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Q86Y37

- CACL1_HUMAN

UniProt

Q86Y37 - CACL1_HUMAN

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Protein
CDK2-associated and cullin domain-containing protein 1
Gene
CACUL1, C10orf46, CAC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein kinase binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: UniProtKB
  2. positive regulation of cell proliferation Source: UniProtKB
  3. positive regulation of protein kinase activity Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
CDK2-associated and cullin domain-containing protein 1
Alternative name(s):
Cdk-associated cullin1
Gene namesi
Name:CACUL1
Synonyms:C10orf46, CAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23727. CACUL1.

Subcellular locationi

GO - Cellular componenti

  1. cullin-RING ubiquitin ligase complex Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869023.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369CDK2-associated and cullin domain-containing protein 1
PRO_0000119817Add
BLAST

Proteomic databases

MaxQBiQ86Y37.
PaxDbiQ86Y37.
PRIDEiQ86Y37.

PTM databases

PhosphoSiteiQ86Y37.

Expressioni

Tissue specificityi

Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase.1 Publication

Gene expression databases

BgeeiQ86Y37.
CleanExiHS_C10orf46.
GenevestigatoriQ86Y37.

Interactioni

Subunit structurei

Interacts with CDK2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033725EBI-8168227,EBI-78473

Protein-protein interaction databases

BioGridi126801. 3 interactions.
IntActiQ86Y37. 2 interactions.
MINTiMINT-8401202.
STRINGi9606.ENSP00000358147.

Structurei

3D structure databases

ProteinModelPortaliQ86Y37.
SMRiQ86Y37. Positions 130-237.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 8248Pro-rich
Add
BLAST
Compositional biasi96 – 10611Poly-Ala
Add
BLAST

Sequence similaritiesi

Belongs to the cullin family.

Phylogenomic databases

eggNOGiNOG302356.
HOGENOMiHOG000111684.
HOVERGENiHBG059519.
InParanoidiQ86Y37.
OMAiVMNVITI.
OrthoDBiEOG7G7KPG.
PhylomeDBiQ86Y37.
TreeFamiTF329263.

Family and domain databases

InterProiIPR001373. Cullin_N.
IPR016159. Cullin_repeat-like_dom.
[Graphical view]
PfamiPF00888. Cullin. 1 hit.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86Y37-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR    50
EPPGGQLLAV PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV 100
AKAAPAPTAS STININTSTS KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ 150
SPGDYIPISY EQIYSCVYKC VCQQHSEQMY SDLIKKITNH LERVSKELQA 200
SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL NRDLKDDLIK 250
LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM 300
APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA 350
GDELAYNSSS ACASSRGYR 369
Length:369
Mass (Da):41,064
Last modified:June 1, 2003 - v1
Checksum:i7ABA2F6846C4F737
GO
Isoform 2 (identifier: Q86Y37-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-303: EWVQMAPT → VSQNFTAV
     304-369: Missing.

Show »
Length:303
Mass (Da):33,584
Checksum:iE868EE20EEDC574A
GO
Isoform 4 (identifier: Q86Y37-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Show »
Length:246
Mass (Da):28,293
Checksum:iF89A36DE19D2A4A6
GO

Sequence cautioni

The sequence AAU89709.1 differs from that shown. Reason: Frameshift at position 296.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 123123Missing in isoform 4.
VSP_013933Add
BLAST
Alternative sequencei296 – 3038EWVQMAPT → VSQNFTAV in isoform 2.
VSP_013936
Alternative sequencei304 – 36966Missing in isoform 2.
VSP_013937Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ544771 mRNA. Translation: CAD67614.1.
AY743663 mRNA. Translation: AAU89709.1. Frameshift.
AK097728 mRNA. Translation: BAC05153.1.
AL139407 Genomic DNA. Translation: CAH73727.1.
BC038294 mRNA. Translation: AAH38294.1.
CCDSiCCDS41570.1. [Q86Y37-1]
RefSeqiNP_722517.3. NM_153810.4. [Q86Y37-1]
UniGeneiHs.420024.

Genome annotation databases

EnsembliENST00000340214; ENSP00000342487; ENSG00000151893. [Q86Y37-2]
ENST00000369151; ENSP00000358147; ENSG00000151893. [Q86Y37-1]
ENST00000493518; ENSP00000431329; ENSG00000151893. [Q86Y37-2]
GeneIDi143384.
KEGGihsa:143384.
UCSCiuc001lds.1. human. [Q86Y37-1]

Polymorphism databases

DMDMi67460542.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ544771 mRNA. Translation: CAD67614.1 .
AY743663 mRNA. Translation: AAU89709.1 . Frameshift.
AK097728 mRNA. Translation: BAC05153.1 .
AL139407 Genomic DNA. Translation: CAH73727.1 .
BC038294 mRNA. Translation: AAH38294.1 .
CCDSi CCDS41570.1. [Q86Y37-1 ]
RefSeqi NP_722517.3. NM_153810.4. [Q86Y37-1 ]
UniGenei Hs.420024.

3D structure databases

ProteinModelPortali Q86Y37.
SMRi Q86Y37. Positions 130-237.
ModBasei Search...

Protein-protein interaction databases

BioGridi 126801. 3 interactions.
IntActi Q86Y37. 2 interactions.
MINTi MINT-8401202.
STRINGi 9606.ENSP00000358147.

PTM databases

PhosphoSitei Q86Y37.

Polymorphism databases

DMDMi 67460542.

Proteomic databases

MaxQBi Q86Y37.
PaxDbi Q86Y37.
PRIDEi Q86Y37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340214 ; ENSP00000342487 ; ENSG00000151893 . [Q86Y37-2 ]
ENST00000369151 ; ENSP00000358147 ; ENSG00000151893 . [Q86Y37-1 ]
ENST00000493518 ; ENSP00000431329 ; ENSG00000151893 . [Q86Y37-2 ]
GeneIDi 143384.
KEGGi hsa:143384.
UCSCi uc001lds.1. human. [Q86Y37-1 ]

Organism-specific databases

CTDi 143384.
GeneCardsi GC10M120433.
HGNCi HGNC:23727. CACUL1.
neXtProti NX_Q86Y37.
PharmGKBi PA134869023.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302356.
HOGENOMi HOG000111684.
HOVERGENi HBG059519.
InParanoidi Q86Y37.
OMAi VMNVITI.
OrthoDBi EOG7G7KPG.
PhylomeDBi Q86Y37.
TreeFami TF329263.

Miscellaneous databases

GenomeRNAii 143384.
NextBioi 84703.
PROi Q86Y37.

Gene expression databases

Bgeei Q86Y37.
CleanExi HS_C10orf46.
Genevestigatori Q86Y37.

Family and domain databases

InterProi IPR001373. Cullin_N.
IPR016159. Cullin_repeat-like_dom.
[Graphical view ]
Pfami PF00888. Cullin. 1 hit.
[Graphical view ]
SUPFAMi SSF74788. SSF74788. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Huang C., Wu S., Liu S.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The expression of gene in human rectum carcinoma."
    Kong Y., Chen Y., Xia Q.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Rectum tumor.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  6. "Identification and characterization of CAC1 as a novel CDK2-associated cullin."
    Kong Y., Nan K., Yin Y.
    Cell Cycle 8:3544-3553(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH CDK2.

Entry informationi

Entry nameiCACL1_HUMAN
AccessioniPrimary (citable) accession number: Q86Y37
Secondary accession number(s): Q5XPL7, Q8IY11, Q8N7S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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