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Protein

CDK2-associated and cullin domain-containing protein 1

Gene

CACUL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of protein kinase activity Source: UniProtKB
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
CDK2-associated and cullin domain-containing protein 1
Alternative name(s):
Cdk-associated cullin1
Gene namesi
Name:CACUL1
Synonyms:C10orf46, CAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23727. CACUL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869023.

Polymorphism and mutation databases

BioMutaiCACUL1.
DMDMi67460542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369CDK2-associated and cullin domain-containing protein 1PRO_0000119817Add
BLAST

Proteomic databases

MaxQBiQ86Y37.
PaxDbiQ86Y37.
PRIDEiQ86Y37.

PTM databases

PhosphoSiteiQ86Y37.

Expressioni

Tissue specificityi

Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase.1 Publication

Gene expression databases

BgeeiQ86Y37.
CleanExiHS_C10orf46.
GenevestigatoriQ86Y37.

Interactioni

Subunit structurei

Interacts with CDK2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033725EBI-8168227,EBI-78473

Protein-protein interaction databases

BioGridi126801. 3 interactions.
IntActiQ86Y37. 2 interactions.
MINTiMINT-8401202.
STRINGi9606.ENSP00000358147.

Structurei

3D structure databases

ProteinModelPortaliQ86Y37.
SMRiQ86Y37. Positions 130-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 8248Pro-richAdd
BLAST
Compositional biasi96 – 10611Poly-AlaAdd
BLAST

Sequence similaritiesi

Belongs to the cullin family.Curated

Phylogenomic databases

eggNOGiNOG302356.
GeneTreeiENSGT00390000000403.
HOGENOMiHOG000111684.
HOVERGENiHBG059519.
InParanoidiQ86Y37.
OMAiVMNVITI.
OrthoDBiEOG7G7KPG.
PhylomeDBiQ86Y37.
TreeFamiTF329263.

Family and domain databases

InterProiIPR001373. Cullin_N.
IPR016159. Cullin_repeat-like_dom.
[Graphical view]
PfamiPF00888. Cullin. 1 hit.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86Y37-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR
60 70 80 90 100
EPPGGQLLAV PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV
110 120 130 140 150
AKAAPAPTAS STININTSTS KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ
160 170 180 190 200
SPGDYIPISY EQIYSCVYKC VCQQHSEQMY SDLIKKITNH LERVSKELQA
210 220 230 240 250
SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL NRDLKDDLIK
260 270 280 290 300
LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM
310 320 330 340 350
APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA
360
GDELAYNSSS ACASSRGYR
Length:369
Mass (Da):41,064
Last modified:June 1, 2003 - v1
Checksum:i7ABA2F6846C4F737
GO
Isoform 2 (identifier: Q86Y37-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-303: EWVQMAPT → VSQNFTAV
     304-369: Missing.

Show »
Length:303
Mass (Da):33,584
Checksum:iE868EE20EEDC574A
GO
Isoform 4 (identifier: Q86Y37-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Show »
Length:246
Mass (Da):28,293
Checksum:iF89A36DE19D2A4A6
GO

Sequence cautioni

The sequence AAU89709.1 differs from that shown. Reason: Frameshift at position 296. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 123123Missing in isoform 4. 1 PublicationVSP_013933Add
BLAST
Alternative sequencei296 – 3038EWVQMAPT → VSQNFTAV in isoform 2. 1 PublicationVSP_013936
Alternative sequencei304 – 36966Missing in isoform 2. 1 PublicationVSP_013937Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ544771 mRNA. Translation: CAD67614.1.
AY743663 mRNA. Translation: AAU89709.1. Frameshift.
AK097728 mRNA. Translation: BAC05153.1.
AL139407 Genomic DNA. Translation: CAH73727.1.
BC038294 mRNA. Translation: AAH38294.1.
CCDSiCCDS41570.1. [Q86Y37-1]
RefSeqiNP_722517.3. NM_153810.4. [Q86Y37-1]
UniGeneiHs.420024.

Genome annotation databases

EnsembliENST00000369151; ENSP00000358147; ENSG00000151893. [Q86Y37-1]
ENST00000493518; ENSP00000431329; ENSG00000151893. [Q86Y37-2]
GeneIDi143384.
KEGGihsa:143384.
UCSCiuc001lds.1. human. [Q86Y37-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ544771 mRNA. Translation: CAD67614.1.
AY743663 mRNA. Translation: AAU89709.1. Frameshift.
AK097728 mRNA. Translation: BAC05153.1.
AL139407 Genomic DNA. Translation: CAH73727.1.
BC038294 mRNA. Translation: AAH38294.1.
CCDSiCCDS41570.1. [Q86Y37-1]
RefSeqiNP_722517.3. NM_153810.4. [Q86Y37-1]
UniGeneiHs.420024.

3D structure databases

ProteinModelPortaliQ86Y37.
SMRiQ86Y37. Positions 130-237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126801. 3 interactions.
IntActiQ86Y37. 2 interactions.
MINTiMINT-8401202.
STRINGi9606.ENSP00000358147.

PTM databases

PhosphoSiteiQ86Y37.

Polymorphism and mutation databases

BioMutaiCACUL1.
DMDMi67460542.

Proteomic databases

MaxQBiQ86Y37.
PaxDbiQ86Y37.
PRIDEiQ86Y37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369151; ENSP00000358147; ENSG00000151893. [Q86Y37-1]
ENST00000493518; ENSP00000431329; ENSG00000151893. [Q86Y37-2]
GeneIDi143384.
KEGGihsa:143384.
UCSCiuc001lds.1. human. [Q86Y37-1]

Organism-specific databases

CTDi143384.
GeneCardsiGC10M120433.
HGNCiHGNC:23727. CACUL1.
neXtProtiNX_Q86Y37.
PharmGKBiPA134869023.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG302356.
GeneTreeiENSGT00390000000403.
HOGENOMiHOG000111684.
HOVERGENiHBG059519.
InParanoidiQ86Y37.
OMAiVMNVITI.
OrthoDBiEOG7G7KPG.
PhylomeDBiQ86Y37.
TreeFamiTF329263.

Miscellaneous databases

GenomeRNAii143384.
NextBioi84703.
PROiQ86Y37.

Gene expression databases

BgeeiQ86Y37.
CleanExiHS_C10orf46.
GenevestigatoriQ86Y37.

Family and domain databases

InterProiIPR001373. Cullin_N.
IPR016159. Cullin_repeat-like_dom.
[Graphical view]
PfamiPF00888. Cullin. 1 hit.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Huang C., Wu S., Liu S.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The expression of gene in human rectum carcinoma."
    Kong Y., Chen Y., Xia Q.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Rectum tumor.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  6. "Identification and characterization of CAC1 as a novel CDK2-associated cullin."
    Kong Y., Nan K., Yin Y.
    Cell Cycle 8:3544-3553(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH CDK2.

Entry informationi

Entry nameiCACL1_HUMAN
AccessioniPrimary (citable) accession number: Q86Y37
Secondary accession number(s): Q5XPL7, Q8IY11, Q8N7S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: May 27, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.