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Protein

Probable G-protein coupled receptor 97

Gene

GPR97

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 97
Alternative name(s):
G-protein coupled receptor PGR26
Gene namesi
Name:GPR97
Synonyms:PGR26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13728. GPR97.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 272252ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini294 – 30714CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei308 – 32821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini329 – 34719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei348 – 36821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini369 – 3746CytoplasmicSequence Analysis
Transmembranei375 – 39521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini396 – 43439ExtracellularSequence AnalysisAdd
BLAST
Transmembranei435 – 45521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini456 – 48833CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei489 – 50921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini510 – 5134ExtracellularSequence Analysis
Transmembranei514 – 53421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini535 – 54915CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28936.

Polymorphism and mutation databases

BioMutaiGPR97.
DMDMi50400483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 549529Probable G-protein coupled receptor 97PRO_0000012889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86Y34.
PRIDEiQ86Y34.

PTM databases

PhosphoSiteiQ86Y34.

Expressioni

Gene expression databases

BgeeiQ86Y34.
CleanExiHS_GPR97.
ExpressionAtlasiQ86Y34. baseline and differential.
GenevestigatoriQ86Y34.

Organism-specific databases

HPAiHPA040469.

Structurei

3D structure databases

ProteinModelPortaliQ86Y34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 26150GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281289.
GeneTreeiENSGT00760000118787.
HOGENOMiHOG000112795.
HOVERGENiHBG051822.
InParanoidiQ86Y34.
KOiK08452.
OMAiLFKGPQL.
OrthoDBiEOG7X6M07.
PhylomeDBiQ86Y34.
TreeFamiTF321769.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR003910. GPCR_2_orphan_rcpt_GPR56.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86Y34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPRGLGAL LLLLLLPTSG QEKPTEGPRN TCLGSNNMYD IFNLNDKALC
60 70 80 90 100
FTKCRQSGSD SCNVENLQRY WLNYEAHLMK EGLTQKVNTP FLKALVQNLS
110 120 130 140 150
TNTAEDFYFS LEPSQVPRQV MKDEDKPPDR VRLPKSLFRS LPGNRSVVRL
160 170 180 190 200
AVTILDIGPG TLFKGPRLGL GDGSGVLNNR LVGLSVGQMH VTKLAEPLEI
210 220 230 240 250
VFSHQRPPPN MTLTCVFWDV TKGTTGDWSS EGCSTEVRPE GTVCCCDHLT
260 270 280 290 300
FFALLLRPTL DQSTVHILTR ISQAGCGVSM IFLAFTIILY AFLRLSRERF
310 320 330 340 350
KSEDAPKIHV ALGGSLFLLN LAFLVNVGSG SKGSDAACWA RGAVFHYFLL
360 370 380 390 400
CAFTWMGLEA FHLYLLAVRV FNTYFGHYFL KLSLVGWGLP ALMVIGTGSA
410 420 430 440 450
NSYGLYTIRD RENRTSLELC WFREGTTMYA LYITVHGYFL ITFLFGMVVL
460 470 480 490 500
ALVVWKIFTL SRATAVKERG KNRKKVLTLL GLSSLVGVTW GLAIFTPLGL
510 520 530 540
STVYIFALFN SLQGVFICCW FTILYLPSQS TTVSSSTARL DQAHSASQE
Length:549
Mass (Da):60,861
Last modified:June 1, 2003 - v1
Checksum:iC9AB0D95B2F26DDA
GO

Sequence cautioni

The sequence BAD18774.1 differs from that shown. Reason: Frameshift at position 492. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81G → W in AAN46673 (PubMed:12435584).Curated
Sequence conflicti24 – 241P → S in BAD18774 (PubMed:14702039).Curated
Sequence conflicti193 – 1931K → R in BAD18774 (PubMed:14702039).Curated
Sequence conflicti457 – 4571I → V in BAD18774 (PubMed:14702039).Curated
Sequence conflicti465 – 4651A → V in AAH64508 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti430 – 4301A → T.
Corresponds to variant rs2290178 [ dbSNP | Ensembl ].
VAR_055927

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049169 mRNA. Translation: BAC67700.1.
AY140959 mRNA. Translation: AAN46673.1.
AK172801 mRNA. Translation: BAD18774.1. Frameshift.
BC064508 mRNA. Translation: AAH64508.1.
AY255601 mRNA. Translation: AAO85113.1.
CCDSiCCDS10786.1.
RefSeqiNP_740746.4. NM_170776.4.
UniGeneiHs.383403.

Genome annotation databases

EnsembliENST00000333493; ENSP00000332900; ENSG00000182885.
GeneIDi222487.
KEGGihsa:222487.
UCSCiuc002emh.3. human.

Polymorphism and mutation databases

BioMutaiGPR97.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049169 mRNA. Translation: BAC67700.1.
AY140959 mRNA. Translation: AAN46673.1.
AK172801 mRNA. Translation: BAD18774.1. Frameshift.
BC064508 mRNA. Translation: AAH64508.1.
AY255601 mRNA. Translation: AAO85113.1.
CCDSiCCDS10786.1.
RefSeqiNP_740746.4. NM_170776.4.
UniGeneiHs.383403.

3D structure databases

ProteinModelPortaliQ86Y34.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi188.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ86Y34.

Polymorphism and mutation databases

BioMutaiGPR97.
DMDMi50400483.

Proteomic databases

PaxDbiQ86Y34.
PRIDEiQ86Y34.

Protocols and materials databases

DNASUi222487.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333493; ENSP00000332900; ENSG00000182885.
GeneIDi222487.
KEGGihsa:222487.
UCSCiuc002emh.3. human.

Organism-specific databases

CTDi222487.
GeneCardsiGC16P057702.
HGNCiHGNC:13728. GPR97.
HPAiHPA040469.
neXtProtiNX_Q86Y34.
PharmGKBiPA28936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG281289.
GeneTreeiENSGT00760000118787.
HOGENOMiHOG000112795.
HOVERGENiHBG051822.
InParanoidiQ86Y34.
KOiK08452.
OMAiLFKGPQL.
OrthoDBiEOG7X6M07.
PhylomeDBiQ86Y34.
TreeFamiTF321769.

Miscellaneous databases

ChiTaRSiGPR97. human.
GeneWikiiGPR97.
GenomeRNAii222487.
NextBioi91606.
PROiQ86Y34.

Gene expression databases

BgeeiQ86Y34.
CleanExiHS_GPR97.
ExpressionAtlasiQ86Y34. baseline and differential.
GenevestigatoriQ86Y34.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR003910. GPCR_2_orphan_rcpt_GPR56.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A member of G-protein coupled receptor family."
    Okaze H., Hayashi A., Kozuma S., Saito T.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
    Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
    FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-35.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 299-387.

Entry informationi

Entry nameiGPR97_HUMAN
AccessioniPrimary (citable) accession number: Q86Y34
Secondary accession number(s): Q6ZMF4, Q86SL9, Q8IZF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: April 29, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.