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Protein

Partner and localizer of BRCA2

Gene

PALB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity.8 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-5685942. HDR through Homologous Recombination (HRR).
R-HSA-5693554. Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).
R-HSA-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-HSA-5693579. Homologous DNA Pairing and Strand Exchange.
SIGNORiQ86YC2.

Names & Taxonomyi

Protein namesi
Recommended name:
Partner and localizer of BRCA2
Gene namesi
Name:PALB2
Synonyms:FANCN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26144. PALB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Breast cancer (BC)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry. Breast cancer susceptibility is strongly associated with PALB2 truncating mutations. Conversely, rare missense mutations do not strongly influence breast cancer risk (PubMed:22241545).1 Publication
Disease descriptionA common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
See also OMIM:114480
Fanconi anemia complementation group N (FANCN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
See also OMIM:610832
Pancreatic cancer 3 (PNCA3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.
See also OMIM:613348

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi14K → A: Loss of interaction with BRCA1 but no effect on interaction with BRCA2. 1 Publication1
Mutagenesisi21L → A: Loss of interaction with BRCA1 but no effect on interaction with BRCA2. 1 Publication1
Mutagenesisi28Y → A: Loss of interaction with BRCA1 but no effect on interaction with BRCA2. 1 Publication1
Mutagenesisi35L → A: Loss of interaction with BRCA1 but no effect on interaction with BRCA2. 1 Publication1
Mutagenesisi42E → A: Loss of interaction with BRCA1 but no effect on interaction with BRCA2. 1 Publication1
Mutagenesisi1030T → I: Unstable and promotes protein degradation; reduces interaction with RAD51C and RAD51. 1 Publication1

Keywords - Diseasei

Fanconi anemia, Tumor suppressor

Organism-specific databases

DisGeNETi79728.
MalaCardsiPALB2.
MIMi114480. phenotype.
610832. phenotype.
613348. phenotype.
OpenTargetsiENSG00000083093.
Orphaneti1333. Familial pancreatic carcinoma.
84. Fanconi anemia.
145. Hereditary breast and ovarian cancer syndrome.
227535. Hereditary breast cancer.
PharmGKBiPA162398608.

Polymorphism and mutation databases

BioMutaiPALB2.
DMDMi74727919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002523911 – 1186Partner and localizer of BRCA2Add BLAST1186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Modified residuei781PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86YC2.
MaxQBiQ86YC2.
PaxDbiQ86YC2.
PeptideAtlasiQ86YC2.
PRIDEiQ86YC2.

PTM databases

iPTMnetiQ86YC2.
PhosphoSitePlusiQ86YC2.

Expressioni

Gene expression databases

BgeeiENSG00000083093.
CleanExiHS_PALB2.
ExpressionAtlasiQ86YC2. baseline and differential.
GenevisibleiQ86YC2. HS.

Organism-specific databases

HPAiCAB014895.
HPA057000.
HPA059851.

Interactioni

Subunit structurei

Homooligomer; dissociated upon DNA damage thus allowing association with BRCA1. Oligomerization is essential for its focal accumulation at DNA breaks. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts with BRCA1 and this interaction is essential for its function in HRR. Interacts with RAD51AP1 and MORF4L1/MRG15. Interacts with BRCA2, RAD51C, RAD51 and XRCC3; the interactions are direct and it may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with POLH; the interaction is direct.9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BRCA2P5158715EBI-1222653,EBI-79792
POLHQ9Y2537EBI-1222653,EBI-2827270
RAD51Q066095EBI-1222653,EBI-297202
RAD51CO4350210EBI-1222653,EBI-2267048
XRCC3O435423EBI-1222653,EBI-2849976

Protein-protein interaction databases

BioGridi122843. 41 interactors.
DIPiDIP-38427N.
IntActiQ86YC2. 31 interactors.
MINTiMINT-7262182.
STRINGi9606.ENSP00000261584.

Structurei

Secondary structure

11186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi855 – 861Combined sources7
Beta strandi869 – 877Combined sources9
Beta strandi884 – 913Combined sources30
Beta strandi919 – 922Combined sources4
Beta strandi932 – 936Combined sources5
Beta strandi938 – 947Combined sources10
Beta strandi958 – 972Combined sources15
Turni973 – 975Combined sources3
Beta strandi976 – 984Combined sources9
Beta strandi988 – 994Combined sources7
Beta strandi1000 – 1006Combined sources7
Beta strandi1013 – 1020Combined sources8
Beta strandi1025 – 1030Combined sources6
Beta strandi1033 – 1039Combined sources7
Turni1040 – 1042Combined sources3
Beta strandi1045 – 1050Combined sources6
Beta strandi1053 – 1055Combined sources3
Beta strandi1059 – 1066Combined sources8
Beta strandi1069 – 1075Combined sources7
Beta strandi1090 – 1096Combined sources7
Turni1097 – 1100Combined sources4
Beta strandi1101 – 1108Combined sources8
Beta strandi1118 – 1124Combined sources7
Beta strandi1127 – 1132Combined sources6
Beta strandi1137 – 1141Combined sources5
Turni1142 – 1144Combined sources3
Beta strandi1146 – 1151Combined sources6
Beta strandi1161 – 1164Combined sources4
Beta strandi1166 – 1174Combined sources9
Beta strandi1180 – 1185Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W18X-ray1.90A835-1186[»]
3EU7X-ray2.20A835-1186[»]
ProteinModelPortaliQ86YC2.
SMRiQ86YC2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86YC2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati854 – 915WD 1Add BLAST62
Repeati917 – 961WD 2Add BLAST45
Repeati962 – 1009WD 3Add BLAST48
Repeati1010 – 1052WD 4Add BLAST43
Repeati1058 – 1109WD 5Add BLAST52
Repeati1115 – 1153WD 6Add BLAST39
Repeati1155 – 1186WD 7Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 579DNA-binding (with the preference D loop > dsDNA > ssDNA)Add BLAST579
Regioni1 – 319Interaction with BRCA11 PublicationAdd BLAST319
Regioni1 – 200Interaction with RAD51Add BLAST200
Regioni1 – 160Required for its oligomerization and is important for its focal concentration at DNA damage sitesAdd BLAST160
Regioni395 – 446ChAM (Chromatin-association motif); required for chromatin association, mediates nucleosome associationAdd BLAST52
Regioni775 – 1186Required for interaction with POLH and POLH DNA synthesis stimulation1 PublicationAdd BLAST412
Regioni853 – 1186Interaction with RAD51, BRCA2 and POLH1 PublicationAdd BLAST334

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili9 – 41Sequence analysisAdd BLAST33

Domaini

Interaction with BRCA2 occurs through a hydrophobic pocket at the crossover between WD repeats 4 and 5.1 Publication
The coiled coil domain mediates self-association.2 Publications
The chromatin-association motif (ChAM) mediates association with chromatin, probably through nucleosome core particles, independently from binding to D loop, ssDNA or dsDNA structures.2 Publications

Sequence similaritiesi

Contains 7 WD repeats.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IIBP. Eukaryota.
ENOG4111F80. LUCA.
GeneTreeiENSGT00390000014423.
HOGENOMiHOG000115428.
HOVERGENiHBG082102.
InParanoidiQ86YC2.
KOiK10897.
OMAiNIVIWNL.
OrthoDBiEOG091G0264.
PhylomeDBiQ86YC2.
TreeFamiTF351544.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR031920. PALB2_WD40.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF16756. PALB2_WD40. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequencei

Sequence statusi: Complete.

Q86YC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEPPGKPLS CEEKEKLKEK LAFLKREYSK TLARLQRAQR AEKIKHSIKK
60 70 80 90 100
TVEEQDCLSQ QDLSPQLKHS EPKNKICVYD KLHIKTHLDE ETGEKTSITL
110 120 130 140 150
DVGPESFNPG DGPGGLPIQR TDDTQEHFPH RVSDPSGEQK QKLPSRRKKQ
160 170 180 190 200
QKRTFISQER DCVFGTDSLR LSGKRLKEQE EISSKNPARS PVTEIRTHLL
210 220 230 240 250
SLKSELPDSP EPVTEINEDS VLIPPTAQPE KGVDTFLRRP NFTRATTVPL
260 270 280 290 300
QTLSDSGSSQ HLEHIPPKGS SELTTHDLKN IRFTSPVSLE AQGKKMTVST
310 320 330 340 350
DNLLVNKAIS KSGQLPTSSN LEANISCSLN ELTYNNLPAN ENQNLKEQNQ
360 370 380 390 400
TEKSLKSPSD TLDGRNENLQ ESEILSQPKS LSLEATSPLS AEKHSCTVPE
410 420 430 440 450
GLLFPAEYYV RTTRSMSNCQ RKVAVEAVIQ SHLDVKKKGF KNKNKDASKN
460 470 480 490 500
LNLSNEETDQ SEIRMSGTCT GQPSSRTSQK LLSLTKVSSP AGPTEDNDLS
510 520 530 540 550
RKAVAQAPGR RYTGKRKSAC TPASDHCEPL LPTSSLSIVN RSKEEVTSHK
560 570 580 590 600
YQHEKLFIQV KGKKSRHQKE DSLSWSNSAY LSLDDDAFTA PFHRDGMLSL
610 620 630 640 650
KQLLSFLSIT DFQLPDEDFG PLKLEKVKSC SEKPVEPFES KMFGERHLKE
660 670 680 690 700
GSCIFPEELS PKRMDTEMED LEEDLIVLPG KSHPKRPNSQ SQHTKTGLSS
710 720 730 740 750
SILLYTPLNT VAPDDNDRPT TDMCSPAFPI LGTTPAFGPQ GSYEKASTEV
760 770 780 790 800
AGRTCCTPQL AHLKDSVCLA SDTKQFDSSG SPAKPHTTLQ VSGRQGQPTC
810 820 830 840 850
DCDSVPPGTP PPIESFTFKE NQLCRNTCQE LHKHSVEQTE TAELPASDSI
860 870 880 890 900
NPGNLQLVSE LKNPSGSCSV DVSAMFWERA GCKEPCIITA CEDVVSLWKA
910 920 930 940 950
LDAWQWEKLY TWHFAEVPVL QIVPVPDVYN LVCVALGNLE IREIRALFCS
960 970 980 990 1000
SDDESEKQVL LKSGNIKAVL GLTKRRLVSS SGTLSDQQVE VMTFAEDGGG
1010 1020 1030 1040 1050
KENQFLMPPE ETILTFAEVQ GMQEALLGTT IMNNIVIWNL KTGQLLKKMH
1060 1070 1080 1090 1100
IDDSYQASVC HKAYSEMGLL FIVLSHPCAK ESESLRSPVF QLIVINPKTT
1110 1120 1130 1140 1150
LSVGVMLYCL PPGQAGRFLE GDVKDHCAAA ILTSGTIAIW DLLLGQCTAL
1160 1170 1180
LPPVSDQHWS FVKWSGTDSH LLAGQKDGNI FVYHYS
Length:1,186
Mass (Da):131,295
Last modified:June 1, 2003 - v1
Checksum:i215EC32291315FA2
GO

Sequence cautioni

The sequence BAB15140 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06636146H → Y.1 Publication1
Natural variantiVAR_066362219D → G.1 PublicationCorresponds to variant rs45594034dbSNPEnsembl.1
Natural variantiVAR_032959309I → V.Corresponds to variant rs3809683dbSNPEnsembl.1
Natural variantiVAR_066363334Y → C.1 PublicationCorresponds to variant rs200620434dbSNPEnsembl.1
Natural variantiVAR_066364337L → S.1 PublicationCorresponds to variant rs45494092dbSNPEnsembl.1
Natural variantiVAR_066365414R → Q.1 PublicationCorresponds to variant rs749461008dbSNPEnsembl.1
Natural variantiVAR_066366425V → M.1 PublicationCorresponds to variant rs576081828dbSNPEnsembl.1
Natural variantiVAR_066367491A → T.1 PublicationCorresponds to variant rs577969558dbSNPEnsembl.1
Natural variantiVAR_066368515K → R.1 PublicationCorresponds to variant rs515726072dbSNPEnsembl.1
Natural variantiVAR_066369559Q → R.1 PublicationCorresponds to variant rs152451dbSNPEnsembl.1
Natural variantiVAR_066370672E → Q.1 PublicationCorresponds to variant rs45532440dbSNPEnsembl.1
Natural variantiVAR_066371712A → V.1 PublicationCorresponds to variant rs141458731dbSNPEnsembl.1
Natural variantiVAR_066372728F → L.1 Publication1
Natural variantiVAR_054150864P → S.2 PublicationsCorresponds to variant rs45568339dbSNPEnsembl.1
Natural variantiVAR_066373917V → A.1 PublicationCorresponds to variant rs763645981dbSNPEnsembl.1
Natural variantiVAR_066374932V → M.1 PublicationCorresponds to variant rs45624036dbSNPEnsembl.1
Natural variantiVAR_066375939L → W May be associated with breast cancer susceptibility; reduces interaction with BRCA2, RAD51 and XRCC3; decreases double-stranded DNA break-initiated homologous recombination; increases sensitivity to IR. 2 PublicationsCorresponds to variant rs45478192dbSNPEnsembl.1
Natural variantiVAR_066376966I → V.1 PublicationCorresponds to variant rs786204248dbSNPEnsembl.1
Natural variantiVAR_066377998G → E May be associated with breast cancer susceptibility. 1 PublicationCorresponds to variant rs45551636dbSNPEnsembl.1
Natural variantiVAR_0663781025A → T.1 PublicationCorresponds to variant rs746872839dbSNPEnsembl.1
Natural variantiVAR_0663791043G → A May be associated with breast cancer susceptibility; reduces interaction with BRCA2, RAD51C, RAD51 and XRCC3; decreases double-stranded DNA break-initiated homologous recombination; increases sensitivity to IR. 1 PublicationCorresponds to variant rs377713277dbSNPEnsembl.1
Natural variantiVAR_0663801075S → G.1 Publication1
Natural variantiVAR_0663811105V → A.1 Publication1
Natural variantiVAR_0663821114Q → H.1 Publication1
Natural variantiVAR_0663831143L → P May be associated with breast cancer susceptibility. 2 PublicationsCorresponds to variant rs62625284dbSNPEnsembl.1
Natural variantiVAR_0663841170H → Y.1 PublicationCorresponds to variant rs200283306dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834425 mRNA. Translation: CAD39086.1.
CR749637 mRNA. Translation: CAH18431.1.
AC008870 Genomic DNA. No translation available.
CH471145 Genomic DNA. Translation: EAW55813.1.
BC044254 mRNA. Translation: AAH44254.1.
AK025469 mRNA. Translation: BAB15140.1. Different initiation.
AK097533 mRNA. Translation: BAC05090.1.
CCDSiCCDS32406.1.
RefSeqiNP_078951.2. NM_024675.3.
UniGeneiHs.444664.

Genome annotation databases

EnsembliENST00000261584; ENSP00000261584; ENSG00000083093.
GeneIDi79728.
KEGGihsa:79728.
UCSCiuc002dlx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834425 mRNA. Translation: CAD39086.1.
CR749637 mRNA. Translation: CAH18431.1.
AC008870 Genomic DNA. No translation available.
CH471145 Genomic DNA. Translation: EAW55813.1.
BC044254 mRNA. Translation: AAH44254.1.
AK025469 mRNA. Translation: BAB15140.1. Different initiation.
AK097533 mRNA. Translation: BAC05090.1.
CCDSiCCDS32406.1.
RefSeqiNP_078951.2. NM_024675.3.
UniGeneiHs.444664.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W18X-ray1.90A835-1186[»]
3EU7X-ray2.20A835-1186[»]
ProteinModelPortaliQ86YC2.
SMRiQ86YC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122843. 41 interactors.
DIPiDIP-38427N.
IntActiQ86YC2. 31 interactors.
MINTiMINT-7262182.
STRINGi9606.ENSP00000261584.

PTM databases

iPTMnetiQ86YC2.
PhosphoSitePlusiQ86YC2.

Polymorphism and mutation databases

BioMutaiPALB2.
DMDMi74727919.

Proteomic databases

EPDiQ86YC2.
MaxQBiQ86YC2.
PaxDbiQ86YC2.
PeptideAtlasiQ86YC2.
PRIDEiQ86YC2.

Protocols and materials databases

DNASUi79728.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261584; ENSP00000261584; ENSG00000083093.
GeneIDi79728.
KEGGihsa:79728.
UCSCiuc002dlx.2. human.

Organism-specific databases

CTDi79728.
DisGeNETi79728.
GeneCardsiPALB2.
GeneReviewsiPALB2.
HGNCiHGNC:26144. PALB2.
HPAiCAB014895.
HPA057000.
HPA059851.
MalaCardsiPALB2.
MIMi114480. phenotype.
610355. gene.
610832. phenotype.
613348. phenotype.
neXtProtiNX_Q86YC2.
OpenTargetsiENSG00000083093.
Orphaneti1333. Familial pancreatic carcinoma.
84. Fanconi anemia.
145. Hereditary breast and ovarian cancer syndrome.
227535. Hereditary breast cancer.
PharmGKBiPA162398608.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIBP. Eukaryota.
ENOG4111F80. LUCA.
GeneTreeiENSGT00390000014423.
HOGENOMiHOG000115428.
HOVERGENiHBG082102.
InParanoidiQ86YC2.
KOiK10897.
OMAiNIVIWNL.
OrthoDBiEOG091G0264.
PhylomeDBiQ86YC2.
TreeFamiTF351544.

Enzyme and pathway databases

ReactomeiR-HSA-5685942. HDR through Homologous Recombination (HRR).
R-HSA-5693554. Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).
R-HSA-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-HSA-5693579. Homologous DNA Pairing and Strand Exchange.
SIGNORiQ86YC2.

Miscellaneous databases

EvolutionaryTraceiQ86YC2.
GeneWikiiPALB2.
GenomeRNAii79728.
PROiQ86YC2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000083093.
CleanExiHS_PALB2.
ExpressionAtlasiQ86YC2. baseline and differential.
GenevisibleiQ86YC2. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR031920. PALB2_WD40.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF16756. PALB2_WD40. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPALB2_HUMAN
AccessioniPrimary (citable) accession number: Q86YC2
Secondary accession number(s): A6NIE1
, Q8N7Y6, Q8ND31, Q9H6W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.