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Protein

Protein FAM90A1

Gene

FAM90A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM90A1
Gene namesi
Name:FAM90A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25526. FAM90A1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171847.
PharmGKBiPA142671796.

Polymorphism and mutation databases

BioMutaiFAM90A1.
DMDMi269849691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002995921 – 464Protein FAM90A1Add BLAST464

Proteomic databases

PaxDbiQ86YD7.
PeptideAtlasiQ86YD7.
PRIDEiQ86YD7.

PTM databases

iPTMnetiQ86YD7.
PhosphoSitePlusiQ86YD7.

Expressioni

Gene expression databases

BgeeiENSG00000171847.
CleanExiHS_FAM90A1.
ExpressionAtlasiQ86YD7. baseline and differential.
GenevisibleiQ86YD7. HS.

Organism-specific databases

HPAiCAB025653.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-6658203,EBI-744695
CALCOCO2Q131376EBI-6658203,EBI-739580
CCDC155Q8N6L03EBI-6658203,EBI-749265
CCDC57Q2TAC23EBI-6658203,EBI-2808286
CEP55D3DR373EBI-6658203,EBI-10173536
CEP72Q9P2093EBI-6658203,EBI-739498
CEP76Q8TAP65EBI-6658203,EBI-742887
COG6Q9Y2V74EBI-6658203,EBI-3866319
EXOSC8Q96B265EBI-6658203,EBI-371922
FHL3Q136435EBI-6658203,EBI-741101
FHL3Q96C983EBI-6658203,EBI-10229248
FSD2A1L4K15EBI-6658203,EBI-5661036
FXR2P511163EBI-6658203,EBI-740459
GABPB1Q065473EBI-6658203,EBI-618165
GNPTABQ3T9063EBI-6658203,EBI-1104907
GOLGA2A0A0C4DGS54EBI-6658203,EBI-11522202
GOLGA2Q083793EBI-6658203,EBI-618309
GOPCQ9HD263EBI-6658203,EBI-349832
KRT31Q153235EBI-6658203,EBI-948001
KRT38O760153EBI-6658203,EBI-1047263
KRT40Q6A1623EBI-6658203,EBI-10171697
LDOC1O957515EBI-6658203,EBI-740738
MID2Q9UJV3-25EBI-6658203,EBI-10172526
MTUS2Q5JR593EBI-6658203,EBI-742948
PSTPIP1O435865EBI-6658203,EBI-1050964
RINT1Q6NUQ13EBI-6658203,EBI-726876
SIAH1Q8IUQ43EBI-6658203,EBI-747107
STAC3Q96MF25EBI-6658203,EBI-745680
STX11O755583EBI-6658203,EBI-714135
TMCC2Q7Z6C63EBI-6658203,EBI-10177480
TRAF2Q129335EBI-6658203,EBI-355744
TRIM23P364063EBI-6658203,EBI-740098
ZBTB14O438293EBI-6658203,EBI-10176632
ZNF212Q9UDV65EBI-6658203,EBI-1640204

Protein-protein interaction databases

BioGridi120442. 49 interactors.
IntActiQ86YD7. 94 interactors.
STRINGi9606.ENSP00000307798.

Structurei

3D structure databases

ProteinModelPortaliQ86YD7.
SMRiQ86YD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM90 family.Curated

Phylogenomic databases

eggNOGiENOG410JA2C. Eukaryota.
ENOG4111A8B. LUCA.
GeneTreeiENSGT00530000063065.
HOGENOMiHOG000015373.
HOVERGENiHBG107893.
InParanoidiQ86YD7.
OMAiCKNCEAF.
OrthoDBiEOG091G0D9U.
PhylomeDBiQ86YD7.
TreeFamiTF338572.

Sequencei

Sequence statusi: Complete.

Q86YD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMARRDPKPG AKRLVRAQTL QKQRRAPVGP RAPPPDEEDP RLKCKNCEAF
60 70 80 90 100
GHTARSTRCP MKCWKAALVP PNFGEKEGKE NLKPWKPQVE ANPGPLNKDK
110 120 130 140 150
GEKEERPRPQ DPQRKALLHI FSRKPPEKPL PNQKGSTESS DYLRVASGPM
160 170 180 190 200
PVHTTSKRPR VDPVLSDRSA TEMSDRGSVL ASLSPLRKAS LSSSSSLGPK
210 220 230 240 250
ERQTGAAADI PQTAVRHQGP EPLLVVKPTH SSPAGGCREV PQAASKTHGL
260 270 280 290 300
LQAVSPQAQD KRPAVTSQPC PPAATHSLGL GSNLSFGPGA KRSAPAPIQA
310 320 330 340 350
CLNFPKKPRL GPFQIPESAI QGGELGAPEN LQPPPAATEL GPRTSPQTGT
360 370 380 390 400
RTPAQVLSGD RQPPHSRPCL PTAQACTMSH HPAASHDGAQ PLRVLFRRLE
410 420 430 440 450
NGRWSSSLLT APSFHSPEKP GAFLAQSPHV SEKSEGPCVR VPPSVLYEDL
460
QVPSSSEDSD SDLE
Length:464
Mass (Da):49,793
Last modified:November 24, 2009 - v3
Checksum:iD9E36FCEE5021250
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti254 – 255VS → AR in AAH42608 (PubMed:15489334).Curated2
Sequence conflicti344T → TV in BAA91593 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060293123R → G.2 PublicationsCorresponds to variant rs9738115dbSNPEnsembl.1
Natural variantiVAR_057778234A → E.1 PublicationCorresponds to variant rs9668582dbSNPEnsembl.1
Natural variantiVAR_060294334P → L.1 PublicationCorresponds to variant rs17855656dbSNPEnsembl.1
Natural variantiVAR_060154343R → S.Corresponds to variant rs9668475dbSNPEnsembl.1
Natural variantiVAR_060295348T → I.3 PublicationsCorresponds to variant rs9668474dbSNPEnsembl.1
Natural variantiVAR_060155410T → A.Corresponds to variant rs11044098dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001270 mRNA. Translation: BAA91593.1.
AC092111 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88629.1.
CH471116 Genomic DNA. Translation: EAW88630.1.
BC042608 mRNA. Translation: AAH42608.1.
CCDSiCCDS31738.1.
RefSeqiNP_001306911.1. NM_001319982.1.
NP_060558.3. NM_018088.3.
XP_011519021.1. XM_011520719.1.
XP_016875036.1. XM_017019547.1.
UniGeneiHs.196086.

Genome annotation databases

EnsembliENST00000307435; ENSP00000307798; ENSG00000171847.
ENST00000538603; ENSP00000445418; ENSG00000171847.
GeneIDi55138.
KEGGihsa:55138.
UCSCiuc001quh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001270 mRNA. Translation: BAA91593.1.
AC092111 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88629.1.
CH471116 Genomic DNA. Translation: EAW88630.1.
BC042608 mRNA. Translation: AAH42608.1.
CCDSiCCDS31738.1.
RefSeqiNP_001306911.1. NM_001319982.1.
NP_060558.3. NM_018088.3.
XP_011519021.1. XM_011520719.1.
XP_016875036.1. XM_017019547.1.
UniGeneiHs.196086.

3D structure databases

ProteinModelPortaliQ86YD7.
SMRiQ86YD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120442. 49 interactors.
IntActiQ86YD7. 94 interactors.
STRINGi9606.ENSP00000307798.

PTM databases

iPTMnetiQ86YD7.
PhosphoSitePlusiQ86YD7.

Polymorphism and mutation databases

BioMutaiFAM90A1.
DMDMi269849691.

Proteomic databases

PaxDbiQ86YD7.
PeptideAtlasiQ86YD7.
PRIDEiQ86YD7.

Protocols and materials databases

DNASUi55138.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307435; ENSP00000307798; ENSG00000171847.
ENST00000538603; ENSP00000445418; ENSG00000171847.
GeneIDi55138.
KEGGihsa:55138.
UCSCiuc001quh.3. human.

Organism-specific databases

CTDi55138.
GeneCardsiFAM90A1.
HGNCiHGNC:25526. FAM90A1.
HPAiCAB025653.
MIMi613041. gene.
neXtProtiNX_Q86YD7.
OpenTargetsiENSG00000171847.
PharmGKBiPA142671796.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JA2C. Eukaryota.
ENOG4111A8B. LUCA.
GeneTreeiENSGT00530000063065.
HOGENOMiHOG000015373.
HOVERGENiHBG107893.
InParanoidiQ86YD7.
OMAiCKNCEAF.
OrthoDBiEOG091G0D9U.
PhylomeDBiQ86YD7.
TreeFamiTF338572.

Miscellaneous databases

GenomeRNAii55138.
PROiQ86YD7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171847.
CleanExiHS_FAM90A1.
ExpressionAtlasiQ86YD7. baseline and differential.
GenevisibleiQ86YD7. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiF90A1_HUMAN
AccessioniPrimary (citable) accession number: Q86YD7
Secondary accession number(s): D3DUU9, Q9NVZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.