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Protein

Keratin, type II cytoskeletal 73

Gene

KRT73

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).Curated

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei383Stutter1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 73
Alternative name(s):
Cytokeratin-73
Short name:
CK-73
Keratin-73
Short name:
K73
Type II inner root sheath-specific keratin-K6irs3
Type-II keratin Kb36
Gene namesi
Name:KRT73
Synonyms:K6IRS3, KB36, KRT6IRS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000186049.8
HGNCiHGNC:28928 KRT73
MIMi608247 gene
neXtProtiNX_Q86Y46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi319101
OpenTargetsiENSG00000186049
PharmGKBiPA147031702

Polymorphism and mutation databases

BioMutaiKRT73
DMDMi74750553

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148811 – 540Keratin, type II cytoskeletal 73Add BLAST540

Proteomic databases

PaxDbiQ86Y46
PeptideAtlasiQ86Y46
PRIDEiQ86Y46

PTM databases

iPTMnetiQ86Y46
PhosphoSitePlusiQ86Y46
SwissPalmiQ86Y46

Expressioni

Tissue specificityi

Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region where Henle cells undergo abrupt terminal differentiation. Detected up to the uppermost cortex region where cuticle cells terminally differentiate (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000186049
CleanExiHS_KRT73
ExpressionAtlasiQ86Y46 baseline and differential
GenevisibleiQ86Y46 HS

Organism-specific databases

HPAiHPA044031

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT15P190123EBI-2830994,EBI-739566

Protein-protein interaction databases

BioGridi130489, 14 interactors
IntActiQ86Y46, 12 interactors
STRINGi9606.ENSP00000307014

Structurei

3D structure databases

ProteinModelPortaliQ86Y46
SMRiQ86Y46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 445IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 131HeadAdd BLAST131
Regioni132 – 167Coil 1AAdd BLAST36
Regioni168 – 186Linker 1Add BLAST19
Regioni187 – 278Coil 1BAdd BLAST92
Regioni279 – 302Linker 12Add BLAST24
Regioni303 – 441Coil 2Add BLAST139
Regioni442 – 540TailAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 103Gly-richAdd BLAST94

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IQKP Eukaryota
ENOG4111AD7 LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ86Y46
KOiK07605
OMAiGTYGYWP
OrthoDBiEOG091G09KR
PhylomeDBiQ86Y46
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86Y46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRQFTYKSG AAAKGGFSGC SAVLSGGSSS SYRAGGKGLS GGFSSRSLYS
60 70 80 90 100
LGGARSISFN VASGSGWAGG YGFGRGRASG FAGSMFGSVA LGSVCPSLCP
110 120 130 140 150
PGGIHQVTIN KSLLAPLNVE LDPEIQKVRA QEREQIKVLN NKFASFIDKV
160 170 180 190 200
RFLEQQNQVL ETKWELLQQL DLNNCKNNLE PILEGYISNL RKQLETLSGD
210 220 230 240 250
RVRLDSELRS VREVVEDYKK RYEEEINKRT TAENEFVVLK KDVDAAYTSK
260 270 280 290 300
VELQAKVDAL DGEIKFFKCL YEGETAQIQS HISDTSIILS MDNNRNLDLD
310 320 330 340 350
SIIAEVRAQY EEIARKSKAE AEALYQTKFQ ELQLAAGRHG DDLKHTKNEI
360 370 380 390 400
SELTRLIQRL RSEIESVKKQ CANLETAIAD AEQRGDCALK DARAKLDELE
410 420 430 440 450
GALQQAKEEL ARMLREYQEL LSVKLSLDIE IATYRKLLEG EECRMSGEYT
460 470 480 490 500
NSVSISVINS SMAGMAGTGA GFGFSNAGTY GYWPSSVSGG YSMLPGGCVT
510 520 530 540
GSGNCSPRGE ARTRLGSASE FRDSQGKTLA LSSPTKKTMR
Length:540
Mass (Da):58,923
Last modified:June 1, 2003 - v1
Checksum:i7B4FC058FDE3191B
GO
Isoform 2 (identifier: Q86Y46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-381: CANLETAIADA → VKGTGAFLTHS
     382-540: Missing.

Note: No experimental confirmation available.
Show »
Length:381
Mass (Da):41,984
Checksum:i9FEC4084462CDB18
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11A → P in AAI09214 (PubMed:15489334).Curated1
Sequence conflicti11A → P in AAI09213 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03809161V → M. Corresponds to variant dbSNP:rs35417182Ensembl.1
Natural variantiVAR_03809296P → L. Corresponds to variant dbSNP:rs659436Ensembl.1
Natural variantiVAR_038093212R → H in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_038094248T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs142246988Ensembl.1
Natural variantiVAR_038095365E → G. Corresponds to variant dbSNP:rs607426Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030417371 – 381CANLETAIADA → VKGTGAFLTHS in isoform 2. CuratedAdd BLAST11
Alternative sequenceiVSP_030418382 – 540Missing in isoform 2. CuratedAdd BLAST159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ508776 mRNA Translation: CAD48513.1
CH471054 Genomic DNA Translation: EAW96640.1
BC109212 mRNA Translation: AAI09213.1
BC109213 mRNA Translation: AAI09214.1
CCDSiCCDS8834.1 [Q86Y46-1]
RefSeqiNP_778238.1, NM_175068.2 [Q86Y46-1]
UniGeneiHs.55410

Genome annotation databases

EnsembliENST00000305748; ENSP00000307014; ENSG00000186049 [Q86Y46-1]
GeneIDi319101
KEGGihsa:319101
UCSCiuc001sas.3 human [Q86Y46-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiK2C73_HUMAN
AccessioniPrimary (citable) accession number: Q86Y46
Secondary accession number(s): Q32MB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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