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Q86Y33 (CD20B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division cycle protein 20 homolog B
Gene names
Name:CDC20B
ORF Names:G6VTS76519
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the WD repeat CDC20/Fizzy family.

Contains 7 WD repeats.

Sequence caution

The sequence BAB97393.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86Y33-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86Y33-2)

The sequence of this isoform differs from the canonical sequence as follows:
     483-486: Missing.
Isoform 3 (identifier: Q86Y33-3)

The sequence of this isoform differs from the canonical sequence as follows:
     406-447: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q86Y33-4)

The sequence of this isoform differs from the canonical sequence as follows:
     330-372: SGSRLGRVYH...WSPDGRLLSS → RLEFSGVISA...WGVFIITMFG
     373-519: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q86Y33-5)

The sequence of this isoform differs from the canonical sequence as follows:
     22-42: Missing.
     194-213: GCKDGVRDESFHLKSSGDIN → DHFSGSMKKRFEQEDVGGKD
     214-519: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Cell division cycle protein 20 homolog B
PRO_0000339110

Regions

Repeat229 – 26638WD 1
Repeat271 – 31040WD 2
Repeat311 – 34131WD 3
Repeat353 – 39240WD 4
Repeat399 – 44143WD 5
Repeat443 – 48442WD 6
Repeat487 – 51933WD 7

Natural variations

Alternative sequence22 – 4221Missing in isoform 5.
VSP_034089
Alternative sequence194 – 21320GCKDG…SGDIN → DHFSGSMKKRFEQEDVGGKD in isoform 5.
VSP_034090
Alternative sequence214 – 519306Missing in isoform 5.
VSP_034091
Alternative sequence330 – 37243SGSRL…RLLSS → RLEFSGVISAHCNLHLPSSW DYRRPPPCLVGQDWGVFIIT MFG in isoform 4.
VSP_034092
Alternative sequence373 – 519147Missing in isoform 4.
VSP_034093
Alternative sequence406 – 44742Missing in isoform 3.
VSP_034094
Alternative sequence483 – 4864Missing in isoform 2.
VSP_034095
Natural variant81T → P.
Corresponds to variant rs173042 [ dbSNP | Ensembl ].
VAR_043860
Natural variant171E → K.
Corresponds to variant rs423074 [ dbSNP | Ensembl ].
VAR_043861
Natural variant971T → S.
Corresponds to variant rs34132993 [ dbSNP | Ensembl ].
VAR_043862
Natural variant1211R → C. Ref.1 Ref.2 Ref.4 Ref.5
Corresponds to variant rs1021580 [ dbSNP | Ensembl ].
VAR_043863
Natural variant4961S → A. Ref.1 Ref.2 Ref.4 Ref.5
Corresponds to variant rs3104230 [ dbSNP | Ensembl ].
VAR_043864
Natural variant5031R → W. Ref.1 Ref.5
Corresponds to variant rs444527 [ dbSNP | Ensembl ].
VAR_043865

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 10, 2010. Version 3.
Checksum: 2D40A57A4363A349

FASTA51957,335
        10         20         30         40         50         60 
MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT YSDFKSNFAK 

        70         80         90        100        110        120 
RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP EASGSVLKTP PEKETLTLGS 

       130        140        150        160        170        180 
RKEQLKTPSK GISETSNSAL HFCKAPHAMD RDWKESVASK GQKCLKQLFV TQNVVQQANG 

       190        200        210        220        230        240 
KMQLCEQSEC VWKGCKDGVR DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS 

       250        260        270        280        290        300 
FQNLVAIALG SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW 

       310        320        330        340        350        360 
DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG TLRHKQAVCA 

       370        380        390        400        410        420 
LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ STAVKAMDWC PWQSGVLAIG 

       430        440        450        460        470        480 
GGMKDGRLHI LDINAGKSIQ TPSTNSQICS LIWLPKTKEI ATGQGTPKND VTVWTCPTVS 

       490        500        510 
RSGGFFGHRG RVLHLSLSPD QTRVFSAAAD GTASVWNCY 

« Hide

Isoform 2 [UniParc].

Checksum: C9DC5381A7EA8C6D
Show »

FASTA51556,927
Isoform 3 [UniParc].

Checksum: 156E243FF6FF2BBE
Show »

FASTA47752,898
Isoform 4 [UniParc].

Checksum: 6C26758297E77056
Show »

FASTA37241,849
Isoform 5 [UniParc].

Checksum: 0AF24C360751729F
Show »

FASTA19221,697

References

« Hide 'large scale' references
[1]"CDC20-like protein."
Hayashi A., Saito T.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANTS CYS-121; ALA-496 AND TRP-503.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS CYS-121 AND ALA-496.
Tissue: Tongue.
[3]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS CYS-121 AND ALA-496.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), VARIANTS VARIANTS CYS-121; ALA-496 AND TRP-503.
Tissue: Lung and Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB077043 mRNA. Translation: BAC67701.1.
AB077044 mRNA. Translation: BAB97393.1. Different initiation.
AB081750 mRNA. Translation: BAC67702.1.
AB086378 mRNA. Translation: BAC67705.1.
AK095246 mRNA. Translation: BAC04508.1.
AC091977 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54901.1.
BC037547 mRNA. Translation: AAH37547.1.
BC136572 mRNA. Translation: AAI36573.1.
RefSeqNP_001139206.2. NM_001145734.2.
NP_001163873.1. NM_001170402.1.
NP_689836.2. NM_152623.2.
UniGeneHs.669184.

3D structure databases

ProteinModelPortalQ86Y33.
SMRQ86Y33. Positions 228-519.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000296733.

PTM databases

PhosphoSiteQ86Y33.

Polymorphism databases

DMDM302393826.

Proteomic databases

PaxDbQ86Y33.
PRIDEQ86Y33.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296733; ENSP00000296733; ENSG00000164287. [Q86Y33-2]
ENST00000322374; ENSP00000315720; ENSG00000164287. [Q86Y33-3]
ENST00000331730; ENSP00000330566; ENSG00000164287. [Q86Y33-5]
ENST00000334206; ENSP00000335664; ENSG00000164287. [Q86Y33-4]
ENST00000381375; ENSP00000370781; ENSG00000164287. [Q86Y33-1]
ENST00000507931; ENSP00000423919; ENSG00000164287. [Q86Y33-5]
ENST00000513180; ENSP00000426776; ENSG00000164287. [Q86Y33-4]
GeneID166979.
KEGGhsa:166979.
UCSCuc003jpn.2. human. [Q86Y33-2]
uc003jpo.2. human. [Q86Y33-1]
uc010ivu.2. human. [Q86Y33-3]
uc010ivv.2. human. [Q86Y33-4]

Organism-specific databases

CTD166979.
GeneCardsGC05M054445.
HGNCHGNC:24222. CDC20B.
HPAHPA053900.
neXtProtNX_Q86Y33.
PharmGKBPA145149217.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOVERGENHBG107630.
InParanoidQ86Y33.
OMADESFHLK.
OrthoDBEOG7KM5SF.
PhylomeDBQ86Y33.
TreeFamTF337979.

Enzyme and pathway databases

SignaLinkQ86Y33.

Gene expression databases

BgeeQ86Y33.
CleanExHS_CDC20B.
GenevestigatorQ86Y33.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 2 hits.
[Graphical view]
SMARTSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCDC20B. human.
GenomeRNAi166979.
NextBio88648.
PROQ86Y33.

Entry information

Entry nameCD20B_HUMAN
AccessionPrimary (citable) accession number: Q86Y33
Secondary accession number(s): B7WNV8 expand/collapse secondary AC list , B9EGL8, C9J6X8, C9JHE9, C9JKL5, Q86Y31, Q86Y32, Q8IUZ8, Q8N1S1, Q8NG56
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 10, 2010
Last modified: April 16, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM