Q86Y29 (BAGE3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 55.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: B melanoma antigen 3 Alternative name(s): Cancer/testis antigen 2.3 Short name=CT2.3 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 109 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Unknown. Candidate gene encoding tumor antigens. |
| Subcellular location | Secreted Potential. |
| Tissue specificity | Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lung carcinomas. |
| Miscellaneous | The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21. |
| Sequence similarities | Belongs to the BAGE family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 17 | 17 | Potential | ||||||
| Chain | 18 – 109 | 92 | B melanoma antigen 3 | PRO_0000020776 | |||||
Natural variations | |||||||||
| Natural variant | 95 | 1 | R → T. Corresponds to variant rs2740327 [ dbSNP | Ensembl ]. | VAR_059587 | |||||
| Natural variant | 106 | 1 | Q → R. Ref.3 Corresponds to variant rs9808647 [ dbSNP | Ensembl ]. | VAR_059588 | |||||
Experimental info | |||||||||
| Sequence conflict | 72 | 1 | P → A in AAI01135. Ref.3 | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile." Ruault M., van der Bruggen P., Brun M.-E., Boyle S., Roizes G., De Sario A. Eur. J. Hum. Genet. 10:833-840(2002) [PubMed: 12461691] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "BAGE genes generated by juxtacentromeric reshuffling in the hominidae lineage are under selective pressure." Ruault M., Ventura M., Galtier N., Brun M.-E., Archidiacono N., Roizes G., De Sario A. Genomics 81:391-399(2003) [PubMed: 12676563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-106. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF339514 mRNA. Translation: AAO32634.1. BC101134 mRNA. Translation: AAI01135.1. |
| IPI | IPI00329290. |
| RefSeq | NP_872287.1. NM_182481.1. |
| UniGene | Hs.545789. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q86Y29. |
Polymorphism databases | |
| DMDM | 37537780. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 85318. |
| KEGG | hsa:85318. |
Organism-specific databases | |
| CTD | 85318. |
| GeneCards | GC21M010997. |
| HGNC | HGNC:15728. BAGE3. |
| neXtProt | NX_Q86Y29. |
| PharmGKB | PA25244. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG050657. |
Gene expression databases | |
| ArrayExpress | Q86Y29. |
| Genevestigator | Q86Y29. |
Family and domain databases | |
| InterPro | IPR012530. BAGE. [Graphical view] |
| Pfam | PF08180. BAGE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 75823. |
Entry information
| Entry name | BAGE3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q86Y29 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 21 Human chromosome 21: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with