Q86YH7 (Q86YH7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
HDAC4 protein EMBL AAH39904.1

Submitted name:
Histone deacetylase 4, isoform CRA_a EMBL EAW71165.1

Gene names

Name:	HDAC4 EMBL EAW71165.1
ORF Names:	hCG_22188 EMBL EAW71165.1

Organism

Homo sapiens (Human) EMBL AAH39904.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	972 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Hydrolase SAAS SAAS000286
Gene Ontology (GO)
Biological_process	histone deacetylation Inferred from electronic annotation. Source: GOC
Cellular_component	histone deacetylase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	histone deacetylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q86YH7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 86E58F178B37FDC6	FASTA	972	106,367
	10 20 30 40 50 60 MLAMKHQQEL LEHQRKLERH RQEQELEKQH REQKLQQLKN KEKGKESAVA STEVKMKLQE 70 80 90 100 110 120 FVLNKKKALA HRNLNHCISS DPRYWYGKTQ HSSLDQSSPP QSGVSTSYNH PVLGMYDAKD 130 140 150 160 170 180 DFPLRKTASE PNLKLRSRLK QKVAERRSSP LLRRKDGPVV TALKKRPLDV TDSACSSAPG 190 200 210 220 230 240 SGPSSPNNSS GSVSAENGIA PAVPSIPAET SLAHRLVARE GSAAPLPLYT SPSLPNITLG 250 260 270 280 290 300 LPATGPSAGT AGQQDAERLT LPALQQRLSL FPGTHLTPYL STSPLERDGG AAHSPLLQHM 310 320 330 340 350 360 VLLEQPPAQA PLVTDWYLSG LGALPLHAQS LVGADRVSPS IHKLRQHRPL GRTQSAPLPQ 370 380 390 400 410 420 NAQALQHLVI QQQHQQFLEK HKQQFQQQQL QMNKIIPKPS EPARQPESHP EETEEELREH 430 440 450 460 470 480 QALLDEPYLD RLPGQKEAHA QAGVQVKQEP IESDEEEAEP PREVEPGQRQ PSEQELLFRQ 490 500 510 520 530 540 QALLLEQQRI HQLRNYQASM EAAGIPVSFG GHRPLSRAQS SPASATFPVS VQEPPTKPRF 550 560 570 580 590 600 TTGLVYDTLM LKHQCTCGSS SSHPEHAGRI QSIWSRLQET GLRGKCECIR GRKATLEELQ 610 620 630 640 650 660 TVHSEAHTLL YGTNPLNRQK LDSKKLLGSL ASVFVRLPCG GVGVDSDTIW NEVHSAGAAR 670 680 690 700 710 720 LAVGCVVELV FKVATGELKN GFAVVRPPGH HAEESTPMGF CYFNSVAVAA KLLQQRLSVS 730 740 750 760 770 780 KILIVDWDVH HGNGTQQAFY SDPSVLYMSL HRYDDGNFFP GSGAPDEVGT GPGVGFNVNM 790 800 810 820 830 840 AFTGGLDPPM GDAEYLAAFR TVVMPIASEF APDVVLVSSG FDAVEGHPTP LGGYNLSARC 850 860 870 880 890 900 FGYLTKQLMG LAGGRIVLAL EGGHDLTAIC DASEACVSAL LGNELDPLPE KVLQQRPNAN 910 920 930 940 950 960 AVRSMEKVME IHSKYWRCLQ RTTSTAGRSL IEAQTCENEE AETVTAMASL SVGVKPAEKR 970 PDEEPMEEEP PL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis EMBL AAH39904.1.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC039904 mRNA. Translation: AAH39904.1. CH471063 Genomic DNA. Translation: EAW71165.1.
IPI	IPI01014711.
RefSeq	NP_006028.2. NM_006037.3.
UniGene	Hs.20516.
3D structure databases
ProteinModelPortal	Q86YH7.
SMR	Q86YH7. Positions 538-939.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9759.
KEGG	hsa:9759.
Organism-specific databases
CTD	9759.
PharmGKB	PA29229.
Phylogenomic databases
HOVERGEN	HBG057100.
KO	K11406.
Family and domain databases
Gene3D	3.40.800.20. 1 hit.
InterPro	IPR019154. Arb2_domain. IPR000286. His_deacetylse. IPR023801. His_deacetylse_dom. IPR024643. Hist_deacetylase_Gln_rich_N. IPR017320. Histone_deAcase_II_euk. [Graphical view]
PANTHER	PTHR10625. PTHR10625. 1 hit.
Pfam	PF09757. Arb2. 1 hit. PF12203. HDAC4_Gln. 1 hit. PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037911. HDAC_II_euk. 1 hit.
PRINTS	PR01270. HDASUPER.
ProtoNet	Search...
Other
GenomeRNAi	9759.
NextBio	36731.

Entry information

Entry name

Q86YH7_HUMAN

Accession

Primary (citable) accession number: Q86YH7
Secondary accession number(s): E9PGB9

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.