Tissue specificityi

Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.3 Publications

Gene expression databases

BgeeiQ86YL7.
CleanExiHS_PDPN.
ExpressionAtlasiQ86YL7. baseline and differential.
GenevestigatoriQ86YL7.

Organism-specific databases

HPAiCAB008376.
HPA007534.

Interactioni

Protein-protein interaction databases

BioGridi115874. 1 interaction.
IntActiQ86YL7. 1 interaction.
MINTiMINT-1411422.
STRINGi9606.ENSP00000294489.

Structurei

3D structure databases

ProteinModelPortaliQ86YL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the podoplanin family.Sequence Analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46902.
GeneTreeiENSGT00390000000013.
HOVERGENiHBG080131.
InParanoidiQ86YL7.
KOiK16778.
OMAiCDDDITH.
OrthoDBiEOG7DC25R.
PhylomeDBiQ86YL7.
TreeFamiTF337068.

Family and domain databases

InterProiIPR008783. Podoplanin.
[Graphical view]
PANTHERiPTHR16861. PTHR16861. 1 hit.
PfamiPF05808. Podoplanin. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q86YL7-1) [UniParc]FASTAAdd to Basket

Also known as: hT1alpha-21 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWKVSALLFV LGSASLWVLA EGASTGQPED DTETTGLEGG VAMPGAEDDV
60 70 80 90 100
VTPGTSEDRY KSGLTTLVAT SVNSVTGIRI EDLPTSESTV HAQEQSPSAT
110 120 130 140 150
ASNVATSHST EKVDGDTQTT VEKDGLSTVT LVGIIVGVLL AIGFIGAIIV
160
VVMRKMSGRY SP
Length:162
Mass (Da):16,698
Last modified:November 25, 2008 - v3
Checksum:iCD96D46FF5BD56A1
GO
Isoform 21 Publication (identifier: Q86YL7-2) [UniParc]FASTAAdd to Basket

Also known as: hT1alpha-11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.
     101-123: ASNVATSHSTEKVDGDTQTTVEK → MLHILSPMYFFLWGSCFFPLSSS
     162-162: P → EVNSLHPCDR...RQEVHLCPGI

Show »
Length:164
Mass (Da):18,173
Checksum:i009F6A03EE83F72A
GO
Isoform 3 (identifier: Q86YL7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLTPLGKFST...QESNNSTGTM

Show »
Length:238
Mass (Da):24,902
Checksum:iF6A351B5583198FC
GO
Isoform 4 (identifier: Q86YL7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLTPLGKFST...QESNNSTGTM
     160-162: YSP → P

Show »
Length:236
Mass (Da):24,652
Checksum:i5D85583198FCE2C3
GO
Isoform 5 (identifier: Q86YL7-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     160-161: Missing.

Note: No experimental confirmation available.

Show »
Length:118
Mass (Da):12,171
Checksum:i7EB21A53B3CAA7E5
GO
Isoform 6 (identifier: Q86YL7-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.

Show »
Length:120
Mass (Da):12,421
Checksum:i9DE0D2821A53B3CA
GO

Sequence cautioni

The sequence AAM73655.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO22143.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11550.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11557.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG35495.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571E → K in BAC11557. (PubMed:16303743)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti105 – 1051A → G.
Corresponds to variant rs2486188 [ dbSNP | Ensembl ].
VAR_028015
Natural varianti147 – 1471A → G.7 Publications
Corresponds to variant rs2486188 [ dbSNP | Ensembl ].
VAR_028016

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 100100Missing in isoform 2. 1 PublicationVSP_051949Add
BLAST
Alternative sequencei1 – 4242Missing in isoform 5 and isoform 6. CuratedVSP_046799Add
BLAST
Alternative sequencei1 – 11M → MLTPLGKFSTAKFAVRLPRV WEARAPSLSGAPAPTPPAPP PSRSSRLGLWPRCFLIFPQL RILLLGPQESNNSTGTM in isoform 3 and isoform 4. 5 PublicationsVSP_035753
Alternative sequencei101 – 12323ASNVA…TTVEK → MLHILSPMYFFLWGSCFFPL SSS in isoform 2. 1 PublicationVSP_051950Add
BLAST
Alternative sequencei160 – 1623YSP → P in isoform 4. 1 PublicationVSP_035754
Alternative sequencei160 – 1612Missing in isoform 5. CuratedVSP_046800
Alternative sequencei162 – 1621P → EVNSLHPCDRQMKAIVSRTQ IFELIEISDISWVWWLVPVV SAAGQLQTSLGNIVRPCLKK IISGTMVMFQSSLLGPLECS GSHLESQCFERLRRQEVHLC PGI in isoform 2. 1 PublicationVSP_051951

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030427 mRNA. Translation: AAD01899.1.
AF030428 mRNA. Translation: AAD01900.1.
AJ225022 mRNA. Translation: CAA12352.1.
AB127958 mRNA. Translation: BAD04046.1.
AL359771, AL354712 Genomic DNA. Translation: CAI17983.2.
AL359771, AL354712 Genomic DNA. Translation: CAI17984.2.
BC014668 mRNA. Translation: AAH14668.2.
BC022812 mRNA. Translation: AAH22812.2.
AY194238 mRNA. Translation: AAO22143.1. Different initiation.
AK312607 mRNA. Translation: BAG35495.1. Different initiation.
AK075327 mRNA. Translation: BAC11550.1. Different initiation.
AK075345 mRNA. Translation: BAC11557.1. Different initiation.
AF390106 mRNA. Translation: AAM73655.1. Different initiation.
CCDSiCCDS30602.1. [Q86YL7-3]
CCDS41266.1. [Q86YL7-4]
CCDS44060.1. [Q86YL7-6]
CCDS53270.1. [Q86YL7-5]
RefSeqiNP_001006625.1. NM_001006624.1. [Q86YL7-6]
NP_001006626.1. NM_001006625.1. [Q86YL7-5]
NP_006465.3. NM_006474.4. [Q86YL7-3]
NP_938203.2. NM_198389.2. [Q86YL7-4]
XP_006710358.1. XM_006710295.1. [Q86YL7-6]
UniGeneiHs.468675.

Genome annotation databases

EnsembliENST00000294489; ENSP00000294489; ENSG00000162493. [Q86YL7-3]
ENST00000376057; ENSP00000365225; ENSG00000162493. [Q86YL7-4]
ENST00000376061; ENSP00000365229; ENSG00000162493. [Q86YL7-6]
ENST00000475043; ENSP00000426063; ENSG00000162493. [Q86YL7-5]
ENST00000487038; ENSP00000427537; ENSG00000162493. [Q86YL7-6]
ENST00000513143; ENSP00000425304; ENSG00000162493. [Q86YL7-6]
ENST00000617617; ENSP00000479591; ENSG00000162493. [Q86YL7-3]
ENST00000621990; ENSP00000478125; ENSG00000162493. [Q86YL7-1]
GeneIDi10630.
KEGGihsa:10630.
UCSCiuc001avc.3. human. [Q86YL7-4]
uc001avd.3. human. [Q86YL7-3]
uc001avf.3. human. [Q86YL7-1]

Polymorphism databases

DMDMi215274223.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030427 mRNA. Translation: AAD01899.1 .
AF030428 mRNA. Translation: AAD01900.1 .
AJ225022 mRNA. Translation: CAA12352.1 .
AB127958 mRNA. Translation: BAD04046.1 .
AL359771 , AL354712 Genomic DNA. Translation: CAI17983.2 .
AL359771 , AL354712 Genomic DNA. Translation: CAI17984.2 .
BC014668 mRNA. Translation: AAH14668.2 .
BC022812 mRNA. Translation: AAH22812.2 .
AY194238 mRNA. Translation: AAO22143.1 . Different initiation.
AK312607 mRNA. Translation: BAG35495.1 . Different initiation.
AK075327 mRNA. Translation: BAC11550.1 . Different initiation.
AK075345 mRNA. Translation: BAC11557.1 . Different initiation.
AF390106 mRNA. Translation: AAM73655.1 . Different initiation.
CCDSi CCDS30602.1. [Q86YL7-3 ]
CCDS41266.1. [Q86YL7-4 ]
CCDS44060.1. [Q86YL7-6 ]
CCDS53270.1. [Q86YL7-5 ]
RefSeqi NP_001006625.1. NM_001006624.1. [Q86YL7-6 ]
NP_001006626.1. NM_001006625.1. [Q86YL7-5 ]
NP_006465.3. NM_006474.4. [Q86YL7-3 ]
NP_938203.2. NM_198389.2. [Q86YL7-4 ]
XP_006710358.1. XM_006710295.1. [Q86YL7-6 ]
UniGenei Hs.468675.

3D structure databases

ProteinModelPortali Q86YL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115874. 1 interaction.
IntActi Q86YL7. 1 interaction.
MINTi MINT-1411422.
STRINGi 9606.ENSP00000294489.

Polymorphism databases

DMDMi 215274223.

Proteomic databases

PaxDbi Q86YL7.
PRIDEi Q86YL7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294489 ; ENSP00000294489 ; ENSG00000162493 . [Q86YL7-3 ]
ENST00000376057 ; ENSP00000365225 ; ENSG00000162493 . [Q86YL7-4 ]
ENST00000376061 ; ENSP00000365229 ; ENSG00000162493 . [Q86YL7-6 ]
ENST00000475043 ; ENSP00000426063 ; ENSG00000162493 . [Q86YL7-5 ]
ENST00000487038 ; ENSP00000427537 ; ENSG00000162493 . [Q86YL7-6 ]
ENST00000513143 ; ENSP00000425304 ; ENSG00000162493 . [Q86YL7-6 ]
ENST00000617617 ; ENSP00000479591 ; ENSG00000162493 . [Q86YL7-3 ]
ENST00000621990 ; ENSP00000478125 ; ENSG00000162493 . [Q86YL7-1 ]
GeneIDi 10630.
KEGGi hsa:10630.
UCSCi uc001avc.3. human. [Q86YL7-4 ]
uc001avd.3. human. [Q86YL7-3 ]
uc001avf.3. human. [Q86YL7-1 ]

Organism-specific databases

CTDi 10630.
GeneCardsi GC01P013909.
H-InvDB HIX0000141.
HGNCi HGNC:29602. PDPN.
HPAi CAB008376.
HPA007534.
MIMi 608863. gene.
neXtProti NX_Q86YL7.
PharmGKBi PA142671187.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46902.
GeneTreei ENSGT00390000000013.
HOVERGENi HBG080131.
InParanoidi Q86YL7.
KOi K16778.
OMAi CDDDITH.
OrthoDBi EOG7DC25R.
PhylomeDBi Q86YL7.
TreeFami TF337068.

Miscellaneous databases

ChiTaRSi PDPN. human.
GeneWikii PDPN.
GenomeRNAii 10630.
NextBioi 40389.
PROi Q86YL7.
SOURCEi Search...

Gene expression databases

Bgeei Q86YL7.
CleanExi HS_PDPN.
ExpressionAtlasi Q86YL7. baseline and differential.
Genevestigatori Q86YL7.

Family and domain databases

InterProi IPR008783. Podoplanin.
[Graphical view ]
PANTHERi PTHR16861. PTHR16861. 1 hit.
Pfami PF05808. Podoplanin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evidence against a role of mouse, rat, and two cloned human T1alpha isoforms as a water channel or a regulator of aquaporin-type water channels."
    Ma T., Yang B., Matthay M.A., Verkman A.S.
    Am. J. Respir. Cell Mol. Biol. 19:143-149(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, VARIANT GLY-147.
  2. "Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium."
    Zimmer G., Oeffner F., von Messling V., Tschernig T., Groene H.-J., Klenk H.-D., Herrler G.
    Biochem. J. 341:277-284(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, GLYCOSYLATION, VARIANT GLY-147.
    Tissue: PlacentaImported.
  3. Kato Y., Fujita N., Tsuruo T.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLY-147.
    Tissue: LungImported.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLY-147.
    Tissue: EyeImported.
  6. "Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas."
    Martin-Villar E., Scholl F.G., Gamallo C., Yurrita M.M., Munoz-Guerra M., Cruces J., Quintanilla M.
    Int. J. Cancer 113:899-910(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-162 (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-162 (ISOFORM 3), VARIANT GLY-147.
    Tissue: Brain.
  8. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-162 (ISOFORM 4), VARIANT GLY-147.
  9. "Molecular cloning and characterization of human podoplanin, a small mucin-type glycoprotein of glomerular podocytes."
    Kowalski H., Kalt R., Auer H., Dontscho K.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-162 (ISOFORM 3), VARIANT GLY-147.
    Tissue: KidneyImported.
  10. "Molecular identification of aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors."
    Kato Y., Fujita N., Kunita A., Sato S., Kaneko M., Osawa M., Tsuruo T.
    J. Biol. Chem. 278:51599-51605(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-52.
  11. "Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells."
    Kaneko M., Kato Y., Kunita A., Fujita N., Tsuruo T., Osawa M.
    J. Biol. Chem. 279:38838-38843(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GLYCOSYLATION.

Entry informationi

Entry nameiPDPN_HUMAN
AccessioniPrimary (citable) accession number: Q86YL7
Secondary accession number(s): A9Z1Y2
, B2R6J8, E9PB68, F6QWX5, O60836, O95128, Q7L375, Q8NBQ8, Q8NBR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3