Q86YE8 (ZN573_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 573

Gene names

Name:

ZNF573

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	645 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 19 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86YE8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86YE8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q86YE8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: MTCFQELVTF...WMILREETQF → MESCSVAQAG...SCHSLQVAGI

Note: No experimental confirmation available.

Isoform 4 (identifier: Q86YE8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     48-78: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 645	645	Zinc finger protein 573		PRO_0000274877
Regions
	Domain	8 – 80	73	KRAB
	Zinc finger	114 – 136	23	C2H2-type 1
	Zinc finger	142 – 164	23	C2H2-type 2
	Zinc finger	170 – 192	23	C2H2-type 3
	Zinc finger	198 – 220	23	C2H2-type 4
	Zinc finger	226 – 248	23	C2H2-type 5
	Zinc finger	254 – 276	23	C2H2-type 6
	Zinc finger	282 – 304	23	C2H2-type 7
	Zinc finger	310 – 332	23	C2H2-type 8
	Zinc finger	338 – 360	23	C2H2-type 9
	Zinc finger	366 – 388	23	C2H2-type 10
	Zinc finger	394 – 416	23	C2H2-type 11
	Zinc finger	422 – 444	23	C2H2-type 12
	Zinc finger	450 – 472	23	C2H2-type 13
	Zinc finger	478 – 500	23	C2H2-type 14
	Zinc finger	506 – 528	23	C2H2-type 15
	Zinc finger	534 – 556	23	C2H2-type 16
	Zinc finger	562 – 584	23	C2H2-type 17
	Zinc finger	590 – 612	23	C2H2-type 18
	Zinc finger	618 – 640	23	C2H2-type 19
Natural variations
	Alternative sequence	1 – 77	77	MTCFQ…EETQF → MESCSVAQAGVQWPDLSSLQ PPPPRFKQFSCHSLQVAGI in isoform 3.		VSP_022894
	Alternative sequence	1 – 68	68	Missing in isoform 2.		VSP_022895
	Alternative sequence	1 – 36	36	Missing in isoform 4.		VSP_022896
	Alternative sequence	48 – 78	31	Missing in isoform 4.		VSP_022897
	Natural variant	166	1	G → A. Corresponds to variant rs3752365 [ dbSNP | Ensembl ].		VAR_030356
	Natural variant	204	1	G → A. Corresponds to variant rs3752365 [ dbSNP | Ensembl ].		VAR_057426
Experimental info
	Sequence conflict	109	1	K → E in BAB70929. Ref.1
	Sequence conflict	309	1	P → L in BAB70929. Ref.1
	Sequence conflict	503	1	M → V in AAH15418. Ref.3
	Sequence conflict	503	1	M → V in AAH42170. Ref.3
	Sequence conflict	503	1	M → V in AAH51263. Ref.3
	Sequence conflict	503	1	M → V in AAH64962. Ref.3
	Sequence conflict	571	1	F → L in BAC11047. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2007. Version 3. Checksum: 5340D0936CB13F5E	FASTA	645	75,883
	10 20 30 40 50 60 MTCFQELVTF RDVAIDFSRQ EWEYLDPNQR DLYRDVMLEN YRNLVSLGGH SISKPVVVDL 70 80 90 100 110 120 LERGKEPWMI LREETQFTDL DLQCEIISYI EVPTYETDIS STQLQSIYKR EKLYECKKCQ 130 140 150 160 170 180 KKFSSGYQLI LHHRFHVIER PYECKECGKN FRSGYQLTLH QRFHTGEKPY ECTECGKNFR 190 200 210 220 230 240 SGYQLTVHQR FHTGEKTYEC RQCGKAFIYA SHIVQHERIH TGGKPYECQE CGRAFSQGGH 250 260 270 280 290 300 LRIHQRVHTG EKPYKCKECG KTFSRRSNLV EHGQFHTDEK PYICEKCGKA FRRGHQLTVH 310 320 330 340 350 360 QRVHTGKKPY ECKECGKGYT TASYFLLHQR IHKGGKPYEC KECKKTFTLY RNLTRHQNIH 370 380 390 400 410 420 TGEKLFECKQ CGKTYTTGSK LFQHQKTHTG EKPYECKECG KAFSLYGYLK QHQKIHTGMK 430 440 450 460 470 480 HFECKECKKT FTLYRNLTRH QNIHTGKKLF ECQECGKAYS TGSNLIQHRK THTGEKPYKC 490 500 510 520 530 540 KECGKTFSLH GYLNQHQKIH TGMKPYECKV CRKTFTFYRN LTLHQSIHTD EKPFECKECG 550 560 570 580 590 600 KTFRRSSHLT AHQSIHADKK PYECKECGKA FKMYGYLTQH QKIHTGGKPY ECKECGKAFS 610 620 630 640 RASNLVQHER IHTGEKPYVC KQCGKTFRYG SALKAHQRIH RSIKV
	Isoform 2 [UniParc]. Checksum: 6C4035AEC4264743	FASTA	577	67,782
	10 20 30 40 50 60 MILREETQFT DLDLQCEIIS YIEVPTYETD ISSTQLQSIY KREKLYECKK CQKKFSSGYQ 70 80 90 100 110 120 LILHHRFHVI ERPYECKECG KNFRSGYQLT LHQRFHTGEK PYECTECGKN FRSGYQLTVH 130 140 150 160 170 180 QRFHTGEKTY ECRQCGKAFI YASHIVQHER IHTGGKPYEC QECGRAFSQG GHLRIHQRVH 190 200 210 220 230 240 TGEKPYKCKE CGKTFSRRSN LVEHGQFHTD EKPYICEKCG KAFRRGHQLT VHQRVHTGKK 250 260 270 280 290 300 PYECKECGKG YTTASYFLLH QRIHKGGKPY ECKECKKTFT LYRNLTRHQN IHTGEKLFEC 310 320 330 340 350 360 KQCGKTYTTG SKLFQHQKTH TGEKPYECKE CGKAFSLYGY LKQHQKIHTG MKHFECKECK 370 380 390 400 410 420 KTFTLYRNLT RHQNIHTGKK LFECQECGKA YSTGSNLIQH RKTHTGEKPY KCKECGKTFS 430 440 450 460 470 480 LHGYLNQHQK IHTGMKPYEC KVCRKTFTFY RNLTLHQSIH TDEKPFECKE CGKTFRRSSH 490 500 510 520 530 540 LTAHQSIHAD KKPYECKECG KAFKMYGYLT QHQKIHTGGK PYECKECGKA FSRASNLVQH 550 560 570 ERIHTGEKPY VCKQCGKTFR YGSALKAHQR IHRSIKV
	Isoform 3 [UniParc]. Checksum: 3D334D27E866B5EB	FASTA	607	70,843
	10 20 30 40 50 60 MESCSVAQAG VQWPDLSSLQ PPPPRFKQFS CHSLQVAGIT DLDLQCEIIS YIEVPTYETD 70 80 90 100 110 120 ISSTQLQSIY KREKLYECKK CQKKFSSGYQ LILHHRFHVI ERPYECKECG KNFRSGYQLT 130 140 150 160 170 180 LHQRFHTGEK PYECTECGKN FRSGYQLTVH QRFHTGEKTY ECRQCGKAFI YASHIVQHER 190 200 210 220 230 240 IHTGGKPYEC QECGRAFSQG GHLRIHQRVH TGEKPYKCKE CGKTFSRRSN LVEHGQFHTD 250 260 270 280 290 300 EKPYICEKCG KAFRRGHQLT VHQRVHTGKK PYECKECGKG YTTASYFLLH QRIHKGGKPY 310 320 330 340 350 360 ECKECKKTFT LYRNLTRHQN IHTGEKLFEC KQCGKTYTTG SKLFQHQKTH TGEKPYECKE 370 380 390 400 410 420 CGKAFSLYGY LKQHQKIHTG MKHFECKECK KTFTLYRNLT RHQNIHTGKK LFECQECGKA 430 440 450 460 470 480 YSTGSNLIQH RKTHTGEKPY KCKECGKTFS LHGYLNQHQK IHTGMKPYEC KVCRKTFTFY 490 500 510 520 530 540 RNLTLHQSIH TDEKPFECKE CGKTFRRSSH LTAHQSIHAD KKPYECKECG KAFKMYGYLT 550 560 570 580 590 600 QHQKIHTGGK PYECKECGKA FSRASNLVQH ERIHTGEKPY VCKQCGKTFR YGSALKAHQR IHRSIKV
	Isoform 4 [UniParc]. Checksum: 43E2AE3301CA6BAF	FASTA	578	67,866
	10 20 30 40 50 60 MLENYRNLVS LDLDLQCEII SYIEVPTYET DISSTQLQSI YKREKLYECK KCQKKFSSGY 70 80 90 100 110 120 QLILHHRFHV IERPYECKEC GKNFRSGYQL TLHQRFHTGE KPYECTECGK NFRSGYQLTV 130 140 150 160 170 180 HQRFHTGEKT YECRQCGKAF IYASHIVQHE RIHTGGKPYE CQECGRAFSQ GGHLRIHQRV 190 200 210 220 230 240 HTGEKPYKCK ECGKTFSRRS NLVEHGQFHT DEKPYICEKC GKAFRRGHQL TVHQRVHTGK 250 260 270 280 290 300 KPYECKECGK GYTTASYFLL HQRIHKGGKP YECKECKKTF TLYRNLTRHQ NIHTGEKLFE 310 320 330 340 350 360 CKQCGKTYTT GSKLFQHQKT HTGEKPYECK ECGKAFSLYG YLKQHQKIHT GMKHFECKEC 370 380 390 400 410 420 KKTFTLYRNL TRHQNIHTGK KLFECQECGK AYSTGSNLIQ HRKTHTGEKP YKCKECGKTF 430 440 450 460 470 480 SLHGYLNQHQ KIHTGMKPYE CKVCRKTFTF YRNLTLHQSI HTDEKPFECK ECGKTFRRSS 490 500 510 520 530 540 HLTAHQSIHA DKKPYECKEC GKAFKMYGYL TQHQKIHTGG KPYECKECGK AFSRASNLVQ 550 560 570 HERIHTGEKP YVCKQCGKTF RYGSALKAHQ RIHRSIKV

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Tissue: Brain and Embryo.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Duodenum, Eye, Lung and Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK055483 mRNA. Translation: BAB70929.1. AK074539 mRNA. Translation: BAC11047.1. AC093227 Genomic DNA. No translation available. BC015418 mRNA. Translation: AAH15418.1. BC042170 mRNA. Translation: AAH42170.2. BC051263 mRNA. Translation: AAH51263.1. BC064962 mRNA. Translation: AAH64962.1.
IPI	IPI00398310. IPI00418297. IPI00827652. IPI00827764.
RefSeq	NP_001166160.1. NM_001172689.1. NP_001166161.1. NM_001172690.1. NP_001166162.1. NM_001172691.1. NP_001166163.1. NM_001172692.1. NP_689573.3. NM_152360.3.
UniGene	Hs.531262.
3D structure databases
ProteinModelPortal	Q86YE8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000340171.
PTM databases
PhosphoSite	Q86YE8.
Polymorphism databases
DMDM	143811478.
Proteomic databases
PaxDb	Q86YE8.
PRIDE	Q86YE8.
Protocols and materials databases
DNASU	126231.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339503; ENSP00000340171; ENSG00000189144. ENST00000357309; ENSP00000349861; ENSG00000189144. ENST00000392138; ENSP00000375983; ENSG00000189144. ENST00000536220; ENSP00000440464; ENSG00000189144.
GeneID	126231.
KEGG	hsa:126231.
UCSC	uc002ohd.3. human. uc002ohf.3. human. uc010efs.2. human.
Organism-specific databases
CTD	126231.
GeneCards	GC19M038229.
HGNC	HGNC:26420. ZNF573.
HPA	HPA042776.
neXtProt	NX_Q86YE8.
PharmGKB	PA134883623.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOVERGEN	HBG018163.
InParanoid	Q86YE8.
OMA	KTFTLYR.
OrthoDB	EOG4ZS92K.
PhylomeDB	Q86YE8.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q86YE8.
Bgee	Q86YE8.
CleanEx	HS_ZNF573.
Genevestigator	Q86YE8.
Family and domain databases
Gene3D	3.30.160.60. 19 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 19 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 19 hits. PS50157. ZINC_FINGER_C2H2_2. 19 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF573. human.
GenomeRNAi	126231.
NextBio	81726.

Entry information

Entry name

ZN573_HUMAN

Accession

Primary (citable) accession number: Q86YE8
Secondary accession number(s): B7WPE1 , Q6P1P1, Q7Z7Q3, Q8N2Q1, Q96BM3, Q96NH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	April 3, 2007
Last modified:	May 29, 2013
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.