Q86Y29 (BAGE3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B melanoma antigen 3

Alternative name(s):
Cancer/testis antigen 2.3
Short name=CT2.3

Gene names

Name:

BAGE3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Unknown. Candidate gene encoding tumor antigens.
Subcellular location	Secreted Potential.
Tissue specificity	Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lung carcinomas.
Miscellaneous	The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.
Sequence similarities	Belongs to the BAGE family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 109	92	B melanoma antigen 3		PRO_0000020776
Natural variations
	Natural variant	95	1	R → T. Corresponds to variant rs2740327 [ dbSNP | Ensembl ].		VAR_059587
	Natural variant	106	1	Q → R. Ref.3 Corresponds to variant rs9808647 [ dbSNP | Ensembl ].		VAR_059588
Experimental info
	Sequence conflict	72	1	P → A in AAI01135. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q86Y29 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: A477B7A8FC3A2F4E	FASTA	109	12,112
	10 20 30 40 50 60 MAAGVVFLAL SAQLLQARLM KEESPVVSWR LEPEDGTALD VHFVSTLEPL SNAVKRNVPR 70 80 90 100 CIIILVLQEP TPFRISVTSS CFVQNTLTKL LKDRRKMQTV QCATAQETS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile." Ruault M., van der Bruggen P., Brun M.-E., Boyle S., Roizes G., De Sario A. Eur. J. Hum. Genet. 10:833-840(2002) [PubMed: 12461691] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"BAGE genes generated by juxtacentromeric reshuffling in the hominidae lineage are under selective pressure." Ruault M., Ventura M., Galtier N., Brun M.-E., Archidiacono N., Roizes G., De Sario A. Genomics 81:391-399(2003) [PubMed: 12676563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-106.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF339514 mRNA. Translation: AAO32634.1. BC101134 mRNA. Translation: AAI01135.1.
IPI	IPI00329290.
RefSeq	NP_872287.1. NM_182481.1.
UniGene	Hs.545789.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q86Y29.
Polymorphism databases
DMDM	37537780.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	85318.
KEGG	hsa:85318.
Organism-specific databases
CTD	85318.
GeneCards	GC21M010997.
HGNC	HGNC:15728. BAGE3.
neXtProt	NX_Q86Y29.
PharmGKB	PA25244.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG050657.
Gene expression databases
ArrayExpress	Q86Y29.
Genevestigator	Q86Y29.
Family and domain databases
InterPro	IPR012530. BAGE. [Graphical view]
Pfam	PF08180. BAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	75823.

Entry information

Entry name

BAGE3_HUMAN

Accession

Primary (citable) accession number: Q86Y29

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.