Q86Y28 (BAGE4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B melanoma antigen 4

Alternative name(s):
Cancer/testis antigen 2.4
Short name=CT2.4

Gene names

Name:	BAGE4
Synonyms:	MLL3P

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	39 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Unknown. Candidate gene encoding tumor antigens.
Subcellular location	Secreted Potential.
Tissue specificity	Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lung carcinomas.
Miscellaneous	The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.
Sequence similarities	Belongs to the BAGE family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 39	22	B melanoma antigen 4		PRO_0000020777

Sequences

	Sequence		Length	Mass (Da)
	Q86Y28 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0016A0A6D0266FFF	FASTA	39	4,230
	10 20 30 MAAGAVFLAL SAQLLQARLM KEESPVVSWW LEPEDGTAL

References

[1]	"BAGE a family of centromeric genes coding for tumor antigens." Ruault M., Rocchi M., Boyle S., Roizes G., van der Bruggen P., De Sario A. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF339515 mRNA. Translation: AAO32635.1.
IPI	IPI00329289.
RefSeq	NP_859055.1. NM_181704.1.
UniGene	Hs.545789.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q86Y28.
Polymorphism databases
DMDM	37537779.
Proteomic databases
PRIDE	Q86Y28.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	85317.
KEGG	hsa:85317.
Organism-specific databases
CTD	85317.
GeneCards	GC21M014741.
HGNC	HGNC:15730. BAGE4.
neXtProt	NX_Q86Y28.
PharmGKB	PA25245.
GenAtlas	Search...
Gene expression databases
ArrayExpress	Q86Y28.
Genevestigator	Q86Y28.
Family and domain databases
InterPro	IPR012530. BAGE. [Graphical view]
Pfam	PF08180. BAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	75819.

Entry information

Entry name

BAGE4_HUMAN

Accession

Primary (citable) accession number: Q86Y28

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.