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Q86YH7

- Q86YH7_HUMAN

UniProt

Q86YH7 - Q86YH7_HUMAN

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Protein
Submitted name:

HDAC4 protein

Gene

HDAC4

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi555 – 5551ZincUniRule annotation
Metal bindingi557 – 5571ZincUniRule annotation
Metal bindingi563 – 5631ZincUniRule annotation
Metal bindingi639 – 6391ZincUniRule annotation
Active sitei691 – 6911UniRule annotation

GO - Molecular functioni

  1. core promoter binding Source: Ensembl
  2. histone deacetylase activity Sources: Ensembl, InterPro
  3. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. negative regulation of cell proliferation Source: Ensembl
  2. negative regulation of glycolytic process Source: Ensembl
  3. negative regulation of osteoblast differentiation Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. osteoblast development Source: Ensembl
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. regulation of cardiac muscle contraction by calcium ion signaling Source: Ensembl
  8. regulation of skeletal muscle fiber development Source: Ensembl
  9. response to denervation involved in regulation of muscle adaptation Source: Ensembl
  10. response to drug Source: Ensembl
  11. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
HDAC4 proteinImported
Submitted name:
Histone deacetylase 4Imported
Submitted name:
Histone deacetylase 4, isoform CRA_aImported
Gene namesi
Name:HDAC4Imported
ORF Names:hCG_22188Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:14063. HDAC4.

Subcellular locationi

GO - Cellular componenti

  1. A band Source: Ensembl
  2. actomyosin Source: Ensembl
  3. cytosol Source: Ensembl
  4. histone deacetylase complex Source: InterPro
  5. neuromuscular junction Source: Ensembl
  6. nucleus Source: Ensembl
  7. protein complex Source: Ensembl
  8. Z disc Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29229.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
HOVERGENiHBG057100.
KOiK11406.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR019154. Arb2_domain.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF09757. Arb2. 1 hit.
PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q86YH7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAMKHQQEL LEHQRKLERH RQEQELEKQH REQKLQQLKN KEKGKESAVA
60 70 80 90 100
STEVKMKLQE FVLNKKKALA HRNLNHCISS DPRYWYGKTQ HSSLDQSSPP
110 120 130 140 150
QSGVSTSYNH PVLGMYDAKD DFPLRKTASE PNLKLRSRLK QKVAERRSSP
160 170 180 190 200
LLRRKDGPVV TALKKRPLDV TDSACSSAPG SGPSSPNNSS GSVSAENGIA
210 220 230 240 250
PAVPSIPAET SLAHRLVARE GSAAPLPLYT SPSLPNITLG LPATGPSAGT
260 270 280 290 300
AGQQDAERLT LPALQQRLSL FPGTHLTPYL STSPLERDGG AAHSPLLQHM
310 320 330 340 350
VLLEQPPAQA PLVTDWYLSG LGALPLHAQS LVGADRVSPS IHKLRQHRPL
360 370 380 390 400
GRTQSAPLPQ NAQALQHLVI QQQHQQFLEK HKQQFQQQQL QMNKIIPKPS
410 420 430 440 450
EPARQPESHP EETEEELREH QALLDEPYLD RLPGQKEAHA QAGVQVKQEP
460 470 480 490 500
IESDEEEAEP PREVEPGQRQ PSEQELLFRQ QALLLEQQRI HQLRNYQASM
510 520 530 540 550
EAAGIPVSFG GHRPLSRAQS SPASATFPVS VQEPPTKPRF TTGLVYDTLM
560 570 580 590 600
LKHQCTCGSS SSHPEHAGRI QSIWSRLQET GLRGKCECIR GRKATLEELQ
610 620 630 640 650
TVHSEAHTLL YGTNPLNRQK LDSKKLLGSL ASVFVRLPCG GVGVDSDTIW
660 670 680 690 700
NEVHSAGAAR LAVGCVVELV FKVATGELKN GFAVVRPPGH HAEESTPMGF
710 720 730 740 750
CYFNSVAVAA KLLQQRLSVS KILIVDWDVH HGNGTQQAFY SDPSVLYMSL
760 770 780 790 800
HRYDDGNFFP GSGAPDEVGT GPGVGFNVNM AFTGGLDPPM GDAEYLAAFR
810 820 830 840 850
TVVMPIASEF APDVVLVSSG FDAVEGHPTP LGGYNLSARC FGYLTKQLMG
860 870 880 890 900
LAGGRIVLAL EGGHDLTAIC DASEACVSAL LGNELDPLPE KVLQQRPNAN
910 920 930 940 950
AVRSMEKVME IHSKYWRCLQ RTTSTAGRSL IEAQTCENEE AETVTAMASL
960 970
SVGVKPAEKR PDEEPMEEEP PL
Length:972
Mass (Da):106,367
Last modified:June 1, 2003 - v1
Checksum:i86E58F178B37FDC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC017028 Genomic DNA. No translation available.
AC062017 Genomic DNA. No translation available.
KF510800 Genomic DNA. No translation available.
KF510801 Genomic DNA. No translation available.
BC039904 mRNA. Translation: AAH39904.1.
CH471063 Genomic DNA. Translation: EAW71165.1.
RefSeqiNP_006028.2. NM_006037.3.
UniGeneiHs.20516.

Genome annotation databases

EnsembliENST00000543185; ENSP00000440481; ENSG00000068024.
GeneIDi9759.
KEGGihsa:9759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC017028 Genomic DNA. No translation available.
AC062017 Genomic DNA. No translation available.
KF510800 Genomic DNA. No translation available.
KF510801 Genomic DNA. No translation available.
BC039904 mRNA. Translation: AAH39904.1 .
CH471063 Genomic DNA. Translation: EAW71165.1 .
RefSeqi NP_006028.2. NM_006037.3.
UniGenei Hs.20516.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000543185 ; ENSP00000440481 ; ENSG00000068024 .
GeneIDi 9759.
KEGGi hsa:9759.

Organism-specific databases

CTDi 9759.
HGNCi HGNC:14063. HDAC4.
PharmGKBi PA29229.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000062809.
HOVERGENi HBG057100.
KOi K11406.

Miscellaneous databases

GenomeRNAii 9759.
NextBioi 35507317.
36731.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR019154. Arb2_domain.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF09757. Arb2. 1 hit.
PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ86YH7_HUMAN
AccessioniPrimary (citable) accession number: Q86YH7
Secondary accession number(s): E9PGB9, F5GX36
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3