Q86Y30 (BAGE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B melanoma antigen 2

Alternative name(s):
Cancer/testis antigen 2.2
Short name=CT2.2

Gene names

Name:

BAGE2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Unknown. Candidate gene encoding tumor antigens.
Subcellular location	Secreted Potential.
Tissue specificity	Not expressed in normal tissues except in testis. Expressed in 22% of melanomas, in bladder and lung carcinomas.
Miscellaneous	The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.
Sequence similarities	Belongs to the BAGE family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 109	92	B melanoma antigen 2		PRO_0000020775
Natural variations
	Natural variant	95	1	R → T. Corresponds to variant rs2740327 [ dbSNP | Ensembl ].		VAR_059585
	Natural variant	106	1	R → Q. Corresponds to variant rs9808647 [ dbSNP | Ensembl ].		VAR_059586

Sequences

	Sequence		Length	Mass (Da)
	Q86Y30 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 5177B7AA2C2135FF	FASTA	109	12,114
	10 20 30 40 50 60 MAAGVVFLAL SAQLLQARLM KEESPVVSWR LEPEDGTALD VHFVSTLEPL SNAVKRNVPR 70 80 90 100 CIIILVLQEP TAFRISVTSS CFVQNTLTKL LKDRRKMQTV QCATARETS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile." Ruault M., van der Bruggen P., Brun M.-E., Boyle S., Roizes G., De Sario A. Eur. J. Hum. Genet. 10:833-840(2002) [PubMed: 12461691] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"BAGE genes generated by juxtacentromeric reshuffling in the hominidae lineage are under selective pressure." Ruault M., Ventura M., Galtier N., Brun M.-E., Archidiacono N., Roizes G., De Sario A. Genomics 81:391-399(2003) [PubMed: 12676563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF218570 mRNA. Translation: AAL55648.1. AK292540 mRNA. Translation: BAF85229.1. BC101132 mRNA. Translation: AAI01133.1. BC101133 mRNA. Translation: AAI01134.1.
IPI	IPI00334200.
UniGene	Hs.545789.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q86Y30.
Polymorphism databases
DMDM	37537781.
Proteomic databases
PRIDE	Q86Y30.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC21M010996.
HGNC	HGNC:15723. BAGE2.
neXtProt	NX_Q86Y30.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG050657.
Gene expression databases
ArrayExpress	Q86Y30.
Genevestigator	Q86Y30.
Family and domain databases
InterPro	IPR012530. BAGE. [Graphical view]
Pfam	PF08180. BAGE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BAGE2_HUMAN

Accession

Primary (citable) accession number: Q86Y30
Secondary accession number(s): A8K925, Q08ER0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.