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Protein

Protein FAM90A1

Gene

FAM90A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM90A1
Gene namesi
Name:FAM90A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25526. FAM90A1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671796.

Polymorphism and mutation databases

BioMutaiFAM90A1.
DMDMi269849691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Protein FAM90A1PRO_0000299592Add
BLAST

Proteomic databases

EPDiQ86YD7.
PaxDbiQ86YD7.
PRIDEiQ86YD7.

PTM databases

iPTMnetiQ86YD7.
PhosphoSiteiQ86YD7.

Expressioni

Gene expression databases

BgeeiQ86YD7.
CleanExiHS_FAM90A1.
ExpressionAtlasiQ86YD7. baseline and differential.
GenevisibleiQ86YD7. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-6658203,EBI-744695
CALCOCO2Q131374EBI-6658203,EBI-739580
CCDC155Q8N6L03EBI-6658203,EBI-749265
CCDC57Q2TAC23EBI-6658203,EBI-2808286
CEP55D3DR373EBI-6658203,EBI-10173536
CEP72Q9P2093EBI-6658203,EBI-739498
CEP76Q8TAP63EBI-6658203,EBI-742887
EXOSC8Q96B263EBI-6658203,EBI-371922
FHL3Q136433EBI-6658203,EBI-741101
FHL3Q96C983EBI-6658203,EBI-10229248
FSD2A1L4K13EBI-6658203,EBI-5661036
FXR2P511163EBI-6658203,EBI-740459
GABPB1Q065473EBI-6658203,EBI-618165
GNPTABQ3T9063EBI-6658203,EBI-1104907
GOLGA2Q083793EBI-6658203,EBI-618309
GOPCQ9HD263EBI-6658203,EBI-349832
KRT31Q153233EBI-6658203,EBI-948001
KRT38O760153EBI-6658203,EBI-1047263
KRT40Q6A1623EBI-6658203,EBI-10171697
LDOC1O957513EBI-6658203,EBI-740738
MID2Q9UJV3-23EBI-6658203,EBI-10172526
MTUS2Q5JR593EBI-6658203,EBI-742948
PSTPIP1O435863EBI-6658203,EBI-1050964
RINT1Q6NUQ13EBI-6658203,EBI-726876
SIAH1Q8IUQ43EBI-6658203,EBI-747107
STAC3Q96MF23EBI-6658203,EBI-745680
STX11O755583EBI-6658203,EBI-714135
TMCC2Q7Z6C63EBI-6658203,EBI-10177480
TRAF2Q129333EBI-6658203,EBI-355744
TRIM23P364063EBI-6658203,EBI-740098
ZBTB14O438293EBI-6658203,EBI-10176632
ZNF212Q9UDV63EBI-6658203,EBI-1640204

Protein-protein interaction databases

BioGridi120442. 49 interactions.
IntActiQ86YD7. 34 interactions.
STRINGi9606.ENSP00000307798.

Structurei

3D structure databases

ProteinModelPortaliQ86YD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM90 family.Curated

Phylogenomic databases

eggNOGiENOG410JA2C. Eukaryota.
ENOG4111A8B. LUCA.
GeneTreeiENSGT00530000063065.
HOGENOMiHOG000015373.
HOVERGENiHBG107893.
InParanoidiQ86YD7.
OMAiCKNCEAF.
OrthoDBiEOG7Q2N57.
PhylomeDBiQ86YD7.
TreeFamiTF338572.

Sequencei

Sequence statusi: Complete.

Q86YD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMARRDPKPG AKRLVRAQTL QKQRRAPVGP RAPPPDEEDP RLKCKNCEAF
60 70 80 90 100
GHTARSTRCP MKCWKAALVP PNFGEKEGKE NLKPWKPQVE ANPGPLNKDK
110 120 130 140 150
GEKEERPRPQ DPQRKALLHI FSRKPPEKPL PNQKGSTESS DYLRVASGPM
160 170 180 190 200
PVHTTSKRPR VDPVLSDRSA TEMSDRGSVL ASLSPLRKAS LSSSSSLGPK
210 220 230 240 250
ERQTGAAADI PQTAVRHQGP EPLLVVKPTH SSPAGGCREV PQAASKTHGL
260 270 280 290 300
LQAVSPQAQD KRPAVTSQPC PPAATHSLGL GSNLSFGPGA KRSAPAPIQA
310 320 330 340 350
CLNFPKKPRL GPFQIPESAI QGGELGAPEN LQPPPAATEL GPRTSPQTGT
360 370 380 390 400
RTPAQVLSGD RQPPHSRPCL PTAQACTMSH HPAASHDGAQ PLRVLFRRLE
410 420 430 440 450
NGRWSSSLLT APSFHSPEKP GAFLAQSPHV SEKSEGPCVR VPPSVLYEDL
460
QVPSSSEDSD SDLE
Length:464
Mass (Da):49,793
Last modified:November 24, 2009 - v3
Checksum:iD9E36FCEE5021250
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2552VS → AR in AAH42608 (PubMed:15489334).Curated
Sequence conflicti344 – 3441T → TV in BAA91593 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231R → G.2 Publications
Corresponds to variant rs9738115 [ dbSNP | Ensembl ].
VAR_060293
Natural varianti234 – 2341A → E.1 Publication
Corresponds to variant rs9668582 [ dbSNP | Ensembl ].
VAR_057778
Natural varianti334 – 3341P → L.1 Publication
Corresponds to variant rs17855656 [ dbSNP | Ensembl ].
VAR_060294
Natural varianti343 – 3431R → S.
Corresponds to variant rs9668475 [ dbSNP | Ensembl ].
VAR_060154
Natural varianti348 – 3481T → I.3 Publications
Corresponds to variant rs9668474 [ dbSNP | Ensembl ].
VAR_060295
Natural varianti410 – 4101T → A.
Corresponds to variant rs11044098 [ dbSNP | Ensembl ].
VAR_060155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001270 mRNA. Translation: BAA91593.1.
AC092111 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88629.1.
CH471116 Genomic DNA. Translation: EAW88630.1.
BC042608 mRNA. Translation: AAH42608.1.
CCDSiCCDS31738.1.
RefSeqiNP_001306911.1. NM_001319982.1.
NP_060558.3. NM_018088.3.
XP_011519021.1. XM_011520719.1.
XP_011519023.1. XM_011520721.1.
UniGeneiHs.196086.

Genome annotation databases

EnsembliENST00000307435; ENSP00000307798; ENSG00000171847.
ENST00000538603; ENSP00000445418; ENSG00000171847.
GeneIDi55138.
KEGGihsa:55138.
UCSCiuc001quh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001270 mRNA. Translation: BAA91593.1.
AC092111 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88629.1.
CH471116 Genomic DNA. Translation: EAW88630.1.
BC042608 mRNA. Translation: AAH42608.1.
CCDSiCCDS31738.1.
RefSeqiNP_001306911.1. NM_001319982.1.
NP_060558.3. NM_018088.3.
XP_011519021.1. XM_011520719.1.
XP_011519023.1. XM_011520721.1.
UniGeneiHs.196086.

3D structure databases

ProteinModelPortaliQ86YD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120442. 49 interactions.
IntActiQ86YD7. 34 interactions.
STRINGi9606.ENSP00000307798.

PTM databases

iPTMnetiQ86YD7.
PhosphoSiteiQ86YD7.

Polymorphism and mutation databases

BioMutaiFAM90A1.
DMDMi269849691.

Proteomic databases

EPDiQ86YD7.
PaxDbiQ86YD7.
PRIDEiQ86YD7.

Protocols and materials databases

DNASUi55138.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307435; ENSP00000307798; ENSG00000171847.
ENST00000538603; ENSP00000445418; ENSG00000171847.
GeneIDi55138.
KEGGihsa:55138.
UCSCiuc001quh.3. human.

Organism-specific databases

CTDi55138.
GeneCardsiFAM90A1.
HGNCiHGNC:25526. FAM90A1.
MIMi613041. gene.
neXtProtiNX_Q86YD7.
PharmGKBiPA142671796.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JA2C. Eukaryota.
ENOG4111A8B. LUCA.
GeneTreeiENSGT00530000063065.
HOGENOMiHOG000015373.
HOVERGENiHBG107893.
InParanoidiQ86YD7.
OMAiCKNCEAF.
OrthoDBiEOG7Q2N57.
PhylomeDBiQ86YD7.
TreeFamiTF338572.

Miscellaneous databases

GenomeRNAii55138.
PROiQ86YD7.
SOURCEiSearch...

Gene expression databases

BgeeiQ86YD7.
CleanExiHS_FAM90A1.
ExpressionAtlasiQ86YD7. baseline and differential.
GenevisibleiQ86YD7. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-123 AND ILE-348.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-348.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-123; GLU-234; LEU-334 AND ILE-348.
    Tissue: Brain.

Entry informationi

Entry nameiF90A1_HUMAN
AccessioniPrimary (citable) accession number: Q86YD7
Secondary accession number(s): D3DUU9, Q9NVZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 24, 2009
Last modified: June 8, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.