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Protein

Zinc finger protein 280B

Gene

ZNF280B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri343 – 366C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri373 – 396C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri432 – 454C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 483C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32846-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 280B
Alternative name(s):
5'OY11.1
Suppressor of hairy wing homolog 2
Zinc finger protein 279
Zinc finger protein 632
Gene namesi
Name:ZNF280B
Synonyms:SUHW2, ZNF279, ZNF632
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:23022. ZNF280B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi140883.
PharmGKBiPA162409948.

Polymorphism and mutation databases

BioMutaiZNF280B.
DMDMi313104081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470561 – 543Zinc finger protein 280BAdd BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ86YH2.
MaxQBiQ86YH2.
PaxDbiQ86YH2.
PeptideAtlasiQ86YH2.
PRIDEiQ86YH2.

PTM databases

iPTMnetiQ86YH2.
PhosphoSitePlusiQ86YH2.

Expressioni

Gene expression databases

BgeeiENSG00000198477.
CleanExiHS_ZNF280B.
ExpressionAtlasiQ86YH2. baseline and differential.
GenevisibleiQ86YH2. HS.

Organism-specific databases

HPAiHPA059519.

Interactioni

Protein-protein interaction databases

BioGridi126751. 3 interactors.
STRINGi9606.ENSP00000353586.

Structurei

3D structure databases

ProteinModelPortaliQ86YH2.
SMRiQ86YH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri343 – 366C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri373 – 396C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri432 – 454C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 483C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000013047.
HOVERGENiHBG060885.
InParanoidiQ86YH2.
OrthoDBiEOG091G01UE.
PhylomeDBiQ86YH2.
TreeFamiTF331707.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86YH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQSCEEEKE PEPQKNIQET KQVDDEDAEL IFVGVEHVNE DAELIFVGVT
60 70 80 90 100
SNSKPVVSNI LNRVTPGSWS RRKKYDHLRK DTARKLQPKS HETVTSEAVT
110 120 130 140 150
VLPASQLESR STDSPIIIEP LSKPDYRNSS PQVVPNNSSE LPSPLITFTD
160 170 180 190 200
SLHHPVSTAL SVGGINESPR VSKQLSTFEV NSINPKRAKL RDGIIEGNSS
210 220 230 240 250
ASFPSDTFHT MNTQQSTPSN NVHTSLSHVQ NGAPFPAAFP KDNIHFKPIN
260 270 280 290 300
TNLDRENELA KTDILSLTSQ NKTFDPKKEN PIVLLSDFYY GQHKGEGQPE
310 320 330 340 350
QKTHTTFKCL SCVKVLKNVK FMNHVKHHLE FEKQRNDSWE NHTTCQHCHR
360 370 380 390 400
QFPTPFQLQC HIENVHTAQE PSTVCKICEL SFETDQVLLQ HMKDHHKPGE
410 420 430 440 450
MPYVCQVCHY RSSVFADVET HFRTCHENTK NLLCPFCLKI FKTATPYMCH
460 470 480 490 500
YRGHWGKSAH QCSKCRLQFL TFKEKMEHKT QCHQMFKKPK QLEGLPPETK
510 520 530 540
VTIQVSLEPL QPGSVDVASI TVSTSDSEPS LPRSKSKISK KSH
Length:543
Mass (Da):61,584
Last modified:November 30, 2010 - v2
Checksum:iF39D795E8478DAD7
GO

Sequence cautioni

The sequence BAA20005 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028013256E → A.2 PublicationsCorresponds to variant rs2236729dbSNPEnsembl.1
Natural variantiVAR_028014522V → G.Corresponds to variant rs12484816dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87009 Genomic DNA. Translation: BAA20005.1. Different initiation.
CR456614 mRNA. Translation: CAG30500.1.
BC040020 mRNA. Translation: AAH40020.1.
CCDSiCCDS13799.1.
RefSeqiNP_542942.2. NM_080764.3.
XP_011528195.1. XM_011529893.2.
XP_011528197.1. XM_011529895.2.
XP_011528198.1. XM_011529896.2.
XP_011528199.1. XM_011529897.2.
UniGeneiHs.43834.

Genome annotation databases

EnsembliENST00000613655; ENSP00000481008; ENSG00000275004.
ENST00000619852; ENSP00000480958; ENSG00000275004.
GeneIDi140883.
KEGGihsa:140883.
UCSCiuc032qhv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87009 Genomic DNA. Translation: BAA20005.1. Different initiation.
CR456614 mRNA. Translation: CAG30500.1.
BC040020 mRNA. Translation: AAH40020.1.
CCDSiCCDS13799.1.
RefSeqiNP_542942.2. NM_080764.3.
XP_011528195.1. XM_011529893.2.
XP_011528197.1. XM_011529895.2.
XP_011528198.1. XM_011529896.2.
XP_011528199.1. XM_011529897.2.
UniGeneiHs.43834.

3D structure databases

ProteinModelPortaliQ86YH2.
SMRiQ86YH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126751. 3 interactors.
STRINGi9606.ENSP00000353586.

PTM databases

iPTMnetiQ86YH2.
PhosphoSitePlusiQ86YH2.

Polymorphism and mutation databases

BioMutaiZNF280B.
DMDMi313104081.

Proteomic databases

EPDiQ86YH2.
MaxQBiQ86YH2.
PaxDbiQ86YH2.
PeptideAtlasiQ86YH2.
PRIDEiQ86YH2.

Protocols and materials databases

DNASUi140883.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000613655; ENSP00000481008; ENSG00000275004.
ENST00000619852; ENSP00000480958; ENSG00000275004.
GeneIDi140883.
KEGGihsa:140883.
UCSCiuc032qhv.2. human.

Organism-specific databases

CTDi140883.
DisGeNETi140883.
GeneCardsiZNF280B.
HGNCiHGNC:23022. ZNF280B.
HPAiHPA059519.
neXtProtiNX_Q86YH2.
PharmGKBiPA162409948.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000013047.
HOVERGENiHBG060885.
InParanoidiQ86YH2.
OrthoDBiEOG091G01UE.
PhylomeDBiQ86YH2.
TreeFamiTF331707.

Enzyme and pathway databases

BioCyciZFISH:G66-32846-MONOMER.

Miscellaneous databases

GenomeRNAii140883.
PROiQ86YH2.

Gene expression databases

BgeeiENSG00000198477.
CleanExiHS_ZNF280B.
ExpressionAtlasiQ86YH2. baseline and differential.
GenevisibleiQ86YH2. HS.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ280B_HUMAN
AccessioniPrimary (citable) accession number: Q86YH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.