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Protein

Ankyrin repeat domain-containing protein 13B

Gene

ANKRD13B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 13B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000198720.12
HGNCiHGNC:26363 ANKRD13B
MIMi615124 gene
neXtProtiNX_Q86YJ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198720
PharmGKBiPA142672616

Polymorphism and mutation databases

BioMutaiANKRD13B
DMDMi269849747

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406431 – 626Ankyrin repeat domain-containing protein 13BAdd BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ86YJ7
MaxQBiQ86YJ7
PaxDbiQ86YJ7
PeptideAtlasiQ86YJ7
PRIDEiQ86YJ7

PTM databases

iPTMnetiQ86YJ7
PhosphoSitePlusiQ86YJ7

Expressioni

Gene expression databases

BgeeiENSG00000198720
CleanExiHS_ANKRD13B
ExpressionAtlasiQ86YJ7 baseline and differential
GenevisibleiQ86YJ7 HS

Organism-specific databases

HPAiHPA051886
HPA063748

Interactioni

Subunit structurei

Interacts with EGFR (ubiquitinated); the interaction is direct and may regulate EGFR internalization.1 Publication

Protein-protein interaction databases

BioGridi125900, 10 interactors
IntActiQ86YJ7, 5 interactors
STRINGi9606.ENSP00000378328

Structurei

3D structure databases

ProteinModelPortaliQ86YJ7
SMRiQ86YJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 76ANK 1Add BLAST30
Repeati80 – 109ANK 2Add BLAST30
Domaini503 – 522UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini585 – 604UIM 2PROSITE-ProRule annotationAdd BLAST20
Domaini610 – 626UIM 3PROSITE-ProRule annotationAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi445 – 472Ser-richAdd BLAST28

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0522 Eukaryota
ENOG410XNMS LUCA
GeneTreeiENSGT00410000025381
HOGENOMiHOG000230821
HOVERGENiHBG059287
InParanoidiQ86YJ7
KOiK21437
OMAiCNATYEH
OrthoDBiEOG091G0JTJ
PhylomeDBiQ86YJ7
TreeFamiTF314176

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR021832 ANKRD13
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR003903 UIM_dom
PANTHERiPTHR12447 PTHR12447, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF11904 GPCR_chapero_1, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00726 UIM, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50330 UIM, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86YJ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPANASARK GPEGKYPLHY LVWHNRHREL EKEVRAGQVD IEQLDPRGRT
60 70 80 90 100
PLHLATTLGH LECARVLLAH GADVGRENRS GWTVLQEAVS TRDLELVQLV
110 120 130 140 150
LRYRDYQRVV KRLAGIPVLL EKLRKAQDFY VEMKWEFTSW VPLVSKICPS
160 170 180 190 200
DTYKVWKSGQ NLRVDTTLLG FDHMTWQRGN RSFVFRGQDT SAVVMEIDHD
210 220 230 240 250
RRVVYTETLA LAGQDRELLL AAAQPTEEQV LSRLTAPVVT TQLDTKNISF
260 270 280 290 300
ERNKTGILGW RSEKTEMVNG YEAKVYGASN VELITRTRTE HLSEQHKGKV
310 320 330 340 350
KGCKTPLQSF LGIAEQHGGP QNGTLITQTL SQANPTAITA EEYFNPNFEL
360 370 380 390 400
GNRDMGRPME LTTKTQKFKA KLWLCEEHPL SLCEQVAPII DLMAVSNALF
410 420 430 440 450
AKLRDFITLR LPPGFPVKIE IPIFHILNAR ITFGNLNGCD EPVPSVRGSP
460 470 480 490 500
SSETPSPGSD SSSVSSSSST TSCRGCEISP ALFEAPRGYS MMGGQREAAT
510 520 530 540 550
RDDDDDLLQF AIQQSLLEAG SEYDQVTIWE ALTNSKPGTH PMSYEGRRQD
560 570 580 590 600
RSAPPTPQRQ PAPPASVPSP RPSSGPGSGG HVFRSYDEQL RLAMELSAQE
610 620
QEERRRRARQ EEEELERILR LSLTEQ
Length:626
Mass (Da):70,205
Last modified:November 24, 2009 - v4
Checksum:i8807A784A21F395C
GO
Isoform 2 (identifier: Q86YJ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: No experimental confirmation available.
Show »
Length:494
Mass (Da):55,056
Checksum:i38961D1F8493EE0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126A → P in AAH32554 (PubMed:15489334).Curated1
Sequence conflicti295Q → H in AAH32554 (PubMed:15489334).Curated1
Sequence conflicti304K → E in BAC05148 (PubMed:14702039).Curated1
Sequence conflicti332Q → R in BAC05148 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0194041 – 132Missing in isoform 2. 1 PublicationAdd BLAST132

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097716 mRNA Translation: BAC05148.1
AC104564 Genomic DNA No translation available.
BC032554 mRNA Translation: AAH32554.3
CCDSiCCDS11251.1 [Q86YJ7-1]
RefSeqiNP_689558.4, NM_152345.4 [Q86YJ7-1]
UniGeneiHs.662164

Genome annotation databases

EnsembliENST00000394859; ENSP00000378328; ENSG00000198720 [Q86YJ7-1]
ENST00000488766; ENSP00000431958; ENSG00000198720 [Q86YJ7-1]
ENST00000614878; ENSP00000481530; ENSG00000198720 [Q86YJ7-1]
GeneIDi124930
KEGGihsa:124930
UCSCiuc002hei.4 human [Q86YJ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAN13B_HUMAN
AccessioniPrimary (citable) accession number: Q86YJ7
Secondary accession number(s): Q8N7S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 24, 2009
Last modified: March 28, 2018
This is version 118 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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