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Q86YE8 (ZN573_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 573
Gene names
Name:ZNF573
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length645 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 19 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86YE8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86YE8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q86YE8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: MTCFQELVTF...WMILREETQF → MESCSVAQAG...SCHSLQVAGI
Note: No experimental confirmation available.
Isoform 4 (identifier: Q86YE8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     48-78: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 645645Zinc finger protein 573
PRO_0000274877

Regions

Domain8 – 8073KRAB
Zinc finger114 – 13623C2H2-type 1
Zinc finger142 – 16423C2H2-type 2
Zinc finger170 – 19223C2H2-type 3
Zinc finger198 – 22023C2H2-type 4
Zinc finger226 – 24823C2H2-type 5
Zinc finger254 – 27623C2H2-type 6
Zinc finger282 – 30423C2H2-type 7
Zinc finger310 – 33223C2H2-type 8
Zinc finger338 – 36023C2H2-type 9
Zinc finger366 – 38823C2H2-type 10
Zinc finger394 – 41623C2H2-type 11
Zinc finger422 – 44423C2H2-type 12
Zinc finger450 – 47223C2H2-type 13
Zinc finger478 – 50023C2H2-type 14
Zinc finger506 – 52823C2H2-type 15
Zinc finger534 – 55623C2H2-type 16
Zinc finger562 – 58423C2H2-type 17
Zinc finger590 – 61223C2H2-type 18
Zinc finger618 – 64023C2H2-type 19

Natural variations

Alternative sequence1 – 7777MTCFQ…EETQF → MESCSVAQAGVQWPDLSSLQ PPPPRFKQFSCHSLQVAGI in isoform 3.
VSP_022894
Alternative sequence1 – 6868Missing in isoform 2.
VSP_022895
Alternative sequence1 – 3636Missing in isoform 4.
VSP_022896
Alternative sequence48 – 7831Missing in isoform 4.
VSP_022897
Natural variant1661G → A.
Corresponds to variant rs3752365 [ dbSNP | Ensembl ].
VAR_030356
Natural variant2041G → A.
Corresponds to variant rs3752365 [ dbSNP | Ensembl ].
VAR_057426

Experimental info

Sequence conflict1091K → E in BAB70929. Ref.1
Sequence conflict3091P → L in BAB70929. Ref.1
Sequence conflict5031M → V in AAH15418. Ref.3
Sequence conflict5031M → V in AAH42170. Ref.3
Sequence conflict5031M → V in AAH51263. Ref.3
Sequence conflict5031M → V in AAH64962. Ref.3
Sequence conflict5711F → L in BAC11047. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 3.
Checksum: 5340D0936CB13F5E

FASTA64575,883
        10         20         30         40         50         60 
MTCFQELVTF RDVAIDFSRQ EWEYLDPNQR DLYRDVMLEN YRNLVSLGGH SISKPVVVDL 

        70         80         90        100        110        120 
LERGKEPWMI LREETQFTDL DLQCEIISYI EVPTYETDIS STQLQSIYKR EKLYECKKCQ 

       130        140        150        160        170        180 
KKFSSGYQLI LHHRFHVIER PYECKECGKN FRSGYQLTLH QRFHTGEKPY ECTECGKNFR 

       190        200        210        220        230        240 
SGYQLTVHQR FHTGEKTYEC RQCGKAFIYA SHIVQHERIH TGGKPYECQE CGRAFSQGGH 

       250        260        270        280        290        300 
LRIHQRVHTG EKPYKCKECG KTFSRRSNLV EHGQFHTDEK PYICEKCGKA FRRGHQLTVH 

       310        320        330        340        350        360 
QRVHTGKKPY ECKECGKGYT TASYFLLHQR IHKGGKPYEC KECKKTFTLY RNLTRHQNIH 

       370        380        390        400        410        420 
TGEKLFECKQ CGKTYTTGSK LFQHQKTHTG EKPYECKECG KAFSLYGYLK QHQKIHTGMK 

       430        440        450        460        470        480 
HFECKECKKT FTLYRNLTRH QNIHTGKKLF ECQECGKAYS TGSNLIQHRK THTGEKPYKC 

       490        500        510        520        530        540 
KECGKTFSLH GYLNQHQKIH TGMKPYECKV CRKTFTFYRN LTLHQSIHTD EKPFECKECG 

       550        560        570        580        590        600 
KTFRRSSHLT AHQSIHADKK PYECKECGKA FKMYGYLTQH QKIHTGGKPY ECKECGKAFS 

       610        620        630        640 
RASNLVQHER IHTGEKPYVC KQCGKTFRYG SALKAHQRIH RSIKV 

« Hide

Isoform 2 [UniParc].

Checksum: 6C4035AEC4264743
Show »

FASTA57767,782
Isoform 3 [UniParc].

Checksum: 3D334D27E866B5EB
Show »

FASTA60770,843
Isoform 4 [UniParc].

Checksum: 43E2AE3301CA6BAF
Show »

FASTA57867,866

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
Tissue: Brain and Embryo.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Duodenum, Eye, Lung and Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK055483 mRNA. Translation: BAB70929.1.
AK074539 mRNA. Translation: BAC11047.1.
AC093227 Genomic DNA. No translation available.
BC015418 mRNA. Translation: AAH15418.1.
BC042170 mRNA. Translation: AAH42170.2.
BC051263 mRNA. Translation: AAH51263.1.
BC064962 mRNA. Translation: AAH64962.1.
RefSeqNP_001166160.1. NM_001172689.1.
NP_001166161.1. NM_001172690.1.
NP_001166162.1. NM_001172691.1.
NP_001166163.1. NM_001172692.1.
NP_689573.3. NM_152360.3.
UniGeneHs.531262.

3D structure databases

ProteinModelPortalQ86YE8.
SMRQ86YE8. Positions 8-48, 112-642.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125967. 2 interactions.
STRING9606.ENSP00000340171.

PTM databases

PhosphoSiteQ86YE8.

Polymorphism databases

DMDM143811478.

Proteomic databases

PaxDbQ86YE8.
PRIDEQ86YE8.

Protocols and materials databases

DNASU126231.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339503; ENSP00000340171; ENSG00000189144. [Q86YE8-3]
ENST00000357309; ENSP00000349861; ENSG00000189144. [Q86YE8-2]
ENST00000392138; ENSP00000375983; ENSG00000189144. [Q86YE8-4]
ENST00000536220; ENSP00000440464; ENSG00000189144. [Q86YE8-2]
GeneID126231.
KEGGhsa:126231.
UCSCuc002ohd.3. human. [Q86YE8-1]
uc002ohf.3. human. [Q86YE8-3]
uc010efs.2. human. [Q86YE8-4]

Organism-specific databases

CTD126231.
GeneCardsGC19M038229.
HGNCHGNC:26420. ZNF573.
HPAHPA042776.
neXtProtNX_Q86YE8.
PharmGKBPA134883623.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG018163.
InParanoidQ86YE8.
PhylomeDBQ86YE8.
TreeFamTF341817.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ86YE8.
BgeeQ86YE8.
CleanExHS_ZNF573.
GenevestigatorQ86YE8.

Family and domain databases

Gene3D3.30.160.60. 19 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF573. human.
GenomeRNAi126231.
NextBio81726.
PROQ86YE8.

Entry information

Entry nameZN573_HUMAN
AccessionPrimary (citable) accession number: Q86YE8
Secondary accession number(s): B7WPE1 expand/collapse secondary AC list , Q6P1P1, Q7Z7Q3, Q8N2Q1, Q96BM3, Q96NH0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM