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Q86Y37 (CACL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CDK2-associated and cullin domain-containing protein 1
Alternative name(s):
Cdk-associated cullin1
Gene names
Name:CACUL1
Synonyms:C10orf46, CAC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. Ref.6

Subunit structure

Interacts with CDK2. Ref.6

Tissue specificity

Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase. Ref.6

Sequence similarities

Belongs to the cullin family.

Sequence caution

The sequence AAU89709.1 differs from that shown. Reason: Frameshift at position 296.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ESR1P033725EBI-8168227,EBI-78473

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86Y37-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86Y37-2)

The sequence of this isoform differs from the canonical sequence as follows:
     296-303: EWVQMAPT → VSQNFTAV
     304-369: Missing.
Isoform 4 (identifier: Q86Y37-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369CDK2-associated and cullin domain-containing protein 1
PRO_0000119817

Regions

Compositional bias35 – 8248Pro-rich
Compositional bias96 – 10611Poly-Ala

Natural variations

Alternative sequence1 – 123123Missing in isoform 4.
VSP_013933
Alternative sequence296 – 3038EWVQMAPT → VSQNFTAV in isoform 2.
VSP_013936
Alternative sequence304 – 36966Missing in isoform 2.
VSP_013937

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7ABA2F6846C4F737

FASTA36941,064
        10         20         30         40         50         60 
MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR EPPGGQLLAV 

        70         80         90        100        110        120 
PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV AKAAPAPTAS STININTSTS 

       130        140        150        160        170        180 
KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ SPGDYIPISY EQIYSCVYKC VCQQHSEQMY 

       190        200        210        220        230        240 
SDLIKKITNH LERVSKELQA SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL 

       250        260        270        280        290        300 
NRDLKDDLIK LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM 

       310        320        330        340        350        360 
APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA GDELAYNSSS 


ACASSRGYR 

« Hide

Isoform 2 [UniParc].

Checksum: E868EE20EEDC574A
Show »

FASTA30333,584
Isoform 4 [UniParc].

Checksum: F89A36DE19D2A4A6
Show »

FASTA24628,293

References

« Hide 'large scale' references
[1]Huang C., Wu S., Liu S.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The expression of gene in human rectum carcinoma."
Kong Y., Chen Y., Xia Q.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Rectum tumor.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Testis.
[4]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[6]"Identification and characterization of CAC1 as a novel CDK2-associated cullin."
Kong Y., Nan K., Yin Y.
Cell Cycle 8:3544-3553(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH CDK2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ544771 mRNA. Translation: CAD67614.1.
AY743663 mRNA. Translation: AAU89709.1. Frameshift.
AK097728 mRNA. Translation: BAC05153.1.
AL139407 Genomic DNA. Translation: CAH73727.1.
BC038294 mRNA. Translation: AAH38294.1.
CCDSCCDS41570.1. [Q86Y37-1]
RefSeqNP_722517.3. NM_153810.4. [Q86Y37-1]
UniGeneHs.420024.

3D structure databases

ProteinModelPortalQ86Y37.
SMRQ86Y37. Positions 130-237.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126801. 3 interactions.
IntActQ86Y37. 2 interactions.
MINTMINT-8401202.
STRING9606.ENSP00000358147.

PTM databases

PhosphoSiteQ86Y37.

Polymorphism databases

DMDM67460542.

Proteomic databases

MaxQBQ86Y37.
PaxDbQ86Y37.
PRIDEQ86Y37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340214; ENSP00000342487; ENSG00000151893. [Q86Y37-2]
ENST00000369151; ENSP00000358147; ENSG00000151893. [Q86Y37-1]
ENST00000493518; ENSP00000431329; ENSG00000151893. [Q86Y37-2]
GeneID143384.
KEGGhsa:143384.
UCSCuc001lds.1. human. [Q86Y37-1]

Organism-specific databases

CTD143384.
GeneCardsGC10M120433.
HGNCHGNC:23727. CACUL1.
neXtProtNX_Q86Y37.
PharmGKBPA134869023.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302356.
HOGENOMHOG000111684.
HOVERGENHBG059519.
InParanoidQ86Y37.
OMAVMNVITI.
OrthoDBEOG7G7KPG.
PhylomeDBQ86Y37.
TreeFamTF329263.

Gene expression databases

BgeeQ86Y37.
CleanExHS_C10orf46.
GenevestigatorQ86Y37.

Family and domain databases

InterProIPR001373. Cullin_N.
IPR016159. Cullin_repeat-like_dom.
[Graphical view]
PfamPF00888. Cullin. 1 hit.
[Graphical view]
SUPFAMSSF74788. SSF74788. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi143384.
NextBio84703.
PROQ86Y37.

Entry information

Entry nameCACL1_HUMAN
AccessionPrimary (citable) accession number: Q86Y37
Secondary accession number(s): Q5XPL7, Q8IY11, Q8N7S4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM