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Protein

Probable peptidyl-tRNA hydrolase

Gene

PTRH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

GO - Molecular functioni

  • aminoacyl-tRNA hydrolase activity Source: GO_Central
  • RNA binding Source: UniProtKB

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peptidyl-tRNA hydrolase (EC:3.1.1.29)
Short name:
PTH
Gene namesi
Name:PTRH1
Synonyms:C9orf115
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000187024.13.
HGNCiHGNC:27039. PTRH1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi138428.
OpenTargetsiENSG00000187024.
PharmGKBiPA134917129.

Polymorphism and mutation databases

BioMutaiPTRH1.
DMDMi74750555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404411 – 214Probable peptidyl-tRNA hydrolaseAdd BLAST214

Proteomic databases

EPDiQ86Y79.
MaxQBiQ86Y79.
PaxDbiQ86Y79.
PeptideAtlasiQ86Y79.
PRIDEiQ86Y79.

PTM databases

iPTMnetiQ86Y79.
PhosphoSitePlusiQ86Y79.

Expressioni

Gene expression databases

BgeeiENSG00000187024.
CleanExiHS_PTRH1.
ExpressionAtlasiQ86Y79. baseline and differential.
GenevisibleiQ86Y79. HS.

Organism-specific databases

HPAiHPA021223.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-2602515,EBI-10175124

Protein-protein interaction databases

BioGridi126512. 3 interactors.
IntActiQ86Y79. 5 interactors.
STRINGi9606.ENSP00000418661.

Structurei

3D structure databases

ProteinModelPortaliQ86Y79.
SMRiQ86Y79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH family.Curated

Phylogenomic databases

eggNOGiKOG2255. Eukaryota.
COG0193. LUCA.
GeneTreeiENSGT00390000004247.
HOGENOMiHOG000004797.
HOVERGENiHBG067636.
InParanoidiQ86Y79.
KOiK01056.
OMAiRYAHTRH.
OrthoDBiEOG091G0L6U.
PhylomeDBiQ86Y79.
TreeFamiTF332601.

Family and domain databases

CDDicd00462. PTH. 1 hit.
Gene3Di3.40.50.1470. 1 hit.
InterProiView protein in InterPro
IPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiView protein in Pfam
PF01195. Pept_tRNA_hydro. 1 hit.
SUPFAMiSSF53178. SSF53178. 1 hit.
PROSITEiView protein in PROSITE
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86Y79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPGGFLGAG QRLSRAMSRC VLEPRPPGKR WMVAGLGNPG LPGTRHSVGM
60 70 80 90 100
AVLGQLARRL GVAESWTRDR HCAADLALAP LGDAQLVLLR PRRLMNANGR
110 120 130 140 150
SVARAAELFG LTAEEVYLVH DELDKPLGRL ALKLGGSARG HNGVRSCISC
160 170 180 190 200
LNSNAMPRLR VGIGRPAHPE AVQAHVLGCF SPAEQELLPL LLDRATDLIL
210
DHIRERSQGP SLGP
Length:214
Mass (Da):22,937
Last modified:June 1, 2003 - v1
Checksum:iDBA3959411DA8248
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047012 mRNA. Translation: AAH47012.1.
CCDSiCCDS35147.1.
RefSeqiNP_001002913.1. NM_001002913.2.
UniGeneiHs.653265.

Genome annotation databases

EnsembliENST00000419060; ENSP00000418661; ENSG00000187024.
ENST00000543175; ENSP00000439469; ENSG00000187024.
GeneIDi138428.
KEGGihsa:138428.
UCSCiuc004bro.4. human.

Similar proteinsi

Entry informationi

Entry nameiPTH_HUMAN
AccessioniPrimary (citable) accession number: Q86Y79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: September 27, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families