##gff-version 3 Q86YC2 UniProtKB Chain 1 1186 . . . ID=PRO_0000252391;Note=Partner and localizer of BRCA2 Q86YC2 UniProtKB Repeat 854 915 . . . Note=WD 1 Q86YC2 UniProtKB Repeat 917 961 . . . Note=WD 2 Q86YC2 UniProtKB Repeat 962 1009 . . . Note=WD 3 Q86YC2 UniProtKB Repeat 1010 1052 . . . Note=WD 4 Q86YC2 UniProtKB Repeat 1058 1109 . . . Note=WD 5 Q86YC2 UniProtKB Repeat 1115 1153 . . . Note=WD 6 Q86YC2 UniProtKB Repeat 1155 1186 . . . Note=WD 7 Q86YC2 UniProtKB Region 1 579 . . . Note=DNA-binding (with the preference D loop > dsDNA > ssDNA) Q86YC2 UniProtKB Region 1 319 . . . Note=Interaction with BRCA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19369211;Dbxref=PMID:19369211 Q86YC2 UniProtKB Region 1 200 . . . Note=Interaction with RAD51 Q86YC2 UniProtKB Region 1 160 . . . Note=Required for its oligomerization and is important for its focal concentration at DNA damage sites Q86YC2 UniProtKB Region 52 72 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YC2 UniProtKB Region 95 157 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YC2 UniProtKB Region 252 273 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YC2 UniProtKB Region 346 365 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YC2 UniProtKB Region 395 446 . . . Note=ChAM (Chromatin-association motif)%3B required for chromatin association%2C mediates nucleosome association Q86YC2 UniProtKB Region 440 525 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YC2 UniProtKB Region 679 698 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YC2 UniProtKB Region 774 798 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YC2 UniProtKB Region 775 1186 . . . Note=Required for interaction with POLH and POLH DNA synthesis stimulation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24485656;Dbxref=PMID:24485656 Q86YC2 UniProtKB Region 853 1186 . . . Note=Interaction with RAD51%2C BRCA2 and POLH;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24485656;Dbxref=PMID:24485656 Q86YC2 UniProtKB Coiled coil 9 41 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86YC2 UniProtKB Compositional bias 123 144 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YC2 UniProtKB Compositional bias 446 495 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YC2 UniProtKB Compositional bias 684 698 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86YC2 UniProtKB Modified residue 172 172 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86YC2 UniProtKB Modified residue 190 190 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86YC2 UniProtKB Modified residue 285 285 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86YC2 UniProtKB Modified residue 376 376 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17525332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:17525332,PMID:20068231,PMID:23186163 Q86YC2 UniProtKB Modified residue 387 387 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163 Q86YC2 UniProtKB Modified residue 454 454 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86YC2 UniProtKB Modified residue 660 660 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86YC2 UniProtKB Modified residue 781 781 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86YC2 UniProtKB Natural variant 18 18 . . . ID=VAR_079842;Note=Decreases double-stranded DNA break-initiated homologous recombination. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28319063;Dbxref=dbSNP:rs138789658,PMID:28319063 Q86YC2 UniProtKB Natural variant 28 28 . . . ID=VAR_079843;Note=Abrogates the interaction with BRCA1%3B decreases double-stranded DNA break-initiated homologous recombination%3B reduces PALB2 and RAD51 localization to ionizing radiation-induced foci%3B may weaken homooligomerization. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28319063;Dbxref=dbSNP:rs515726129,PMID:28319063 Q86YC2 UniProtKB Natural variant 35 35 . . . ID=VAR_079844;Note=Found in breast cancer patients%3B uncertain significance%3B abrogates the interaction with BRCA1%3B abrogates double-stranded DNA break-initiated homologous recombination%3B abrogates PALB2 and RAD51 localization to ionizing radiation-induced foci%3B may weaken homooligomerization. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28319063;Dbxref=dbSNP:rs141047069,PMID:28319063 Q86YC2 UniProtKB Natural variant 37 37 . . . ID=VAR_079845;Note=Decreases double-stranded DNA break-initiated homologous recombination. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28319063;Dbxref=dbSNP:rs202194596,PMID:28319063 Q86YC2 UniProtKB Natural variant 46 46 . . . ID=VAR_066361;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=PMID:21618343 Q86YC2 UniProtKB Natural variant 219 219 . . . ID=VAR_066362;Note=D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs45594034,PMID:21618343 Q86YC2 UniProtKB Natural variant 309 309 . . . ID=VAR_032959;Note=I->V;Dbxref=dbSNP:rs3809683 Q86YC2 UniProtKB Natural variant 334 334 . . . ID=VAR_066363;Note=Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs200620434,PMID:21618343 Q86YC2 UniProtKB Natural variant 337 337 . . . ID=VAR_066364;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs45494092,PMID:21618343 Q86YC2 UniProtKB Natural variant 343 1186 . . . ID=VAR_088781;Note=Risk factor for BROVCA5. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24556926,ECO:0000269|PubMed:31841383;Dbxref=PMID:24556926,PMID:31841383 Q86YC2 UniProtKB Natural variant 414 414 . . . ID=VAR_066365;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs749461008,PMID:21618343 Q86YC2 UniProtKB Natural variant 425 425 . . . ID=VAR_066366;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs576081828,PMID:21618343 Q86YC2 UniProtKB Natural variant 491 491 . . . ID=VAR_066367;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs577969558,PMID:21618343 Q86YC2 UniProtKB Natural variant 515 515 . . . ID=VAR_066368;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs515726072,PMID:21618343 Q86YC2 UniProtKB Natural variant 551 1186 . . . ID=VAR_088782;Note=In FANCN%3B risk factor for BROVCA5. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17200672,ECO:0000269|PubMed:31841383;Dbxref=PMID:17200672,PMID:31841383 Q86YC2 UniProtKB Natural variant 559 559 . . . ID=VAR_066369;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs152451,PMID:21618343 Q86YC2 UniProtKB Natural variant 672 672 . . . ID=VAR_066370;Note=E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs45532440,PMID:21618343 Q86YC2 UniProtKB Natural variant 712 712 . . . ID=VAR_066371;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs141458731,PMID:21618343 Q86YC2 UniProtKB Natural variant 728 728 . . . ID=VAR_066372;Note=F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=PMID:21618343 Q86YC2 UniProtKB Natural variant 775 1186 . . . ID=VAR_088783;Note=Risk factor for BROVCA5. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18053174,ECO:0000269|PubMed:31841383;Dbxref=PMID:18053174,PMID:31841383 Q86YC2 UniProtKB Natural variant 864 864 . . . ID=VAR_054150;Note=P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18987736,ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs45568339,PMID:18987736,PMID:21618343 Q86YC2 UniProtKB Natural variant 917 917 . . . ID=VAR_066373;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs763645981,PMID:21618343 Q86YC2 UniProtKB Natural variant 932 932 . . . ID=VAR_066374;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs45624036,PMID:21618343 Q86YC2 UniProtKB Natural variant 939 939 . . . ID=VAR_066375;Note=May be associated with breast cancer susceptibility%3B reduces interaction with BRCA2%2C RAD51 and XRCC3%3B decreases double-stranded DNA break-initiated homologous recombination%3B increases sensitivity to IR. L->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21618343,ECO:0000269|PubMed:24141787;Dbxref=dbSNP:rs45478192,PMID:21618343,PMID:24141787 Q86YC2 UniProtKB Natural variant 966 966 . . . ID=VAR_066376;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs786204248,PMID:21618343 Q86YC2 UniProtKB Natural variant 988 1186 . . . ID=VAR_088784;Note=In FANCN%3B risk factor for BROVCA5. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17200671,ECO:0000269|PubMed:31841383;Dbxref=PMID:17200671,PMID:31841383 Q86YC2 UniProtKB Natural variant 998 998 . . . ID=VAR_066377;Note=G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs45551636,PMID:21618343 Q86YC2 UniProtKB Natural variant 1025 1025 . . . ID=VAR_066378;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs746872839,PMID:21618343 Q86YC2 UniProtKB Natural variant 1038 1186 . . . ID=VAR_088785;Note=Risk factor for BROVCA5. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17200668,ECO:0000269|PubMed:23448497,ECO:0000269|PubMed:31841383;Dbxref=PMID:17200668,PMID:23448497,PMID:31841383 Q86YC2 UniProtKB Natural variant 1043 1043 . . . ID=VAR_066379;Note=May be associated with breast cancer susceptibility%3B reduces interaction with BRCA2%2C RAD51C%2C RAD51 and XRCC3%3B decreases double-stranded DNA break-initiated homologous recombination%3B increases sensitivity to IR. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs377713277,PMID:21618343 Q86YC2 UniProtKB Natural variant 1075 1075 . . . ID=VAR_066380;Note=S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=PMID:21618343 Q86YC2 UniProtKB Natural variant 1086 1186 . . . ID=VAR_088786;Note=Risk factor for BROVCA5%3B risk factor for PNCA3. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19264984,ECO:0000269|PubMed:31841383;Dbxref=PMID:19264984,PMID:31841383 Q86YC2 UniProtKB Natural variant 1105 1105 . . . ID=VAR_066381;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=PMID:21618343 Q86YC2 UniProtKB Natural variant 1114 1114 . . . ID=VAR_066382;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs1567206753,PMID:21618343 Q86YC2 UniProtKB Natural variant 1143 1143 . . . ID=VAR_066383;Note=May be associated with breast cancer susceptibility. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21618343,ECO:0000269|PubMed:24141787;Dbxref=dbSNP:rs62625284,PMID:21618343,PMID:24141787 Q86YC2 UniProtKB Natural variant 1170 1170 . . . ID=VAR_066384;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21618343;Dbxref=dbSNP:rs200283306,PMID:21618343 Q86YC2 UniProtKB Natural variant 1183 1186 . . . ID=VAR_088787;Note=In FANCN%3B risk factor for BROVCA5. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17200668,ECO:0000269|PubMed:17200671,ECO:0000269|PubMed:31841383;Dbxref=PMID:17200668,PMID:17200671,PMID:31841383 Q86YC2 UniProtKB Mutagenesis 14 14 . . . Note=Loss of interaction with BRCA1 but no effect on interaction with BRCA2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19369211;Dbxref=PMID:19369211 Q86YC2 UniProtKB Mutagenesis 21 21 . . . Note=Loss of interaction with BRCA1 but no effect on interaction with BRCA2. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19369211;Dbxref=PMID:19369211 Q86YC2 UniProtKB Mutagenesis 28 28 . . . Note=Loss of interaction with BRCA1 but no effect on interaction with BRCA2. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19369211;Dbxref=PMID:19369211 Q86YC2 UniProtKB Mutagenesis 35 35 . . . Note=Loss of interaction with BRCA1 but no effect on interaction with BRCA2. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19369211;Dbxref=PMID:19369211 Q86YC2 UniProtKB Mutagenesis 42 42 . . . Note=Loss of interaction with BRCA1 but no effect on interaction with BRCA2. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19369211;Dbxref=PMID:19369211 Q86YC2 UniProtKB Mutagenesis 1030 1030 . . . Note=Unstable and promotes protein degradation%3B reduces interaction with RAD51C and RAD51. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24141787;Dbxref=PMID:24141787 Q86YC2 UniProtKB Helix 600 606 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7S4A Q86YC2 UniProtKB Helix 616 627 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7S4A Q86YC2 UniProtKB Beta strand 855 861 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 869 877 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 884 913 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 919 922 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 932 936 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 938 947 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 958 972 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Turn 973 975 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 976 984 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 988 994 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1000 1006 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1013 1020 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1025 1030 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1033 1039 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Turn 1040 1042 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1045 1050 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1053 1055 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3EU7 Q86YC2 UniProtKB Beta strand 1059 1066 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1069 1075 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1090 1096 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Turn 1097 1100 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1101 1108 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1118 1124 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1127 1132 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1137 1141 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Turn 1142 1144 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1146 1151 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1161 1164 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1166 1174 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18 Q86YC2 UniProtKB Beta strand 1180 1185 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W18