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Protein

Threonine synthase-like 2

Gene

THNSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).By similarity
Isoform SOFAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.1 Publication

Cofactori

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • lyase activity Source: UniProtKB-KW
  • pyridoxal phosphate binding Source: BHF-UCL
  • serine binding Source: BHF-UCL

GO - Biological processi

  • 2-oxobutyrate biosynthetic process Source: BHF-UCL
  • dephosphorylation Source: BHF-UCL
  • serine family amino acid catabolic process Source: BHF-UCL

Keywordsi

Molecular functionCytokine, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

SignaLinkiQ86YJ6.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase-like 2 (EC:4.2.3.-)
Short name:
TSH2
Alternative name(s):
Secreted osteoclastogenic factor of activated T-cells
Short name:
SOFAT
Gene namesi
Name:THNSL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144115.16.
HGNCiHGNC:25602. THNSL2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55258.
OpenTargetsiENSG00000144115.
PharmGKBiPA162405692.

Polymorphism and mutation databases

BioMutaiTHNSL2.
DMDMi313104279.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003064071 – 484Threonine synthase-like 2Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

EPDiQ86YJ6.
MaxQBiQ86YJ6.
PaxDbiQ86YJ6.
PeptideAtlasiQ86YJ6.
PRIDEiQ86YJ6.

PTM databases

PhosphoSitePlusiQ86YJ6.

Expressioni

Gene expression databases

BgeeiENSG00000144115.
CleanExiHS_THNSL2.
ExpressionAtlasiQ86YJ6. baseline and differential.
GenevisibleiQ86YJ6. HS.

Organism-specific databases

HPAiHPA035395.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120549. 1 interactor.
IntActiQ86YJ6. 2 interactors.
MINTiMINT-1391634.
STRINGi9606.ENSP00000327323.

Structurei

3D structure databases

ProteinModelPortaliQ86YJ6.
SMRiQ86YJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiKOG2616. Eukaryota.
COG0498. LUCA.
GeneTreeiENSGT00530000063879.
HOVERGENiHBG108568.
InParanoidiQ86YJ6.
OMAiDIFILHP.
OrthoDBiEOG091G08UM.
PhylomeDBiQ86YJ6.
TreeFamiTF329641.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiView protein in InterPro
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase-like.
IPR001926. TrpB-like_PLP-dep.
PfamiView protein in Pfam
PF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86YJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWYVSTRGVA PRVNFEGALF SGYAPDGGLF MPEELPQLDR GTLCQWSTLS
60 70 80 90 100
YPGLVKELCA LFIGSELLPK DELNDLIDRA FSRFRHREVV HLSRLRNGLN
110 120 130 140 150
VLELWHGVTY AFKDLSLSCT TQFLQYFLEK REKHVTVVVG TSGDTGSAAI
160 170 180 190 200
ESVQGAKNMD IIVLLPKGHC TKIQELQMTT VLKQNVHVFG VEGNSDELDE
210 220 230 240 250
PIKTVFADVA FVKKHNLMSL NSINWSRVLV QMAHHFFAYF QCTPSLDTHP
260 270 280 290 300
LPLVEVVVPT GAAGNLAAGY IAQKIGLPIR LVVAVNRNDI IHRTVQQGDF
310 320 330 340 350
SLSEAVKSTL ASAMDIQVPY NMERVFWLLS GSDSQVTRAL MEQFERTQSV
360 370 380 390 400
NLPKELHSKL SEAVTSVSVS DEAITQTMGR CWDENQYLLC PHSAVAVNYH
410 420 430 440 450
YQQIDRQQPS TPRCCLAPAS AAKFPEAVLA AGLTPETPAE IVALEHKETR
460 470 480
CTLMRRGDNW MLMLRDTIED LSRQWRSHAL NTSQ
Length:484
Mass (Da):54,116
Last modified:November 30, 2010 - v3
Checksum:iF177B2B7DE6E8752
GO
Isoform 2 (identifier: Q86YJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-484: LSEAVTSVSV...WRSHALNTSQ → WERQDYEKMA...PGTAMVRGGG

Note: No experimental confirmation available.
Show »
Length:405
Mass (Da):45,037
Checksum:i5A2B03980DD1B3ED
GO
Isoform 3 (identifier: Q86YJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-484: LSEAVTSVSV...WRSHALNTSQ → HSPVLPRPCLCSQVPGSCPGCWPDP

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):42,718
Checksum:iBE36DE86123D5733
GO
Isoform 4 (identifier: Q86YJ6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-274: Missing.

Note: No experimental confirmation available.
Show »
Length:423
Mass (Da):47,428
Checksum:i14A1A6D8308BC93F
GO
Isoform SOFAT (identifier: Q86YJ6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.
     360-484: LSEAVTSVSV...WRSHALNTSQ → WERQDYEKMA...PGTAMVRGGD

Show »
Length:247
Mass (Da):27,414
Checksum:i0124469439FCFD9D
GO

Sequence cautioni

The sequence AAX88906 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91904 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63I → V in BAA91904 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05463541G → E2 PublicationsCorresponds to variant dbSNP:rs4129190Ensembl.1
Natural variantiVAR_054636108V → I. Corresponds to variant dbSNP:rs35541720Ensembl.1
Natural variantiVAR_054637204T → N. Corresponds to variant dbSNP:rs34136143Ensembl.1
Natural variantiVAR_054638324R → G1 PublicationCorresponds to variant dbSNP:rs17855905Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0416591 – 158Missing in isoform SOFAT. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_028468214 – 274Missing in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_028469360 – 484LSEAV…LNTSQ → WERQDYEKMAVMECDGCCVE LCLGNCGPRRGSVTDIPGTA MVRGGG in isoform 2. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_028470360 – 484LSEAV…LNTSQ → HSPVLPRPCLCSQVPGSCPG CWPDP in isoform 3. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_041660360 – 484LSEAV…LNTSQ → WERQDYEKMAVMECDGCCVE LCLGNCGPRRGSVTDIPGTA MVRGGD in isoform SOFAT. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM185274 mRNA. Translation: ADL14696.1.
AK001778 mRNA. Translation: BAA91904.1. Different initiation.
AK095303 mRNA. Translation: BAG53023.1.
AC092836 Genomic DNA. Translation: AAX88906.1. Sequence problems.
BC035315 mRNA. Translation: AAH35315.1.
BC047758 mRNA. Translation: AAH47758.2.
BC064423 mRNA. Translation: AAH64423.1.
CCDSiCCDS2002.2. [Q86YJ6-1]
CCDS58718.1. [Q86YJ6-2]
RefSeqiNP_001231605.1. NM_001244676.1. [Q86YJ6-2]
NP_060741.3. NM_018271.4. [Q86YJ6-1]
XP_005264457.1. XM_005264400.4. [Q86YJ6-1]
XP_005264458.1. XM_005264401.4. [Q86YJ6-1]
XP_005264460.1. XM_005264403.4. [Q86YJ6-3]
XP_006712106.1. XM_006712043.2. [Q86YJ6-2]
UniGeneiHs.739080.
Hs.740434.

Genome annotation databases

EnsembliENST00000324166; ENSP00000327323; ENSG00000144115. [Q86YJ6-1]
ENST00000343544; ENSP00000339563; ENSG00000144115. [Q86YJ6-2]
GeneIDi55258.
KEGGihsa:55258.
UCSCiuc002ssw.5. human. [Q86YJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTHNS2_HUMAN
AccessioniPrimary (citable) accession number: Q86YJ6
Secondary accession number(s): B3KTB1
, B5MDX8, B7WPF8, D9ZZB8, Q6P2M7, Q6PI27, Q9NV54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 30, 2010
Last modified: September 27, 2017
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families