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Q86Y33

- CD20B_HUMAN

UniProt

Q86Y33 - CD20B_HUMAN

Protein

Cell division cycle protein 20 homolog B

Gene

CDC20B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    SignaLinkiQ86Y33.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division cycle protein 20 homolog B
    Gene namesi
    Name:CDC20B
    ORF Names:G6VTS76519
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:24222. CDC20B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145149217.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Cell division cycle protein 20 homolog BPRO_0000339110Add
    BLAST

    Proteomic databases

    PaxDbiQ86Y33.
    PRIDEiQ86Y33.

    PTM databases

    PhosphoSiteiQ86Y33.

    Expressioni

    Gene expression databases

    BgeeiQ86Y33.
    CleanExiHS_CDC20B.
    GenevestigatoriQ86Y33.

    Organism-specific databases

    HPAiHPA053900.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000296733.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86Y33.
    SMRiQ86Y33. Positions 228-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati229 – 26638WD 1Add
    BLAST
    Repeati271 – 31040WD 2Add
    BLAST
    Repeati311 – 34131WD 3Add
    BLAST
    Repeati353 – 39240WD 4Add
    BLAST
    Repeati399 – 44143WD 5Add
    BLAST
    Repeati443 – 48442WD 6Add
    BLAST
    Repeati487 – 51933WD 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat CDC20/Fizzy family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOVERGENiHBG107630.
    InParanoidiQ86Y33.
    OMAiFGHRGRV.
    OrthoDBiEOG7KM5SF.
    PhylomeDBiQ86Y33.
    TreeFamiTF337979.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86Y33-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT    50
    YSDFKSNFAK RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP 100
    EASGSVLKTP PEKETLTLGS RKEQLKTPSK GISETSNSAL HFCKAPHAMD 150
    RDWKESVASK GQKCLKQLFV TQNVVQQANG KMQLCEQSEC VWKGCKDGVR 200
    DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS FQNLVAIALG 250
    SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW 300
    DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG 350
    TLRHKQAVCA LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ 400
    STAVKAMDWC PWQSGVLAIG GGMKDGRLHI LDINAGKSIQ TPSTNSQICS 450
    LIWLPKTKEI ATGQGTPKND VTVWTCPTVS RSGGFFGHRG RVLHLSLSPD 500
    QTRVFSAAAD GTASVWNCY 519
    Length:519
    Mass (Da):57,335
    Last modified:August 10, 2010 - v3
    Checksum:i2D40A57A4363A349
    GO
    Isoform 2 (identifier: Q86Y33-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         483-486: Missing.

    Show »
    Length:515
    Mass (Da):56,927
    Checksum:iC9DC5381A7EA8C6D
    GO
    Isoform 3 (identifier: Q86Y33-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         406-447: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:477
    Mass (Da):52,898
    Checksum:i156E243FF6FF2BBE
    GO
    Isoform 4 (identifier: Q86Y33-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         330-372: SGSRLGRVYH...WSPDGRLLSS → RLEFSGVISA...WGVFIITMFG
         373-519: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:372
    Mass (Da):41,849
    Checksum:i6C26758297E77056
    GO
    Isoform 5 (identifier: Q86Y33-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         22-42: Missing.
         194-213: GCKDGVRDESFHLKSSGDIN → DHFSGSMKKRFEQEDVGGKD
         214-519: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:192
    Mass (Da):21,697
    Checksum:i0AF24C360751729F
    GO

    Sequence cautioni

    The sequence BAB97393.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81T → P.
    Corresponds to variant rs173042 [ dbSNP | Ensembl ].
    VAR_043860
    Natural varianti17 – 171E → K.
    Corresponds to variant rs423074 [ dbSNP | Ensembl ].
    VAR_043861
    Natural varianti97 – 971T → S.
    Corresponds to variant rs34132993 [ dbSNP | Ensembl ].
    VAR_043862
    Natural varianti121 – 1211R → C.4 Publications
    Corresponds to variant rs1021580 [ dbSNP | Ensembl ].
    VAR_043863
    Natural varianti496 – 4961S → A.4 Publications
    Corresponds to variant rs3104230 [ dbSNP | Ensembl ].
    VAR_043864
    Natural varianti503 – 5031R → W.2 Publications
    Corresponds to variant rs444527 [ dbSNP | Ensembl ].
    VAR_043865

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei22 – 4221Missing in isoform 5. 1 PublicationVSP_034089Add
    BLAST
    Alternative sequencei194 – 21320GCKDG…SGDIN → DHFSGSMKKRFEQEDVGGKD in isoform 5. 1 PublicationVSP_034090Add
    BLAST
    Alternative sequencei214 – 519306Missing in isoform 5. 1 PublicationVSP_034091Add
    BLAST
    Alternative sequencei330 – 37243SGSRL…RLLSS → RLEFSGVISAHCNLHLPSSW DYRRPPPCLVGQDWGVFIIT MFG in isoform 4. 1 PublicationVSP_034092Add
    BLAST
    Alternative sequencei373 – 519147Missing in isoform 4. 1 PublicationVSP_034093Add
    BLAST
    Alternative sequencei406 – 44742Missing in isoform 3. 1 PublicationVSP_034094Add
    BLAST
    Alternative sequencei483 – 4864Missing in isoform 2. 2 PublicationsVSP_034095

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077043 mRNA. Translation: BAC67701.1.
    AB077044 mRNA. Translation: BAB97393.1. Different initiation.
    AB081750 mRNA. Translation: BAC67702.1.
    AB086378 mRNA. Translation: BAC67705.1.
    AK095246 mRNA. Translation: BAC04508.1.
    AC091977 Genomic DNA. No translation available.
    CH471123 Genomic DNA. Translation: EAW54901.1.
    BC037547 mRNA. Translation: AAH37547.1.
    BC136572 mRNA. Translation: AAI36573.1.
    CCDSiCCDS3966.1. [Q86Y33-2]
    CCDS47207.1. [Q86Y33-3]
    CCDS54852.1. [Q86Y33-1]
    RefSeqiNP_001139206.2. NM_001145734.2. [Q86Y33-3]
    NP_001163873.1. NM_001170402.1. [Q86Y33-1]
    NP_689836.2. NM_152623.2. [Q86Y33-2]
    UniGeneiHs.669184.

    Genome annotation databases

    EnsembliENST00000296733; ENSP00000296733; ENSG00000164287. [Q86Y33-2]
    ENST00000322374; ENSP00000315720; ENSG00000164287. [Q86Y33-3]
    ENST00000381375; ENSP00000370781; ENSG00000164287. [Q86Y33-1]
    ENST00000507931; ENSP00000423919; ENSG00000164287. [Q86Y33-5]
    ENST00000513180; ENSP00000426776; ENSG00000164287. [Q86Y33-4]
    GeneIDi166979.
    KEGGihsa:166979.
    UCSCiuc003jpn.2. human. [Q86Y33-2]
    uc003jpo.2. human. [Q86Y33-1]
    uc010ivu.2. human. [Q86Y33-3]
    uc010ivv.2. human. [Q86Y33-4]

    Polymorphism databases

    DMDMi302393826.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077043 mRNA. Translation: BAC67701.1 .
    AB077044 mRNA. Translation: BAB97393.1 . Different initiation.
    AB081750 mRNA. Translation: BAC67702.1 .
    AB086378 mRNA. Translation: BAC67705.1 .
    AK095246 mRNA. Translation: BAC04508.1 .
    AC091977 Genomic DNA. No translation available.
    CH471123 Genomic DNA. Translation: EAW54901.1 .
    BC037547 mRNA. Translation: AAH37547.1 .
    BC136572 mRNA. Translation: AAI36573.1 .
    CCDSi CCDS3966.1. [Q86Y33-2 ]
    CCDS47207.1. [Q86Y33-3 ]
    CCDS54852.1. [Q86Y33-1 ]
    RefSeqi NP_001139206.2. NM_001145734.2. [Q86Y33-3 ]
    NP_001163873.1. NM_001170402.1. [Q86Y33-1 ]
    NP_689836.2. NM_152623.2. [Q86Y33-2 ]
    UniGenei Hs.669184.

    3D structure databases

    ProteinModelPortali Q86Y33.
    SMRi Q86Y33. Positions 228-519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000296733.

    PTM databases

    PhosphoSitei Q86Y33.

    Polymorphism databases

    DMDMi 302393826.

    Proteomic databases

    PaxDbi Q86Y33.
    PRIDEi Q86Y33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296733 ; ENSP00000296733 ; ENSG00000164287 . [Q86Y33-2 ]
    ENST00000322374 ; ENSP00000315720 ; ENSG00000164287 . [Q86Y33-3 ]
    ENST00000381375 ; ENSP00000370781 ; ENSG00000164287 . [Q86Y33-1 ]
    ENST00000507931 ; ENSP00000423919 ; ENSG00000164287 . [Q86Y33-5 ]
    ENST00000513180 ; ENSP00000426776 ; ENSG00000164287 . [Q86Y33-4 ]
    GeneIDi 166979.
    KEGGi hsa:166979.
    UCSCi uc003jpn.2. human. [Q86Y33-2 ]
    uc003jpo.2. human. [Q86Y33-1 ]
    uc010ivu.2. human. [Q86Y33-3 ]
    uc010ivv.2. human. [Q86Y33-4 ]

    Organism-specific databases

    CTDi 166979.
    GeneCardsi GC05M054445.
    HGNCi HGNC:24222. CDC20B.
    HPAi HPA053900.
    neXtProti NX_Q86Y33.
    PharmGKBi PA145149217.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOVERGENi HBG107630.
    InParanoidi Q86Y33.
    OMAi FGHRGRV.
    OrthoDBi EOG7KM5SF.
    PhylomeDBi Q86Y33.
    TreeFami TF337979.

    Enzyme and pathway databases

    SignaLinki Q86Y33.

    Miscellaneous databases

    ChiTaRSi CDC20B. human.
    GenomeRNAii 166979.
    NextBioi 88648.
    PROi Q86Y33.

    Gene expression databases

    Bgeei Q86Y33.
    CleanExi HS_CDC20B.
    Genevestigatori Q86Y33.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CDC20-like protein."
      Hayashi A., Saito T.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANTS CYS-121; ALA-496 AND TRP-503.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS CYS-121 AND ALA-496.
      Tissue: Tongue.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS CYS-121 AND ALA-496.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), VARIANTS VARIANTS CYS-121; ALA-496 AND TRP-503.
      Tissue: Lung and Testis.

    Entry informationi

    Entry nameiCD20B_HUMAN
    AccessioniPrimary (citable) accession number: Q86Y33
    Secondary accession number(s): B7WNV8
    , B9EGL8, C9J6X8, C9JHE9, C9JKL5, Q86Y31, Q86Y32, Q8IUZ8, Q8N1S1, Q8NG56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3