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Q86Y33

- CD20B_HUMAN

UniProt

Q86Y33 - CD20B_HUMAN

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Protein

Cell division cycle protein 20 homolog B

Gene

CDC20B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ86Y33.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle protein 20 homolog B
Gene namesi
Name:CDC20B
ORF Names:G6VTS76519
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:24222. CDC20B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Cell division cycle protein 20 homolog BPRO_0000339110Add
BLAST

Proteomic databases

PaxDbiQ86Y33.
PRIDEiQ86Y33.

PTM databases

PhosphoSiteiQ86Y33.

Expressioni

Gene expression databases

BgeeiQ86Y33.
CleanExiHS_CDC20B.
GenevestigatoriQ86Y33.

Organism-specific databases

HPAiHPA053900.

Interactioni

Protein-protein interaction databases

BioGridi127940. 6 interactions.
STRINGi9606.ENSP00000296733.

Structurei

3D structure databases

ProteinModelPortaliQ86Y33.
SMRiQ86Y33. Positions 228-519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati229 – 26638WD 1Add
BLAST
Repeati271 – 31040WD 2Add
BLAST
Repeati311 – 34131WD 3Add
BLAST
Repeati353 – 39240WD 4Add
BLAST
Repeati399 – 44143WD 5Add
BLAST
Repeati443 – 48442WD 6Add
BLAST
Repeati487 – 51933WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat CDC20/Fizzy family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000119352.
HOVERGENiHBG107630.
InParanoidiQ86Y33.
OMAiFGHRGRV.
OrthoDBiEOG7KM5SF.
PhylomeDBiQ86Y33.
TreeFamiTF337979.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86Y33-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT
60 70 80 90 100
YSDFKSNFAK RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP
110 120 130 140 150
EASGSVLKTP PEKETLTLGS RKEQLKTPSK GISETSNSAL HFCKAPHAMD
160 170 180 190 200
RDWKESVASK GQKCLKQLFV TQNVVQQANG KMQLCEQSEC VWKGCKDGVR
210 220 230 240 250
DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS FQNLVAIALG
260 270 280 290 300
SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW
310 320 330 340 350
DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG
360 370 380 390 400
TLRHKQAVCA LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ
410 420 430 440 450
STAVKAMDWC PWQSGVLAIG GGMKDGRLHI LDINAGKSIQ TPSTNSQICS
460 470 480 490 500
LIWLPKTKEI ATGQGTPKND VTVWTCPTVS RSGGFFGHRG RVLHLSLSPD
510
QTRVFSAAAD GTASVWNCY
Length:519
Mass (Da):57,335
Last modified:August 10, 2010 - v3
Checksum:i2D40A57A4363A349
GO
Isoform 2 (identifier: Q86Y33-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     483-486: Missing.

Show »
Length:515
Mass (Da):56,927
Checksum:iC9DC5381A7EA8C6D
GO
Isoform 3 (identifier: Q86Y33-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-447: Missing.

Note: No experimental confirmation available.

Show »
Length:477
Mass (Da):52,898
Checksum:i156E243FF6FF2BBE
GO
Isoform 4 (identifier: Q86Y33-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-372: SGSRLGRVYH...WSPDGRLLSS → RLEFSGVISA...WGVFIITMFG
     373-519: Missing.

Note: No experimental confirmation available.

Show »
Length:372
Mass (Da):41,849
Checksum:i6C26758297E77056
GO
Isoform 5 (identifier: Q86Y33-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-42: Missing.
     194-213: GCKDGVRDESFHLKSSGDIN → DHFSGSMKKRFEQEDVGGKD
     214-519: Missing.

Note: No experimental confirmation available.

Show »
Length:192
Mass (Da):21,697
Checksum:i0AF24C360751729F
GO

Sequence cautioni

The sequence BAB97393.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81T → P.
Corresponds to variant rs173042 [ dbSNP | Ensembl ].
VAR_043860
Natural varianti17 – 171E → K.
Corresponds to variant rs423074 [ dbSNP | Ensembl ].
VAR_043861
Natural varianti97 – 971T → S.
Corresponds to variant rs34132993 [ dbSNP | Ensembl ].
VAR_043862
Natural varianti121 – 1211R → C.4 Publications
Corresponds to variant rs1021580 [ dbSNP | Ensembl ].
VAR_043863
Natural varianti496 – 4961S → A.4 Publications
Corresponds to variant rs3104230 [ dbSNP | Ensembl ].
VAR_043864
Natural varianti503 – 5031R → W.2 Publications
Corresponds to variant rs444527 [ dbSNP | Ensembl ].
VAR_043865

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 4221Missing in isoform 5. 1 PublicationVSP_034089Add
BLAST
Alternative sequencei194 – 21320GCKDG…SGDIN → DHFSGSMKKRFEQEDVGGKD in isoform 5. 1 PublicationVSP_034090Add
BLAST
Alternative sequencei214 – 519306Missing in isoform 5. 1 PublicationVSP_034091Add
BLAST
Alternative sequencei330 – 37243SGSRL…RLLSS → RLEFSGVISAHCNLHLPSSW DYRRPPPCLVGQDWGVFIIT MFG in isoform 4. 1 PublicationVSP_034092Add
BLAST
Alternative sequencei373 – 519147Missing in isoform 4. 1 PublicationVSP_034093Add
BLAST
Alternative sequencei406 – 44742Missing in isoform 3. 1 PublicationVSP_034094Add
BLAST
Alternative sequencei483 – 4864Missing in isoform 2. 2 PublicationsVSP_034095

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB077043 mRNA. Translation: BAC67701.1.
AB077044 mRNA. Translation: BAB97393.1. Different initiation.
AB081750 mRNA. Translation: BAC67702.1.
AB086378 mRNA. Translation: BAC67705.1.
AK095246 mRNA. Translation: BAC04508.1.
AC091977 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54901.1.
BC037547 mRNA. Translation: AAH37547.1.
BC136572 mRNA. Translation: AAI36573.1.
CCDSiCCDS3966.1. [Q86Y33-2]
CCDS47207.1. [Q86Y33-3]
CCDS54852.1. [Q86Y33-1]
RefSeqiNP_001139206.2. NM_001145734.2. [Q86Y33-3]
NP_001163873.1. NM_001170402.1. [Q86Y33-1]
NP_689836.2. NM_152623.2. [Q86Y33-2]
UniGeneiHs.669184.

Genome annotation databases

EnsembliENST00000296733; ENSP00000296733; ENSG00000164287. [Q86Y33-2]
ENST00000322374; ENSP00000315720; ENSG00000164287. [Q86Y33-3]
ENST00000381375; ENSP00000370781; ENSG00000164287. [Q86Y33-1]
ENST00000507931; ENSP00000423919; ENSG00000164287. [Q86Y33-5]
ENST00000513180; ENSP00000426776; ENSG00000164287. [Q86Y33-4]
GeneIDi166979.
KEGGihsa:166979.
UCSCiuc003jpn.2. human. [Q86Y33-2]
uc003jpo.2. human. [Q86Y33-1]
uc010ivu.2. human. [Q86Y33-3]
uc010ivv.2. human. [Q86Y33-4]

Polymorphism databases

DMDMi302393826.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB077043 mRNA. Translation: BAC67701.1 .
AB077044 mRNA. Translation: BAB97393.1 . Different initiation.
AB081750 mRNA. Translation: BAC67702.1 .
AB086378 mRNA. Translation: BAC67705.1 .
AK095246 mRNA. Translation: BAC04508.1 .
AC091977 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54901.1 .
BC037547 mRNA. Translation: AAH37547.1 .
BC136572 mRNA. Translation: AAI36573.1 .
CCDSi CCDS3966.1. [Q86Y33-2 ]
CCDS47207.1. [Q86Y33-3 ]
CCDS54852.1. [Q86Y33-1 ]
RefSeqi NP_001139206.2. NM_001145734.2. [Q86Y33-3 ]
NP_001163873.1. NM_001170402.1. [Q86Y33-1 ]
NP_689836.2. NM_152623.2. [Q86Y33-2 ]
UniGenei Hs.669184.

3D structure databases

ProteinModelPortali Q86Y33.
SMRi Q86Y33. Positions 228-519.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127940. 6 interactions.
STRINGi 9606.ENSP00000296733.

PTM databases

PhosphoSitei Q86Y33.

Polymorphism databases

DMDMi 302393826.

Proteomic databases

PaxDbi Q86Y33.
PRIDEi Q86Y33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296733 ; ENSP00000296733 ; ENSG00000164287 . [Q86Y33-2 ]
ENST00000322374 ; ENSP00000315720 ; ENSG00000164287 . [Q86Y33-3 ]
ENST00000381375 ; ENSP00000370781 ; ENSG00000164287 . [Q86Y33-1 ]
ENST00000507931 ; ENSP00000423919 ; ENSG00000164287 . [Q86Y33-5 ]
ENST00000513180 ; ENSP00000426776 ; ENSG00000164287 . [Q86Y33-4 ]
GeneIDi 166979.
KEGGi hsa:166979.
UCSCi uc003jpn.2. human. [Q86Y33-2 ]
uc003jpo.2. human. [Q86Y33-1 ]
uc010ivu.2. human. [Q86Y33-3 ]
uc010ivv.2. human. [Q86Y33-4 ]

Organism-specific databases

CTDi 166979.
GeneCardsi GC05M054445.
HGNCi HGNC:24222. CDC20B.
HPAi HPA053900.
neXtProti NX_Q86Y33.
PharmGKBi PA145149217.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000119352.
HOVERGENi HBG107630.
InParanoidi Q86Y33.
OMAi FGHRGRV.
OrthoDBi EOG7KM5SF.
PhylomeDBi Q86Y33.
TreeFami TF337979.

Enzyme and pathway databases

SignaLinki Q86Y33.

Miscellaneous databases

ChiTaRSi CDC20B. human.
GenomeRNAii 166979.
NextBioi 88648.
PROi Q86Y33.

Gene expression databases

Bgeei Q86Y33.
CleanExi HS_CDC20B.
Genevestigatori Q86Y33.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CDC20-like protein."
    Hayashi A., Saito T.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANTS CYS-121; ALA-496 AND TRP-503.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS CYS-121 AND ALA-496.
    Tissue: Tongue.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS CYS-121 AND ALA-496.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), VARIANTS VARIANTS CYS-121; ALA-496 AND TRP-503.
    Tissue: Lung and Testis.

Entry informationi

Entry nameiCD20B_HUMAN
AccessioniPrimary (citable) accession number: Q86Y33
Secondary accession number(s): B7WNV8
, B9EGL8, C9J6X8, C9JHE9, C9JKL5, Q86Y31, Q86Y32, Q8IUZ8, Q8N1S1, Q8NG56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3