Q86Y33 (CD20B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division cycle protein 20 homolog B

Gene names

Name:	CDC20B
ORF Names:	G6VTS76519

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	519 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the WD repeat CDC20/Fizzy family. Contains 7 WD repeats.
Sequence caution	The sequence BAB97393.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86Y33-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86Y33-2)

The sequence of this isoform differs from the canonical sequence as follows:
     483-486: Missing.

Isoform 3 (identifier: Q86Y33-3)

The sequence of this isoform differs from the canonical sequence as follows:
     406-447: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q86Y33-4)

The sequence of this isoform differs from the canonical sequence as follows:
     330-372: SGSRLGRVYH...WSPDGRLLSS → RLEFSGVISA...WGVFIITMFG
     373-519: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q86Y33-5)

The sequence of this isoform differs from the canonical sequence as follows:
     22-42: Missing.
     194-213: GCKDGVRDESFHLKSSGDIN → DHFSGSMKKRFEQEDVGGKD
     214-519: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 519	519	Cell division cycle protein 20 homolog B		PRO_0000339110
Regions
	Repeat	229 – 266	38	WD 1
	Repeat	271 – 310	40	WD 2
	Repeat	311 – 341	31	WD 3
	Repeat	353 – 392	40	WD 4
	Repeat	399 – 441	43	WD 5
	Repeat	443 – 484	42	WD 6
	Repeat	487 – 519	33	WD 7
Natural variations
	Alternative sequence	22 – 42	21	Missing in isoform 5.		VSP_034089
	Alternative sequence	194 – 213	20	GCKDG…SGDIN → DHFSGSMKKRFEQEDVGGKD in isoform 5.		VSP_034090
	Alternative sequence	214 – 519	306	Missing in isoform 5.		VSP_034091
	Alternative sequence	330 – 372	43	SGSRL…RLLSS → RLEFSGVISAHCNLHLPSSW DYRRPPPCLVGQDWGVFIIT MFG in isoform 4.		VSP_034092
	Alternative sequence	373 – 519	147	Missing in isoform 4.		VSP_034093
	Alternative sequence	406 – 447	42	Missing in isoform 3.		VSP_034094
	Alternative sequence	483 – 486	4	Missing in isoform 2.		VSP_034095
	Natural variant	8	1	T → P. Corresponds to variant rs173042 [ dbSNP | Ensembl ].		VAR_043860
	Natural variant	17	1	E → K. Corresponds to variant rs423074 [ dbSNP | Ensembl ].		VAR_043861
	Natural variant	97	1	T → S. Corresponds to variant rs34132993 [ dbSNP | Ensembl ].		VAR_043862
	Natural variant	121	1	R → C. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs1021580 [ dbSNP | Ensembl ].		VAR_043863
	Natural variant	496	1	S → A. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs3104230 [ dbSNP | Ensembl ].		VAR_043864
	Natural variant	503	1	R → W. Ref.1 Ref.5 Corresponds to variant rs444527 [ dbSNP | Ensembl ].		VAR_043865

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 10, 2010. Version 3. Checksum: 2D40A57A4363A349	FASTA	519	57,335
	10 20 30 40 50 60 MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT YSDFKSNFAK 70 80 90 100 110 120 RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP EASGSVLKTP PEKETLTLGS 130 140 150 160 170 180 RKEQLKTPSK GISETSNSAL HFCKAPHAMD RDWKESVASK GQKCLKQLFV TQNVVQQANG 190 200 210 220 230 240 KMQLCEQSEC VWKGCKDGVR DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS 250 260 270 280 290 300 FQNLVAIALG SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW 310 320 330 340 350 360 DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG TLRHKQAVCA 370 380 390 400 410 420 LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ STAVKAMDWC PWQSGVLAIG 430 440 450 460 470 480 GGMKDGRLHI LDINAGKSIQ TPSTNSQICS LIWLPKTKEI ATGQGTPKND VTVWTCPTVS 490 500 510 RSGGFFGHRG RVLHLSLSPD QTRVFSAAAD GTASVWNCY
	Isoform 2 [UniParc]. Checksum: C9DC5381A7EA8C6D	FASTA	515	56,927
	10 20 30 40 50 60 MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT YSDFKSNFAK 70 80 90 100 110 120 RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP EASGSVLKTP PEKETLTLGS 130 140 150 160 170 180 RKEQLKTPSK GISETSNSAL HFCKAPHAMD RDWKESVASK GQKCLKQLFV TQNVVQQANG 190 200 210 220 230 240 KMQLCEQSEC VWKGCKDGVR DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS 250 260 270 280 290 300 FQNLVAIALG SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW 310 320 330 340 350 360 DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG TLRHKQAVCA 370 380 390 400 410 420 LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ STAVKAMDWC PWQSGVLAIG 430 440 450 460 470 480 GGMKDGRLHI LDINAGKSIQ TPSTNSQICS LIWLPKTKEI ATGQGTPKND VTVWTCPTVS 490 500 510 RSGHRGRVLH LSLSPDQTRV FSAAADGTAS VWNCY
	Isoform 3 [UniParc]. Checksum: 156E243FF6FF2BBE	FASTA	477	52,898
	10 20 30 40 50 60 MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT YSDFKSNFAK 70 80 90 100 110 120 RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP EASGSVLKTP PEKETLTLGS 130 140 150 160 170 180 RKEQLKTPSK GISETSNSAL HFCKAPHAMD RDWKESVASK GQKCLKQLFV TQNVVQQANG 190 200 210 220 230 240 KMQLCEQSEC VWKGCKDGVR DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS 250 260 270 280 290 300 FQNLVAIALG SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW 310 320 330 340 350 360 DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG TLRHKQAVCA 370 380 390 400 410 420 LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ STAVKICSLI WLPKTKEIAT 430 440 450 460 470 GQGTPKNDVT VWTCPTVSRS GGFFGHRGRV LHLSLSPDQT RVFSAAADGT ASVWNCY
	Isoform 4 [UniParc]. Checksum: 6C26758297E77056	FASTA	372	41,849
	10 20 30 40 50 60 MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT YSDFKSNFAK 70 80 90 100 110 120 RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP EASGSVLKTP PEKETLTLGS 130 140 150 160 170 180 RKEQLKTPSK GISETSNSAL HFCKAPHAMD RDWKESVASK GQKCLKQLFV TQNVVQQANG 190 200 210 220 230 240 KMQLCEQSEC VWKGCKDGVR DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS 250 260 270 280 290 300 FQNLVAIALG SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW 310 320 330 340 350 360 DVVTKKRLRN MLGHLSVVGA LSWNHFILSR LEFSGVISAH CNLHLPSSWD YRRPPPCLVG 370 QDWGVFIITM FG
	Isoform 5 [UniParc]. Checksum: 0AF24C360751729F	FASTA	192	21,697
	10 20 30 40 50 60 MEWKLERTAP RRVRTEEEML WVLDSVNATY SDFKSNFAKR LSAEVPVASS PITTRWQQSQ 70 80 90 100 110 120 TRALSSDSFG EEQSTTYLPE ASGSVLKTPP EKETLTLGSR KEQLKTPSKG ISETSNSALH 130 140 150 160 170 180 FCKAPHAMDR DWKESVASKG QKCLKQLFVT QNVVQQANGK MQLCEQSECV WKDHFSGSMK 190 KRFEQEDVGG KD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CDC20-like protein." Hayashi A., Saito T. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANTS CYS-121; ALA-496 AND TRP-503.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS CYS-121 AND ALA-496. Tissue: Tongue.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS CYS-121 AND ALA-496.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), VARIANTS VARIANTS CYS-121; ALA-496 AND TRP-503. Tissue: Lung and Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB077043 mRNA. Translation: BAC67701.1. AB077044 mRNA. Translation: BAB97393.1. Different initiation. AB081750 mRNA. Translation: BAC67702.1. AB086378 mRNA. Translation: BAC67705.1. AK095246 mRNA. Translation: BAC04508.1. AC091977 Genomic DNA. No translation available. CH471123 Genomic DNA. Translation: EAW54901.1. BC037547 mRNA. Translation: AAH37547.1. BC136572 mRNA. Translation: AAI36573.1.
IPI	IPI00171693. IPI00216931. IPI00384588. IPI00410318. IPI00748149.
RefSeq	NP_001139206.2. NM_001145734.2. NP_001163873.1. NM_001170402.1. NP_689836.2. NM_152623.2.
UniGene	Hs.669184.
3D structure databases
ProteinModelPortal	Q86Y33.
SMR	Q86Y33. Positions 228-519.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000296733.
PTM databases
PhosphoSite	Q86Y33.
Polymorphism databases
DMDM	302393826.
Proteomic databases
PaxDb	Q86Y33.
PRIDE	Q86Y33.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296733; ENSP00000296733; ENSG00000164287. ENST00000322374; ENSP00000315720; ENSG00000164287. ENST00000331730; ENSP00000330566; ENSG00000164287. ENST00000334206; ENSP00000335664; ENSG00000164287. ENST00000381375; ENSP00000370781; ENSG00000164287. ENST00000507931; ENSP00000423919; ENSG00000164287. ENST00000513180; ENSP00000426776; ENSG00000164287.
GeneID	166979.
KEGG	hsa:166979.
UCSC	uc003jpn.2. human. uc003jpo.2. human. uc010ivu.2. human. uc010ivv.2. human.
Organism-specific databases
CTD	166979.
GeneCards	GC05M054445.
HGNC	HGNC:24222. CDC20B.
HPA	HPA053900.
neXtProt	NX_Q86Y33.
PharmGKB	PA145149217.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2319.
HOVERGEN	HBG107630.
InParanoid	Q86Y33.
OMA	QTRVFSA.
OrthoDB	EOG4JDH6N.
Gene expression databases
Bgee	Q86Y33.
CleanEx	HS_CDC20B.
Genevestigator	Q86Y33.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 2 hits. [Graphical view]
SMART	SM00320. WD40. 5 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CDC20B. human.
GenomeRNAi	166979.
NextBio	88648.

Entry information

Entry name

CD20B_HUMAN

Accession

Primary (citable) accession number: Q86Y33
Secondary accession number(s): B7WNV8 , B9EGL8, C9J6X8, C9JHE9, C9JKL5, Q86Y31, Q86Y32, Q8IUZ8, Q8N1S1, Q8NG56

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	August 10, 2010
Last modified:	May 1, 2013
This is version 88 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.