Q86Y37 (CACL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDK2-associated and cullin domain-containing protein 1

Alternative name(s):
Cdk-associated cullin1

Gene names

Name:	CACUL1
Synonyms:	C10orf46, CAC1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. Ref.6
Subunit structure	Interacts with CDK2. Ref.6
Tissue specificity	Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase. Ref.6
Sequence similarities	Belongs to the cullin family.
Sequence caution	The sequence AAU89709.1 differs from that shown. Reason: Frameshift at position 296.

Ontologies

Keywords
Biological process	Cell cycle
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G1/S transition of mitotic cell cycle Inferred from mutant phenotype Ref.6. Source: UniProtKB positive regulation of cell proliferation Inferred from mutant phenotype Ref.6. Source: UniProtKB positive regulation of protein kinase activity Inferred from mutant phenotype Ref.6. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cullin-RING ubiquitin ligase complex Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86Y37-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86Y37-2)

The sequence of this isoform differs from the canonical sequence as follows:
     296-303: EWVQMAPT → VSQNFTAV
     304-369: Missing.

Isoform 4 (identifier: Q86Y37-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	CDK2-associated and cullin domain-containing protein 1		PRO_0000119817
Regions
	Compositional bias	35 – 82	48	Pro-rich
	Compositional bias	96 – 106	11	Poly-Ala
Natural variations
	Alternative sequence	1 – 123	123	Missing in isoform 4.		VSP_013933
	Alternative sequence	296 – 303	8	EWVQMAPT → VSQNFTAV in isoform 2.		VSP_013936
	Alternative sequence	304 – 369	66	Missing in isoform 2.		VSP_013937

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7ABA2F6846C4F737	FASTA	369	41,064
	10 20 30 40 50 60 MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR EPPGGQLLAV 70 80 90 100 110 120 PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV AKAAPAPTAS STININTSTS 130 140 150 160 170 180 KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ SPGDYIPISY EQIYSCVYKC VCQQHSEQMY 190 200 210 220 230 240 SDLIKKITNH LERVSKELQA SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL 250 260 270 280 290 300 NRDLKDDLIK LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM 310 320 330 340 350 360 APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA GDELAYNSSS ACASSRGYR
	Isoform 2 [UniParc]. Checksum: E868EE20EEDC574A	FASTA	303	33,584
	10 20 30 40 50 60 MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR EPPGGQLLAV 70 80 90 100 110 120 PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV AKAAPAPTAS STININTSTS 130 140 150 160 170 180 KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ SPGDYIPISY EQIYSCVYKC VCQQHSEQMY 190 200 210 220 230 240 SDLIKKITNH LERVSKELQA SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL 250 260 270 280 290 300 NRDLKDDLIK LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPVSQNF TAV
	Isoform 4 [UniParc]. Checksum: F89A36DE19D2A4A6	FASTA	246	28,293
	10 20 30 40 50 60 MNVITIEDYK STYWPKLDGA IDQLLTQSPG DYIPISYEQI YSCVYKCVCQ QHSEQMYSDL 70 80 90 100 110 120 IKKITNHLER VSKELQASPP DLYIERFNIA LGQYMGALQS IVPLFIYMNK FYIETKLNRD 130 140 150 160 170 180 LKDDLIKLFT EHVAEKHIYS LMPLLLEAQS TPFQVTPSTM ANIVKGLYTL RPEWVQMAPT 190 200 210 220 230 240 LFSKFIPNIL PPAVESELSE YAAQDQKFQR ELIQNGFTRG DQSRKRAGDE LAYNSSSACA SSRGYR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Huang C., Wu S., Liu S. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The expression of gene in human rectum carcinoma." Kong Y., Chen Y., Xia Q. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Rectum tumor.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Testis.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[6]	"Identification and characterization of CAC1 as a novel CDK2-associated cullin." Kong Y., Nan K., Yin Y. Cell Cycle 8:3544-3553(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH CDK2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ544771 mRNA. Translation: CAD67614.1. AY743663 mRNA. Translation: AAU89709.1. Frameshift. AK097728 mRNA. Translation: BAC05153.1. AL139407 Genomic DNA. Translation: CAH73727.1. BC038294 mRNA. Translation: AAH38294.1.
IPI	IPI00410319. IPI00604719. IPI00604792.
RefSeq	NP_722517.3. NM_153810.4.
UniGene	Hs.420024.
3D structure databases
ProteinModelPortal	Q86Y37.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000358147.
PTM databases
PhosphoSite	Q86Y37.
Polymorphism databases
DMDM	67460542.
Proteomic databases
PaxDb	Q86Y37.
PRIDE	Q86Y37.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340214; ENSP00000342487; ENSG00000151893. ENST00000369151; ENSP00000358147; ENSG00000151893. ENST00000369156; ENSP00000358152; ENSG00000151893. ENST00000493518; ENSP00000431329; ENSG00000151893.
GeneID	143384.
KEGG	hsa:143384.
UCSC	uc001lds.1. human.
Organism-specific databases
CTD	143384.
GeneCards	GC10M120433.
HGNC	HGNC:23727. CACUL1.
neXtProt	NX_Q86Y37.
PharmGKB	PA134869023.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302356.
HOGENOM	HOG000111684.
HOVERGEN	HBG059519.
InParanoid	Q86Y37.
OMA	VMNVITI.
Gene expression databases
ArrayExpress	Q86Y37.
Bgee	Q86Y37.
CleanEx	HS_C10orf46.
Genevestigator	Q86Y37.
GermOnline	ENSG00000151893. Homo sapiens.
Family and domain databases
InterPro	IPR001373. Cullin_N. IPR016159. Cullin_repeat-like_dom. [Graphical view]
Pfam	PF00888. Cullin. 1 hit. [Graphical view]
SUPFAM	SSF74788. Cullin_repeat-like. 1 hit.
PROSITE	PS01256. CULLIN_1. False negative. PS50069. CULLIN_2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	143384.
NextBio	84703.

Entry information

Entry name

CACL1_HUMAN

Accession

Primary (citable) accession number: Q86Y37
Secondary accession number(s): Q5XPL7, Q8IY11, Q8N7S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.