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Q86Y34 (GPR97_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 97
Alternative name(s):
G-protein coupled receptor PGR26
Gene names
Name:GPR97
Synonyms:PGR26
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 GPS domain.

Sequence caution

The sequence BAD18774.1 differs from that shown. Reason: Frameshift at position 492.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.5
Chain21 – 549529Probable G-protein coupled receptor 97
PRO_0000012889

Regions

Topological domain21 – 272252Extracellular Potential
Transmembrane273 – 29321Helical; Name=1; Potential
Topological domain294 – 30714Cytoplasmic Potential
Transmembrane308 – 32821Helical; Name=2; Potential
Topological domain329 – 34719Extracellular Potential
Transmembrane348 – 36821Helical; Name=3; Potential
Topological domain369 – 3746Cytoplasmic Potential
Transmembrane375 – 39521Helical; Name=4; Potential
Topological domain396 – 43439Extracellular Potential
Transmembrane435 – 45521Helical; Name=5; Potential
Topological domain456 – 48833Cytoplasmic Potential
Transmembrane489 – 50921Helical; Name=6; Potential
Topological domain510 – 5134Extracellular Potential
Transmembrane514 – 53421Helical; Name=7; Potential
Topological domain535 – 54915Cytoplasmic Potential
Domain212 – 26150GPS

Amino acid modifications

Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation4131N-linked (GlcNAc...) Potential

Natural variations

Natural variant4301A → T.
Corresponds to variant rs2290178 [ dbSNP | Ensembl ].
VAR_055927

Experimental info

Sequence conflict81G → W in AAN46673. Ref.2
Sequence conflict241P → S in BAD18774. Ref.3
Sequence conflict1931K → R in BAD18774. Ref.3
Sequence conflict4571I → V in BAD18774. Ref.3
Sequence conflict4651A → V in AAH64508. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q86Y34 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: C9AB0D95B2F26DDA

FASTA54960,861
        10         20         30         40         50         60 
MATPRGLGAL LLLLLLPTSG QEKPTEGPRN TCLGSNNMYD IFNLNDKALC FTKCRQSGSD 

        70         80         90        100        110        120 
SCNVENLQRY WLNYEAHLMK EGLTQKVNTP FLKALVQNLS TNTAEDFYFS LEPSQVPRQV 

       130        140        150        160        170        180 
MKDEDKPPDR VRLPKSLFRS LPGNRSVVRL AVTILDIGPG TLFKGPRLGL GDGSGVLNNR 

       190        200        210        220        230        240 
LVGLSVGQMH VTKLAEPLEI VFSHQRPPPN MTLTCVFWDV TKGTTGDWSS EGCSTEVRPE 

       250        260        270        280        290        300 
GTVCCCDHLT FFALLLRPTL DQSTVHILTR ISQAGCGVSM IFLAFTIILY AFLRLSRERF 

       310        320        330        340        350        360 
KSEDAPKIHV ALGGSLFLLN LAFLVNVGSG SKGSDAACWA RGAVFHYFLL CAFTWMGLEA 

       370        380        390        400        410        420 
FHLYLLAVRV FNTYFGHYFL KLSLVGWGLP ALMVIGTGSA NSYGLYTIRD RENRTSLELC 

       430        440        450        460        470        480 
WFREGTTMYA LYITVHGYFL ITFLFGMVVL ALVVWKIFTL SRATAVKERG KNRKKVLTLL 

       490        500        510        520        530        540 
GLSSLVGVTW GLAIFTPLGL STVYIFALFN SLQGVFICCW FTILYLPSQS TTVSSSTARL 


DQAHSASQE 

« Hide

References

« Hide 'large scale' references
[1]"A member of G-protein coupled receptor family."
Okaze H., Hayashi A., Kozuma S., Saito T.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-35.
[6]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 299-387.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB049169 mRNA. Translation: BAC67700.1.
AY140959 mRNA. Translation: AAN46673.1.
AK172801 mRNA. Translation: BAD18774.1. Frameshift.
BC064508 mRNA. Translation: AAH64508.1.
AY255601 mRNA. Translation: AAO85113.1.
RefSeqNP_740746.4. NM_170776.4.
UniGeneHs.383403.

3D structure databases

ProteinModelPortalQ86Y34.
SMRQ86Y34. Positions 125-258, 266-525.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY188.

Protein family/group databases

MEROPSS63.026.
GPCRDBSearch...

PTM databases

PhosphoSiteQ86Y34.

Polymorphism databases

DMDM50400483.

Proteomic databases

PaxDbQ86Y34.
PRIDEQ86Y34.

Protocols and materials databases

DNASU222487.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333493; ENSP00000332900; ENSG00000182885.
GeneID222487.
KEGGhsa:222487.
UCSCuc002emh.3. human.

Organism-specific databases

CTD222487.
GeneCardsGC16P057702.
HGNCHGNC:13728. GPR97.
HPAHPA040469.
neXtProtNX_Q86Y34.
PharmGKBPA28936.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281289.
HOGENOMHOG000112795.
HOVERGENHBG051822.
KOK08452.
OMARYWLNYE.
OrthoDBEOG7X6M07.
PhylomeDBQ86Y34.
TreeFamTF321769.

Gene expression databases

ArrayExpressQ86Y34.
BgeeQ86Y34.
CleanExHS_GPR97.
GenevestigatorQ86Y34.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR003910. GPCR_2_orphan_rcpt_GPR56.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTSM00303. GPS. 1 hit.
[Graphical view]
PROSITEPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPR97. human.
GeneWikiGPR97.
GenomeRNAi222487.
NextBio91606.
PROQ86Y34.

Entry information

Entry nameGPR97_HUMAN
AccessionPrimary (citable) accession number: Q86Y34
Secondary accession number(s): Q6ZMF4, Q86SL9, Q8IZF1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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