Reviewed, UniProtKB/Swiss-Prot Q86Y78 (LYPD6_HUMAN)

Names and origin

Protein names

Recommended name:
    Ly6/PLAUR domain-containing protein 6

Gene names

Name:	LYPD6
ORF Names:	UNQ3023/PRO9821

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted Probable.
Sequence similarities	Contains 1 UPAR/Ly6 domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.3
	Chain	23 – 171	149	Ly6/PLAUR domain-containing protein 6		PRO_0000036178
Regions
	Domain	47 – 141	95	UPAR/Ly6
Amino acid modifications
	Glycosylation	134	1	N-linked (GlcNAc...) Potential
	Glycosylation	147	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q86Y78-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 1BAEEE9CD18F5470	FASTA	171	19,118
	10 20 30 40 50 60 MEPGPALAWL LLLSLLADCL KAAQSRDFTV KDIIYLHPST TPYPGGFKCF TCEKAADNYE 70 80 90 100 110 120 CNRWAPDIYC PRETRYCYTQ HTMEVTGNSI SVTKRCVPLE ECLSTGCRDS EHEGHKVCTS 130 140 150 160 170 CCEGNICNLP LPRNETDATF ATTSPINQTN GHPRCMSVIV SCLWLWLGLM L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358623 mRNA. Translation: AAQ88986.1. BC047013 mRNA. Translation: AAH47013.1.
IPI	IPI00046763.
RefSeq	NP_919298.1.
UniGene	Hs.21929
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q86Y78.
Genome annotation databases
Ensembl	ENST00000334166; ENSP00000334463; ENSG00000187123; Homo sapiens. [Genome view] ENST00000409381; ENSP00000386413; ENSG00000187123; Homo sapiens. [Genome view]
GeneID	130574.
KEGG	hsa:130574.
UCSC	uc002twy.1. human.
Organism-specific databases
CTD	130574.
GeneCards	GC02P149894.
H-InvDB	HIX0023934.
HGNC	HGNC:28751. LYPD6.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG715413.
HOVERGEN	Q86Y78.
InParanoid	Q86Y78.
OMA	CVSVIVS.
OrthoDB	EOG95B41F.
PhylomeDB	Q86Y78.
Gene expression databases
ArrayExpress	Q86Y78.
Bgee	Q86Y78.
CleanEx	HS_LYPD6.
Genevestigator	Q86Y78.
Family and domain databases
InterPro	IPR016054. LY6_UPA_recep-like. [Graphical view]
SMART	SM00134. LU. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	82776.

Entry information

Entry name

LYPD6_HUMAN

Accession

Primary (citable) accession number: Q86Y78

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	June 1, 2003
Last modified:	January 19, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.