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Protein

Adhesion G protein-coupled receptor G3

Gene

ADGRG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-33887-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiP02.023.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor G31 Publication
Alternative name(s):
G-protein coupled receptor 97
G-protein coupled receptor PGR26
Gene namesi
Name:ADGRG3Imported
Synonyms:GPR97, PGR26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13728. ADGRG3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 272ExtracellularCuratedAdd BLAST252
Transmembranei273 – 293Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini294 – 307CytoplasmicCuratedAdd BLAST14
Transmembranei308 – 328Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini329 – 347ExtracellularCuratedAdd BLAST19
Transmembranei348 – 368Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini369 – 374CytoplasmicCurated6
Transmembranei375 – 395Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini396 – 434ExtracellularCuratedAdd BLAST39
Transmembranei435 – 455Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini456 – 488CytoplasmicCuratedAdd BLAST33
Transmembranei489 – 509Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini510 – 513ExtracellularCurated4
Transmembranei514 – 534Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini535 – 549CytoplasmicCuratedAdd BLAST15

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi222487.
OpenTargetsiENSG00000182885.
PharmGKBiPA28936.

Chemistry databases

GuidetoPHARMACOLOGYi188.

Polymorphism and mutation databases

BioMutaiGPR97.
DMDMi50400483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001288921 – 549Adhesion G protein-coupled receptor G3Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ86Y34.
PaxDbiQ86Y34.
PeptideAtlasiQ86Y34.
PRIDEiQ86Y34.

PTM databases

iPTMnetiQ86Y34.
PhosphoSitePlusiQ86Y34.

Expressioni

Tissue specificityi

Expressed in cultured primary dermal lymphatic endothelial cells.1 Publication

Gene expression databases

BgeeiENSG00000182885.
CleanExiHS_GPR97.
ExpressionAtlasiQ86Y34. baseline and differential.
GenevisibleiQ86Y34. HS.

Organism-specific databases

HPAiHPA040469.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332900.

Structurei

3D structure databases

ProteinModelPortaliQ86Y34.
SMRiQ86Y34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 261GPSPROSITE-ProRule annotationAdd BLAST50

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000112795.
HOVERGENiHBG051822.
InParanoidiQ86Y34.
KOiK08452.
OMAiCVFWDVT.
OrthoDBiEOG091G0FP0.
PhylomeDBiQ86Y34.
TreeFamiTF321769.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR003910. GPR1/GPR3/GPR5.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86Y34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPRGLGAL LLLLLLPTSG QEKPTEGPRN TCLGSNNMYD IFNLNDKALC
60 70 80 90 100
FTKCRQSGSD SCNVENLQRY WLNYEAHLMK EGLTQKVNTP FLKALVQNLS
110 120 130 140 150
TNTAEDFYFS LEPSQVPRQV MKDEDKPPDR VRLPKSLFRS LPGNRSVVRL
160 170 180 190 200
AVTILDIGPG TLFKGPRLGL GDGSGVLNNR LVGLSVGQMH VTKLAEPLEI
210 220 230 240 250
VFSHQRPPPN MTLTCVFWDV TKGTTGDWSS EGCSTEVRPE GTVCCCDHLT
260 270 280 290 300
FFALLLRPTL DQSTVHILTR ISQAGCGVSM IFLAFTIILY AFLRLSRERF
310 320 330 340 350
KSEDAPKIHV ALGGSLFLLN LAFLVNVGSG SKGSDAACWA RGAVFHYFLL
360 370 380 390 400
CAFTWMGLEA FHLYLLAVRV FNTYFGHYFL KLSLVGWGLP ALMVIGTGSA
410 420 430 440 450
NSYGLYTIRD RENRTSLELC WFREGTTMYA LYITVHGYFL ITFLFGMVVL
460 470 480 490 500
ALVVWKIFTL SRATAVKERG KNRKKVLTLL GLSSLVGVTW GLAIFTPLGL
510 520 530 540
STVYIFALFN SLQGVFICCW FTILYLPSQS TTVSSSTARL DQAHSASQE
Length:549
Mass (Da):60,861
Last modified:June 1, 2003 - v1
Checksum:iC9AB0D95B2F26DDA
GO

Sequence cautioni

The sequence BAD18774 differs from that shown. Reason: Frameshift at position 492.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8G → W in AAN46673 (PubMed:12435584).Curated1
Sequence conflicti24P → S in BAD18774 (PubMed:14702039).Curated1
Sequence conflicti193K → R in BAD18774 (PubMed:14702039).Curated1
Sequence conflicti457I → V in BAD18774 (PubMed:14702039).Curated1
Sequence conflicti465A → V in AAH64508 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055927430A → T.Corresponds to variant rs2290178dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049169 mRNA. Translation: BAC67700.1.
AY140959 mRNA. Translation: AAN46673.1.
AK172801 mRNA. Translation: BAD18774.1. Frameshift.
BC064508 mRNA. Translation: AAH64508.1.
AY255601 mRNA. Translation: AAO85113.1.
CCDSiCCDS10786.1.
RefSeqiNP_001295289.1. NM_001308360.1.
NP_740746.4. NM_170776.4.
UniGeneiHs.383403.

Genome annotation databases

EnsembliENST00000333493; ENSP00000332900; ENSG00000182885.
GeneIDi222487.
KEGGihsa:222487.
UCSCiuc002emh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049169 mRNA. Translation: BAC67700.1.
AY140959 mRNA. Translation: AAN46673.1.
AK172801 mRNA. Translation: BAD18774.1. Frameshift.
BC064508 mRNA. Translation: AAH64508.1.
AY255601 mRNA. Translation: AAO85113.1.
CCDSiCCDS10786.1.
RefSeqiNP_001295289.1. NM_001308360.1.
NP_740746.4. NM_170776.4.
UniGeneiHs.383403.

3D structure databases

ProteinModelPortaliQ86Y34.
SMRiQ86Y34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332900.

Chemistry databases

GuidetoPHARMACOLOGYi188.

Protein family/group databases

MEROPSiP02.023.
GPCRDBiSearch...

PTM databases

iPTMnetiQ86Y34.
PhosphoSitePlusiQ86Y34.

Polymorphism and mutation databases

BioMutaiGPR97.
DMDMi50400483.

Proteomic databases

EPDiQ86Y34.
PaxDbiQ86Y34.
PeptideAtlasiQ86Y34.
PRIDEiQ86Y34.

Protocols and materials databases

DNASUi222487.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333493; ENSP00000332900; ENSG00000182885.
GeneIDi222487.
KEGGihsa:222487.
UCSCiuc002emh.4. human.

Organism-specific databases

CTDi222487.
DisGeNETi222487.
GeneCardsiADGRG3.
HGNCiHGNC:13728. ADGRG3.
HPAiHPA040469.
neXtProtiNX_Q86Y34.
OpenTargetsiENSG00000182885.
PharmGKBiPA28936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000112795.
HOVERGENiHBG051822.
InParanoidiQ86Y34.
KOiK08452.
OMAiCVFWDVT.
OrthoDBiEOG091G0FP0.
PhylomeDBiQ86Y34.
TreeFamiTF321769.

Enzyme and pathway databases

BioCyciZFISH:G66-33887-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiGPR97. human.
GeneWikiiGPR97.
GenomeRNAii222487.
PROiQ86Y34.

Gene expression databases

BgeeiENSG00000182885.
CleanExiHS_GPR97.
ExpressionAtlasiQ86Y34. baseline and differential.
GenevisibleiQ86Y34. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR003910. GPR1/GPR3/GPR5.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRG3_HUMAN
AccessioniPrimary (citable) accession number: Q86Y34
Secondary accession number(s): Q6ZMF4, Q86SL9, Q8IZF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.