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Q86YE8

- ZN573_HUMAN

UniProt

Q86YE8 - ZN573_HUMAN

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Protein
Zinc finger protein 573
Gene
ZNF573
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri134 – 15623C2H2-type 1
Add
BLAST
Zinc fingeri162 – 18423C2H2-type 2
Add
BLAST
Zinc fingeri190 – 21223C2H2-type 3
Add
BLAST
Zinc fingeri218 – 24023C2H2-type 4
Add
BLAST
Zinc fingeri246 – 26823C2H2-type 5
Add
BLAST
Zinc fingeri274 – 29623C2H2-type 6
Add
BLAST
Zinc fingeri302 – 32423C2H2-type 7
Add
BLAST
Zinc fingeri330 – 35223C2H2-type 8
Add
BLAST
Zinc fingeri358 – 38023C2H2-type 9
Add
BLAST
Zinc fingeri386 – 40823C2H2-type 10
Add
BLAST
Zinc fingeri414 – 43623C2H2-type 11
Add
BLAST
Zinc fingeri442 – 46423C2H2-type 12
Add
BLAST
Zinc fingeri470 – 49223C2H2-type 13
Add
BLAST
Zinc fingeri498 – 52023C2H2-type 14
Add
BLAST
Zinc fingeri526 – 54823C2H2-type 15
Add
BLAST
Zinc fingeri554 – 57623C2H2-type 16
Add
BLAST
Zinc fingeri582 – 60423C2H2-type 17
Add
BLAST
Zinc fingeri610 – 63223C2H2-type 18
Add
BLAST
Zinc fingeri638 – 66023C2H2-type 19
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 573
Gene namesi
Name:ZNF573
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26420. ZNF573.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134883623.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665Zinc finger protein 573
PRO_0000274877Add
BLAST

Proteomic databases

MaxQBiQ86YE8.
PaxDbiQ86YE8.
PRIDEiQ86YE8.

PTM databases

PhosphoSiteiQ86YE8.

Expressioni

Gene expression databases

ArrayExpressiQ86YE8.
BgeeiQ86YE8.
CleanExiHS_ZNF573.
GenevestigatoriQ86YE8.

Organism-specific databases

HPAiHPA042776.

Interactioni

Protein-protein interaction databases

BioGridi125967. 2 interactions.
STRINGi9606.ENSP00000340171.

Structurei

3D structure databases

ProteinModelPortaliQ86YE8.
SMRiQ86YE8. Positions 8-48, 101-640.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10073KRAB
Add
BLAST

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG018163.
InParanoidiQ86YE8.
OMAiKKTFTLY.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ86YE8.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86YE8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFPVLEPHQV GLIRSYNSKT MTCFQELVTF RDVAIDFSRQ EWEYLDPNQR    50
DLYRDVMLEN YRNLVSLGGH SISKPVVVDL LERGKEPWMI LREETQFTDL 100
DLQCEIISYI EVPTYETDIS STQLQSIYKR EKLYECKKCQ KKFSSGYQLI 150
LHHRFHVIER PYECKECGKN FRSGYQLTLH QRFHTGEKPY ECTECGKNFR 200
SGYQLTVHQR FHTGEKTYEC RQCGKAFIYA SHIVQHERIH TGGKPYECQE 250
CGRAFSQGGH LRIHQRVHTG EKPYKCKECG KTFSRRSNLV EHGQFHTDEK 300
PYICEKCGKA FRRGHQLTVH QRVHTGKKPY ECKECGKGYT TASYFLLHQR 350
IHKGGKPYEC KECKKTFTLY RNLTRHQNIH TGEKLFECKQ CGKTYTTGSK 400
LFQHQKTHTG EKPYECKECG KAFSLYGYLK QHQKIHTGMK HFECKECKKT 450
FTLYRNLTRH QNIHTGKKLF ECQECGKAYS TGSNLIQHRK THTGEKPYKC 500
KECGKTFSLH GYLNQHQKIH TGMKPYECKV CRKTFTFYRN LTLHQSIHTD 550
EKPFECKECG KTFRRSSHLT AHQSIHADKK PYECKECGKA FKMYGYLTQH 600
QKIHTGGKPY ECKECGKAFS RASNLVQHER IHTGEKPYVC KQCGKTFRYG 650
SALKAHQRIH RSIKV 665
Length:665
Mass (Da):78,181
Last modified:September 3, 2014 - v4
Checksum:iF3BC0CDF3ADD2241
GO
Isoform 2 (identifier: Q86YE8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Note: No experimental confirmation available.

Show »
Length:577
Mass (Da):67,782
Checksum:i6C4035AEC4264743
GO
Isoform 3 (identifier: Q86YE8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MFPVLEPHQV...WMILREETQF → MESCSVAQAG...SCHSLQVAGI

Note: No experimental confirmation available.

Show »
Length:607
Mass (Da):70,843
Checksum:i3D334D27E866B5EB
GO
Isoform 4 (identifier: Q86YE8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     68-98: Missing.

Note: No experimental confirmation available.

Show »
Length:578
Mass (Da):67,866
Checksum:i43E2AE3301CA6BAF
GO

Sequence cautioni

The sequence AAH42170.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti186 – 1861G → A.
Corresponds to variant rs3752365 [ dbSNP | Ensembl ].
VAR_030356
Natural varianti224 – 2241G → A.
Corresponds to variant rs3752365 [ dbSNP | Ensembl ].
VAR_057426

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797MFPVL…EETQF → MESCSVAQAGVQWPDLSSLQ PPPPRFKQFSCHSLQVAGI in isoform 3.
VSP_022894Add
BLAST
Alternative sequencei1 – 8888Missing in isoform 2.
VSP_022895Add
BLAST
Alternative sequencei1 – 5656Missing in isoform 4.
VSP_022896Add
BLAST
Alternative sequencei68 – 9831Missing in isoform 4.
VSP_022897Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti129 – 1291K → E in BAB70929. 1 Publication
Sequence conflicti329 – 3291P → L in BAB70929. 1 Publication
Sequence conflicti523 – 5231M → V in AAH15418. 1 Publication
Sequence conflicti523 – 5231M → V in AAH42170. 1 Publication
Sequence conflicti523 – 5231M → V in AAH51263. 1 Publication
Sequence conflicti523 – 5231M → V in AAH64962. 1 Publication
Sequence conflicti591 – 5911F → L in BAC11047. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055483 mRNA. Translation: BAB70929.1.
AK074539 mRNA. Translation: BAC11047.1.
AC093227 Genomic DNA. No translation available.
AC016582 Genomic DNA. No translation available.
BC015418 mRNA. Translation: AAH15418.1.
BC042170 mRNA. Translation: AAH42170.2. Different initiation.
BC051263 mRNA. Translation: AAH51263.1.
BC064962 mRNA. Translation: AAH64962.1.
CCDSiCCDS12508.1. [Q86YE8-3]
CCDS54260.1. [Q86YE8-2]
RefSeqiNP_001166160.1. NM_001172689.1. [Q86YE8-2]
NP_001166161.1. NM_001172690.1.
NP_001166162.1. NM_001172691.1.
NP_001166163.1. NM_001172692.1. [Q86YE8-2]
NP_689573.3. NM_152360.3. [Q86YE8-3]
UniGeneiHs.531262.

Genome annotation databases

EnsembliENST00000339503; ENSP00000340171; ENSG00000189144. [Q86YE8-3]
ENST00000357309; ENSP00000349861; ENSG00000189144. [Q86YE8-2]
ENST00000392138; ENSP00000375983; ENSG00000189144. [Q86YE8-4]
ENST00000536220; ENSP00000440464; ENSG00000189144. [Q86YE8-2]
ENST00000590414; ENSP00000465020; ENSG00000189144.
GeneIDi126231.
KEGGihsa:126231.
UCSCiuc002ohd.3. human. [Q86YE8-1]
uc002ohf.3. human. [Q86YE8-3]
uc010efs.2. human. [Q86YE8-4]

Polymorphism databases

DMDMi143811478.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055483 mRNA. Translation: BAB70929.1 .
AK074539 mRNA. Translation: BAC11047.1 .
AC093227 Genomic DNA. No translation available.
AC016582 Genomic DNA. No translation available.
BC015418 mRNA. Translation: AAH15418.1 .
BC042170 mRNA. Translation: AAH42170.2 . Different initiation.
BC051263 mRNA. Translation: AAH51263.1 .
BC064962 mRNA. Translation: AAH64962.1 .
CCDSi CCDS12508.1. [Q86YE8-3 ]
CCDS54260.1. [Q86YE8-2 ]
RefSeqi NP_001166160.1. NM_001172689.1. [Q86YE8-2 ]
NP_001166161.1. NM_001172690.1.
NP_001166162.1. NM_001172691.1.
NP_001166163.1. NM_001172692.1. [Q86YE8-2 ]
NP_689573.3. NM_152360.3. [Q86YE8-3 ]
UniGenei Hs.531262.

3D structure databases

ProteinModelPortali Q86YE8.
SMRi Q86YE8. Positions 8-48, 101-640.
ModBasei Search...

Protein-protein interaction databases

BioGridi 125967. 2 interactions.
STRINGi 9606.ENSP00000340171.

PTM databases

PhosphoSitei Q86YE8.

Polymorphism databases

DMDMi 143811478.

Proteomic databases

MaxQBi Q86YE8.
PaxDbi Q86YE8.
PRIDEi Q86YE8.

Protocols and materials databases

DNASUi 126231.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339503 ; ENSP00000340171 ; ENSG00000189144 . [Q86YE8-3 ]
ENST00000357309 ; ENSP00000349861 ; ENSG00000189144 . [Q86YE8-2 ]
ENST00000392138 ; ENSP00000375983 ; ENSG00000189144 . [Q86YE8-4 ]
ENST00000536220 ; ENSP00000440464 ; ENSG00000189144 . [Q86YE8-2 ]
ENST00000590414 ; ENSP00000465020 ; ENSG00000189144 .
GeneIDi 126231.
KEGGi hsa:126231.
UCSCi uc002ohd.3. human. [Q86YE8-1 ]
uc002ohf.3. human. [Q86YE8-3 ]
uc010efs.2. human. [Q86YE8-4 ]

Organism-specific databases

CTDi 126231.
GeneCardsi GC19M038229.
HGNCi HGNC:26420. ZNF573.
HPAi HPA042776.
neXtProti NX_Q86YE8.
PharmGKBi PA134883623.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOVERGENi HBG018163.
InParanoidi Q86YE8.
OMAi KKTFTLY.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q86YE8.
TreeFami TF341817.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF573. human.
GenomeRNAii 126231.
NextBioi 81726.
PROi Q86YE8.

Gene expression databases

ArrayExpressi Q86YE8.
Bgeei Q86YE8.
CleanExi HS_ZNF573.
Genevestigatori Q86YE8.

Family and domain databases

Gene3Di 3.30.160.60. 19 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Brain and Embryo.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Duodenum, Eye, Lung and Uterus.

Entry informationi

Entry nameiZN573_HUMAN
AccessioniPrimary (citable) accession number: Q86YE8
Secondary accession number(s): B7WPE1
, K7EJ45, Q6P1P1, Q7Z7Q3, Q8N2Q1, Q96BM3, Q96NH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: September 3, 2014
Last modified: September 3, 2014
This is version 106 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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