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Protein

Prostate tumor-overexpressed gene 1 protein

Gene

PTOV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate tumor-overexpressed gene 1 protein
Short name:
PTOV-1
Alternative name(s):
Activator interaction domain-containing protein 2
Gene namesi
Name:PTOV1
Synonyms:ACID2
ORF Names:PP642, UNQ6127/PRO20092
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9632. PTOV1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33976.

Polymorphism and mutation databases

BioMutaiPTOV1.
DMDMi74762466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Prostate tumor-overexpressed gene 1 proteinPRO_0000304965Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86YD1.
MaxQBiQ86YD1.
PaxDbiQ86YD1.
PRIDEiQ86YD1.

PTM databases

iPTMnetiQ86YD1.
PhosphoSiteiQ86YD1.

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine.1 Publication

Developmental stagei

Expressed at low levels in quiescent cells. Expression rises upon entry into S-phase.1 Publication

Inductioni

By testosterone.1 Publication

Gene expression databases

BgeeiQ86YD1.
CleanExiHS_PTOV1.
ExpressionAtlasiQ86YD1. baseline and differential.
GenevisibleiQ86YD1. HS.

Organism-specific databases

HPAiHPA051812.

Interactioni

Subunit structurei

May interact with CREBBP. Interacts with FLOT1.2 Publications

Protein-protein interaction databases

BioGridi119792. 19 interactions.
IntActiQ86YD1. 9 interactions.
MINTiMINT-1376653.
STRINGi9606.ENSP00000375717.

Structurei

3D structure databases

ProteinModelPortaliQ86YD1.
SMRiQ86YD1. Positions 88-234, 253-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni184 – 416233Interaction with FLOT1Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IHD9. Eukaryota.
ENOG410Z0HI. LUCA.
GeneTreeiENSGT00520000055653.
HOGENOMiHOG000115777.
HOVERGENiHBG108306.
InParanoidiQ86YD1.
OMAiDEGELDC.
PhylomeDBiQ86YD1.
TreeFamiTF329598.

Family and domain databases

InterProiIPR021394. Mediator_Med25.
[Graphical view]
PfamiPF11232. Med25. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86YD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRPRRAPYR SGAGGPLGGR GRPPRPLVVR AVRSRSWPAS PRGPQPPRIR
60 70 80 90 100
ARSAPPMEGA RVFGALGPIG PSSPGLTLGG LAVSEHRLSN KLLAWSGVLE
110 120 130 140 150
WQEKRRPYSD STAKLKRTLP CQAYVNQGEN LETDQWPQKL IMQLIPQQLL
160 170 180 190 200
TTLGPLFRNS QLAQFHFTNR DCDSLKGLCR IMGNGFAGCM LFPHISPCEV
210 220 230 240 250
RVLMLLYSSK KKIFMGLIPY DQSGFVSAIR QVITTRKQAV GPGGVNSGPV
260 270 280 290 300
QIVNNKFLAW SGVMEWQEPR PEPNSRSKRW LPSHVYVNQG EILRTEQWPR
310 320 330 340 350
KLYMQLIPQQ LLTTLVPLFR NSRLVQFHFT KDLETLKSLC RIMDNGFAGC
360 370 380 390 400
VHFSYKASCE IRVLMLLYSS EKKIFIGLIP HDQGNFVNGI RRVIANQQQV
410
LQRNLEQEQQ QRGMGG
Length:416
Mass (Da):46,869
Last modified:June 1, 2003 - v1
Checksum:i888573E714E75180
GO
Isoform 2 (identifier: Q86YD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
     33-57: RSRSWPASPRGPQPPRIRARSAPPM → MRSPAVPTPARGQLGVAFVLLPPHS
     348-397: AGCVHFSYKA...NGIRRVIANQ → RRKSSLASSP...NEGWGGSGYP

Show »
Length:384
Mass (Da):42,777
Checksum:iE6E36282C1744757
GO
Isoform 3 (identifier: Q86YD1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: Missing.

Show »
Length:227
Mass (Da):26,145
Checksum:i2F3BF5F7F6F419F2
GO

Sequence cautioni

The sequence AAF70635.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 189189Missing in isoform 3. 1 PublicationVSP_028153Add
BLAST
Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_028154Add
BLAST
Alternative sequencei33 – 5725RSRSW…SAPPM → MRSPAVPTPARGQLGVAFVL LPPHS in isoform 2. 1 PublicationVSP_028155Add
BLAST
Alternative sequencei348 – 39750AGCVH…VIANQ → RRKSSLASSPMTRATLSTAS GVSLPTSSRSCSGTWSRSNS NEGWGGSGYP in isoform 2. 1 PublicationVSP_028156Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238381 Genomic DNA. Translation: AAF70635.1. Sequence problems.
AJ617480 mRNA. Translation: CAE84582.1.
AF218026 mRNA. Translation: AAG17268.1.
AY358168 mRNA. Translation: AAQ88535.1.
CH471177 Genomic DNA. Translation: EAW52558.1.
BC015172 mRNA. Translation: AAH15172.1.
BC042921 mRNA. Translation: AAH42921.1.
CCDSiCCDS12782.1. [Q86YD1-1]
RefSeqiNP_001292034.1. NM_001305105.1. [Q86YD1-1]
NP_001292037.1. NM_001305108.1.
NP_059128.2. NM_017432.4. [Q86YD1-1]
XP_011525338.1. XM_011527036.1. [Q86YD1-3]
UniGeneiHs.587979.

Genome annotation databases

EnsembliENST00000391842; ENSP00000375717; ENSG00000104960. [Q86YD1-1]
ENST00000599732; ENSP00000469128; ENSG00000104960. [Q86YD1-1]
ENST00000601675; ENSP00000472816; ENSG00000104960. [Q86YD1-1]
GeneIDi53635.
KEGGihsa:53635.
UCSCiuc002pqb.5. human. [Q86YD1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238381 Genomic DNA. Translation: AAF70635.1. Sequence problems.
AJ617480 mRNA. Translation: CAE84582.1.
AF218026 mRNA. Translation: AAG17268.1.
AY358168 mRNA. Translation: AAQ88535.1.
CH471177 Genomic DNA. Translation: EAW52558.1.
BC015172 mRNA. Translation: AAH15172.1.
BC042921 mRNA. Translation: AAH42921.1.
CCDSiCCDS12782.1. [Q86YD1-1]
RefSeqiNP_001292034.1. NM_001305105.1. [Q86YD1-1]
NP_001292037.1. NM_001305108.1.
NP_059128.2. NM_017432.4. [Q86YD1-1]
XP_011525338.1. XM_011527036.1. [Q86YD1-3]
UniGeneiHs.587979.

3D structure databases

ProteinModelPortaliQ86YD1.
SMRiQ86YD1. Positions 88-234, 253-396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119792. 19 interactions.
IntActiQ86YD1. 9 interactions.
MINTiMINT-1376653.
STRINGi9606.ENSP00000375717.

PTM databases

iPTMnetiQ86YD1.
PhosphoSiteiQ86YD1.

Polymorphism and mutation databases

BioMutaiPTOV1.
DMDMi74762466.

Proteomic databases

EPDiQ86YD1.
MaxQBiQ86YD1.
PaxDbiQ86YD1.
PRIDEiQ86YD1.

Protocols and materials databases

DNASUi53635.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391842; ENSP00000375717; ENSG00000104960. [Q86YD1-1]
ENST00000599732; ENSP00000469128; ENSG00000104960. [Q86YD1-1]
ENST00000601675; ENSP00000472816; ENSG00000104960. [Q86YD1-1]
GeneIDi53635.
KEGGihsa:53635.
UCSCiuc002pqb.5. human. [Q86YD1-1]

Organism-specific databases

CTDi53635.
GeneCardsiPTOV1.
HGNCiHGNC:9632. PTOV1.
HPAiHPA051812.
MIMi610195. gene.
neXtProtiNX_Q86YD1.
PharmGKBiPA33976.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHD9. Eukaryota.
ENOG410Z0HI. LUCA.
GeneTreeiENSGT00520000055653.
HOGENOMiHOG000115777.
HOVERGENiHBG108306.
InParanoidiQ86YD1.
OMAiDEGELDC.
PhylomeDBiQ86YD1.
TreeFamiTF329598.

Miscellaneous databases

ChiTaRSiPTOV1. human.
GeneWikiiPTOV1.
GenomeRNAii53635.
PROiQ86YD1.
SOURCEiSearch...

Gene expression databases

BgeeiQ86YD1.
CleanExiHS_PTOV1.
ExpressionAtlasiQ86YD1. baseline and differential.
GenevisibleiQ86YD1. HS.

Family and domain databases

InterProiIPR021394. Mediator_Med25.
[Graphical view]
PfamiPF11232. Med25. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks."
    Benedit P., Paciucci R., Thomson T.M., Valeri M., Nadal M., Caceres C., de Torres I., Estivill X., Lozano J.J., Morote J., Reventos J.
    Oncogene 20:1455-1464(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "A novel docking site on Mediator is critical for activation by VP16 in mammalian cells."
    Mittler G., Stuehler T., Santolin L., Uhlmann T., Kremmer E., Lottspeich F., Berti L., Meisterernst M.
    EMBO J. 22:6494-6504(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 260-416 (ISOFORMS 1/3).
    Tissue: Colon adenocarcinoma.
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Pancreas.
  7. "PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle."
    Santamaria A., Fernandez P.L., Farre X., Benedit P., Reventos J., Morote J., Paciucci R., Thomson T.M.
    Am. J. Pathol. 162:897-905(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts."
    Santamaria A., Castellanos E., Gomez V., Benedit P., Renau-Piqueras J., Morote J., Reventos J., Thomson T.M., Paciucci R.
    Mol. Cell. Biol. 25:1900-1911(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FLOT1, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  9. "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer."
    Benzinger A., Muster N., Koch H.B., Yates J.R. III, Hermeking H.
    Mol. Cell. Proteomics 4:785-795(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
  10. Cited for: SUBCELLULAR LOCATION, INDUCTION.
  11. "MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation."
    Lee H.-K., Park U.-H., Kim E.-J., Um S.-J.
    EMBO J. 26:3545-3557(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CREBBP.

Entry informationi

Entry nameiPTOV1_HUMAN
AccessioniPrimary (citable) accession number: Q86YD1
Secondary accession number(s): Q6UXX7
, Q96BU3, Q9HBN4, Q9NYL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite sequence similarity to MED25, to date this protein has not been identified as a component of the Mediator complex.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.