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Protein

Ly6/PLAUR domain-containing protein 6

Gene

LYPD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 6
Gene namesi
Name:LYPD6
ORF Names:UNQ3023/PRO9821
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28751. LYPD6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147357619.

Polymorphism and mutation databases

BioMutaiLYPD6.
DMDMi55583932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 171149Ly6/PLAUR domain-containing protein 6PRO_0000036178Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86Y78.
PRIDEiQ86Y78.

PTM databases

iPTMnetiQ86Y78.

Expressioni

Gene expression databases

BgeeiQ86Y78.
CleanExiHS_LYPD6.
ExpressionAtlasiQ86Y78. baseline and differential.
GenevisibleiQ86Y78. HS.

Organism-specific databases

HPAiHPA042805.

Interactioni

Protein-protein interaction databases

BioGridi126242. 30 interactions.
STRINGi9606.ENSP00000334463.

Structurei

3D structure databases

ProteinModelPortaliQ86Y78.
SMRiQ86Y78. Positions 36-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 14195UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJMQ. Eukaryota.
ENOG4111IG8. LUCA.
GeneTreeiENSGT00390000000220.
HOGENOMiHOG000231796.
HOVERGENiHBG054166.
InParanoidiQ86Y78.
OMAiHPHCVSV.
OrthoDBiEOG7XH6RK.
PhylomeDBiQ86Y78.
TreeFamiTF332443.

Family and domain databases

InterProiIPR031574. LYPD6.
[Graphical view]
PANTHERiPTHR31171:SF0. PTHR31171:SF0. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86Y78-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPGPALAWL LLLSLLADCL KAAQSRDFTV KDIIYLHPST TPYPGGFKCF
60 70 80 90 100
TCEKAADNYE CNRWAPDIYC PRETRYCYTQ HTMEVTGNSI SVTKRCVPLE
110 120 130 140 150
ECLSTGCRDS EHEGHKVCTS CCEGNICNLP LPRNETDATF ATTSPINQTN
160 170
GHPRCMSVIV SCLWLWLGLM L
Length:171
Mass (Da):19,118
Last modified:June 1, 2003 - v1
Checksum:i1BAEEE9CD18F5470
GO
Isoform 2 (identifier: Q86Y78-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-76: ETRY → GTMI
     77-171: Missing.

Note: No experimental confirmation available.
Show »
Length:76
Mass (Da):8,514
Checksum:i42AD01EBD5572A37
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731E → V in BAG54082 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei73 – 764ETRY → GTMI in isoform 2. 1 PublicationVSP_039306
Alternative sequencei77 – 17195Missing in isoform 2. 1 PublicationVSP_039307Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358623 mRNA. Translation: AAQ88986.1.
AK124733 mRNA. Translation: BAG54082.1.
AC007394 Genomic DNA. Translation: AAY14698.1.
CH471058 Genomic DNA. Translation: EAX11539.1.
BC032836 mRNA. Translation: AAH32836.1.
BC047013 mRNA. Translation: AAH47013.1.
AL831852 mRNA. Translation: CAH56278.1.
CCDSiCCDS2188.1. [Q86Y78-1]
RefSeqiNP_001182614.1. NM_001195685.1. [Q86Y78-1]
NP_919298.1. NM_194317.3. [Q86Y78-1]
UniGeneiHs.21929.

Genome annotation databases

EnsembliENST00000334166; ENSP00000334463; ENSG00000187123. [Q86Y78-1]
ENST00000392854; ENSP00000376594; ENSG00000187123. [Q86Y78-2]
ENST00000409381; ENSP00000386413; ENSG00000187123. [Q86Y78-1]
ENST00000418762; ENSP00000396855; ENSG00000187123. [Q86Y78-2]
GeneIDi130574.
KEGGihsa:130574.
UCSCiuc002twy.4. human. [Q86Y78-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358623 mRNA. Translation: AAQ88986.1.
AK124733 mRNA. Translation: BAG54082.1.
AC007394 Genomic DNA. Translation: AAY14698.1.
CH471058 Genomic DNA. Translation: EAX11539.1.
BC032836 mRNA. Translation: AAH32836.1.
BC047013 mRNA. Translation: AAH47013.1.
AL831852 mRNA. Translation: CAH56278.1.
CCDSiCCDS2188.1. [Q86Y78-1]
RefSeqiNP_001182614.1. NM_001195685.1. [Q86Y78-1]
NP_919298.1. NM_194317.3. [Q86Y78-1]
UniGeneiHs.21929.

3D structure databases

ProteinModelPortaliQ86Y78.
SMRiQ86Y78. Positions 36-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126242. 30 interactions.
STRINGi9606.ENSP00000334463.

PTM databases

iPTMnetiQ86Y78.

Polymorphism and mutation databases

BioMutaiLYPD6.
DMDMi55583932.

Proteomic databases

PaxDbiQ86Y78.
PRIDEiQ86Y78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334166; ENSP00000334463; ENSG00000187123. [Q86Y78-1]
ENST00000392854; ENSP00000376594; ENSG00000187123. [Q86Y78-2]
ENST00000409381; ENSP00000386413; ENSG00000187123. [Q86Y78-1]
ENST00000418762; ENSP00000396855; ENSG00000187123. [Q86Y78-2]
GeneIDi130574.
KEGGihsa:130574.
UCSCiuc002twy.4. human. [Q86Y78-1]

Organism-specific databases

CTDi130574.
GeneCardsiLYPD6.
HGNCiHGNC:28751. LYPD6.
HPAiHPA042805.
MIMi613359. gene.
neXtProtiNX_Q86Y78.
PharmGKBiPA147357619.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJMQ. Eukaryota.
ENOG4111IG8. LUCA.
GeneTreeiENSGT00390000000220.
HOGENOMiHOG000231796.
HOVERGENiHBG054166.
InParanoidiQ86Y78.
OMAiHPHCVSV.
OrthoDBiEOG7XH6RK.
PhylomeDBiQ86Y78.
TreeFamiTF332443.

Miscellaneous databases

GenomeRNAii130574.
PROiQ86Y78.
SOURCEiSearch...

Gene expression databases

BgeeiQ86Y78.
CleanExiHS_LYPD6.
ExpressionAtlasiQ86Y78. baseline and differential.
GenevisibleiQ86Y78. HS.

Family and domain databases

InterProiIPR031574. LYPD6.
[Graphical view]
PANTHERiPTHR31171:SF0. PTHR31171:SF0. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-37.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-171.
    Tissue: Amygdala.

Entry informationi

Entry nameiLYPD6_HUMAN
AccessioniPrimary (citable) accession number: Q86Y78
Secondary accession number(s): B3KWC0
, Q4G121, Q53TR3, Q659B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.