Q86Y34 (GPR97_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 97

Alternative name(s):
G-protein coupled receptor PGR26

Gene names

Name:	GPR97
Synonyms:	PGR26

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain.
Sequence caution	The sequence BAD18774.1 differs from that shown. Reason: Frameshift at position 492.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Traceable author statement PubMed 15203201. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.5
	Chain	21 – 549	529	Probable G-protein coupled receptor 97		PRO_0000012889
Regions
	Topological domain	21 – 272	252	Extracellular Potential
	Transmembrane	273 – 293	21	Helical; Name=1; Potential
	Topological domain	294 – 307	14	Cytoplasmic Potential
	Transmembrane	308 – 328	21	Helical; Name=2; Potential
	Topological domain	329 – 347	19	Extracellular Potential
	Transmembrane	348 – 368	21	Helical; Name=3; Potential
	Topological domain	369 – 374	6	Cytoplasmic Potential
	Transmembrane	375 – 395	21	Helical; Name=4; Potential
	Topological domain	396 – 434	39	Extracellular Potential
	Transmembrane	435 – 455	21	Helical; Name=5; Potential
	Topological domain	456 – 488	33	Cytoplasmic Potential
	Transmembrane	489 – 509	21	Helical; Name=6; Potential
	Topological domain	510 – 513	4	Extracellular Potential
	Transmembrane	514 – 534	21	Helical; Name=7; Potential
	Topological domain	535 – 549	15	Cytoplasmic Potential
	Domain	212 – 261	50	GPS
Amino acid modifications
	Glycosylation	98	1	N-linked (GlcNAc...) Potential
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
	Glycosylation	210	1	N-linked (GlcNAc...) Potential
	Glycosylation	413	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	430	1	A → T. Corresponds to variant rs2290178 [ dbSNP | Ensembl ].		VAR_055927
Experimental info
	Sequence conflict	8	1	G → W in AAN46673. Ref.2
	Sequence conflict	24	1	P → S in BAD18774. Ref.3
	Sequence conflict	193	1	K → R in BAD18774. Ref.3
	Sequence conflict	457	1	I → V in BAD18774. Ref.3
	Sequence conflict	465	1	A → V in AAH64508. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q86Y34 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: C9AB0D95B2F26DDA	FASTA	549	60,861
	10 20 30 40 50 60 MATPRGLGAL LLLLLLPTSG QEKPTEGPRN TCLGSNNMYD IFNLNDKALC FTKCRQSGSD 70 80 90 100 110 120 SCNVENLQRY WLNYEAHLMK EGLTQKVNTP FLKALVQNLS TNTAEDFYFS LEPSQVPRQV 130 140 150 160 170 180 MKDEDKPPDR VRLPKSLFRS LPGNRSVVRL AVTILDIGPG TLFKGPRLGL GDGSGVLNNR 190 200 210 220 230 240 LVGLSVGQMH VTKLAEPLEI VFSHQRPPPN MTLTCVFWDV TKGTTGDWSS EGCSTEVRPE 250 260 270 280 290 300 GTVCCCDHLT FFALLLRPTL DQSTVHILTR ISQAGCGVSM IFLAFTIILY AFLRLSRERF 310 320 330 340 350 360 KSEDAPKIHV ALGGSLFLLN LAFLVNVGSG SKGSDAACWA RGAVFHYFLL CAFTWMGLEA 370 380 390 400 410 420 FHLYLLAVRV FNTYFGHYFL KLSLVGWGLP ALMVIGTGSA NSYGLYTIRD RENRTSLELC 430 440 450 460 470 480 WFREGTTMYA LYITVHGYFL ITFLFGMVVL ALVVWKIFTL SRATAVKERG KNRKKVLTLL 490 500 510 520 530 540 GLSSLVGVTW GLAIFTPLGL STVYIFALFN SLQGVFICCW FTILYLPSQS TTVSSSTARL DQAHSASQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A member of G-protein coupled receptor family." Okaze H., Hayashi A., Kozuma S., Saito T. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions." Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B. FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-35.
[6]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 299-387.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB049169 mRNA. Translation: BAC67700.1. AY140959 mRNA. Translation: AAN46673.1. AK172801 mRNA. Translation: BAD18774.1. Frameshift. BC064508 mRNA. Translation: AAH64508.1. AY255601 mRNA. Translation: AAO85113.1.
IPI	IPI00384590.
RefSeq	NP_740746.4. NM_170776.4.
UniGene	Hs.383403.
3D structure databases
ProteinModelPortal	Q86Y34.
ModBase	Search...
Protein family/group databases
MEROPS	S63.026.
GPCRDB	Search...
PTM databases
PhosphoSite	Q86Y34.
Polymorphism databases
DMDM	50400483.
Proteomic databases
PaxDb	Q86Y34.
PRIDE	Q86Y34.
Protocols and materials databases
DNASU	222487.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333493; ENSP00000332900; ENSG00000182885.
GeneID	222487.
KEGG	hsa:222487.
UCSC	uc002emh.3. human.
Organism-specific databases
CTD	222487.
GeneCards	GC16P057702.
HGNC	HGNC:13728. GPR97.
HPA	HPA040469.
neXtProt	NX_Q86Y34.
PharmGKB	PA28936.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG281289.
HOGENOM	HOG000112795.
HOVERGEN	HBG051822.
KO	K08452.
OrthoDB	EOG4BP1BW.
Gene expression databases
ArrayExpress	Q86Y34.
Bgee	Q86Y34.
CleanEx	HS_GPR97.
Genevestigator	Q86Y34.
GermOnline	ENSG00000182885. Homo sapiens.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR003910. GPCR_2_orphan_rcpt_GPR56. IPR000832. GPCR_2_secretin-like. IPR000203. GPS_dom. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF01825. GPS. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN. PR01422. GPR56ORPHANR.
SMART	SM00303. GPS. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. False negative. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GPR97. human.
GenomeRNAi	222487.
NextBio	91606.

Entry information

Entry name

GPR97_HUMAN

Accession

Primary (citable) accession number: Q86Y34
Secondary accession number(s): Q6ZMF4, Q86SL9, Q8IZF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.