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Protein

Cell division cycle protein 20 homolog B

Gene

CDC20B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ86Y33.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle protein 20 homolog B
Gene namesi
Name:CDC20B
ORF Names:G6VTS76519
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24222. CDC20B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149217.

Polymorphism and mutation databases

BioMutaiCDC20B.
DMDMi302393826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Cell division cycle protein 20 homolog BPRO_0000339110Add
BLAST

Proteomic databases

PaxDbiQ86Y33.
PRIDEiQ86Y33.

PTM databases

PhosphoSiteiQ86Y33.

Expressioni

Gene expression databases

BgeeiQ86Y33.
CleanExiHS_CDC20B.
GenevisibleiQ86Y33. HS.

Organism-specific databases

HPAiHPA053900.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC57Q2TAC23EBI-10260504,EBI-2808286
GOLGA2Q083793EBI-10260504,EBI-618309
KRT31Q153233EBI-10260504,EBI-948001
KRT40Q6A1623EBI-10260504,EBI-10171697
MAGEA11P43364-23EBI-10260504,EBI-10178634
MTUS2Q5JR593EBI-10260504,EBI-742948
PLK2Q9NYY33EBI-10260504,EBI-721354
SPAG5Q96R063EBI-10260504,EBI-413317
TRAF2Q129333EBI-10260504,EBI-355744
TRIM23P364063EBI-10260504,EBI-740098
TRIM27P143733EBI-10260504,EBI-719493
TRIM37O949723EBI-10260504,EBI-741602

Protein-protein interaction databases

BioGridi127940. 19 interactions.
IntActiQ86Y33. 12 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ86Y33.
SMRiQ86Y33. Positions 228-519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati229 – 26638WD 1Add
BLAST
Repeati271 – 31040WD 2Add
BLAST
Repeati311 – 34131WD 3Add
BLAST
Repeati353 – 39240WD 4Add
BLAST
Repeati399 – 44143WD 5Add
BLAST
Repeati443 – 48442WD 6Add
BLAST
Repeati487 – 51933WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat CDC20/Fizzy family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00790000123016.
HOVERGENiHBG107630.
InParanoidiQ86Y33.
OMAiNILDWNF.
OrthoDBiEOG7KM5SF.
PhylomeDBiQ86Y33.
TreeFamiTF337979.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86Y33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT
60 70 80 90 100
YSDFKSNFAK RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP
110 120 130 140 150
EASGSVLKTP PEKETLTLGS RKEQLKTPSK GISETSNSAL HFCKAPHAMD
160 170 180 190 200
RDWKESVASK GQKCLKQLFV TQNVVQQANG KMQLCEQSEC VWKGCKDGVR
210 220 230 240 250
DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS FQNLVAIALG
260 270 280 290 300
SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW
310 320 330 340 350
DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG
360 370 380 390 400
TLRHKQAVCA LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ
410 420 430 440 450
STAVKAMDWC PWQSGVLAIG GGMKDGRLHI LDINAGKSIQ TPSTNSQICS
460 470 480 490 500
LIWLPKTKEI ATGQGTPKND VTVWTCPTVS RSGGFFGHRG RVLHLSLSPD
510
QTRVFSAAAD GTASVWNCY
Length:519
Mass (Da):57,335
Last modified:August 10, 2010 - v3
Checksum:i2D40A57A4363A349
GO
Isoform 2 (identifier: Q86Y33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     483-486: Missing.

Show »
Length:515
Mass (Da):56,927
Checksum:iC9DC5381A7EA8C6D
GO
Isoform 3 (identifier: Q86Y33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-447: Missing.

Note: No experimental confirmation available.
Show »
Length:477
Mass (Da):52,898
Checksum:i156E243FF6FF2BBE
GO
Isoform 4 (identifier: Q86Y33-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-372: SGSRLGRVYH...WSPDGRLLSS → RLEFSGVISA...WGVFIITMFG
     373-519: Missing.

Note: No experimental confirmation available.
Show »
Length:372
Mass (Da):41,849
Checksum:i6C26758297E77056
GO
Isoform 5 (identifier: Q86Y33-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-42: Missing.
     194-213: GCKDGVRDESFHLKSSGDIN → DHFSGSMKKRFEQEDVGGKD
     214-519: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):21,697
Checksum:i0AF24C360751729F
GO

Sequence cautioni

The sequence BAB97393.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81T → P.
Corresponds to variant rs173042 [ dbSNP | Ensembl ].
VAR_043860
Natural varianti17 – 171E → K.
Corresponds to variant rs423074 [ dbSNP | Ensembl ].
VAR_043861
Natural varianti97 – 971T → S.
Corresponds to variant rs34132993 [ dbSNP | Ensembl ].
VAR_043862
Natural varianti121 – 1211R → C.4 Publications
Corresponds to variant rs1021580 [ dbSNP | Ensembl ].
VAR_043863
Natural varianti496 – 4961S → A.4 Publications
Corresponds to variant rs3104230 [ dbSNP | Ensembl ].
VAR_043864
Natural varianti503 – 5031R → W.2 Publications
Corresponds to variant rs444527 [ dbSNP | Ensembl ].
VAR_043865

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 4221Missing in isoform 5. 1 PublicationVSP_034089Add
BLAST
Alternative sequencei194 – 21320GCKDG…SGDIN → DHFSGSMKKRFEQEDVGGKD in isoform 5. 1 PublicationVSP_034090Add
BLAST
Alternative sequencei214 – 519306Missing in isoform 5. 1 PublicationVSP_034091Add
BLAST
Alternative sequencei330 – 37243SGSRL…RLLSS → RLEFSGVISAHCNLHLPSSW DYRRPPPCLVGQDWGVFIIT MFG in isoform 4. 1 PublicationVSP_034092Add
BLAST
Alternative sequencei373 – 519147Missing in isoform 4. 1 PublicationVSP_034093Add
BLAST
Alternative sequencei406 – 44742Missing in isoform 3. 1 PublicationVSP_034094Add
BLAST
Alternative sequencei483 – 4864Missing in isoform 2. 2 PublicationsVSP_034095

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077043 mRNA. Translation: BAC67701.1.
AB077044 mRNA. Translation: BAB97393.1. Different initiation.
AB081750 mRNA. Translation: BAC67702.1.
AB086378 mRNA. Translation: BAC67705.1.
AK095246 mRNA. Translation: BAC04508.1.
AC091977 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54901.1.
BC037547 mRNA. Translation: AAH37547.1.
BC136572 mRNA. Translation: AAI36573.1.
CCDSiCCDS3966.1. [Q86Y33-2]
CCDS47207.1. [Q86Y33-3]
CCDS54852.1. [Q86Y33-1]
RefSeqiNP_001139206.2. NM_001145734.2. [Q86Y33-3]
NP_001163873.1. NM_001170402.1. [Q86Y33-1]
NP_689836.2. NM_152623.2. [Q86Y33-2]
UniGeneiHs.669184.

Genome annotation databases

EnsembliENST00000296733; ENSP00000296733; ENSG00000164287. [Q86Y33-2]
ENST00000322374; ENSP00000315720; ENSG00000164287. [Q86Y33-3]
ENST00000381375; ENSP00000370781; ENSG00000164287. [Q86Y33-1]
ENST00000507931; ENSP00000423919; ENSG00000164287. [Q86Y33-5]
ENST00000513180; ENSP00000426776; ENSG00000164287. [Q86Y33-4]
GeneIDi166979.
KEGGihsa:166979.
UCSCiuc003jpn.2. human. [Q86Y33-2]
uc003jpo.2. human. [Q86Y33-1]
uc010ivu.2. human. [Q86Y33-3]
uc010ivv.2. human. [Q86Y33-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077043 mRNA. Translation: BAC67701.1.
AB077044 mRNA. Translation: BAB97393.1. Different initiation.
AB081750 mRNA. Translation: BAC67702.1.
AB086378 mRNA. Translation: BAC67705.1.
AK095246 mRNA. Translation: BAC04508.1.
AC091977 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54901.1.
BC037547 mRNA. Translation: AAH37547.1.
BC136572 mRNA. Translation: AAI36573.1.
CCDSiCCDS3966.1. [Q86Y33-2]
CCDS47207.1. [Q86Y33-3]
CCDS54852.1. [Q86Y33-1]
RefSeqiNP_001139206.2. NM_001145734.2. [Q86Y33-3]
NP_001163873.1. NM_001170402.1. [Q86Y33-1]
NP_689836.2. NM_152623.2. [Q86Y33-2]
UniGeneiHs.669184.

3D structure databases

ProteinModelPortaliQ86Y33.
SMRiQ86Y33. Positions 228-519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127940. 19 interactions.
IntActiQ86Y33. 12 interactions.

PTM databases

PhosphoSiteiQ86Y33.

Polymorphism and mutation databases

BioMutaiCDC20B.
DMDMi302393826.

Proteomic databases

PaxDbiQ86Y33.
PRIDEiQ86Y33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296733; ENSP00000296733; ENSG00000164287. [Q86Y33-2]
ENST00000322374; ENSP00000315720; ENSG00000164287. [Q86Y33-3]
ENST00000381375; ENSP00000370781; ENSG00000164287. [Q86Y33-1]
ENST00000507931; ENSP00000423919; ENSG00000164287. [Q86Y33-5]
ENST00000513180; ENSP00000426776; ENSG00000164287. [Q86Y33-4]
GeneIDi166979.
KEGGihsa:166979.
UCSCiuc003jpn.2. human. [Q86Y33-2]
uc003jpo.2. human. [Q86Y33-1]
uc010ivu.2. human. [Q86Y33-3]
uc010ivv.2. human. [Q86Y33-4]

Organism-specific databases

CTDi166979.
GeneCardsiGC05M054445.
HGNCiHGNC:24222. CDC20B.
HPAiHPA053900.
neXtProtiNX_Q86Y33.
PharmGKBiPA145149217.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00790000123016.
HOVERGENiHBG107630.
InParanoidiQ86Y33.
OMAiNILDWNF.
OrthoDBiEOG7KM5SF.
PhylomeDBiQ86Y33.
TreeFamiTF337979.

Enzyme and pathway databases

SignaLinkiQ86Y33.

Miscellaneous databases

ChiTaRSiCDC20B. human.
GenomeRNAii166979.
NextBioi88648.
PROiQ86Y33.

Gene expression databases

BgeeiQ86Y33.
CleanExiHS_CDC20B.
GenevisibleiQ86Y33. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CDC20-like protein."
    Hayashi A., Saito T.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANTS CYS-121; ALA-496 AND TRP-503.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS CYS-121 AND ALA-496.
    Tissue: Tongue.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS CYS-121 AND ALA-496.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), VARIANTS VARIANTS CYS-121; ALA-496 AND TRP-503.
    Tissue: Lung and Testis.

Entry informationi

Entry nameiCD20B_HUMAN
AccessioniPrimary (citable) accession number: Q86Y33
Secondary accession number(s): B7WNV8
, B9EGL8, C9J6X8, C9JHE9, C9JKL5, Q86Y31, Q86Y32, Q8IUZ8, Q8N1S1, Q8NG56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 10, 2010
Last modified: June 24, 2015
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.