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Protein

Transmembrane protein 25

Gene

TMEM25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 25
Gene namesi
Name:TMEM25
ORF Names:UNQ2531/PRO6030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25890. TMEM25.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 232206ExtracellularSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Topological domaini254 – 366113CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919013.

Polymorphism and mutation databases

BioMutaiTMEM25.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 366340Transmembrane protein 25PRO_0000014984Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 107PROSITE-ProRule annotation
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence analysis
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86YD3.
PeptideAtlasiQ86YD3.
PRIDEiQ86YD3.

PTM databases

iPTMnetiQ86YD3.
PhosphoSiteiQ86YD3.

Expressioni

Gene expression databases

BgeeiENSG00000149582.
CleanExiHS_TMEM25.
ExpressionAtlasiQ86YD3. baseline and differential.
GenevisibleiQ86YD3. HS.

Organism-specific databases

HPAiHPA012163.
HPA051562.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GLRX3O760033EBI-10260688,EBI-374781
RABGGTBP536113EBI-10260688,EBI-536715

Protein-protein interaction databases

BioGridi124311. 84 interactions.
IntActiQ86YD3. 2 interactions.
MINTiMINT-2877607.
STRINGi9606.ENSP00000315635.

Structurei

3D structure databases

ProteinModelPortaliQ86YD3.
SMRiQ86YD3. Positions 141-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 12394Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF2Y. Eukaryota.
ENOG410ZNWF. LUCA.
GeneTreeiENSGT00390000003414.
HOGENOMiHOG000261622.
HOVERGENiHBG057137.
InParanoidiQ86YD3.
PhylomeDBiQ86YD3.
TreeFamiTF333068.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86YD3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPPGPAAL RHTLLLLPAL LSSGWGELEP QIDGQTWAER ALRENERHAF
60 70 80 90 100
TCRVAGGPGT PRLAWYLDGQ LQEASTSRLL SVGGEAFSGG TSTFTVTAHR
110 120 130 140 150
AQHELNCSLQ DPRSGRSANA SVILNVQFKP EIAQVGAKYQ EAQGPGLLVV
160 170 180 190 200
LFALVRANPP ANVTWIDQDG PVTVNTSDFL VLDAQNYPWL TNHTVQLQLR
210 220 230 240 250
SLAHNLSVVA TNDVGVTSAS LPAPGLLATR VEVPLLGIVV AAGLALGTLV
260 270 280 290 300
GFSTLVACLV CRKEKKTKGP SRHPSLISSD SNNLKLNNVR LPRENMSLPS
310 320 330 340 350
NLQLNDLTPD SRAVKPADRQ MAQNNSRPEL LDPEPGGLLT SQGFIRLPVL
360
GYIYRVSSVS SDEIWL
Length:366
Mass (Da):39,285
Last modified:June 1, 2003 - v1
Checksum:i82B06A7B55A10129
GO
Isoform 2 (identifier: Q86YD3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-268: Missing.

Show »
Length:322
Mass (Da):34,793
Checksum:i91F6B96B4D992B35
GO
Isoform 3 (identifier: Q86YD3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-128: GWGELEPQID...NASVILNVQF → V
     225-268: Missing.

Show »
Length:218
Mass (Da):23,526
Checksum:iDC027919F836EDA2
GO
Isoform 4 (identifier: Q86YD3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-366: FIRLPVLGYIYRVSSVSSDEIWL → RRNQDKDA

Show »
Length:351
Mass (Da):37,574
Checksum:iEC41C2A68831855A
GO
Isoform 5 (identifier: Q86YD3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-268: Missing.
     313-313: Missing.
     344-366: FIRLPVLGYIYRVSSVSSDEIWL → RRNQDKDA

Note: No experimental confirmation available.
Show »
Length:306
Mass (Da):33,011
Checksum:i49AA63E43E178145
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti277 – 2771I → V in BAC11620 (PubMed:16303743).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251W → C.
Corresponds to variant rs35915434 [ dbSNP | Ensembl ].
VAR_033623
Natural varianti342 – 3421Q → R.2 Publications
Corresponds to variant rs12289253 [ dbSNP | Ensembl ].
VAR_021391

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei24 – 128105GWGEL…LNVQF → V in isoform 3. 1 PublicationVSP_012939Add
BLAST
Alternative sequencei225 – 26844Missing in isoform 2, isoform 3 and isoform 5. 4 PublicationsVSP_012940Add
BLAST
Alternative sequencei313 – 3131Missing in isoform 5. 1 PublicationVSP_045635
Alternative sequencei344 – 36623FIRLP…DEIWL → RRNQDKDA in isoform 4 and isoform 5. 2 PublicationsVSP_012941Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358919 mRNA. Translation: AAQ89278.1.
AK027305 mRNA. Translation: BAB55029.1.
AK056325 mRNA. Translation: BAB71151.1.
AK292359 mRNA. Translation: BAF85048.1.
AK075437 mRNA. Translation: BAC11620.1.
EF445037 Genomic DNA. Translation: ACA06084.1.
EF445037 Genomic DNA. Translation: ACA06085.1.
EF445037 Genomic DNA. Translation: ACA06086.1.
EF445037 Genomic DNA. Translation: ACA06087.1.
AP000941 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67388.1.
CH471065 Genomic DNA. Translation: EAW67389.1.
CH471065 Genomic DNA. Translation: EAW67393.1.
BC042896 mRNA. Translation: AAH42896.1.
BC051841 mRNA. Translation: AAH51841.1.
CCDSiCCDS44745.1. [Q86YD3-4]
CCDS44746.1. [Q86YD3-5]
CCDS44747.1. [Q86YD3-2]
CCDS44748.1. [Q86YD3-3]
CCDS8398.1. [Q86YD3-1]
RefSeqiNP_001137506.1. NM_001144034.1. [Q86YD3-2]
NP_001137507.1. NM_001144035.1. [Q86YD3-2]
NP_001137508.1. NM_001144036.1. [Q86YD3-3]
NP_001137509.1. NM_001144037.1. [Q86YD3-4]
NP_001137510.1. NM_001144038.1. [Q86YD3-5]
NP_001305684.1. NM_001318755.1.
NP_001305686.1. NM_001318757.1.
NP_116169.2. NM_032780.3. [Q86YD3-1]
UniGeneiHs.564188.

Genome annotation databases

EnsembliENST00000313236; ENSP00000315635; ENSG00000149582. [Q86YD3-1]
ENST00000354064; ENSP00000278959; ENSG00000149582. [Q86YD3-3]
ENST00000354284; ENSP00000346237; ENSG00000149582. [Q86YD3-4]
ENST00000359862; ENSP00000352924; ENSG00000149582. [Q86YD3-2]
ENST00000411589; ENSP00000411882; ENSG00000149582. [Q86YD3-2]
ENST00000442938; ENSP00000416071; ENSG00000149582. [Q86YD3-5]
ENST00000524725; ENSP00000431205; ENSG00000149582. [Q86YD3-2]
GeneIDi84866.
KEGGihsa:84866.
UCSCiuc001pth.4. human. [Q86YD3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358919 mRNA. Translation: AAQ89278.1.
AK027305 mRNA. Translation: BAB55029.1.
AK056325 mRNA. Translation: BAB71151.1.
AK292359 mRNA. Translation: BAF85048.1.
AK075437 mRNA. Translation: BAC11620.1.
EF445037 Genomic DNA. Translation: ACA06084.1.
EF445037 Genomic DNA. Translation: ACA06085.1.
EF445037 Genomic DNA. Translation: ACA06086.1.
EF445037 Genomic DNA. Translation: ACA06087.1.
AP000941 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67388.1.
CH471065 Genomic DNA. Translation: EAW67389.1.
CH471065 Genomic DNA. Translation: EAW67393.1.
BC042896 mRNA. Translation: AAH42896.1.
BC051841 mRNA. Translation: AAH51841.1.
CCDSiCCDS44745.1. [Q86YD3-4]
CCDS44746.1. [Q86YD3-5]
CCDS44747.1. [Q86YD3-2]
CCDS44748.1. [Q86YD3-3]
CCDS8398.1. [Q86YD3-1]
RefSeqiNP_001137506.1. NM_001144034.1. [Q86YD3-2]
NP_001137507.1. NM_001144035.1. [Q86YD3-2]
NP_001137508.1. NM_001144036.1. [Q86YD3-3]
NP_001137509.1. NM_001144037.1. [Q86YD3-4]
NP_001137510.1. NM_001144038.1. [Q86YD3-5]
NP_001305684.1. NM_001318755.1.
NP_001305686.1. NM_001318757.1.
NP_116169.2. NM_032780.3. [Q86YD3-1]
UniGeneiHs.564188.

3D structure databases

ProteinModelPortaliQ86YD3.
SMRiQ86YD3. Positions 141-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124311. 84 interactions.
IntActiQ86YD3. 2 interactions.
MINTiMINT-2877607.
STRINGi9606.ENSP00000315635.

PTM databases

iPTMnetiQ86YD3.
PhosphoSiteiQ86YD3.

Polymorphism and mutation databases

BioMutaiTMEM25.

Proteomic databases

PaxDbiQ86YD3.
PeptideAtlasiQ86YD3.
PRIDEiQ86YD3.

Protocols and materials databases

DNASUi84866.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313236; ENSP00000315635; ENSG00000149582. [Q86YD3-1]
ENST00000354064; ENSP00000278959; ENSG00000149582. [Q86YD3-3]
ENST00000354284; ENSP00000346237; ENSG00000149582. [Q86YD3-4]
ENST00000359862; ENSP00000352924; ENSG00000149582. [Q86YD3-2]
ENST00000411589; ENSP00000411882; ENSG00000149582. [Q86YD3-2]
ENST00000442938; ENSP00000416071; ENSG00000149582. [Q86YD3-5]
ENST00000524725; ENSP00000431205; ENSG00000149582. [Q86YD3-2]
GeneIDi84866.
KEGGihsa:84866.
UCSCiuc001pth.4. human. [Q86YD3-1]

Organism-specific databases

CTDi84866.
GeneCardsiTMEM25.
HGNCiHGNC:25890. TMEM25.
HPAiHPA012163.
HPA051562.
MIMi613934. gene.
neXtProtiNX_Q86YD3.
PharmGKBiPA134919013.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF2Y. Eukaryota.
ENOG410ZNWF. LUCA.
GeneTreeiENSGT00390000003414.
HOGENOMiHOG000261622.
HOVERGENiHBG057137.
InParanoidiQ86YD3.
PhylomeDBiQ86YD3.
TreeFamiTF333068.

Miscellaneous databases

ChiTaRSiTMEM25. human.
GeneWikiiTMEM25.
GenomeRNAii84866.
PROiQ86YD3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149582.
CleanExiHS_TMEM25.
ExpressionAtlasiQ86YD3. baseline and differential.
GenevisibleiQ86YD3. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM25_HUMAN
AccessioniPrimary (citable) accession number: Q86YD3
Secondary accession number(s): A8K8J4
, B0YJA6, B0YJA7, B0YJA9, G5E9U4, Q6UW89, Q86UA7, Q8NBL5, Q96KA6, Q96MW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.