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Q86Y37

- CACL1_HUMAN

UniProt

Q86Y37 - CACL1_HUMAN

Protein

CDK2-associated and cullin domain-containing protein 1

Gene

CACUL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. G1/S transition of mitotic cell cycle Source: UniProtKB
    2. positive regulation of cell proliferation Source: UniProtKB
    3. positive regulation of protein kinase activity Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDK2-associated and cullin domain-containing protein 1
    Alternative name(s):
    Cdk-associated cullin1
    Gene namesi
    Name:CACUL1
    Synonyms:C10orf46, CAC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23727. CACUL1.

    Subcellular locationi

    GO - Cellular componenti

    1. cullin-RING ubiquitin ligase complex Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134869023.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369CDK2-associated and cullin domain-containing protein 1PRO_0000119817Add
    BLAST

    Proteomic databases

    MaxQBiQ86Y37.
    PaxDbiQ86Y37.
    PRIDEiQ86Y37.

    PTM databases

    PhosphoSiteiQ86Y37.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase.1 Publication

    Gene expression databases

    BgeeiQ86Y37.
    CleanExiHS_C10orf46.
    GenevestigatoriQ86Y37.

    Interactioni

    Subunit structurei

    Interacts with CDK2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ESR1P033725EBI-8168227,EBI-78473

    Protein-protein interaction databases

    BioGridi126801. 3 interactions.
    IntActiQ86Y37. 2 interactions.
    MINTiMINT-8401202.
    STRINGi9606.ENSP00000358147.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86Y37.
    SMRiQ86Y37. Positions 130-237.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi35 – 8248Pro-richAdd
    BLAST
    Compositional biasi96 – 10611Poly-AlaAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cullin family.Curated

    Phylogenomic databases

    eggNOGiNOG302356.
    HOGENOMiHOG000111684.
    HOVERGENiHBG059519.
    InParanoidiQ86Y37.
    OMAiVMNVITI.
    OrthoDBiEOG7G7KPG.
    PhylomeDBiQ86Y37.
    TreeFamiTF329263.

    Family and domain databases

    InterProiIPR001373. Cullin_N.
    IPR016159. Cullin_repeat-like_dom.
    [Graphical view]
    PfamiPF00888. Cullin. 1 hit.
    [Graphical view]
    SUPFAMiSSF74788. SSF74788. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86Y37-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR    50
    EPPGGQLLAV PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV 100
    AKAAPAPTAS STININTSTS KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ 150
    SPGDYIPISY EQIYSCVYKC VCQQHSEQMY SDLIKKITNH LERVSKELQA 200
    SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL NRDLKDDLIK 250
    LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM 300
    APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA 350
    GDELAYNSSS ACASSRGYR 369
    Length:369
    Mass (Da):41,064
    Last modified:June 1, 2003 - v1
    Checksum:i7ABA2F6846C4F737
    GO
    Isoform 2 (identifier: Q86Y37-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         296-303: EWVQMAPT → VSQNFTAV
         304-369: Missing.

    Show »
    Length:303
    Mass (Da):33,584
    Checksum:iE868EE20EEDC574A
    GO
    Isoform 4 (identifier: Q86Y37-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-123: Missing.

    Show »
    Length:246
    Mass (Da):28,293
    Checksum:iF89A36DE19D2A4A6
    GO

    Sequence cautioni

    The sequence AAU89709.1 differs from that shown. Reason: Frameshift at position 296.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 123123Missing in isoform 4. 1 PublicationVSP_013933Add
    BLAST
    Alternative sequencei296 – 3038EWVQMAPT → VSQNFTAV in isoform 2. 1 PublicationVSP_013936
    Alternative sequencei304 – 36966Missing in isoform 2. 1 PublicationVSP_013937Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ544771 mRNA. Translation: CAD67614.1.
    AY743663 mRNA. Translation: AAU89709.1. Frameshift.
    AK097728 mRNA. Translation: BAC05153.1.
    AL139407 Genomic DNA. Translation: CAH73727.1.
    BC038294 mRNA. Translation: AAH38294.1.
    CCDSiCCDS41570.1. [Q86Y37-1]
    RefSeqiNP_722517.3. NM_153810.4. [Q86Y37-1]
    UniGeneiHs.420024.

    Genome annotation databases

    EnsembliENST00000369151; ENSP00000358147; ENSG00000151893. [Q86Y37-1]
    ENST00000493518; ENSP00000431329; ENSG00000151893. [Q86Y37-2]
    GeneIDi143384.
    KEGGihsa:143384.
    UCSCiuc001lds.1. human. [Q86Y37-1]

    Polymorphism databases

    DMDMi67460542.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ544771 mRNA. Translation: CAD67614.1 .
    AY743663 mRNA. Translation: AAU89709.1 . Frameshift.
    AK097728 mRNA. Translation: BAC05153.1 .
    AL139407 Genomic DNA. Translation: CAH73727.1 .
    BC038294 mRNA. Translation: AAH38294.1 .
    CCDSi CCDS41570.1. [Q86Y37-1 ]
    RefSeqi NP_722517.3. NM_153810.4. [Q86Y37-1 ]
    UniGenei Hs.420024.

    3D structure databases

    ProteinModelPortali Q86Y37.
    SMRi Q86Y37. Positions 130-237.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126801. 3 interactions.
    IntActi Q86Y37. 2 interactions.
    MINTi MINT-8401202.
    STRINGi 9606.ENSP00000358147.

    PTM databases

    PhosphoSitei Q86Y37.

    Polymorphism databases

    DMDMi 67460542.

    Proteomic databases

    MaxQBi Q86Y37.
    PaxDbi Q86Y37.
    PRIDEi Q86Y37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369151 ; ENSP00000358147 ; ENSG00000151893 . [Q86Y37-1 ]
    ENST00000493518 ; ENSP00000431329 ; ENSG00000151893 . [Q86Y37-2 ]
    GeneIDi 143384.
    KEGGi hsa:143384.
    UCSCi uc001lds.1. human. [Q86Y37-1 ]

    Organism-specific databases

    CTDi 143384.
    GeneCardsi GC10M120433.
    HGNCi HGNC:23727. CACUL1.
    neXtProti NX_Q86Y37.
    PharmGKBi PA134869023.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302356.
    HOGENOMi HOG000111684.
    HOVERGENi HBG059519.
    InParanoidi Q86Y37.
    OMAi VMNVITI.
    OrthoDBi EOG7G7KPG.
    PhylomeDBi Q86Y37.
    TreeFami TF329263.

    Miscellaneous databases

    GenomeRNAii 143384.
    NextBioi 84703.
    PROi Q86Y37.

    Gene expression databases

    Bgeei Q86Y37.
    CleanExi HS_C10orf46.
    Genevestigatori Q86Y37.

    Family and domain databases

    InterProi IPR001373. Cullin_N.
    IPR016159. Cullin_repeat-like_dom.
    [Graphical view ]
    Pfami PF00888. Cullin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF74788. SSF74788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Huang C., Wu S., Liu S.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The expression of gene in human rectum carcinoma."
      Kong Y., Chen Y., Xia Q.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Rectum tumor.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Testis.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    6. "Identification and characterization of CAC1 as a novel CDK2-associated cullin."
      Kong Y., Nan K., Yin Y.
      Cell Cycle 8:3544-3553(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH CDK2.

    Entry informationi

    Entry nameiCACL1_HUMAN
    AccessioniPrimary (citable) accession number: Q86Y37
    Secondary accession number(s): Q5XPL7, Q8IY11, Q8N7S4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3