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Q86YH7

- Q86YH7_HUMAN

UniProt

Q86YH7 - Q86YH7_HUMAN

Protein
Submitted name:

HDAC4 protein

Gene

HDAC4

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. histone deacetylase activity Source: InterPro

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HDAC4 proteinImported
    Submitted name:
    Histone deacetylase 4, isoform CRA_aImported
    Gene namesi
    Name:HDAC4Imported
    ORF Names:hCG_22188Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. histone deacetylase complex Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29229.

    Structurei

    3D structure databases

    SMRiQ86YH7. Positions 538-939.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG057100.
    KOiK11406.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR019154. Arb2_domain.
    IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF09757. Arb2. 1 hit.
    PF12203. HDAC4_Gln. 1 hit.
    PF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q86YH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAMKHQQEL LEHQRKLERH RQEQELEKQH REQKLQQLKN KEKGKESAVA    50
    STEVKMKLQE FVLNKKKALA HRNLNHCISS DPRYWYGKTQ HSSLDQSSPP 100
    QSGVSTSYNH PVLGMYDAKD DFPLRKTASE PNLKLRSRLK QKVAERRSSP 150
    LLRRKDGPVV TALKKRPLDV TDSACSSAPG SGPSSPNNSS GSVSAENGIA 200
    PAVPSIPAET SLAHRLVARE GSAAPLPLYT SPSLPNITLG LPATGPSAGT 250
    AGQQDAERLT LPALQQRLSL FPGTHLTPYL STSPLERDGG AAHSPLLQHM 300
    VLLEQPPAQA PLVTDWYLSG LGALPLHAQS LVGADRVSPS IHKLRQHRPL 350
    GRTQSAPLPQ NAQALQHLVI QQQHQQFLEK HKQQFQQQQL QMNKIIPKPS 400
    EPARQPESHP EETEEELREH QALLDEPYLD RLPGQKEAHA QAGVQVKQEP 450
    IESDEEEAEP PREVEPGQRQ PSEQELLFRQ QALLLEQQRI HQLRNYQASM 500
    EAAGIPVSFG GHRPLSRAQS SPASATFPVS VQEPPTKPRF TTGLVYDTLM 550
    LKHQCTCGSS SSHPEHAGRI QSIWSRLQET GLRGKCECIR GRKATLEELQ 600
    TVHSEAHTLL YGTNPLNRQK LDSKKLLGSL ASVFVRLPCG GVGVDSDTIW 650
    NEVHSAGAAR LAVGCVVELV FKVATGELKN GFAVVRPPGH HAEESTPMGF 700
    CYFNSVAVAA KLLQQRLSVS KILIVDWDVH HGNGTQQAFY SDPSVLYMSL 750
    HRYDDGNFFP GSGAPDEVGT GPGVGFNVNM AFTGGLDPPM GDAEYLAAFR 800
    TVVMPIASEF APDVVLVSSG FDAVEGHPTP LGGYNLSARC FGYLTKQLMG 850
    LAGGRIVLAL EGGHDLTAIC DASEACVSAL LGNELDPLPE KVLQQRPNAN 900
    AVRSMEKVME IHSKYWRCLQ RTTSTAGRSL IEAQTCENEE AETVTAMASL 950
    SVGVKPAEKR PDEEPMEEEP PL 972
    Length:972
    Mass (Da):106,367
    Last modified:June 1, 2003 - v1
    Checksum:i86E58F178B37FDC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC039904 mRNA. Translation: AAH39904.1.
    CH471063 Genomic DNA. Translation: EAW71165.1.
    RefSeqiNP_006028.2. NM_006037.3.
    UniGeneiHs.20516.

    Genome annotation databases

    GeneIDi9759.
    KEGGihsa:9759.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC039904 mRNA. Translation: AAH39904.1 .
    CH471063 Genomic DNA. Translation: EAW71165.1 .
    RefSeqi NP_006028.2. NM_006037.3.
    UniGenei Hs.20516.

    3D structure databases

    SMRi Q86YH7. Positions 538-939.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9759.
    KEGGi hsa:9759.

    Organism-specific databases

    CTDi 9759.
    PharmGKBi PA29229.

    Phylogenomic databases

    HOVERGENi HBG057100.
    KOi K11406.

    Miscellaneous databases

    GenomeRNAii 9759.
    NextBioi 36731.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR019154. Arb2_domain.
    IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF09757. Arb2. 1 hit.
    PF12203. HDAC4_Gln. 1 hit.
    PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ86YH7_HUMAN
    AccessioniPrimary (citable) accession number: Q86YH7
    Secondary accession number(s): E9PGB9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.