Reviewed, UniProtKB/Swiss-Prot Q86YJ7 (AN13B_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 13B

Gene names

Name:

ANKRD13B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 2 ANK repeats. Contains 3 UIM (ubiquitin-interacting motif) repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86YJ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86YJ7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 626	626	Ankyrin repeat domain-containing protein 13B		PRO_0000240643
Regions
	Repeat	47 – 76	30	ANK 1
	Repeat	80 – 109	30	ANK 2
	Repeat	503 – 522	20	UIM 1
	Repeat	585 – 604	20	UIM 2
	Repeat	610 – 626	17	UIM 3
	Compositional bias	445 – 472	28	Ser-rich
Natural variations
	Alternative sequence	1 – 132	132	Missing in isoform 2.		VSP_019404
Experimental info
	Sequence conflict	126	1	A → P in AAH32554. Ref.3
	Sequence conflict	295	1	Q → H in AAH32554. Ref.3
	Sequence conflict	304	1	K → E in BAC05148. Ref.1
	Sequence conflict	332	1	Q → R in BAC05148. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 24, 2009. Version 4. Checksum: 8807A784A21F395C	FASTA	626	70,205
	10 20 30 40 50 60 MIPANASARK GPEGKYPLHY LVWHNRHREL EKEVRAGQVD IEQLDPRGRT PLHLATTLGH 70 80 90 100 110 120 LECARVLLAH GADVGRENRS GWTVLQEAVS TRDLELVQLV LRYRDYQRVV KRLAGIPVLL 130 140 150 160 170 180 EKLRKAQDFY VEMKWEFTSW VPLVSKICPS DTYKVWKSGQ NLRVDTTLLG FDHMTWQRGN 190 200 210 220 230 240 RSFVFRGQDT SAVVMEIDHD RRVVYTETLA LAGQDRELLL AAAQPTEEQV LSRLTAPVVT 250 260 270 280 290 300 TQLDTKNISF ERNKTGILGW RSEKTEMVNG YEAKVYGASN VELITRTRTE HLSEQHKGKV 310 320 330 340 350 360 KGCKTPLQSF LGIAEQHGGP QNGTLITQTL SQANPTAITA EEYFNPNFEL GNRDMGRPME 370 380 390 400 410 420 LTTKTQKFKA KLWLCEEHPL SLCEQVAPII DLMAVSNALF AKLRDFITLR LPPGFPVKIE 430 440 450 460 470 480 IPIFHILNAR ITFGNLNGCD EPVPSVRGSP SSETPSPGSD SSSVSSSSST TSCRGCEISP 490 500 510 520 530 540 ALFEAPRGYS MMGGQREAAT RDDDDDLLQF AIQQSLLEAG SEYDQVTIWE ALTNSKPGTH 550 560 570 580 590 600 PMSYEGRRQD RSAPPTPQRQ PAPPASVPSP RPSSGPGSGG HVFRSYDEQL RLAMELSAQE 610 620 QEERRRRARQ EEEELERILR LSLTEQ
	Isoform 2. Checksum: 38961D1F8493EE0F	FASTA	494	55,056
	10 20 30 40 50 60 MKWEFTSWVP LVSKICPSDT YKVWKSGQNL RVDTTLLGFD HMTWQRGNRS FVFRGQDTSA 70 80 90 100 110 120 VVMEIDHDRR VVYTETLALA GQDRELLLAA AQPTEEQVLS RLTAPVVTTQ LDTKNISFER 130 140 150 160 170 180 NKTGILGWRS EKTEMVNGYE AKVYGASNVE LITRTRTEHL SEQHKGKVKG CKTPLQSFLG 190 200 210 220 230 240 IAEQHGGPQN GTLITQTLSQ ANPTAITAEE YFNPNFELGN RDMGRPMELT TKTQKFKAKL 250 260 270 280 290 300 WLCEEHPLSL CEQVAPIIDL MAVSNALFAK LRDFITLRLP PGFPVKIEIP IFHILNARIT 310 320 330 340 350 360 FGNLNGCDEP VPSVRGSPSS ETPSPGSDSS SVSSSSSTTS CRGCEISPAL FEAPRGYSMM 370 380 390 400 410 420 GGQREAATRD DDDDLLQFAI QQSLLEAGSE YDQVTIWEAL TNSKPGTHPM SYEGRRQDRS 430 440 450 460 470 480 APPTPQRQPA PPASVPSPRP SSGPGSGGHV FRSYDEQLRL AMELSAQEQE ERRRRARQEE 490 EELERILRLS LTEQ

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK097716 mRNA. Translation: BAC05148.1. AC104564 Genomic DNA. No translation available. BC032554 mRNA. Translation: AAH32554.3.
IPI	IPI00167305. IPI00760874.
UniGene	Hs.662164
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86YJ7. 1 interaction.
Proteomic databases
PRIDE	Q86YJ7.
Genome annotation databases
Ensembl	ENST00000394859; ENSP00000378328; ENSG00000198720; Homo sapiens. [Genome view]
UCSC	uc002heh.1. human.
Organism-specific databases
GeneCards	GC17P024945.
HGNC	HGNC:26363. ANKRD13B.
PharmGKB	PA142672616.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q86YJ7.
HOVERGEN	Q86YJ7.
Gene expression databases
ArrayExpress	Q86YJ7.
Bgee	Q86YJ7.
CleanEx	HS_ANKRD13B.
Genevestigator	Q86YJ7.
GermOnline	ENSG00000198720. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR003903. Ubiquitin-int_motif. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 3 hits. PF02809. UIM. 3 hits. [Graphical view]
SMART	SM00248. ANK. 3 hits. SM00726. UIM. 2 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. PS50330. UIM. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AN13B_HUMAN

Accession

Primary (citable) accession number: Q86YJ7
Secondary accession number(s): Q8N7S9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 24, 2009
Last modified:	November 24, 2009
This is version 48 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.