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Protein

Zinc finger protein 280B

Gene

ZNF280B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri343 – 36624C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39624C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48324C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 280B
Alternative name(s):
5'OY11.1
Suppressor of hairy wing homolog 2
Zinc finger protein 279
Zinc finger protein 632
Gene namesi
Name:ZNF280B
Synonyms:SUHW2, ZNF279, ZNF632
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:23022. ZNF280B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409948.

Polymorphism and mutation databases

BioMutaiZNF280B.
DMDMi313104081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Zinc finger protein 280BPRO_0000047056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ86YH2.
MaxQBiQ86YH2.
PaxDbiQ86YH2.
PRIDEiQ86YH2.

PTM databases

iPTMnetiQ86YH2.
PhosphoSiteiQ86YH2.

Expressioni

Gene expression databases

BgeeiQ86YH2.
CleanExiHS_ZNF280B.
ExpressionAtlasiQ86YH2. baseline and differential.
GenevisibleiQ86YH2. HS.

Organism-specific databases

HPAiHPA052055.

Interactioni

Protein-protein interaction databases

BioGridi126751. 3 interactions.
STRINGi9606.ENSP00000353586.

Structurei

3D structure databases

ProteinModelPortaliQ86YH2.
SMRiQ86YH2. Positions 275-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri343 – 36624C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39624C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48324C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000013047.
HOVERGENiHBG060885.
InParanoidiQ86YH2.
OrthoDBiEOG7QVM24.
PhylomeDBiQ86YH2.
TreeFamiTF331707.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86YH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQSCEEEKE PEPQKNIQET KQVDDEDAEL IFVGVEHVNE DAELIFVGVT
60 70 80 90 100
SNSKPVVSNI LNRVTPGSWS RRKKYDHLRK DTARKLQPKS HETVTSEAVT
110 120 130 140 150
VLPASQLESR STDSPIIIEP LSKPDYRNSS PQVVPNNSSE LPSPLITFTD
160 170 180 190 200
SLHHPVSTAL SVGGINESPR VSKQLSTFEV NSINPKRAKL RDGIIEGNSS
210 220 230 240 250
ASFPSDTFHT MNTQQSTPSN NVHTSLSHVQ NGAPFPAAFP KDNIHFKPIN
260 270 280 290 300
TNLDRENELA KTDILSLTSQ NKTFDPKKEN PIVLLSDFYY GQHKGEGQPE
310 320 330 340 350
QKTHTTFKCL SCVKVLKNVK FMNHVKHHLE FEKQRNDSWE NHTTCQHCHR
360 370 380 390 400
QFPTPFQLQC HIENVHTAQE PSTVCKICEL SFETDQVLLQ HMKDHHKPGE
410 420 430 440 450
MPYVCQVCHY RSSVFADVET HFRTCHENTK NLLCPFCLKI FKTATPYMCH
460 470 480 490 500
YRGHWGKSAH QCSKCRLQFL TFKEKMEHKT QCHQMFKKPK QLEGLPPETK
510 520 530 540
VTIQVSLEPL QPGSVDVASI TVSTSDSEPS LPRSKSKISK KSH
Length:543
Mass (Da):61,584
Last modified:November 30, 2010 - v2
Checksum:iF39D795E8478DAD7
GO

Sequence cautioni

The sequence BAA20005.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti256 – 2561E → A.2 Publications
Corresponds to variant rs2236729 [ dbSNP | Ensembl ].
VAR_028013
Natural varianti522 – 5221V → G.
Corresponds to variant rs12484816 [ dbSNP | Ensembl ].
VAR_028014

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87009 Genomic DNA. Translation: BAA20005.1. Different initiation.
CR456614 mRNA. Translation: CAG30500.1.
BC040020 mRNA. Translation: AAH40020.1.
CCDSiCCDS13799.1.
RefSeqiNP_542942.2. NM_080764.3.
XP_011528195.1. XM_011529893.1.
XP_011528196.1. XM_011529894.1.
XP_011528197.1. XM_011529895.1.
XP_011528198.1. XM_011529896.1.
XP_011528199.1. XM_011529897.1.
XP_011545194.1. XM_011546892.1.
XP_011545195.1. XM_011546893.1.
XP_011545196.1. XM_011546894.1.
XP_011545197.1. XM_011546895.1.
XP_011545198.1. XM_011546896.1.
UniGeneiHs.43834.

Genome annotation databases

EnsembliENST00000613655; ENSP00000481008; ENSG00000275004.
ENST00000619852; ENSP00000480958; ENSG00000275004.
GeneIDi140883.
KEGGihsa:140883.
UCSCiuc032qhv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87009 Genomic DNA. Translation: BAA20005.1. Different initiation.
CR456614 mRNA. Translation: CAG30500.1.
BC040020 mRNA. Translation: AAH40020.1.
CCDSiCCDS13799.1.
RefSeqiNP_542942.2. NM_080764.3.
XP_011528195.1. XM_011529893.1.
XP_011528196.1. XM_011529894.1.
XP_011528197.1. XM_011529895.1.
XP_011528198.1. XM_011529896.1.
XP_011528199.1. XM_011529897.1.
XP_011545194.1. XM_011546892.1.
XP_011545195.1. XM_011546893.1.
XP_011545196.1. XM_011546894.1.
XP_011545197.1. XM_011546895.1.
XP_011545198.1. XM_011546896.1.
UniGeneiHs.43834.

3D structure databases

ProteinModelPortaliQ86YH2.
SMRiQ86YH2. Positions 275-469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126751. 3 interactions.
STRINGi9606.ENSP00000353586.

PTM databases

iPTMnetiQ86YH2.
PhosphoSiteiQ86YH2.

Polymorphism and mutation databases

BioMutaiZNF280B.
DMDMi313104081.

Proteomic databases

EPDiQ86YH2.
MaxQBiQ86YH2.
PaxDbiQ86YH2.
PRIDEiQ86YH2.

Protocols and materials databases

DNASUi140883.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000613655; ENSP00000481008; ENSG00000275004.
ENST00000619852; ENSP00000480958; ENSG00000275004.
GeneIDi140883.
KEGGihsa:140883.
UCSCiuc032qhv.2. human.

Organism-specific databases

CTDi140883.
GeneCardsiZNF280B.
HGNCiHGNC:23022. ZNF280B.
HPAiHPA052055.
neXtProtiNX_Q86YH2.
PharmGKBiPA162409948.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000013047.
HOVERGENiHBG060885.
InParanoidiQ86YH2.
OrthoDBiEOG7QVM24.
PhylomeDBiQ86YH2.
TreeFamiTF331707.

Miscellaneous databases

GenomeRNAii140883.
PROiQ86YH2.

Gene expression databases

BgeeiQ86YH2.
CleanExiHS_ZNF280B.
ExpressionAtlasiQ86YH2. baseline and differential.
GenevisibleiQ86YH2. HS.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "One-megabase sequence analysis of the human immunoglobulin lambda gene locus."
    Kawasaki K., Minoshima S., Nakato E., Shibuya K., Shintani A., Schmeits J.L., Wang J., Shimizu N.
    Genome Res. 7:250-261(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-256.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-256.
    Tissue: Uterus.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZ280B_HUMAN
AccessioniPrimary (citable) accession number: Q86YH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 30, 2010
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.