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Protein

Cell division cycle protein 20 homolog B

Gene

CDC20B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ86Y33.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle protein 20 homolog B
Gene namesi
Name:CDC20B
ORF Names:G6VTS76519
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24222. CDC20B.

Pathology & Biotechi

Organism-specific databases

DisGeNETi166979.
OpenTargetsiENSG00000164287.
PharmGKBiPA145149217.

Polymorphism and mutation databases

BioMutaiCDC20B.
DMDMi302393826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003391101 – 519Cell division cycle protein 20 homolog BAdd BLAST519

Proteomic databases

PaxDbiQ86Y33.
PeptideAtlasiQ86Y33.
PRIDEiQ86Y33.

PTM databases

iPTMnetiQ86Y33.
PhosphoSitePlusiQ86Y33.

Expressioni

Gene expression databases

BgeeiENSG00000164287.
CleanExiHS_CDC20B.
GenevisibleiQ86Y33. HS.

Organism-specific databases

HPAiHPA053900.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC57Q2TAC23EBI-10260504,EBI-2808286
GOLGA2Q083793EBI-10260504,EBI-618309
KRT31Q153233EBI-10260504,EBI-948001
KRT40Q6A1623EBI-10260504,EBI-10171697
MAGEA11P43364-23EBI-10260504,EBI-10178634
MTUS2Q5JR593EBI-10260504,EBI-742948
PLK2Q9NYY33EBI-10260504,EBI-721354
SPAG5Q96R063EBI-10260504,EBI-413317
TRAF2Q129333EBI-10260504,EBI-355744
TRIM23P364063EBI-10260504,EBI-740098
TRIM27P143733EBI-10260504,EBI-719493
TRIM37O949723EBI-10260504,EBI-741602

Protein-protein interaction databases

BioGridi127940. 19 interactors.
IntActiQ86Y33. 19 interactors.
STRINGi9606.ENSP00000370781.

Structurei

3D structure databases

ProteinModelPortaliQ86Y33.
SMRiQ86Y33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati229 – 266WD 1Add BLAST38
Repeati271 – 310WD 2Add BLAST40
Repeati311 – 341WD 3Add BLAST31
Repeati353 – 392WD 4Add BLAST40
Repeati399 – 441WD 5Add BLAST43
Repeati443 – 484WD 6Add BLAST42
Repeati487 – 519WD 7Add BLAST33

Sequence similaritiesi

Belongs to the WD repeat CDC20/Fizzy family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
GeneTreeiENSGT00860000133814.
HOVERGENiHBG107630.
InParanoidiQ86Y33.
OMAiSQCVWKG.
OrthoDBiEOG091G08T6.
PhylomeDBiQ86Y33.
TreeFamiTF337979.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19918. PTHR19918. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86Y33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT
60 70 80 90 100
YSDFKSNFAK RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP
110 120 130 140 150
EASGSVLKTP PEKETLTLGS RKEQLKTPSK GISETSNSAL HFCKAPHAMD
160 170 180 190 200
RDWKESVASK GQKCLKQLFV TQNVVQQANG KMQLCEQSEC VWKGCKDGVR
210 220 230 240 250
DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS FQNLVAIALG
260 270 280 290 300
SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW
310 320 330 340 350
DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG
360 370 380 390 400
TLRHKQAVCA LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ
410 420 430 440 450
STAVKAMDWC PWQSGVLAIG GGMKDGRLHI LDINAGKSIQ TPSTNSQICS
460 470 480 490 500
LIWLPKTKEI ATGQGTPKND VTVWTCPTVS RSGGFFGHRG RVLHLSLSPD
510
QTRVFSAAAD GTASVWNCY
Length:519
Mass (Da):57,335
Last modified:August 10, 2010 - v3
Checksum:i2D40A57A4363A349
GO
Isoform 2 (identifier: Q86Y33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     483-486: Missing.

Show »
Length:515
Mass (Da):56,927
Checksum:iC9DC5381A7EA8C6D
GO
Isoform 3 (identifier: Q86Y33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-447: Missing.

Note: No experimental confirmation available.
Show »
Length:477
Mass (Da):52,898
Checksum:i156E243FF6FF2BBE
GO
Isoform 4 (identifier: Q86Y33-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-372: SGSRLGRVYH...WSPDGRLLSS → RLEFSGVISA...WGVFIITMFG
     373-519: Missing.

Note: No experimental confirmation available.
Show »
Length:372
Mass (Da):41,849
Checksum:i6C26758297E77056
GO
Isoform 5 (identifier: Q86Y33-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-42: Missing.
     194-213: GCKDGVRDESFHLKSSGDIN → DHFSGSMKKRFEQEDVGGKD
     214-519: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):21,697
Checksum:i0AF24C360751729F
GO

Sequence cautioni

The sequence BAB97393 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0438608T → P.Corresponds to variant rs173042dbSNPEnsembl.1
Natural variantiVAR_04386117E → K.Corresponds to variant rs423074dbSNPEnsembl.1
Natural variantiVAR_04386297T → S.Corresponds to variant rs34132993dbSNPEnsembl.1
Natural variantiVAR_043863121R → C.4 PublicationsCorresponds to variant rs1021580dbSNPEnsembl.1
Natural variantiVAR_043864496S → A.4 PublicationsCorresponds to variant rs3104230dbSNPEnsembl.1
Natural variantiVAR_043865503R → W.2 PublicationsCorresponds to variant rs444527dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03408922 – 42Missing in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_034090194 – 213GCKDG…SGDIN → DHFSGSMKKRFEQEDVGGKD in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_034091214 – 519Missing in isoform 5. 1 PublicationAdd BLAST306
Alternative sequenceiVSP_034092330 – 372SGSRL…RLLSS → RLEFSGVISAHCNLHLPSSW DYRRPPPCLVGQDWGVFIIT MFG in isoform 4. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_034093373 – 519Missing in isoform 4. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_034094406 – 447Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_034095483 – 486Missing in isoform 2. 2 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077043 mRNA. Translation: BAC67701.1.
AB077044 mRNA. Translation: BAB97393.1. Different initiation.
AB081750 mRNA. Translation: BAC67702.1.
AB086378 mRNA. Translation: BAC67705.1.
AK095246 mRNA. Translation: BAC04508.1.
AC091977 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54901.1.
BC037547 mRNA. Translation: AAH37547.1.
BC136572 mRNA. Translation: AAI36573.1.
CCDSiCCDS3966.1. [Q86Y33-2]
CCDS47207.1. [Q86Y33-3]
CCDS54852.1. [Q86Y33-1]
RefSeqiNP_001139206.2. NM_001145734.2. [Q86Y33-3]
NP_001163873.1. NM_001170402.1. [Q86Y33-1]
NP_689836.2. NM_152623.2. [Q86Y33-2]
UniGeneiHs.669184.

Genome annotation databases

EnsembliENST00000296733; ENSP00000296733; ENSG00000164287. [Q86Y33-2]
ENST00000322374; ENSP00000315720; ENSG00000164287. [Q86Y33-3]
ENST00000381375; ENSP00000370781; ENSG00000164287. [Q86Y33-1]
ENST00000507931; ENSP00000423919; ENSG00000164287. [Q86Y33-5]
ENST00000513180; ENSP00000426776; ENSG00000164287. [Q86Y33-4]
GeneIDi166979.
KEGGihsa:166979.
UCSCiuc003jpn.3. human. [Q86Y33-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077043 mRNA. Translation: BAC67701.1.
AB077044 mRNA. Translation: BAB97393.1. Different initiation.
AB081750 mRNA. Translation: BAC67702.1.
AB086378 mRNA. Translation: BAC67705.1.
AK095246 mRNA. Translation: BAC04508.1.
AC091977 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54901.1.
BC037547 mRNA. Translation: AAH37547.1.
BC136572 mRNA. Translation: AAI36573.1.
CCDSiCCDS3966.1. [Q86Y33-2]
CCDS47207.1. [Q86Y33-3]
CCDS54852.1. [Q86Y33-1]
RefSeqiNP_001139206.2. NM_001145734.2. [Q86Y33-3]
NP_001163873.1. NM_001170402.1. [Q86Y33-1]
NP_689836.2. NM_152623.2. [Q86Y33-2]
UniGeneiHs.669184.

3D structure databases

ProteinModelPortaliQ86Y33.
SMRiQ86Y33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127940. 19 interactors.
IntActiQ86Y33. 19 interactors.
STRINGi9606.ENSP00000370781.

PTM databases

iPTMnetiQ86Y33.
PhosphoSitePlusiQ86Y33.

Polymorphism and mutation databases

BioMutaiCDC20B.
DMDMi302393826.

Proteomic databases

PaxDbiQ86Y33.
PeptideAtlasiQ86Y33.
PRIDEiQ86Y33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296733; ENSP00000296733; ENSG00000164287. [Q86Y33-2]
ENST00000322374; ENSP00000315720; ENSG00000164287. [Q86Y33-3]
ENST00000381375; ENSP00000370781; ENSG00000164287. [Q86Y33-1]
ENST00000507931; ENSP00000423919; ENSG00000164287. [Q86Y33-5]
ENST00000513180; ENSP00000426776; ENSG00000164287. [Q86Y33-4]
GeneIDi166979.
KEGGihsa:166979.
UCSCiuc003jpn.3. human. [Q86Y33-1]

Organism-specific databases

CTDi166979.
DisGeNETi166979.
GeneCardsiCDC20B.
HGNCiHGNC:24222. CDC20B.
HPAiHPA053900.
neXtProtiNX_Q86Y33.
OpenTargetsiENSG00000164287.
PharmGKBiPA145149217.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
GeneTreeiENSGT00860000133814.
HOVERGENiHBG107630.
InParanoidiQ86Y33.
OMAiSQCVWKG.
OrthoDBiEOG091G08T6.
PhylomeDBiQ86Y33.
TreeFamiTF337979.

Enzyme and pathway databases

SignaLinkiQ86Y33.

Miscellaneous databases

ChiTaRSiCDC20B. human.
GenomeRNAii166979.
PROiQ86Y33.

Gene expression databases

BgeeiENSG00000164287.
CleanExiHS_CDC20B.
GenevisibleiQ86Y33. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19918. PTHR19918. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD20B_HUMAN
AccessioniPrimary (citable) accession number: Q86Y33
Secondary accession number(s): B7WNV8
, B9EGL8, C9J6X8, C9JHE9, C9JKL5, Q86Y31, Q86Y32, Q8IUZ8, Q8N1S1, Q8NG56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 10, 2010
Last modified: November 30, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.