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Protein

Syntaxin-12

Gene

STX12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • autophagosome assembly Source: ParkinsonsUK-UCL
  • cholesterol efflux Source: BHF-UCL
  • intracellular protein transport Source: GO_Central
  • protein stabilization Source: BHF-UCL
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-12
Gene namesi
Name:STX12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117758.13.
HGNCiHGNC:11430. STX12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 248CytoplasmicSequence analysisAdd BLAST247
Transmembranei249 – 269Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini270 – 276VesicularSequence analysis7

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23673.
OpenTargetsiENSG00000117758.
PharmGKBiPA36230.

Polymorphism and mutation databases

BioMutaiSTX12.
DMDMi47117211.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002102232 – 276Syntaxin-12Add BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei139PhosphoserineBy similarity1
Modified residuei142PhosphoserineCombined sources1
Modified residuei218PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ86Y82.
MaxQBiQ86Y82.
PaxDbiQ86Y82.
PeptideAtlasiQ86Y82.
PRIDEiQ86Y82.

PTM databases

iPTMnetiQ86Y82.
PhosphoSitePlusiQ86Y82.
SwissPalmiQ86Y82.

Miscellaneous databases

PMAP-CutDBiQ86Y82.

Expressioni

Gene expression databases

BgeeiENSG00000117758.
CleanExiHS_STX12.
ExpressionAtlasiQ86Y82. baseline and differential.
GenevisibleiQ86Y82. HS.

Organism-specific databases

HPAiHPA041038.
HPA055300.

Interactioni

Subunit structurei

Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Associates with the BLOC-1 complex (PubMed:19546860). Interacts with BLOC1S6 (PubMed:19546860). Interacts with GRIPAP1 (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117191. 100 interactors.
CORUMiQ86Y82.
DIPiDIP-44225N.
IntActiQ86Y82. 23 interactors.
MINTiMINT-3036147.
STRINGi9606.ENSP00000363054.

Structurei

Secondary structure

1276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 50Combined sources29
Beta strandi52 – 54Combined sources3
Helixi57 – 86Combined sources30
Helixi93 – 132Combined sources40

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DNXNMR-A18-134[»]
ProteinModelPortaliQ86Y82.
SMRiQ86Y82.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86Y82.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 240t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili33 – 131Sequence analysisAdd BLAST99

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00450000040239.
HOGENOMiHOG000188453.
HOVERGENiHBG053083.
InParanoidiQ86Y82.
KOiK13813.
OMAiMYRNPGA.
OrthoDBiEOG091G0HKZ.
PhylomeDBiQ86Y82.
TreeFamiTF315607.

Family and domain databases

InterProiView protein in InterPro
IPR010989. SNARE.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR000727. T_SNARE_dom.
PfamiView protein in Pfam
PF05739. SNARE. 1 hit.
PF14523. Syntaxin_2. 1 hit.
SMARTiView protein in SMART
SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86Y82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYGPLDMYR NPGPSGPQLR DFSSIIQTCS GNIQRISQAT AQIKNLMSQL
60 70 80 90 100
GTKQDSSKLQ ENLQQLQHST NQLAKETNEL LKELGSLPLP LSTSEQRQQR
110 120 130 140 150
LQKERLMNDF SAALNNFQAV QRRVSEKEKE SIARARAGSR LSAEERQREE
160 170 180 190 200
QLVSFDSHEE WNQMQSQEDE VAITEQDLEL IKERETAIRQ LEADILDVNQ
210 220 230 240 250
IFKDLAMMIH DQGDLIDSIE ANVESSEVHV ERATEQLQRA AYYQKKSRKK
260 270
MCILVLVLSV IILILGLIIW LVYKTK
Length:276
Mass (Da):31,642
Last modified:June 1, 2003 - v1
Checksum:i2338061572ED7DA1
GO

Sequence cautioni

Q86Y82: The sequence CAA22911 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03564388P → R in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123769 mRNA. Translation: AAP97248.1.
AL035306 mRNA. Translation: CAA22911.1. Different initiation.
AK297585 mRNA. Translation: BAG59973.1.
AL020997 Genomic DNA. Translation: CAI20575.1.
CH471059 Genomic DNA. Translation: EAX07738.1.
CH471059 Genomic DNA. Translation: EAX07739.1.
BC046999 mRNA. Translation: AAH46999.1.
CCDSiCCDS310.1.
RefSeqiNP_803173.1. NM_177424.2.
UniGeneiHs.523855.

Genome annotation databases

EnsembliENST00000373943; ENSP00000363054; ENSG00000117758.
GeneIDi23673.
KEGGihsa:23673.
UCSCiuc001bou.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTX12_HUMAN
AccessioniPrimary (citable) accession number: Q86Y82
Secondary accession number(s): B1AJQ7, O95564
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families