ID   Q86YG3_HUMAN            Unreviewed;       468 AA.
AC   Q86YG3;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 113.
DE   SubName: Full=Similar to glutamate receptor, metabotropic 2 {ECO:0000313|EMBL:AAH41447.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH41447.1};
RN   [1] {ECO:0000313|EMBL:AAH41447.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AAH41447.1};
RA   Strausberg R.;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; BC041447; AAH41447.1; -; mRNA.
DR   AlphaFoldDB; Q86YG3; -.
DR   PeptideAtlas; Q86YG3; -.
DR   DNASU; 2912; -.
DR   PharmGKB; PA28991; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008066; F:glutamate receptor activity; IEA:UniProt.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR001458; GPCR_3_mGluR2.
DR   InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR   PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR   PANTHER; PTHR24060:SF147; METABOTROPIC GLUTAMATE RECEPTOR 2; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01052; MTABOTROPC2R.
DR   PRINTS; PR00593; MTABOTROPICR.
DR   PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
DR   Genevisible; Q86YG3; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAH41447.1};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        162..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        232..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        324..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        355..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        383..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          163..429
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAH41447.1"
SQ   SEQUENCE   468 AA;  50888 MW;  06B56DF07838FCA9 CRC64;
     SERAGAGASR PPLHSDSLRA RASAPAPFRP ADTHNEVRFD RFGDGIGRYN IFTYLRAGSG
     RYRYQKVGYW AEGLTLDTSL IPWASPSAGP LPASRCSEPC LQNEVKSVQP GEVCCWLCIP
     CQPYEYRLDE FTCADCGLGY WPNASLTGCF ELPQEYIRWG DAWAVGPVTI ACLGALATLF
     VLGVFVRHNA TPVVKASGRE LCYILLGGVF LCYCMTFIFI AKPSTAVCTL RRLGLGTAFS
     VCYSALLTKT NRIARIFGGA REGAQRPRFI SPASQVAICL ALISGQLLIV VAWLVVEAPG
     TGKETAPERR EVVTLRCNHR DASMLGSLAY NVLLIALCTL YAFKTRKCPE NFNEAKFIGF
     TMYTTCIIWL AFLPIFYVTS SDYRVQTTTM CVSVSLSGSV VLGCLFAPKL HIILFQPQKN
     VVSHRAPTSR FGSAAARASS SLGQGSGSQF VPTVCNGREV VDSTTSSL
//