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Protein

CDK2-associated and cullin domain-containing protein 1

Gene

CACUL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: GO_Central

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of protein kinase activity Source: UniProtKB
  • protein ubiquitination Source: GOC
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
CDK2-associated and cullin domain-containing protein 1
Alternative name(s):
Cdk-associated cullin1
Gene namesi
Name:CACUL1
Synonyms:C10orf46, CAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151893.14
HGNCiHGNC:23727 CACUL1
neXtProtiNX_Q86Y37

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi143384
OpenTargetsiENSG00000151893
PharmGKBiPA134869023

Polymorphism and mutation databases

BioMutaiCACUL1
DMDMi67460542

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198171 – 369CDK2-associated and cullin domain-containing protein 1Add BLAST369

Proteomic databases

EPDiQ86Y37
MaxQBiQ86Y37
PaxDbiQ86Y37
PeptideAtlasiQ86Y37
PRIDEiQ86Y37

PTM databases

iPTMnetiQ86Y37
PhosphoSitePlusiQ86Y37

Expressioni

Tissue specificityi

Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase.1 Publication

Gene expression databases

BgeeiENSG00000151893
CleanExiHS_C10orf46
GenevisibleiQ86Y37 HS

Organism-specific databases

HPAiHPA050611

Interactioni

Subunit structurei

Interacts with CDK2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033725EBI-8168227,EBI-78473

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: GO_Central

Protein-protein interaction databases

BioGridi126801, 4 interactors
IntActiQ86Y37, 2 interactors
MINTiQ86Y37
STRINGi9606.ENSP00000358147

Structurei

3D structure databases

ProteinModelPortaliQ86Y37
SMRiQ86Y37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 82Pro-richAdd BLAST48
Compositional biasi96 – 106Poly-AlaAdd BLAST11

Sequence similaritiesi

Belongs to the cullin family.Curated

Phylogenomic databases

eggNOGiKOG2166 Eukaryota
COG5647 LUCA
GeneTreeiENSGT00390000000403
HOGENOMiHOG000111684
HOVERGENiHBG059519
InParanoidiQ86Y37
OMAiWVQMAPA
OrthoDBiEOG091G0EJ6
PhylomeDBiQ86Y37
TreeFamiTF329263

Family and domain databases

InterProiView protein in InterPro
IPR001373 Cullin_N
IPR016159 Cullin_repeat-like_dom_sf
PfamiView protein in Pfam
PF00888 Cullin, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86Y37-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR
60 70 80 90 100
EPPGGQLLAV PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV
110 120 130 140 150
AKAAPAPTAS STININTSTS KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ
160 170 180 190 200
SPGDYIPISY EQIYSCVYKC VCQQHSEQMY SDLIKKITNH LERVSKELQA
210 220 230 240 250
SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL NRDLKDDLIK
260 270 280 290 300
LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM
310 320 330 340 350
APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA
360
GDELAYNSSS ACASSRGYR
Length:369
Mass (Da):41,064
Last modified:June 1, 2003 - v1
Checksum:i7ABA2F6846C4F737
GO
Isoform 2 (identifier: Q86Y37-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-303: EWVQMAPT → VSQNFTAV
     304-369: Missing.

Show »
Length:303
Mass (Da):33,584
Checksum:iE868EE20EEDC574A
GO
Isoform 4 (identifier: Q86Y37-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Show »
Length:246
Mass (Da):28,293
Checksum:iF89A36DE19D2A4A6
GO

Sequence cautioni

The sequence AAU89709 differs from that shown. Reason: Frameshift at position 296.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0139331 – 123Missing in isoform 4. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_013936296 – 303EWVQMAPT → VSQNFTAV in isoform 2. 1 Publication8
Alternative sequenceiVSP_013937304 – 369Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ544771 mRNA Translation: CAD67614.1
AY743663 mRNA Translation: AAU89709.1 Frameshift.
AK097728 mRNA Translation: BAC05153.1
AL139407 Genomic DNA No translation available.
BC038294 mRNA Translation: AAH38294.1
CCDSiCCDS41570.1 [Q86Y37-1]
RefSeqiNP_722517.3, NM_153810.4 [Q86Y37-1]
UniGeneiHs.420024
Hs.669999

Genome annotation databases

EnsembliENST00000369151; ENSP00000358147; ENSG00000151893 [Q86Y37-1]
ENST00000493518; ENSP00000431329; ENSG00000151893 [Q86Y37-2]
GeneIDi143384
KEGGihsa:143384
UCSCiuc001lds.2 human [Q86Y37-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCACL1_HUMAN
AccessioniPrimary (citable) accession number: Q86Y37
Secondary accession number(s): Q5XPL7, Q8IY11, Q8N7S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health