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Q86Y34

- GPR97_HUMAN

UniProt

Q86Y34 - GPR97_HUMAN

Protein

Probable G-protein coupled receptor 97

Gene

GPR97

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Protein family/group databases

    MEROPSiS63.026.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 97
    Alternative name(s):
    G-protein coupled receptor PGR26
    Gene namesi
    Name:GPR97
    Synonyms:PGR26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:13728. GPR97.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28936.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 549529Probable G-protein coupled receptor 97PRO_0000012889Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ86Y34.
    PRIDEiQ86Y34.

    PTM databases

    PhosphoSiteiQ86Y34.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86Y34.
    BgeeiQ86Y34.
    CleanExiHS_GPR97.
    GenevestigatoriQ86Y34.

    Organism-specific databases

    HPAiHPA040469.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86Y34.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 272252ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 30714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini329 – 34719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini369 – 3746CytoplasmicSequence Analysis
    Topological domaini396 – 43439ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini456 – 48833CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini510 – 5134ExtracellularSequence Analysis
    Topological domaini535 – 54915CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei273 – 29321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei375 – 39521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei435 – 45521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei489 – 50921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei514 – 53421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini212 – 26150GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281289.
    HOGENOMiHOG000112795.
    HOVERGENiHBG051822.
    KOiK08452.
    OMAiRYWLNYE.
    OrthoDBiEOG7X6M07.
    PhylomeDBiQ86Y34.
    TreeFamiTF321769.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR003910. GPCR_2_orphan_rcpt_GPR56.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01422. GPR56ORPHANR.
    SMARTiSM00303. GPS. 1 hit.
    [Graphical view]
    PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q86Y34-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPRGLGAL LLLLLLPTSG QEKPTEGPRN TCLGSNNMYD IFNLNDKALC    50
    FTKCRQSGSD SCNVENLQRY WLNYEAHLMK EGLTQKVNTP FLKALVQNLS 100
    TNTAEDFYFS LEPSQVPRQV MKDEDKPPDR VRLPKSLFRS LPGNRSVVRL 150
    AVTILDIGPG TLFKGPRLGL GDGSGVLNNR LVGLSVGQMH VTKLAEPLEI 200
    VFSHQRPPPN MTLTCVFWDV TKGTTGDWSS EGCSTEVRPE GTVCCCDHLT 250
    FFALLLRPTL DQSTVHILTR ISQAGCGVSM IFLAFTIILY AFLRLSRERF 300
    KSEDAPKIHV ALGGSLFLLN LAFLVNVGSG SKGSDAACWA RGAVFHYFLL 350
    CAFTWMGLEA FHLYLLAVRV FNTYFGHYFL KLSLVGWGLP ALMVIGTGSA 400
    NSYGLYTIRD RENRTSLELC WFREGTTMYA LYITVHGYFL ITFLFGMVVL 450
    ALVVWKIFTL SRATAVKERG KNRKKVLTLL GLSSLVGVTW GLAIFTPLGL 500
    STVYIFALFN SLQGVFICCW FTILYLPSQS TTVSSSTARL DQAHSASQE 549
    Length:549
    Mass (Da):60,861
    Last modified:June 1, 2003 - v1
    Checksum:iC9AB0D95B2F26DDA
    GO

    Sequence cautioni

    The sequence BAD18774.1 differs from that shown. Reason: Frameshift at position 492.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81G → W in AAN46673. (PubMed:12435584)Curated
    Sequence conflicti24 – 241P → S in BAD18774. (PubMed:14702039)Curated
    Sequence conflicti193 – 1931K → R in BAD18774. (PubMed:14702039)Curated
    Sequence conflicti457 – 4571I → V in BAD18774. (PubMed:14702039)Curated
    Sequence conflicti465 – 4651A → V in AAH64508. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti430 – 4301A → T.
    Corresponds to variant rs2290178 [ dbSNP | Ensembl ].
    VAR_055927

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049169 mRNA. Translation: BAC67700.1.
    AY140959 mRNA. Translation: AAN46673.1.
    AK172801 mRNA. Translation: BAD18774.1. Frameshift.
    BC064508 mRNA. Translation: AAH64508.1.
    AY255601 mRNA. Translation: AAO85113.1.
    CCDSiCCDS10786.1.
    RefSeqiNP_740746.4. NM_170776.4.
    UniGeneiHs.383403.

    Genome annotation databases

    EnsembliENST00000333493; ENSP00000332900; ENSG00000182885.
    GeneIDi222487.
    KEGGihsa:222487.
    UCSCiuc002emh.3. human.

    Polymorphism databases

    DMDMi50400483.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049169 mRNA. Translation: BAC67700.1 .
    AY140959 mRNA. Translation: AAN46673.1 .
    AK172801 mRNA. Translation: BAD18774.1 . Frameshift.
    BC064508 mRNA. Translation: AAH64508.1 .
    AY255601 mRNA. Translation: AAO85113.1 .
    CCDSi CCDS10786.1.
    RefSeqi NP_740746.4. NM_170776.4.
    UniGenei Hs.383403.

    3D structure databases

    ProteinModelPortali Q86Y34.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 188.

    Protein family/group databases

    MEROPSi S63.026.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q86Y34.

    Polymorphism databases

    DMDMi 50400483.

    Proteomic databases

    PaxDbi Q86Y34.
    PRIDEi Q86Y34.

    Protocols and materials databases

    DNASUi 222487.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333493 ; ENSP00000332900 ; ENSG00000182885 .
    GeneIDi 222487.
    KEGGi hsa:222487.
    UCSCi uc002emh.3. human.

    Organism-specific databases

    CTDi 222487.
    GeneCardsi GC16P057702.
    HGNCi HGNC:13728. GPR97.
    HPAi HPA040469.
    neXtProti NX_Q86Y34.
    PharmGKBi PA28936.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281289.
    HOGENOMi HOG000112795.
    HOVERGENi HBG051822.
    KOi K08452.
    OMAi RYWLNYE.
    OrthoDBi EOG7X6M07.
    PhylomeDBi Q86Y34.
    TreeFami TF321769.

    Miscellaneous databases

    ChiTaRSi GPR97. human.
    GeneWikii GPR97.
    GenomeRNAii 222487.
    NextBioi 91606.
    PROi Q86Y34.

    Gene expression databases

    ArrayExpressi Q86Y34.
    Bgeei Q86Y34.
    CleanExi HS_GPR97.
    Genevestigatori Q86Y34.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR003910. GPCR_2_orphan_rcpt_GPR56.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01422. GPR56ORPHANR.
    SMARTi SM00303. GPS. 1 hit.
    [Graphical view ]
    PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A member of G-protein coupled receptor family."
      Okaze H., Hayashi A., Kozuma S., Saito T.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
      Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
      FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-35.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 299-387.

    Entry informationi

    Entry nameiGPR97_HUMAN
    AccessioniPrimary (citable) accession number: Q86Y34
    Secondary accession number(s): Q6ZMF4, Q86SL9, Q8IZF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3