Reviewed, UniProtKB/Swiss-Prot Q86Y28 (BAGE4_HUMAN)

Names and origin

Protein names

Recommended name:
    B melanoma antigen 4
Alternative name(s):
    Cancer/testis antigen 2.4
      Short name=CT2.4

Gene names

Name:	BAGE4
Synonyms:	MLL3P

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	39 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Unknown. Candidate gene encoding tumor antigens.
Subcellular location	SecretedPotential.
Tissue specificity	Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lung carcinomas.
Miscellaneous	The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.
Sequence similarities	Belongs to the BAGE family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 39	22	B melanoma antigen 4		PRO_0000020777

Sequences

	Sequence		Length	Mass (Da)
	Q86Y28-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0016A0A6D0266FFF	FASTA	39	4,230
	10 20 30 MAAGAVFLAL SAQLLQARLM KEESPVVSWW LEPEDGTAL

References

[1]	"BAGE a family of centromeric genes coding for tumor antigens." Ruault M., Rocchi M., Boyle S., Roizes G., van der Bruggen P., De Sario A. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF339515 mRNA. Translation: AAO32635.1.
RefSeq	NP_859055.1.
UniGene	Hs.545789
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000187172. Homo sapiens. [Contig view]
GeneID	85317.
KEGG	hsa:85317.
Organism-specific databases
HGNC	HGNC:15730. BAGE4.
PharmGKB	PA25245.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q86Y28.
Family and domain databases
InterPro	IPR012530. BAGE. [Graphical view]
Pfam	PF08180. BAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	75819.

Entry information

Entry name

BAGE4_HUMAN

Accession

Primary (citable) accession number: Q86Y28

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	June 1, 2003
Last modified:	November 4, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)