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Protein

Negative regulator of reactive oxygen species

Gene

NRROS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of reactive oxygen species
Alternative name(s):
Leucine-rich repeat-containing protein 33
Gene namesi
Name:NRROS
Synonyms:LRRC33
ORF Names:UNQ3030/PRO9833
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24613. NRROS.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 650632ExtracellularSequence analysisAdd
BLAST
Transmembranei651 – 67121HelicalSequence analysisAdd
BLAST
Topological domaini672 – 69221CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671521.

Polymorphism and mutation databases

BioMutaiNRROS.
DMDMi74762465.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 692674Negative regulator of reactive oxygen speciesPRO_0000042660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence analysis
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence analysis
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence analysis
Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence analysis
Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence analysis
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence analysis
Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ86YC3.
MaxQBiQ86YC3.
PaxDbiQ86YC3.
PRIDEiQ86YC3.

PTM databases

iPTMnetiQ86YC3.
PhosphoSiteiQ86YC3.

Expressioni

Tissue specificityi

Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen.1 Publication

Gene expression databases

BgeeiQ86YC3.
CleanExiHS_LRRC33.
GenevisibleiQ86YC3. HS.

Organism-specific databases

HPAiHPA031586.

Interactioni

Subunit structurei

Interacts with CYBB/NOX2; the interaction is direct (By similarity). Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors.By similarity1 Publication

Protein-protein interaction databases

BioGridi131978. 18 interactions.
STRINGi9606.ENSP00000328625.

Structurei

3D structure databases

ProteinModelPortaliQ86YC3.
SMRiQ86YC3. Positions 34-687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 7922LRR 1Add
BLAST
Repeati82 – 10322LRR 2Add
BLAST
Repeati106 – 12722LRR 3Add
BLAST
Repeati133 – 15523LRR 4Add
BLAST
Repeati158 – 17922LRR 5Add
BLAST
Repeati182 – 20322LRR 6Add
BLAST
Repeati206 – 22722LRR 7Add
BLAST
Repeati228 – 23912LRR 8Add
BLAST
Repeati251 – 27222LRR 9Add
BLAST
Repeati273 – 29422LRR 10Add
BLAST
Repeati329 – 35022LRR 11Add
BLAST
Repeati353 – 37422LRR 12Add
BLAST
Repeati377 – 39822LRR 13Add
BLAST
Repeati403 – 42422LRR 14Add
BLAST
Repeati427 – 44721LRR 15Add
BLAST
Repeati463 – 48422LRR 16Add
BLAST
Repeati486 – 50722LRR 17Add
BLAST
Repeati512 – 53423LRR 18Add
BLAST
Repeati537 – 55822LRR 19Add
BLAST
Repeati559 – 58022LRR 20Add
BLAST
Repeati585 – 59410LRR 21

Sequence similaritiesi

Contains 21 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00710000106753.
HOGENOMiHOG000113368.
HOVERGENiHBG081928.
InParanoidiQ86YC3.
OMAiRCHWSSV.
OrthoDBiEOG70KGP0.
PhylomeDBiQ86YC3.
TreeFamiTF317167.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13516. LRR_6. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86YC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLPLWLCL GFHFLTVGWR NRSGTATAAS QGVCKLVGGA ADCRGQSLAS
60 70 80 90 100
VPSSLPPHAR MLTLDANPLK TLWNHSLQPY PLLESLSLHS CHLERISRGA
110 120 130 140 150
FQEQGHLRSL VLGDNCLSEN YEETAAALHA LPGLRRLDLS GNALTEDMAA
160 170 180 190 200
LMLQNLSSLR SVSLAGNTIM RLDDSVFEGL ERLRELDLQR NYIFEIEGGA
210 220 230 240 250
FDGLAELRHL NLAFNNLPCI VDFGLTRLRV LNVSYNVLEW FLATGGEAAF
260 270 280 290 300
ELETLDLSHN QLLFFPLLPQ YSKLRTLLLR DNNMGFYRDL YNTSSPREMV
310 320 330 340 350
AQFLLVDGNV TNITTVSLWE EFSSSDLADL RFLDMSQNQF QYLPDGFLRK
360 370 380 390 400
MPSLSHLNLH QNCLMTLHIR EHEPPGALTE LDLSHNQLSE LHLAPGLASC
410 420 430 440 450
LGSLRLFNLS SNQLLGVPPG LFANARNITT LDMSHNQISL CPLPAASDRV
460 470 480 490 500
GPPSCVDFRN MASLRSLSLE GCGLGALPDC PFQGTSLTYL DLSSNWGVLN
510 520 530 540 550
GSLAPLQDVA PMLQVLSLRN MGLHSSFMAL DFSGFGNLRD LDLSGNCLTT
560 570 580 590 600
FPRFGGSLAL ETLDLRRNSL TALPQKAVSE QLSRGLRTIY LSQNPYDCCG
610 620 630 640 650
VDGWGALQHG QTVADWAMVT CNLSSKIIRV TELPGGVPRD CKWERLDLGL
660 670 680 690
LYLVLILPSC LTLLVACTVI VLTFKKPLLQ VIKSRCHWSS VY
Length:692
Mass (Da):76,366
Last modified:June 1, 2003 - v1
Checksum:i1574A06F405DDAA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358322 mRNA. Translation: AAQ88688.1.
BC044233 mRNA. Translation: AAH44233.1.
CCDSiCCDS3319.1.
RefSeqiNP_940967.1. NM_198565.2.
UniGeneiHs.702186.

Genome annotation databases

EnsembliENST00000328557; ENSP00000328625; ENSG00000174004.
GeneIDi375387.
KEGGihsa:375387.
UCSCiuc003fwv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358322 mRNA. Translation: AAQ88688.1.
BC044233 mRNA. Translation: AAH44233.1.
CCDSiCCDS3319.1.
RefSeqiNP_940967.1. NM_198565.2.
UniGeneiHs.702186.

3D structure databases

ProteinModelPortaliQ86YC3.
SMRiQ86YC3. Positions 34-687.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131978. 18 interactions.
STRINGi9606.ENSP00000328625.

PTM databases

iPTMnetiQ86YC3.
PhosphoSiteiQ86YC3.

Polymorphism and mutation databases

BioMutaiNRROS.
DMDMi74762465.

Proteomic databases

EPDiQ86YC3.
MaxQBiQ86YC3.
PaxDbiQ86YC3.
PRIDEiQ86YC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328557; ENSP00000328625; ENSG00000174004.
GeneIDi375387.
KEGGihsa:375387.
UCSCiuc003fwv.4. human.

Organism-specific databases

CTDi375387.
GeneCardsiNRROS.
HGNCiHGNC:24613. NRROS.
HPAiHPA031586.
MIMi615322. gene.
neXtProtiNX_Q86YC3.
PharmGKBiPA142671521.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00710000106753.
HOGENOMiHOG000113368.
HOVERGENiHBG081928.
InParanoidiQ86YC3.
OMAiRCHWSSV.
OrthoDBiEOG70KGP0.
PhylomeDBiQ86YC3.
TreeFamiTF317167.

Miscellaneous databases

GenomeRNAii375387.
PROiQ86YC3.
SOURCEiSearch...

Gene expression databases

BgeeiQ86YC3.
CleanExiHS_LRRC33.
GenevisibleiQ86YC3. HS.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13516. LRR_6. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  3. "Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-kappa-B activation."
    Liu J., Zhang Z., Chai L., Che Y., Min S., Yang R.
    Biochem. Biophys. Res. Commun. 434:28-34(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH TOLL-LIKE RECEPTORS, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNRROS_HUMAN
AccessioniPrimary (citable) accession number: Q86YC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.